scholarly journals MicroRNAs as Potential Biomarkers for Exercise-Based Cancer Rehabilitation in Cancer Survivors

Life ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. 1439
Author(s):  
Yanping Jiang ◽  
Kulsoom Ghias ◽  
Sanjeev Gupta ◽  
Ananya Gupta
Keyword(s):  
Physical Activity ◽  
Cancer Survivors ◽  
Cancer Treatment ◽  
Tissue Damage ◽  
Peripheral Circulation ◽  
Cancer Rehabilitation ◽  
Health Related ◽  
And Function ◽  
Response To Exercise ◽  
Health Related Fitness

Expression and functions of microRNAs (miRNAs) have been widely investigated in cancer treatment-induced complications and as a response to physical activity, respectively, but few studies focus on the application of miRNAs as biomarkers in exercise-based cancer rehabilitation. Research has shown that certain miRNA expression is altered substantially due to tissue damage caused by cancer treatment and chronic inflammation. MiRNAs are released from the damaged tissue and can be easily detected in blood plasma. Levels of the miRNA present in peripheral circulation can therefore be used to measure the extent of tissue damage. Moreover, damage to tissues such as cardiac and skeletal muscle significantly affects the individual’s health-related fitness, which can be determined using physiologic functional assessments. These physiologic parameters are a measure of tissue health and function and can therefore be correlated with the levels of circulating miRNAs. In this paper, we reviewed miRNAs whose expression is altered during cancer treatment and may correlate to physiological, physical, and psychological changes that significantly impact the quality of life of cancer survivors and their role in response to physical activity. We aim to identify potential miRNAs that can not only be used for monitoring changes that occur in health-related fitness during cancer treatment but can also be used to evaluate response to exercise-based rehabilitation and monitor individual progress through the rehabilitation programme.

scholarly journals Fee-for-service cancer rehabilitation programs improve health-related quality of life

2016 ◽  
Vol 23 (4) ◽  
pp. 233 ◽  
Author(s):  
A.A. Kirkham ◽  
S.E. Neil-Sztramko ◽  
J. Morgan ◽  
S. Hodson ◽  
S. Weller ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Cancer Survivors ◽  
Cancer Rehabilitation ◽  
Fee For Service ◽  
Health Related Quality ◽  
Rehabilitation Programs ◽  
Related Quality ◽  
Health Related

BackgroundRigorously applied exercise interventions undertaken in a research setting result in improved health related quality of life (hrqol) in cancer survivors, but research to demonstrate effective translation of that research to practice is needed. The objective of the present study was to determine the effect of fee-for-service cancer rehabilitation programs in the community on hrqol and on self-reported physical activity and its correlates.Methods After enrolment and 17 } 4 weeks later, new clients (n = 48) to two fee-for-service cancer rehabilitation programs completed the 36-Item Short Form Health Survey (rand-36: rand Corporation, Santa Monica, CA, U.S.A.), the Godin Leisure-Time Exercise Questionnaire, and questions about physical activity correlates. Normal fee-for-service operations were maintained, including a fitness assessment and individualized exercise programs supervised in a group or one-on-one setting, with no minimum attendance required. Fees were associated with the assessment and with each exercise session.Results Of the 48 participants, 36 (75%) completed both questionnaires. Improvements in the physical functioning, role physical, pain, and energy/fatigue scales on the rand-36 exceeded minimally important differences and were of a magnitude similar to improvements reported in structured, rigorously applied, and free research interventions. Self-reported levels of vigorous-intensity (p = 0.021), but not moderate-intensity (p = 0.831) physical activity increased. The number of perceived barriers to exercise (p = 0.035) and the prevalence of fatigue as a barrier (p = 0.003) decreased. Exercise self-efficacy improved only in participants who attended 11 or more sessions (p = 0.002). Exercise enjoyment did not change (p = 0.629).Conclusions Enrolment in fee-for-service cancer rehabilitation programs results in meaningful improvements in hrqol comparable to those reported by research interventions, among other benefits. The fee-for-service model could be an effective model for delivery of exercise to more cancer survivors.

Effects of a structured exercise program on physical activity and health-related fitness in colon cancer survivors: One year feasibility results from the NCIC CTG CO.21 (CHALLENGE) trial.

