scholarly journals Sex Hormone Receptor Expression in Craniopharyngiomas and Association with Tumor Aggressiveness Characteristics

2022 ◽  
Vol 11 (1) ◽  
pp. 281
Author(s):  
Antonio Martínez-Ortega ◽  
Álvaro Flores-Martinez ◽  
Eva Venegas-Moreno ◽  
Elena Dios ◽  
Diego Del Can ◽  
...  
Keyword(s):  
Hormone Receptors ◽  
Progesterone Receptors ◽  
Estrogen Receptor Α ◽  
Primary Treatment ◽  
Sex Hormone ◽  
Receptor Expression ◽  
Benign Tumors ◽  
High Recurrence Rate ◽  
Tumor Aggressiveness ◽  
Embryonic Origin

Craniopharyngiomas (CPs) are rare tumors of the sellar and suprasellar regions of embryonic origin. The primary treatment for CPs is surgery but it is often unsuccessful. Although CPs are considered benign tumors, they display a relatively high recurrence rate that might compromise quality of life. Previous studies have reported that CPs express sex hormone receptors, including estrogen and progesterone receptors. Here, we systematically analyzed estrogen receptor α (ERα) and progesterone receptor (PR) expression by immunohistochemistry in a well-characterized series of patients with CP (n = 41) and analyzed their potential association with tumor aggressiveness features. A substantial proportion of CPs displayed a marked expression of PR. However, most CPs expressed low levels of ERα. No major association between PR and ERα expression and clinical aggressiveness features was observed in CPs. Additionally, in our series, β-catenin accumulation was not related to tumor recurrence.

scholarly journals Sex Hormone Receptor Signaling in Bladder Cancer: A Potential Target for Enhancing the Efficacy of Conventional Non-Surgical Therapy

Cells ◽  
2021 ◽  
Vol 10 (5) ◽  
pp. 1169
Author(s):  
Hiroki Ide ◽  
Hiroshi Miyamoto
Keyword(s):  
Bladder Cancer ◽  
Estrogen Receptor ◽  
Androgen Receptor ◽  
Surgical Therapy ◽  
Urothelial Cancer ◽  
Hormone Receptors ◽  
Estrogen Receptor Α ◽  
Vital Role ◽  
Sex Hormone ◽  
Sex Steroid Hormone

There have been critical problems in the non-surgical treatment for bladder cancer, especially residence to intravesical pharmacotherapy, including BCG immunotherapy, cisplatin-based chemotherapy, and radiotherapy. Recent preclinical and clinical evidence has suggested a vital role of sex steroid hormone-mediated signaling in the progression of urothelial cancer. Moreover, activation of the androgen receptor and estrogen receptor pathways has been implicated in modulating sensitivity to conventional non-surgical therapy for bladder cancer. This may indicate the possibility of anti-androgenic and anti-estrogenic drugs, apart from their direct anti-tumor activity, to function as sensitizers of such conventional treatment. This article summarizes available data suggesting the involvement of sex hormone receptors, such as androgen receptor, estrogen receptor-α, and estrogen receptor-β, in the progression of urothelial cancer, focusing on their modulation for the efficacy of conventional therapy, and discusses their potential of overcoming therapeutic resistance.

Expression of androgen and progesterone receptors in primary human meningiomas

1993 ◽  
Vol 78 (3) ◽  
pp. 456-462 ◽  
Author(s):  
Marius Maxwell ◽  
Theofanis Galanopoulos ◽  
Janine Neville-Golden ◽  
Harry N. Antoniades
Keyword(s):  
Cellular Localization ◽  
Hormone Receptors ◽  
Progesterone Receptors ◽  
Protein Product ◽  
Receptor Expression ◽  
Direct Evaluation ◽  
Content Type ◽  
Messenger Ribonucleic Acid ◽  
Human Meningiomas

✓ Meningiomas are common brain tumors that show a predilection for females and become more aggressive during pregnancy and menses. The existence of gender-specific hormone receptors in meningiomas has long been a matter of controversy; the recent cloning of androgen, estrogen, and progesterone receptors has facilitated their direct evaluation. The authors have demonstrated the expression of androgen and progesterone receptor messenger ribonucleic acid and protein product in nine primary human meningiomas by Northern blot analysis. Cellular localization was achieved by in situ hybridization analysis. Estrogen receptor expression was not detected. Normal adult meninges were shown to express very low levels of both androgen and progesterone receptors.

