scholarly journals 5-((8-Hydroxyquinolin-5-yl)diazenyl)-3-methyl-1H-pyrazole-4-carboxylic Acid

Molbank ◽  
10.3390/m1238 ◽  
2021 ◽  
Vol 2021 (2) ◽  
pp. M1238
Author(s):  
Ion Burcă ◽  
Valentin Badea ◽  
Calin Deleanu ◽  
Vasile-Nicolae Bercean
Keyword(s):  
Chemical Structure ◽  
Functional Group ◽  
Coupling Reaction ◽  
2D Nmr ◽  
Azo Coupling ◽  
2D Nmr Spectroscopy ◽  
Azo Compound ◽  
Ft Ir ◽  
New Compounds ◽  
Carboxylic Functional Group

A new azo compound was prepared via the azo coupling reaction between 4-(ethoxycarbonyl)-3-methyl-1H-pyrazole-5-diazonium chloride and 8-hydroxyquinoline (oxine). The ester functional group of the obtained compound was hydrolyzed and thus a new chemical structure with a carboxylic functional group resulted. The structures of the new compounds were fully characterized by: UV–Vis, FT-IR, 1D and 2D NMR spectroscopy, and HRMS spectrometry.

scholarly journals Unusual Polyhydroxylated Steroids from the Starfish Anthenoides laevigatus, Collected off the Coastal Waters of Vietnam

Molecules ◽  
2020 ◽  
Vol 25 (6) ◽  
pp. 1440
Author(s):  
Alla A. Kicha ◽  
Dinh T. Ha ◽  
Timofey V. Malyarenko ◽  
Anatoly I. Kalinovsky ◽  
Roman S. Popov ◽  
...  
Keyword(s):  
Coastal Waters ◽  
2D Nmr ◽  
2D Nmr Spectroscopy ◽  
Cytotoxic Effects ◽  
One Dimensional ◽  
The Common ◽  
Polyhydroxylated Steroids ◽  
New Compounds ◽  
Ht 29 ◽  
Inhibit Cell Proliferation

Four new polyhydroxylated steroids 1–4 were isolated along with two previously known related steroids 5 and 6 from the methanolic extract of the starfish Anthenoides laevigatus collected off the coastal waters of Vietnam. Structures of new compounds were substantially elucidated by one-dimensional (1D) and two-dimensional (2D) NMR spectroscopy and HRESIMS techniques. Heptaol 1 and hexaol 2 contain the common 5α-cholestane skeleton, while hexaol 3 and heptaol 4 have the rare among starfish steroid compounds 5β-cholestane skeleton. Compounds 1, 5, and 6 do not show cytotoxic effects against normal JB6 Cl41 and cancer HT-29 and MDA-MB-231 cells, however they inhibit cell proliferation and colony formation of cancer HT-29 and MDA-MB-231 cells.

A NEW NAPHTHYL SUBSTITUTED Β-SITOSTEROL AND FATTY ACIDS FROM THE BARK OF FICUS RELIGIOSA L.

INDIAN DRUGS ◽  
2017 ◽  
Vol 54 (07) ◽  
pp. 18-22
Author(s):  
A. Ali ◽  
◽  
M. Jameel ◽  
M Ali
Keyword(s):  
Fatty Acids ◽  
Skin Diseases ◽  
Decanoic Acid ◽  
2D Nmr ◽  
Stem Bark ◽  
Gastric Ulcers ◽  
Ficus Religiosa ◽  
Phytochemical Investigation ◽  
Ft Ir ◽  
New Compounds

The stem bark of the holy tree Ficus religiosa L. (family: Moraceae) is traditionally prescribed to treat anxiety, hiccup, burns, scabies and skin diseases, vomiting, gastric ulcers, haemorrhoids, diarrhoea, dysentery, glandular swellings of the neck, gonorrhoea, urinogenital disorders, toothache and for strengthening the gums. Phytochemical investigation of a methanolic extract of the stem bark yielded a β-steryl naphthyl ester, characterized as naphthyl-1',3'-diol-1'-β-sitosteryl-3'-octadec-9′′, 12′′-dienoate (1) and two fatty acids identified as 2β,3β,4β,5β-tetrahydroxy-n-octanoic acid (2) and 2β,3β,4β,5β- tetrahydroxy-n-decanoic acid (3). The structure of isolated compounds was established on the basis of 1D and 2D NMR, FT-IR, UV, and MS data and chemical means. The finding enhance the phytochemical nature of F. religiosa. These new compounds have been isolated for the first time from this plant and may play an important role as chromatographic markers for standardization of crude bark and its marketed herbal formulations.