2016 ◽  
Vol 34 (15_suppl) ◽  
pp. 3621-3621
Author(s):  
Kerry S. Courneya ◽  
Janette L. Vardy ◽  
Christopher J. O'Callaghan ◽  
Christine Friedenreich ◽  
Kristin L. Campbell ◽  
...  
Keyword(s):  
Physical Activity ◽  
Colon Cancer ◽  
Cancer Survivors ◽  
Exercise Program ◽  
Health Related ◽  
One Year ◽  
Health Related Fitness

scholarly journals Effects of Theory-Based Behavioral Interventions on Physical Activity Among Overweight and Obese Female Cancer Survivors: A Systematic Review of Randomized Controlled Trials

2017 ◽  
Vol 17 (2) ◽  
pp. 226-236 ◽  
Author(s):  
Amerigo Rossi ◽  
Ciarán Friel ◽  
Leeja Carter ◽  
Carol Ewing Garber
Keyword(s):  
Physical Activity ◽  
Cancer Survivors ◽  
Controlled Trials ◽  
Randomized Controlled ◽  
Cohen’S D ◽  
Home Based ◽  
Obese Female ◽  
Health Related ◽  
Cohen's D ◽  
Female Cancer Survivors

Purpose. To determine whether theory-based physical activity (PA) interventions for overweight and obese female cancer survivors lead to increased PA and improved health. Methods. This systematic review examined randomized controlled trials analyzing the impact of theory-based PA interventions on overweight and obese female cancer survivors through December 2016. Searches of 5 electronic databases revealed 10 articles that included 1351 participants who met the inclusion criteria. Results. Participants were primarily non-Hispanic white (74%-100%) breast or endometrial cancer survivors. Intervention characteristics and PA assessment tools varied greatly. Adherence (68%-99%) and retention (79%-100%) were relatively high. Social cognitive theory was utilized as the theoretical construct in 9 of the 10 studies. Home-based interventions led to small improvements in PA (Cohen’s d range = 0.25-0.31), whereas home-based plus center-based interventions led to moderate to large improvements (Cohen’s d range = 0.45-1.02). Only three of the studies assessed psychosocial behavioral processes associated with PA, and the results were mixed. Health-related outcomes included improvements in aerobic fitness (Cohen’s d = 0.32-1.1 in 5 studies), large absolute decreases in waist circumferences (>6 cm in 3 of 5 studies; Cohen’s d = −0.31 to −1.02), and no change in inflammatory biomarkers (in 2 studies). Only one serious adverse event (pelvic stress fracture) was attributed to the interventions. Conclusions. Theory-based PA interventions are safe and feasible for overweight and obese female cancer survivors. Interventions that include a center-based component showed moderate to large effect sizes for PA. Future studies should evaluate behavioral variables and more health-related clinical outcomes.

Principal Components of Fitness: Relationship to Physical Activity and Lifestyle

1994 ◽  
Vol 19 (2) ◽  
pp. 200-214 ◽  
Author(s):  
Roy J. Shephard ◽  
Claude Bouchard
Keyword(s):  
Physical Activity ◽  
Principal Components ◽  
Hdl Cholesterol ◽  
Cardiovascular Fitness ◽  
Abdominal Circumference ◽  
Caffeine Consumption ◽  
Exercise Frequency ◽  
F Factor ◽  
Health Related ◽  
Health Related Fitness

Interrelationships between metabolic and cardiorespiratory health were examined in 350 healthy adults. Four principal components accounted for 66.7% of the variance in 172 males (M) and for 62.4% in 178 females (F). Factor 1, "obesity," related to body mass index, abdominal circumference, total skinfold thickness, and (M only) abdominal/hip circumference ratio. Factor 2, "cardiovascular fitness," had loadings from resting heart rate and PWC150/kg. Factors 3 and 4 were related to total cholesterol and HDL-cholesterol, respectively (plus blood pressures, particularly in F). Factor 1 was linked to caffeine consumption and to exercise frequency (F) or perceived intensity (M). Factor 2 was linked to perceptions of activity relative to others (M and F) and to the intensity of activity (M only). Factors 3 and 4 were associated with perceived fitness and physical activity relative to others. Because perceptions of physical activity and fitness lack consistency, it is suggested that health be judged more directly from simple measures of health related fitness that require little subject cooperation. Key words: caffeine consumption, cardiorespiratory fitness, gender differences, health related fitness, metabolic fitness, perceived activity

scholarly journals Children’s Weight Gain and Cardiovascular Fitness Loss over the Summer