Expression and clinical significance of Ki-67, oestrogen and progesterone receptors in acoustic neuroma

2007 ◽  
Vol 122 (2) ◽  
pp. 125-127 ◽  
Author(s):  
S Cafer ◽  
I Bayramoglu ◽  
N Uzum ◽  
M Yilmaz ◽  
L Memis ◽  
...  
Keyword(s):  
Progesterone Receptor ◽  
Acoustic Neuroma ◽  
Oestrogen Receptor ◽  
Hormone Receptors ◽  
Tumour Size ◽  
Progesterone Receptors ◽  
Inhibitory Effect ◽  
Receptor Expression ◽  
Ki 67 ◽  
Tissue Samples

AbstractObjective:The objective was to assess the presence of Ki-67, and oestrogen and progesterone hormone receptors as well as their clinical correlates in acoustic neuroma.Methods:Medical records of 59 patients who were operated on for acoustic neuroma between 1995 and 2003 were evaluated retrospectively. Formaldehyde-fixed paraffin-embedded archival acoustic neuroma specimens of the patients were used for immunohistochemical assessments of oestrogen and progesterone hormone receptors, and Ki-67 proliferative marker.Results:Tumour sizes were small (<19 mm), medium (20–39 mm) and large (>40 mm) in 21, 35 and 3 patients, respectively. On immunohistochemistry, all samples were (+) for progesterone receptor and (–) for oestrogen receptor staining. Ki-67 staining was encountered in 34 of 59 (57.6 per cent) patients, and Ki-67 values ranged from 0 per cent to 10.9 per cent (mean 1.36 per cent). There was no correlation between Ki-67, gender, tumour size and symptoms of the patients (p > 0.05).Conclusion:Oestrogen is not an important hormone in acoustic neuroma due to the absence of oestrogen receptor expression in the tissue samples. Since the progesterone receptor is expressed in all acoustic neuroma samples, further studies are necessary to find out about the inhibitory effect of antiprogesterone treatment on acoustic neuroma growth, which may be important particularly in elderly people or high-risk patients. Although Ki-67 is expressed in the majority of acoustic neuromas, it is not an important marker in clinical practice due to a lack of any correlation with the clinical parameters.

scholarly journals Hormone receptor expression in human fascial tissue

2016 ◽  
Author(s):  
C. Fede ◽  
G. Albertin ◽  
L. Petrelli ◽  
M.M. Sfriso ◽  
C. Biz ◽  
...  
Keyword(s):  
Extracellular Matrix ◽  
Hormone Receptor ◽  
Hormone Receptors ◽  
Myofascial Pain ◽  
Sex Hormone ◽  
Receptor Expression ◽  
Adult Women ◽  
Hormonal Factors ◽  
Hormone Receptor Expression ◽  
Post Menopausal

Many epidemiologic, clinical, and experimental findings point to sex differences in myofascial pain in view of the fact that adult women tend to have more myofascial problems with respect to men. It is possible that one of the stimuli to sensitization of fascial nociceptors could come from hormonal factors such as estrogen and relaxin, that are involved in extracellular matrix and collagen remodeling and thus contribute to functions of myofascial tissue. Immunohistochemical and molecular investigations (real-time PCR analysis) of relaxin receptor 1 (RXFP1) and estrogen receptor-alpha (ERα) localization were carried out on sample of human fascia collected from 8 volunteers patients during orthopedic surgery (all females, between 42 and 70 yrs, divided into pre- and post-menopausal groups), and in fibroblasts isolated from deep fascia, to examine both protein and RNA expression levels. We can assume that the two sex hormone receptors analyzed are expressed in all the human fascial districts examined and in fascial fibroblasts culture cells, to a lesser degree in the post-menopausal with respect to the pre-menopausal women. Hormone receptor expression was concentrated in the fibroblasts, and RXFP1 was also evident in blood vessels and nerves. Our results are the first demonstrating that the fibroblasts located within different districts of the muscular fasciae express sex hormone receptors and can help to explain the link between hormonal factors and myofascial pain. It is known, in fact, that estrogen and relaxin play a key role in extracellular matrix remodeling by inhibiting fibrosis and inflammatory activities, both important factors affecting fascial stiffness and sensitization of fascial nociceptors.