Chiral Polymorphic Hydrazine-based Asymmetric Liquid Crystal Trimers with Resorcinol as Linking Group

2021 ◽  
Vol 18 ◽  
Author(s):  
Wan-Sinn Yam ◽  
Yit-Peng Goh ◽  
Foo-Win Yip ◽  
Gurumurthy Hegde
Keyword(s):  
Liquid Crystal ◽  
2D Nmr ◽  
X Ray Diffraction ◽  
Scanning Calorimetry ◽  
2D Nmr Spectroscopy ◽  
Spacer Length ◽  
X Ray ◽  
Phase Sequence ◽  
Molecular Length ◽  
Ft Ir

Introduction: This is the first report on chiral polymorphic hydrazine-based asymmetric liquid crystal trimers, 1-[4'-(4''- (5-Cholesteryloxy)carbonyl)butyloxy]-3-[N-benzylideneoxy-N'-(4'''-decyloxybenzylidene)hydrazine] butyloxybenzenes, and 1-[4'-(4''-(10-cholesteryloxy)carbonyl)nonyloxy]-3-[N-benzylideneoxy-N'-(4'''- decyloxybenzylidene)hydrazine]butyloxybenzenes., in which the hydrazine and cholesterol arms were connected via two flexible methylene spacers (n = 3-12 units and m = 4 or 9, respectively) to the central resorcinol core. Materials and Methods: FT-IR, 1D and 2D NMR spectroscopy, and CHN microanalysis were used to elucidate the structures of the trimers. Differential scanning calorimetry, polarizing optical microscopy and X-ray diffraction were used to study the transitional and phase properties of the trimers, of which they were length and spacer parity dependent. Trimers with short spacer length in the cholesteryl arm, m = 4 showed interesting phase sequence of BP/N*-TGBA*-SmA*. Results and discussion: The TGBA∗ phase was sensitive to spacer length as it was only observed in trimers with short ester linkage. For the long analogues, m = 9, characteristic visible reflection and a much simpler phase sequence with only N* and SmA* phases were seen. Conclusion: The X-ray diffraction measurements revealed that layer periodicities of the SmA* phase were approximately half the estimated all-trans molecular length (d/L ≈ 0.44-0.52), thus suggesting that the molecules are either strongly intercalated or bent.

scholarly journals Azaphilones from the Red Sea Fungus Aspergillus falconensis

Marine Drugs ◽  
2020 ◽  
Vol 18 (4) ◽  
pp. 204 ◽  
Author(s):  
Dina H. El-Kashef ◽  
Fadia S. Youssef ◽  
Rudolf Hartmann ◽  
Tim-Oliver Knedel ◽  
Christoph Janiak ◽  
...  
Keyword(s):  
Red Sea ◽  
Cancer Cell Line ◽  
2D Nmr ◽  
X Ray Diffraction ◽  
2D Nmr Spectroscopy ◽  
Nmr Data ◽  
Ic50 Values ◽  
Rice Medium ◽  
Optical Rotations ◽  
New Compounds

The marine-derived fungus Aspergillus falconensis, isolated from sediment collected from the Canyon at Dahab, Red Sea, yielded two new chlorinated azaphilones, falconensins O and P (1 and 2) in addition to four known azaphilone derivatives (3−6) following fermentation of the fungus on solid rice medium containing 3.5% NaCl. Replacing NaCl with 3.5% NaBr induced accumulation of three additional new azaphilones, falconensins Q−S (7−9) including two brominated derivatives (7 and 8) together with three known analogues (10−12). The structures of the new compounds were elucidated by 1D and 2D NMR spectroscopy and HRESIMS data as well as by comparison with the literature. The absolute configuration of the azaphilone derivatives was established based on single-crystal X-ray diffraction analysis of 5, comparison of NMR data and optical rotations as well as on biogenetic considerations. Compounds 1, 3−9, and 11 showed NF-κB inhibitory activity against the triple negative breast cancer cell line MDA-MB-231 with IC50 values ranging from 11.9 to 72.0 µM.

scholarly journals Secondary Metabolites from a Strain of Alternaria tenuissima Isolated from Northern Manitoba Soil

2015 ◽  
Vol 10 (1) ◽  
pp. 1934578X1501000 ◽  
Author(s):  
Chukwudi S. Anyanwu ◽  
John L. Sorensen
Keyword(s):  
Mass Spectrometry ◽  
Spectroscopic Data ◽  
National Park ◽  
Fermentation Broth ◽  
2D Nmr ◽  
Comprehensive Analysis ◽  
Its Sequencing ◽  
2D Nmr Spectroscopy ◽  
Alternaria Tenuissima ◽  
Ft Ir