2018 ◽  
Vol 15 (12) ◽  
pp. 2770 ◽  
Author(s):  
Timothy Brusseau ◽  
Ryan Burns
Keyword(s):  
Physical Activity ◽  
Physical Activity Intervention ◽  
Cardiovascular Fitness ◽  
The Body ◽  
School Year ◽  
School Based ◽  
Health Related ◽  
Physical Activity Programming ◽  
The Impact ◽  
Health Related Fitness

The purpose of this study was to examine the impact of summer breaks on the body composition and cardiovascular fitness of elementary school children who participated in a multi-year school-based physical activity intervention. Participants were 404 children who had their height and weight measured and completed the Progressive Aerobic Cardiovascular Endurance Run (PACER) during physical education classes at the beginning and end of the school year for three consecutive years. To examine the effects of time on health-related fitness data, general linear mixed effects models were employed. The results indicate that there was a trend toward an increase in body mass index (BMI) after the summer of 2015 (p = 0.958), and a significant increase in BMI after the summer of 2016 compared to time point 1 (p < 0.001). For PACER laps, there were trends toward decreases in PACER laps after the summers of 2015 (p = 0.515) and 2016 (p = 0.073). Summer breaks tended to attenuate the BMI and PACER lap improvements that were observed during the intervention. While school-based physical activity programming has had some successes in improving health-related fitness markers, the loss of these improvements over the summer is of concern to both practitioners and researchers. It is clear that additional efforts are needed to limit obesogenic behaviors during the summer months.

scholarly journals Effect of self-regulatory behaviour change techniques and predictors of physical activity maintenance in cancer survivors: a 12-month follow-up of the Phys-Can RCT

BMC Cancer ◽  
2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Anne-Sophie Mazzoni ◽  
Hannah L. Brooke ◽  
Sveinung Berntsen ◽  
Karin Nordin ◽  
Ingrid Demmelmaier
Keyword(s):  
Physical Activity ◽  
Cancer Survivors ◽  
Cancer Treatment ◽  
Tobacco Use ◽  
Exercise Intervention ◽  
Behaviour Change Techniques ◽  
Exercise Motivation ◽  
History Of

Abstract Background Current knowledge about the promotion of long-term physical activity (PA) maintenance in cancer survivors is limited. The aims of this study were to 1) determine the effect of self-regulatory BCTs on long-term PA maintenance, and 2) identify predictors of long-term PA maintenance in cancer survivors 12 months after participating in a six-month exercise intervention during cancer treatment. Methods In a multicentre study with a 2 × 2 factorial design, the Phys-Can RCT, 577 participants with curable breast, colorectal or prostate cancer and starting their cancer treatment, were randomized to high intensity exercise with or without self-regulatory behaviour change techniques (BCTs; e.g. goal-setting and self-monitoring) or low-to-moderate intensity exercise with or without self-regulatory BCTs. Participants’ level of PA was assessed at the end of the exercise intervention and 12 months later (i.e. 12-month follow-up), using a PA monitor and a PA diary. Participants were categorized as either maintainers (change in minutes/week of aerobic PA ≥ 0 and/or change in number of sessions/week of resistance training ≥0) or non-maintainers. Data on potential predictors were collected at baseline and at the end of the exercise intervention. Multiple logistic regression analyses were performed to answer both research questions. Results A total of 301 participants (52%) completed the data assessments. A main effect of BCTs on PA maintenance was found (OR = 1.80, 95%CI [1.05–3.08]) at 12-month follow-up. Participants reporting higher health-related quality-of-life (HRQoL) (OR = 1.03, 95%CI [1.00–1.06] and higher exercise motivation (OR = 1.02, 95%CI [1.00–1.04]) at baseline were more likely to maintain PA levels at 12-month follow-up. Participants with higher exercise expectations (OR = 0.88, 95%CI [0.78–0.99]) and a history of tobacco use at baseline (OR = 0.43, 95%CI [0.21–0.86]) were less likely to maintain PA levels at 12-month follow-up. Finally, participants with greater BMI increases over the course of the exercise intervention (OR = 0.63, 95%CI [0.44–0.90]) were less likely to maintain their PA levels at 12-month follow-up. Conclusions Self-regulatory BCTs improved PA maintenance at 12-month follow-up and can be recommended to cancer survivors for long-term PA maintenance. Such support should be considered especially for patients with low HRQoL, low exercise motivation, high exercise expectations or with a history of tobacco use at the start of their cancer treatment, as well as for those gaining weight during their treatment. However, more experimental studies are needed to investigate the efficacy of individual or combinations of BCTs in broader clinical populations. Trial registration NCT02473003 (10/10/2014).