Sex hormone receptors in varicose veins of women with premenstrual syndrome

Phlebologie ◽  
2008 ◽  
Vol 37 (02) ◽  
pp. 68-72 ◽  
Author(s):  
L. Dzieciuchowicz ◽  
M. Kotwicka ◽  
M. Gabriel ◽  
A. Szczęśniak-Chmielecka ◽  
B. Krasińska ◽  
...  
Keyword(s):  
Smooth Muscle ◽  
Smooth Muscle Cells ◽  
Sex Hormones ◽  
Hormone Receptors ◽  
Varicose Veins ◽  
Progesterone Receptors ◽  
Muscle Cells ◽  
Sex Hormone ◽  
Estrogen And Progesterone Receptors ◽  
Premenstrual Tension

SummaryThe pathogenesis of premenstrual tension syndrome is not fully understood. It has been hypothesized that the interaction between sex hormones and target organs is the key event in its pathogenesis. Aim: The purpose of the study was to examine the differences in the prevalence of smooth muscle cells with sex hormones receptors in varicose veins of women with and without premenstrual tension syndrome (PS). Patients, methods: Samples of great saphenous vein were obtained from 50 women during varicose vein surgery. They were divided into group I (20 women with clinically diagnosed PS) and group II (30 women without PS). Estrogen and progesterone receptors were detected with an immunohistochemical method. Superficial densities of smooth muscle cells positive to estrogen and progesterone receptors were analyzed with densitometric program IM-AN and automatic image analyzer Magicall. The results were compared with t-Student test. Results: There were no differences in superficial density of smooth muscle cells positive to estrogen receptors between the groups. In contradiction to this, superficial density of smooth muscle cells positive to progesterone receptors was higher in group with PS than in patients without, 343 (±171) and 240 (±123), respectively. The difference was statistically significant (p < 0.05). Conclusion: The amount of cells with sex hormone receptors, not the level of hormones, could play a role in PS pathology. Our results show that progesterone is more important than estrogen in effector organs.

Solitary and Multiple Meningiomas: an Immunohistochemical Comparison

2015 ◽  
Vol 15 (1) ◽  
pp. 23-28
Author(s):  
Baiba Vikmane ◽  
Arvids Jakovlevs ◽  
Andrejs Vanags ◽  
Ilze Strumfa
Keyword(s):  
Cell Proliferation ◽  
Cell Adhesion ◽  
Hormone Receptor ◽  
Progesterone Receptors ◽  
Sex Hormone ◽  
Receptor Expression ◽  
Proliferation Index ◽  
Histological Types ◽  
Multiple Meningiomas ◽  
Sex Hormone Receptor

SummaryIntroduction. Meningiomas are common primary tumors of brain meninges. These neoplasms develop from arachnoid cap cells and are multiple in 1 - 10% cases. Occasionally, significantly higher multiplicity rates have been reported, at least partially due to the increased application of computed tomography and magnetic resonance imaging in the diagnostics of intracranial pathologies. Meningiomas generally express progesterone receptors, but only few studies have focused on sex hormone receptor differences between solitary and multiple meningiomas. Similarly, there is limited information on cell proliferation and adhesion factors in solitary and multiple meningiomas.Aim of the study. Was to evaluate the immunohistochemical differences in sex hormone receptor expression, cell proliferation and adhesion within solitary and multiple meningiomas.Material and methods. In a retrospective study, 11 consecutive multiple meningiomas and 20 grade-matched solitary meningiomas were assessed by immunohistochemistry (IHC) to detect estrogen receptors (ER), progesterone receptors (PR), Ki-67 and neural cell adhesion molecule (NCAM). IHC was followed by quantitative microscopic evaluation. Descriptive and inferential statistics was applied including confidence interval (CI) analysis, Mann-Whitney U test and Spearmen correlation by IBM SPSS Statistics 22.0 software; p values less than 0.05 were regarded as statistically significant.Results. Although PR were found in all samples, the mean expression was significantly lower in multiple meningiomas (p = 0.03): 30.0% (95% CI: 10.4 - 49.8) versus 70.6% (95% CI: 56.6 - 84.7) in solitary meningiomas. ER were invariably absent in both groups. The proliferation index did not differ in solitary and multiple tumors. There was a trend (p = 0.07) to higher mean expression of NCAM in multiple meningiomas than in control group: 48.3% (95% CI: 25.8 - 70.8) versus 24.6% (95% CI: 13.2 - 36.0), respectively. The multiple meningiomas showed diverse histological types and immunophenotypes in up to 33.3% patients.Conclusions. Multiple meningiomas are characterized by significant down-regulation of PR and up-regulation of NCAM. The last finding can indicate neural differentiation and/ or peculiarities of cell adhesion and signaling that facilitate multifocal proliferation. Diverse histological types as well as PR and NCAM expression in separate meningiomas within same patient indicate independent multicentric origin.

