scholarly journals Individualized Hemodynamic Management in Sepsis

2021 ◽  
Vol 11 (2) ◽  
pp. 157
Author(s):  
Marcell Virág ◽  
Tamas Leiner ◽  
Mate Rottler ◽  
Klementina Ocskay ◽  
Zsolt Molnar
Keyword(s):  
Fluid Overload ◽  
Fluid Management ◽  
Multiple Organ ◽  
Treatment Protocols ◽  
Hemodynamic Management ◽  
New Approach ◽  
Hemodynamic Optimization ◽  
The Individual ◽  
Sepsis And Septic Shock ◽  
Insight Into

Hemodynamic optimization remains the cornerstone of resuscitation in the treatment of sepsis and septic shock. Delay or inadequate management will inevitably lead to hypoperfusion, tissue hypoxia or edema, and fluid overload, leading eventually to multiple organ failure, seriously affecting outcomes. According to a large international survey (FENICE study), physicians frequently use inadequate indices to guide fluid management in intensive care units. Goal-directed and “restrictive” infusion strategies have been recommended by guidelines over “liberal” approaches for several years. Unfortunately, these “fixed regimen” treatment protocols neglect the patient’s individual needs, and what is shown to be beneficial for a given population may not be so for the individual patient. However, applying multimodal, contextualized, and personalized management could potentially overcome this problem. The aim of this review was to give an insight into the pathophysiological rationale and clinical application of this relatively new approach in the hemodynamic management of septic patients.

scholarly journals Viscero-somatic integration: new therapeutic proposals through integrated thermal cures (CIT)

2021 ◽  
pp. 29-34
Author(s):  
Barassi Giovanni ◽  
Irace Giuseppe ◽  
Di Iulio Antonella ◽  
Di Stefano Giuseppe ◽  
Di Simone Edoardo ◽  
...  
Keyword(s):  
Therapeutic Effect ◽  
Therapeutic Target ◽  
Gold Standard ◽  
Treatment Protocols ◽  
New Approach ◽  
Thermal Care ◽  
Thermal Therapies ◽  
The Creation ◽  
Mud Therapy ◽  
The Individual

Traditional thermal medicine, gold standard for some pathologies, focuses its therapeutic target mainly on a sectorial level, focusing only on the pathological symptom and neglecting man as a whole. The importance of the whole, of the phenomena of systemic, viscero-somatic and somato-visceral interrelation, has led to the creation of a new approach called "CTI" - Integrated Thermal Care, which uses all the thermal therapies, integrated and administered according to the individual needs to enhance their therapeutic effect. 235 subjects have received, on average, 40 treatments within about a year. They were treated with hydropinic treatment, inhalation treatments, hydrokinesitherapy, vascular pathways, mud therapy and manual neuromuscular therapy associated with the previous treatments. The results obtained in all the FIM, VAS, TINETTI, EUROQOL scales are positive and statistically significant, which suggests that a modification of the treatment protocols, which provides for a unique and integrated stimulation, is the new objective of thermal medicine for serious disabilities.

In silico modeling of cellular probabilistic nanoparticle radiosensitization in head and neck cancers

Nanomedicine ◽  
2020 ◽  
Vol 15 (29) ◽  
pp. 2837-2850
Author(s):  
Myxuan Huynh ◽  
Ivan Kempson ◽  
Eva Bezak ◽  
Wendy Phillips
Keyword(s):  
Head And Neck ◽  
Patient Outcomes ◽  
Head And Neck Cancers ◽  
New Approach ◽  
Treatment Regimens ◽  
Therapeutic Benefits ◽  
In Silico Modeling ◽  
The Individual ◽  
Dose Deposition ◽  
Therapy Treatment

Background: The use of gold nanoparticles (AuNPs) as radiosensitizers may offer a new approach in the treatment of head and neck cancers; minimizing treatment-associated toxicities and improving patient outcomes. AuNPs promote localized dose deposition; permitting improved local control and/or dose reduction. Aim: This work aimed to address the theoretical optimization of radiation doses, fractionation and nanoparticle injection schedules to maximize therapeutic benefits. Materials & methods: Probabilistic nanoparticle sensitization factors were incorporated into the individual cell-based HYP-RT computer model of tumor growth and radiotherapy. Results: Total dose outcomes across all radiation therapy treatment regimens were found to be significantly reduced with the presence of AuNPs, with bi-weekly injections showing the most decrease. Conclusion: Outcomes suggest the need for regular AuNP administration to permit effective radiosensitization.

