scholarly journals Perspective: Cellular and Molecular Profiling Technologies in Personalized Oncology

2019 ◽  
Vol 9 (3) ◽  
pp. 44 ◽  
Author(s):  
Andrea Cruz ◽  
Weng Kung Peng
Keyword(s):  
Public Health ◽  
Point Of Care ◽  
Molecular Profiling ◽  
Technological Innovations ◽  
Self Monitoring ◽  
Health Concerns ◽  
Important Public Health ◽  
One Step ◽  
Personalized Oncology ◽  
Near Future

Cancer is a leading cause of death worldwide and therefore one of the most important public health concerns. In this contribution, we discuss recent key enabling technological innovations (and their challenges), including biomarker-based technologies, that potentially allow for decentralization (e.g., self-monitoring) with the increasing availability of point-of-care technologies in the near future. These technological innovations are moving the field one step closer toward personalized oncology.

Alternative Therapies

2021 ◽  
pp. 160-182
Author(s):  
Vijay Singh Gondil ◽  
Sanjay Chhibber
Keyword(s):  
Public Health ◽  
Sustainable Development ◽  
Antibiotic Resistance ◽  
Antimicrobial Agents ◽  
Treatment Options ◽  
Alternative Therapies ◽  
Alternative Strategies ◽  
Health Concerns ◽  
Near Future ◽  
Antibiotic Dose

Antibiotic resistance is one of the leading public health concerns across the globe. Antibiotics are losing their effectiveness, leading to uncertainty in available treatment options to clinicians. Resistance to antibiotics is at an all-time high, and there is a pressing demand to look for alternative antimicrobial candidates other than antibiotics. Alternative therapies include use of bacteriophages, lytic proteins, nanoparticles, phytochemicals, quorum quenchers, and other antibacterial or antivirulent agents that can eradicate bacterial infection alone or in conjunction with antibiotics. Alternative therapies can replace or lower the effective antibiotic dose, which can help to tackle antibiotic resistance as well as counter its side effects. For sustainable development of antimicrobials against drug resistant bugs, novel alternative strategies need to be explored in the near future. Alternative therapies can help researchers to construct a toolbox containing a variety of antimicrobial agents, which can be used alone, in combination with other agents, or in rotation.

scholarly journals Point-of-Care Diagnostics for Acute HIV Infection: An Important Public Health Priority

2012 ◽  
Vol 206 (12) ◽  
pp. 1949-1950 ◽  
Author(s):  
N. E. Rosenberg ◽  
G. Kamanga ◽  
S. Phiri ◽  
D. Nsona ◽  
A. Pettifor ◽  
...  
Keyword(s):  
Public Health ◽  
Hiv Infection ◽  
Point Of Care ◽  
Acute Hiv Infection ◽  
Important Public Health ◽  
Public Health Priority ◽  
Health Priority ◽  
Point Of Care Diagnostics ◽  
Acute Hiv

scholarly journals Toxoplasmosis: The Heart of the Diagnosis

2018 ◽  
Vol 6 (1) ◽  
Author(s):  
James H England ◽  
Samuel S Bailin ◽  
Jeffrey R Gehlhausen ◽  
Donald H Rubin
Keyword(s):  
Public Health ◽  
Toxoplasma Gondii ◽  
Medical Care ◽  
Odocoileus Virginianus ◽  
Foodborne Pathogen ◽  
Health Concerns ◽  
Important Public Health ◽  
Acute Toxoplasmosis ◽  
Common Parasite

Abstract Toxoplasma gondii is a common parasite that infects warm-blooded animals, including humans, and is a foodborne pathogen. We report a case of acute toxoplasmosis in a 76-year-old man after ingestion of the undercooked heart of a white-tailed deer (Odocoileus virginianus) in Tennessee. The patient’s adult grandson, who also consumed part of the heart, became ill with nearly identical symptoms, though he did not seek medical care. This case highlights important public health concerns about deer-to-human transmission of Toxoplasma.

Feature extraction and prediction of Dengue Outbreaks

2020 ◽  
pp. 216-222
Author(s):  
Kunal Parikh ◽  
Tanvi Makadia ◽  
Harshil Patel
Keyword(s):  
Public Health ◽  
Machine Learning ◽  
Developing Countries ◽  
Feature Extraction ◽  
Predictive Analytics ◽  
Learning Algorithm ◽  
Machine Learning Algorithm ◽  
Health Concerns ◽  
The World ◽  
Dengue Outbreaks

Dengue is unquestionably one of the biggest health concerns in India and for many other developing countries. Unfortunately, many people have lost their lives because of it. Every year, approximately 390 million dengue infections occur around the world among which 500,000 people are seriously infected and 25,000 people have died annually. Many factors could cause dengue such as temperature, humidity, precipitation, inadequate public health, and many others. In this paper, we are proposing a method to perform predictive analytics on dengue’s dataset using KNN: a machine-learning algorithm. This analysis would help in the prediction of future cases and we could save the lives of many.