scholarly journals Androgen and Estrogen Receptor Expression in Different Types of Perianal Gland Tumors in Male Dogs

Animals ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 875
Author(s):  
Adam Brodzki ◽  
Wojciech Łopuszyński ◽  
Yolanda Millan ◽  
Marcin R. Tatara ◽  
Piotr Brodzki ◽  
...  
Keyword(s):  
Hormone Receptors ◽  
Histopathological Examination ◽  
Sex Hormone ◽  
Receptor Expression ◽  
Neoplastic Progression ◽  
Hormonal Stimulation ◽  
Antihormonal Treatment ◽  
Therapeutic Algorithm ◽  
Immunohistochemical Assessment

Perianal gland tumors are modified sebaceous glands present in the skin of the perianal region in the dog. Hormonal stimulation may induce hyperplasia of the perianal glands or their neoplastic progression. The presence of androgen (AR) and estrogen (ER) receptors have been demonstrated both in normal perianal glands as well as in perianal tumors. The aim of the study was an immunohistochemical assessment of the expression of estrogen and androgen receptors in perianal gland tumors in dogs as an applicatory marker for antihormonal treatment. Biopsy samples of perianal masses were collected from 41 male dogs. A histopathological examination revealed 24 adenomas, 12 epitheliomas and five carcinomas. The immunohistochemical staining showed a mainly nuclear expression of AR and ER in the neoplastic cells. Both the androgen and estrogen receptors were expressed in adenoma, epithelioma and carcinoma cases; however, the highest expression of the receptors was stated in the adenoma and epithelioma. In the case of the carcinoma, the expression of sex hormone receptors was very weak. The differences of the number of cells expressing AR and ER as well as the observed differentiated intensity of staining in the studies demonstrated that the determination of the expression of the sex hormone receptors may be useful to elaborate a diagnostic and therapeutic algorithm.

scholarly journals Regulation of mRNA Translation by Hormone Receptors in Breast and Prostate Cancer

Cancers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 3254
Author(s):  
Jianling Xie ◽  
Eric P. Kusnadi ◽  
Luc Furic ◽  
Luke A. Selth
Keyword(s):  
Prostate Cancer ◽  
Protein Synthesis ◽  
Causes Of Death ◽  
Hormone Receptors ◽  
Mrna Translation ◽  
Estrogen Receptor Α ◽  
Growth And Survival ◽  
Cancer Types ◽  
Breast And Prostate Cancer ◽  
Hormone Signalling

Breast and prostate cancer are the second and third leading causes of death amongst all cancer types, respectively. Pathogenesis of these malignancies is characterised by dysregulation of sex hormone signalling pathways, mediated by the estrogen receptor-α (ER) in breast cancer and androgen receptor (AR) in prostate cancer. ER and AR are transcription factors whose aberrant function drives oncogenic transcriptional programs to promote cancer growth and progression. While ER/AR are known to stimulate cell growth and survival by modulating gene transcription, emerging findings indicate that their effects in neoplasia are also mediated by dysregulation of protein synthesis (i.e., mRNA translation). This suggests that ER/AR can coordinately perturb both transcriptional and translational programs, resulting in the establishment of proteomes that promote malignancy. In this review, we will discuss relatively understudied aspects of ER and AR activity in regulating protein synthesis as well as the potential of targeting mRNA translation in breast and prostate cancer.

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