Deoxyphomalone (1), dimethyl 4-methyl-2,6-pyridinedicarboxylate (2), stemphyperylenol (3), and N-methyl-2-pyrrolidone (4) were isolated from the fermentation broth of a strain of the fungus, Alternaria tenuissima. This fungus was isolated from the soil underlying the lichen, Peltigera didactyla, which had been collected from Wapusk National Park in Northern Manitoba. The structures of the compounds were determined by comprehensive analysis of their spectroscopic data including FT-IR, 1D and 2D NMR spectroscopy and mass spectrometry; and their bioactivities were tested against E.coli cells. The taxonomic identity of the fungus was confirmed by ITS sequencing of its ribosomal DNA.

scholarly journals Free-Radical Photopolymerization of Acrylonitrile Grafted onto Epoxidized Natural Rubber

Polymers ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 660
Author(s):  
Rawdah Whba ◽  
Mohd Sukor Su’ait ◽  
Lee Tian Khoon ◽  
Salmiah Ibrahim ◽  
Nor Sabirin Mohamed ◽  
...  
Keyword(s):  
Mechanical Properties ◽  
Natural Rubber ◽  
Chemical Structure ◽  
Functional Group ◽  
Loss Modulus ◽  
Epoxidized Natural Rubber ◽  
Thermal And Mechanical Properties ◽  
Sample Analysis ◽  
Free Radical Photopolymerization ◽  
Ft Ir

The exploitation of epoxidized natural rubber (ENR) in electrochemical applications is approaching its limits because of its poor thermo-mechanical properties. These properties could be improved by chemical and/or physical modification, including grafting and/or crosslinking techniques. In this work, acrylonitrile (ACN) has been successfully grafted onto ENR- 25 by a radical photopolymerization technique. The effect of (ACN to ENR) mole ratios on chemical structure and interaction, thermo-mechanical behaviour and that related to the viscoelastic properties of the polymer was investigated. The existence of the –C≡N functional group at the end-product of ACN-g-ENR is confirmed by infrared (FT-IR) and nuclear magnetic resonance (NMR) analyses. An enhanced grafting efficiency (~57%) was obtained after ACN was grafted onto the isoprene unit of ENR- 25 and showing a significant improvement in thermal stability and dielectric properties. The viscoelastic behaviour of the sample analysis showed an increase of storage modulus up to 150 × 103 MPa and the temperature of glass transition (Tg) was between −40 and 10 °C. The loss modulus, relaxation process, and tan delta were also described. Overall, the ACN-g-ENR shows a distinctive improvement in characteristics compared to ENR and can be widely used in many applications where natural rubber is used but improved thermal and mechanical properties are required. Likewise, it may also be used in electronic applications, for example, as a polymer electrolyte in batteries or supercapacitor.

scholarly journals Synthesis and Characterization of Some New Azo Dyes Derivatives Via Chalcone and Study Some of Their Biological Activity

2016 ◽  
Vol 13 (1) ◽  
pp. 122-132
Author(s):  
Baghdad Science Journal
Keyword(s):  
Biological Activity ◽  
Azo Dyes ◽  
Coupling Reaction ◽  
Basic Medium ◽  
Synthesis And Characterization ◽  
Diazonium Salts ◽  
Amino Group ◽  
Ft Ir ◽  
New Compounds

This work includes synthesis of new six membered heterocyclic rings with effective amino group using the reaction of benzylideneacetophenone (chalcone) (1) with thiourea or urea in alcoholic basic medium to form: 1,3-thiazen-2-amine (2), and 1,3-oxazin-2-amine (8) respectively. The diazotization reaction was carried out with sodium nitrite in presence of hydrochloric acid to form diazonium salts which suffered coupling reaction with naphthols and phenols in the presence of sodium hydroxide to form colored azo dyes (4-7, and 10-13). o-methylation reaction of compounds (7) and (10) yielded : 1,3-thiazin -2-yl-diazenyl (14), and 1,3-oxazin-2-yl-diazenyl (15) respectively.The new compounds were characterized using various physical techniques like: UV-Vis., FT-IR, and 1HNMR spectra. Some new compounds were tested against bacteria.

scholarly journals An Eco-Friendly Technique: Solvent-Free Microwave Synthesis and Docking Studies of Some New Pyridine Nucleosides and Their Pharmacological Significance