What Can Economists Contribute to the Common Good Tradition?

2017 ◽  
Author(s):  
Andrew M. Yuengert
Keyword(s):  
Common Good ◽  
Common Pool Resources ◽  
Economic Approach ◽  
Public And Private ◽  
Private Provision ◽  
The Public ◽  
The Common Good ◽  
The Common ◽  
The Individual ◽  
Insight Into

Although most economists are skeptical of or puzzled by the Catholic concept of the common good, a rejection of the economic approach as inimical to the common good would be hasty and counterproductive. Economic analysis can enrich the common good tradition in four ways. First, economics embodies a deep respect for economic agency and for the effects of policy and institutions on individual agents. Second, economics offers a rich literature on the nature of unplanned order and how it might be shaped by policy. Third, economics offers insight into the public and private provision of various kinds of goods (private, public, common pool resources). Fourth, recent work on the development and logic of institutions and norms emphasizes sustainability rooted in the good of the individual.

Guideline for the management of long tunnelled external ventricular drains in chronic hydrocephalus

2021 ◽  
Vol 30 (7) ◽  
pp. 416-421
Author(s):  
Phillip Correia Copley ◽  
John Emelifeonwu ◽  
Pasquale Gallo ◽  
Drahoslav Sokol ◽  
Jothy Kandasamy ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Nursing Care ◽  
Pilocytic Astrocytoma ◽  
Parental Education ◽  
Chronic Hydrocephalus ◽  
Treatment Protocols ◽  
New Approach ◽  
Viable Treatment

This article reports on the journey of a child with an inoperable hypothalamic-origin pilocytic astrocytoma causing hydrocephalus, which was refractory to treatment with shunts, and required a new approach. With multidisciplinary support, excellent nursing care and parental education, the child's hydrocephalus was managed long term in the community with bilateral long-tunnelled external ventricular drains (LTEVDs). This article describes the patient's journey and highlights the treatment protocols that were created to achieve this feat. Despite the difficulties in initially setting up these protocols, they proved successful and thus the team managing the patient proposed that LTEVDs are a viable treatment option for children with hydrocephalus in the context of inoperable tumours to help maximise quality of life.

The Role of Histones and Heparin in Sepsis: A Review

2021 ◽  
pp. 088506662199232
Author(s):  
Xiaojuan Zhang ◽  
Xin Li
Keyword(s):  
Septic Shock ◽  
Multiple Organ ◽  
Clinical Settings ◽  
The Past ◽  
Life Saving ◽  
Extracellular Histones ◽  
Sepsis And Septic Shock ◽  
Development And Management ◽  
Made In

Septic shock with multiple organ failure is a devastating situation in clinical settings. Through the past decades, much progress has been made in the management of sepsis and its underlying pathogenesis, but a highly effective therapeutic has not been developed. Recently, macromolecules such as histones have been targeted in the treatment of sepsis. Histones primarily function as chromosomal organizers to pack DNA and regulate its transcription through epigenetic mechanisms. However, a growing body of research has shown that histone family members can also exert cellular toxicity once they relocate from the nucleus into the extracellular space. Heparin, a commonly used anti-coagulant, has been shown to possess life-saving capabilities for septic patients, but the potential interplay between heparin and extracellular histones has not been investigated. In this review, we summarize the pathogenic roles of extracellular histones and the therapeutic roles of heparin in the development and management of sepsis and septic shock.

scholarly journals Intra-Colonial Viral Infections in Western Honey Bees (Apis mellifera)

2021 ◽  
Vol 9 (5) ◽  
pp. 1087
Author(s):  
Loreley Castelli ◽  
María Laura Genchi García ◽  
Anne Dalmon ◽  
Daniela Arredondo ◽  
Karina Antúnez ◽  
...  
Keyword(s):  
Apis Mellifera ◽  
Honey Bee ◽  
Viral Infections ◽  
Sampling Period ◽  
Virus Genome ◽  
The Individual ◽  
Bee Virus ◽  
Insight Into ◽  
Bee Viruses