Gendered Marketing of Food Supplements in Lifestyle Magazines in Greece

2020 ◽  
Vol 1 (1) ◽  
pp. 54-63
Author(s):  
Effrosyni Kotsaga
Keyword(s):  
Public Health ◽  
Statistical Analysis ◽  
Print Media ◽  
Women's Magazines ◽  
Quality Characteristics ◽  
Food Supplements ◽  
Health Concerns ◽  
Comparative Statistical Analysis ◽  
Gendered Stereotypes

Background: Marketing of food supplements in Greece in print media has not been examined and this study is the first attempt to provide a comparative statistical analysis. Methods: Lifestyle magazines that were distributed all over Greece and aimed at women and men were collected in the years 2014 and 2016. Five criteria with their subcriteria were developed and were related to the branding of the food supplements; their quality characteristics; the information given about health concerns; photographs of people who promoted food supplements and to claims of their suitability. Results: It seems that in terms of product branding, women’s magazines were more likely to be targeted. Some quality characteristics such as information about the ingredients of food supplements or information about banned substances were more likely to be seen in women’s magazines in 2016. In 2014 and 2016, not all advertisements provided information about health concerns and among those which informed readers about health concerns, differentiation in target audiences was observed. Photographs that showed people promoting food supplements as well as claims of suitability for various categories of consumers, seem to be gendered in 2014 but this trend was not strong enough in 2016. Conclusion: It can be argued that the marketing of food supplements was aggressive and gendered in 2014 and changed in 2016 with better information on public health but had retained some gendered stereotypes.

“PHONE-CONNECT” - A Pilot Program Prescribing Phones to Address Digital Health Equity Needs in the COVID-19 Era (Preprint)

2020 ◽  
Author(s):  
Gill Kazevman ◽  
Marck Mercado ◽  
Jennifer Hulme ◽  
Andrea Somers
Keyword(s):  
Public Health ◽  
Health Care ◽  
Social Services ◽  
Access To Health Care ◽  
Health Care Services ◽  
Point Of Care ◽  
Digital Health ◽  
Contact Tracing ◽  
Health Care Intervention ◽  
Care Intervention

UNSTRUCTURED Vulnerable populations have been identified as having higher infection rates and poorer COVID-19 related outcomes, likely due to their inability to readily access primary care, follow public health directives and adhere to self-isolation guidelines. As a response to the COVID-19 pandemic, many health care services have adopted new digital solutions, relying on phone and internet connectivity. Yet, persons who are digitally inaccessible, such as those struggling with poverty or homelessness, are often unable to utilize these services. In response to this newly highlighted social disparity known as “digital health inequity”, emergency physicians at the University Health Network, Toronto, initiated a program called “PHONE CONNECT”. This novel approach attempts to improve patients’ access to health care, information and social services, as well as improve their ability to adhere to public health directives (social isolation and contact tracing). While similar programs addressing the same emerging issues have been recently described in the media, this is the first time phones are provided as a health care intervention in an emergency department. This innovative ED point-of-care intervention may have a significant impact on improving the health outcomes for vulnerable people during the COVID-19 pandemic, and even beyond it.

Biosecurity and Public Health Ethics Issues Raised by Biological Threats

2019 ◽  
pp. 773-785
Author(s):  
Nicholas Evans ◽  
Thomas Inglesby
Keyword(s):  
Public Health ◽  
Resource Allocation ◽  
Infectious Diseases ◽  
Ethical Issues ◽  
Emerging Infectious Diseases ◽  
Biological Weapon ◽  
Ethical Values ◽  
Dual Use ◽  
Health Concerns ◽  
Trade Offs

This chapter introduces ethical issues that arise in the context of biosecurity: policies and actions intended to prevent the development or emergence, or mitigate the consequences, of serious biological threats. These threats could include deliberate biological weapon attacks (bioterrorism), pandemics, emerging infectious diseases, or major laboratory accidents. The basic values that underpin these public health concerns are first introduced. Ethical issues that arise before, during, and following a biosecurity crisis are then examined, including issues of resource allocation, dual-use research, and the possibility of quarantine. Their resolution requires trade-offs among different ethical values, including utility, fairness, and liberty.

scholarly journals La Crosse Virus Shows Strain-Specific Differences in Pathogenesis

Pathogens ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 400
Author(s):  
Sarah N. Wilson ◽  
Krisangel López ◽  
Sheryl Coutermash-Ott ◽  
Dawn I. Auguste ◽  
Danielle L. Porier ◽  
...  
Keyword(s):  
Public Health ◽  
North America ◽  
Viral Encephalitis ◽  
Strain Selection ◽  
La Crosse Virus ◽  
Murine Models ◽  
Suckling Mouse ◽  
Important Public Health ◽  
Representative Strain ◽  
Ancestral Strain