Molecules ◽  
2019 ◽  
Vol 24 (10) ◽  
pp. 1969 ◽  
Author(s):  
Majed Alrobaian ◽  
Sana Al Azwari ◽  
Amany Belal ◽  
Hany A. Eldeab
Keyword(s):  
Research Work ◽  
2D Nmr ◽  
Docking Studies ◽  
Microwave Assisted Synthesis ◽  
Bacterial Strains ◽  
Chemical Structures ◽  
Pharmacological Significance ◽  
Ft Ir ◽  
High Yields ◽  
New Compounds

Two series of novel 5-arylazo-3-cyano-2-(2″,3″,4″,6″-tetra-O-acetyl-β-d-galacto pyranosyloxy) pyridines and 3-cyano-2-(2″,3″,4″,6″-tetra-O-acetyl-β-d-galactopyranosyloxy) pyridines were synthesized in high yields utilizing a microwave-assisted synthesis tool guided by the principles of green chemistry. The chemical structures of the new substances were confirmed on the basis of their elemental analysis and spectroscopic data (FT-IR, 1D, 2D-NMR). Activity against different bacterial strains was studied. The anticancer potential of the new compounds is also discussed. Molecular docking was used as a tool in this research work to get better insight into the possible interactions, affinities, and expected modes of binding of the most promising derivatives of the potential chemotherapeutic target (DHFR).

scholarly journals Synthesis of N-Heterocyclic Analogues of 28-O-Methyl Betulinate, and Their Antibacterial and Antifungal Properties

Molbank ◽  
10.3390/m1100 ◽  
2019 ◽  
Vol 2020 (1) ◽  
pp. M1100
Author(s):  
Elvira R. Shakurova ◽  
Lyudmila V. Parfenova
Keyword(s):  
Nmr Spectroscopy ◽  
Minimum Inhibitory Concentration ◽  
Methyl Ester ◽  
Inhibitory Concentration ◽  
2D Nmr ◽  
2D Nmr Spectroscopy ◽  
One Pot ◽  
The One ◽  
Antibacterial And Antifungal ◽  
New Compounds

The paper presents the results on the one-pot pyridine quaternization using betulinic 28-O-methyl ester (1) and Tempo+Br3− cation followed by reduction of the resulting salt (2) to 1,2,5,6-tetrahydropyridine derivative (3). The structures of new compounds are confirmed by means of 1D and 2D-NMR spectroscopy, as well as MALDI TOF/TOF spectrometry. The derivatives 2 and 3 are active against S. aureus at the minimum inhibitory concentration (MIC) of 4 μg/mL and 16 μg/mL, correspondingly.

scholarly journals Six New Phenolic Glycosides and a New Ceramide from the Flowers of Wedelia biflora and Their Cytotoxicity Against Some Cancer Cell Lines

2013 ◽  
Vol 8 (3) ◽  
pp. 1934578X1300800
Author(s):  
Nguyen T. H. Thu ◽  
Le T. Ha ◽  
Vo T. Nga ◽  
Pham N. K. Tuyen ◽  
Ton T. Quang ◽  
...  
Keyword(s):  
Cell Lines ◽  
Cancer Cell ◽  
2D Nmr ◽  
Cancer Cell Lines ◽  
Phenolic Glycosides ◽  
Cytotoxic Activities ◽  
2D Nmr Spectroscopy ◽  
New Compounds ◽  
Potential Use ◽  
Mcf 7

The plant Wedelia biflora has been used in traditional medicine in India and Vietnam to treat various symptoms. However, the chemical composition of its flowers remains mostly unknown. Therefore, we now report the isolation and structural elucidation of six new phenolic glycosides {wedebicoside A – F (1–6)} and one new ceramide [wedebiceramide (9)], together with six known compounds, 1- O-(2′,4′-diangeloyloxy- β-D-fucopyranosyl)-6-hydroxythymol (7), 1- O-[2′,4′-diangeloyloxy-3′-(3′'-angeloyloxy- β-D-fucopyranosyl)- β-D-fucopyranosyl]-6-hydroxythymol (8), anhydrosecoisolariciresinol (10), friedeline (11), epifriedelanol (12) and stigmasterol (13) from the flowers of Wedelia biflora. Their structures were established by 1D and 2D NMR spectroscopy, as well as by high resolution ESI–MS analysis and comparison with literature data. The cytotoxic activities against HeLa, MCF-7 and NCI–H460 were evaluated on some purified compounds at the concentration of 100 μg/mL. Compounds 1, 2, 3 and 5 showed strong cytotoxic activities against three surveyed cancer cell lines. Consequently, this study elucidated the phytochemical composition of W. biflora, as well as the potential use of some of the new compounds against some cancers.

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