scholarly journals The Role of Physical Activity in Cancer Survivors’ Quality of Life

2020 ◽  
Author(s):  
Tayah M. Liska ◽  
Angie Kolen
Keyword(s):  
Quality Of Life ◽  
Physical Activity ◽  
Cancer Survivors ◽  
Cancer Treatment ◽  
Cancer Diagnosis ◽  
Social Engagement ◽  
Healthcare Providers ◽  
Adult Cancer Survivors

Abstract Purpose: As a result of a cancer diagnosis and treatment, many cancer survivors experience persistent physical, mental, and emotional symptoms that affect their quality of life. Physical activity has been identified as an intervention that may help to manage the side effects of a cancer diagnosis and its treatment. The purpose of this study was to investigate the role of physical activity on overall quality of life in adult cancer survivors. Methods: One-on-one semi structured interviews were conducted in person or via telephone with 13 adult (≥18 yrs) cancer survivors who had completed cancer treatment. Results: These cancer survivors described their physical activity as improving their physical functioning and mental health, as a means of positive social engagement, and adding positivity to their daily life. Conclusion: These results support the role of physical activity to enhance cancer survivors’ quality of life regardless of the individuals’ treatment(s) type, duration, or time since the end of active cancer treatment. Further research is warranted to (a) expand this research with a larger sample, (b) examine healthcare providers’ knowledge and application of exercise guidelines to cancer survivors in cancer care, and (c) explore implementation strategies for greater advocacy for healthcare providers to share the exercise recommendations with cancer survivors.

From Cancer Rehabilitation to Recreation: A Coordinated Approach to Increasing Physical Activity

2020 ◽  
Vol 100 (11) ◽  
pp. 2049-2059 ◽  
Author(s):  
Amy M Dennett ◽  
Casey L Peiris ◽  
Nora Shields ◽  
Nicholas F Taylor
Keyword(s):  
Physical Activity ◽  
Cancer Survivors ◽  
Cancer Recurrence ◽  
Cancer Rehabilitation ◽  
Rehabilitation Services ◽  
Appropriate Care ◽  
Low Levels ◽  
Risk Of Cancer ◽  
Practical Implications

Abstract Participation in adequate physical activity improves the health status of cancer survivors, enhances their survival, and reduces their risk of cancer recurrence. However, cancer survivors engage in low levels of physical activity and have limited access to rehabilitation services that could increase their participation. No optimal framework has been developed that supports physical activity participation among cancer survivors. Given the growth in numbers of cancer survivors, development of a framework may provide a pathway to facilitate timely and appropriate care. This perspective paper describes the development of the Cancer Rehabilitation to Recreation (CaReR) Framework and its practical implications. The CaReR Framework uses a tailored, stepped approach to guide health services and clinicians on the design and implementation of interventions to promote physical activity among cancer survivors. Implementation of the CaReR Framework will improve continuity and quality of care for cancer survivors and promote physical activity with the ultimate aim of improving health outcomes.

Childhood Depressive Symptoms, Physical Activity and Health Related Fitness

2003 ◽  
Vol 25 (4) ◽  
pp. 419-439 ◽  
Author(s):  
Lois Michaud Tomson ◽  
Robert P. Pangrazi ◽  
Glenn Friedman ◽  
Ned Hutchison
Keyword(s):  
Physical Activity ◽  
Depressive Symptoms ◽  
Relative Risk ◽  
Negative Relationship ◽  
Physically Active ◽  
Symptoms Of Depression ◽  
Health Related ◽  
Relationship Of ◽  
The Relationship ◽  
Health Related Fitness

While research has confirmed a negative relationship between adult depression and physical activity, there is little evidence for children. This study examined the relationship of being classified as physically active or inactive by a parent or a teacher to depressive symptoms in children 8 to 12 years of age (N = 933). It also assessed the relationship of playing sports outside of school, and of meeting health related fitness standards, to symptoms of depression. Relative risk of depressive symptoms for inactive classification was 2.8 to 3.4 times higher than it was for active, 1.3 to 2.4 times higher for children not playing sports outside of school, and 1.5 to 4.0 times higher for those not meeting health related fitness goals.

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