La Crosse virus (LACV) is the leading cause of pediatric viral encephalitis in North America, and is an important public health pathogen. Historically, studies involving LACV pathogenesis have focused on lineage I strains, but no former work has explored the pathogenesis between or within lineages. Given the absence of LACV disease in endemic regions where a robust entomological risk exists, we hypothesize that some LACV strains are attenuated and demonstrate reduced neuroinvasiveness. Herein, we compared four viral strains representing all three lineages to determine differences in neurovirulence or neuroinvasiveness using three murine models. A representative strain from lineage I was shown to be the most lethal, causing >50% mortality in each of the three mouse studies. However, other strains only presented excessive mortality (>50%) within the suckling mouse neurovirulence model. Neurovirulence was comparable among strains, but viruses differed in their neuroinvasive capacities. Our studies also showed that viruses within lineage III vary in pathogenesis with contemporaneous strains, showing reduced neuroinvasiveness compared to an ancestral strain from the same U.S. state (i.e., Connecticut). These findings demonstrate that LACV strains differ markedly in pathogenesis, and that strain selection is important for assessing vaccine and therapeutic efficacies.

scholarly journals A stochastic time-delayed model for the effectiveness of Moroccan COVID-19 deconfinement strategy

2020 ◽  
Vol 15 ◽  
pp. 50 ◽  
Author(s):  
Houssine Zine ◽  
Adnane Boukhouima ◽  
El Mehdi Lotfi ◽  
Marouane Mahrouf ◽  
Delfim F.M. Torres ◽  
...  
Keyword(s):  
Public Health ◽  
Health Administration ◽  
Policy Makers ◽  
Public Health Administration ◽  
Additional Degree ◽  
Epidemiological Trend ◽  
The Impact ◽  
Near Future ◽  
Stochastic Time ◽  
Delayed Model

Coronavirus disease 2019 (COVID-19) poses a great threat to public health and the economy worldwide. Currently, COVID-19 evolves in many countries to a second stage, characterized by the need for the liberation of the economy and relaxation of the human psychological effects. To this end, numerous countries decided to implement adequate deconfinement strategies. After the first prolongation of the established confinement, Morocco moves to the deconfinement stage on May 20, 2020. The relevant question concerns the impact on the COVID-19 propagation by considering an additional degree of realism related to stochastic noises due to the effectiveness level of the adapted measures. In this paper, we propose a delayed stochastic mathematical model to predict the epidemiological trend of COVID-19 in Morocco after the deconfinement. To ensure the well-posedness of the model, we prove the existence and uniqueness of a positive solution. Based on the large number theorem for martingales, we discuss the extinction of the disease under an appropriate threshold parameter. Moreover, numerical simulations are performed in order to test the efficiency of the deconfinement strategies chosen by the Moroccan authorities to help the policy makers and public health administration to make suitable decisions in the near future.

Public Health Preparedness of Post-Katrina and Rita Shelter Health Staff

2009 ◽  
Vol 24 (6) ◽  
pp. 500-505 ◽  
Author(s):  
Daksha Brahmbhatt ◽  
Jennifer L. Chan ◽  
Edbert B. Hsu ◽  
Hani Mowafi ◽  
Thomas D. Kirsch ◽  
...  
Keyword(s):  
Public Health ◽  
Technical Support ◽  
Health Staff ◽  
Health Training ◽  
Health Concerns ◽  
Health Authorities ◽  
Public Health Training ◽  
Clinical Scenarios ◽  
Public Health Authorities ◽  
Hurricanes Katrina And Rita

AbstractIntroduction:During 2005, Hurricanes Katrina and Rita struck the US Gulf Coast, displacing approximately two million people. With >250,000 evacuees in shelters, volunteers from the American Red Cross (ARC) and other nongovernmental and faith-based organizations provided services. The objective of this study was to evaluate the composition, pre-deployment training, and recognition of scenarios with outbreak potential by shelter health staff.Methods:A rapid assessment using a 36-item questionnaire was conducted through in-person interviews with shelter health staff immediately following Hurricanes Katrina and Rita. Data were collected by sampling at shelters located throughout five ARC regions in Texas. The survey focused on: (1) public health capacity; (2) level of public health awareness among staff; (3) public health training prior to deployment; and (4) interest in technical support for public health concerns. In addition, health staff volunteers were asked to manage 11 clinical scenarios with possible public health implications.Results:Forty-three health staff at 24 shelters were interviewed. Nurses comprised the majority of shelter health volunteers and were present in 93% of shelters; however, there were no public health providers present as staff in any shelter. Less than one-third of shelter health staff had public health training, and only 55% had received public health information specific to managing the health needs of evacuees. Only 37% of the shelters had a systematic method for screening the healthcare needs of evacuees upon arrival. Although specific clinical scenarios involving case clusters were referred appropriately, 60% of the time, 75% of all clinical scenarios with epidemic potential did not elicit proper notification of public health authorities by shelter health staff. In contrast, clinical scenarios requiring medical attention were correctly referred >90% of the time. Greater access and support from health and public health experts was endorsed by 93% of respondents.Conclusions:Public health training for sheltering operations must be enhanced and should be a required component of pre-deployment instruction. Development of a standardized shelter intake health screening instrument may facilitate assessment of needs and appropriate resource allocation. Shelter health staff did not recognize or report the majority of cases with epidemic potential to public health authorities. Direct technical support to shelter health staff for public health concerns could bridge existing gaps and assist surveillance efforts.

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