RNA viruses play a significant role in the current high losses of pollinators. Although many studies have focused on the epidemiology of western honey bee (Apis mellifera) viruses at the colony level, the dynamics of virus infection within colonies remains poorly explored. In this study, the two main variants of the ubiquitous honey bee virus DWV as well as three major honey bee viruses (SBV, ABPV and BQCV) were analyzed from Varroa-destructor-parasitized pupae. More precisely, RT-qPCR was used to quantify and compare virus genome copies across honey bee pupae at the individual and subfamily levels (i.e., patrilines, sharing the same mother queen but with different drones as fathers). Additionally, virus genome copies were compared in cells parasitized by reproducing and non-reproducing mite foundresses to assess the role of this vector. Only DWV was detected in the samples, and the two variants of this virus significantly differed when comparing the sampling period, colonies and patrilines. Moreover, DWV-A and DWV-B exhibited different infection patterns, reflecting contrasting dynamics. Altogether, these results provide new insight into honey bee diseases and stress the need for more studies about the mechanisms of intra-colonial disease variation in social insects.

scholarly journals Can Economic Factors Improve Momentum Trading Strategies? The Case of Managed Futures during the COVID-19 Pandemic

Economies ◽  
2021 ◽  
Vol 9 (2) ◽  
pp. 86
Author(s):  
Renata Guobužaitė ◽  
Deimantė Teresienė
Keyword(s):  
Financial Markets ◽  
Risk Premium ◽  
Trading Strategies ◽  
Economic Factors ◽  
Momentum Strategies ◽  
New Approach ◽  
Managed Futures ◽  
Asset Classes ◽  
Momentum Trading ◽  
Insight Into

Systematic momentum trading is a prevalent risk premium strategy in different portfolios. This paper focuses on the performance of the managed futures strategy based on the momentum signal across different economic regimes, focusing on the COVID-19 pandemic period. COVID-19 had a solid but short-lived impact on financial markets, and therefore gives a unique insight into momentum strategies’ performance during such critical moments of market stress. We offer a new approach to implementing momentum strategies by adding macroeconomic variables to the model. We test a managed futures strategy’s performance with a well-diversified futures portfolio across different asset classes. The research concludes that constructing a portfolio based on academically/economically sound momentum signals with its allocation timing based on broader economic factors significantly improves managed futures strategies and adds significant diversification benefits to the investors’ portfolios.

scholarly journals Sustainable Geographical Changes in Rural Areas: Key Paths, Orientations and Limits

2021 ◽  
Vol 13 (4) ◽  
pp. 2059
Author(s):  
Angel Paniagua
Keyword(s):  
Rural Areas ◽  
Anglo Saxon ◽  
Rural Studies ◽  
New Approach ◽  
Rural Restructuring ◽  
Theoretical Approaches ◽  
Methodological Approaches ◽  
Social Environmental ◽  
The Individual ◽  
New Rurality

Rural differentiation processes have formed the backbone of rural studies. Owing to the strength of rural–urban and local–global relationships, the theoretical approaches to rural restructuring in the Anglo-Saxon world and new rurality in Latin America only have a limited capacity to explain contemporary global phenomena of rural spaces. Due to this, transverse theoretical and methodological approaches have emerged to explain social, environmental and spatial (rural) processes. Here, a new approach is proposed called the individual–global field, based on the individual–global binary category to substitute the traditional relevance of the locality–community–globality association This new approach tries to reinvigorate rural geography in a more flexible way, based on minor theory, to adapt to all the phenomena that can occur globally. In any case, various spatial planes are proposed, dominated by specific socioeconomic processes on which the rural individual would move.

scholarly journals A new catalogue of multiple galaxies in the Local Supercluster

2000 ◽  
Vol 174 ◽  
pp. 40-45
Author(s):  
D. I. Makarov ◽  
I. D. Karachentsev
Keyword(s):  
New Approach ◽  
Galaxy Groups ◽  
Closed Orbits ◽  
Crossing Time ◽  
Local Supercluster ◽  
Virial Mass ◽  
Nearby Galaxies ◽  
The Individual ◽  
Group Member ◽  
Harmonic Radius

AbstractA new approach is suggested which makes use of the individual properties of galaxies, for the identification of small galaxy groups in the Local Supercluster. The criterion is based on the assumption of closed orbits of the companions around the dominating group member within a zero velocity sphere.The criterion is applied to a sample of 6321 nearby galaxies with radial velocities V0 ≤ 3000 km s−1. These 3472 galaxies have been assigned to 839 groups that include 55% of the sample considered. For the groups identified by the new algorithm (with k ≥ 5 members) the median velocity dispersion is 86 km s−1, the median harmonic radius is 247 kpc, the median crossing time is 0.08(1/H), and the median virial-mass-to-light ratio is 56 M⊙/L⊙.

Sign in / Sign up

Export Citation Format

Share Document