scholarly journals Synthesis and Characterization of Pyridine-Grafted Copolymers of Acrylic Acid–Styrene Derivatives for Antimicrobial and Fluorescence Applications

Micromachines ◽  
2021 ◽  
Vol 12 (6) ◽  
pp. 672
Author(s):  
Periyan Durairaju ◽  
Chinnasamy Umarani ◽  
Jothi Ramalingam Rajabather ◽  
Amer M. Alanazi ◽  
Govindasami Periyasami ◽  
...  
Keyword(s):  
Acrylic Acid ◽  
Antimicrobial Properties ◽  
Inhibition Zone ◽  
Broad Emission Band ◽  
Polymer Grafting ◽  
Hantzsch Reaction ◽  
Fluorescent Properties ◽  
Molecular Weights ◽  
Synthetic Strategy ◽  
Styrene Derivatives

The goal of the present study was to copolymerize 3-(4-acetylphenylcarbamoyl) acrylic acid and styrene using azo-bis-isobutyronitrile (AIBN) as a catalyst. The resulting copolymers exhibited number average molecular weights (Mn) of 3.73–5.23 × 104 g/mol with a variable polydispersity (PDI = 2.3–3.8). The amide group of the PMA/PSA polymer was used for grafting poly (-styrene-maleic acid substituted aromatic 2-aminopyridine) by the Hantzsch reaction using a substituted aromatic aldehyde, malononitrile, and ammonium acetate. The polymer can emit strong blue fluorescence (λ = 510 nm) and its thermal stability and solubility were enhanced by polymer grafting. Moreover, the polymer showed the fluorescence spectra of the copolymer had a strong, broad emission band between 300 to 550 nm (maximum wavelength 538 nm) under excitation at 293 nm. The Hantzsch reaction yields an interesting class of nitrogen-based heterocycles that combine with a synthetic strategy for synthesis of grafted co-polymer pyridine-styrene derivatives. The as-prepared pyridine-based polymer compounds were screened against Gram-positive and Gram-negative bacteria, where a maximum inhibition zone toward all four types of bacteria was observed, including specific antifungal activity. Herein, a series of pyridine compounds were synthesized that showed enhanced fluorescent properties and antimicrobial properties due to their unique structure and ability to form polymer assemblies.

scholarly journals Chitosan Cross-Linked Bio-based Antimicrobial Polypropylene Meshes for Hernia Repair Loaded with Levofloxacin HCl via Cold Oxygen Plasma

Coatings ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 168 ◽  
Author(s):  
Noor Sanbhal ◽  
Yan Li ◽  
Awais Khatri ◽  
Mazhar Peerzada ◽  
Lu Wang
Keyword(s):  
Citric Acid ◽  
Hernia Repair ◽  
Agar Plate ◽  
Antimicrobial Properties ◽  
Inhibition Zone ◽  
Molecular Weights ◽  
Hydrophobic Nature ◽  
O2 Plasma Treatment ◽  
Release Method ◽  
O2 Plasma

Polypropylene (PP) large pore size nets have been most widely used implants for hernia repair. Nevertheless, the growth of bacteria within PP mesh pores after operation is a major reason of hernia recurrence. Secondly, pre-operative prophylaxis during mesh implantation has failed due to the hydrophobic nature of PP meshes. Herein, chitosan cross-linked and levofloxacin HCl incorporated, antimicrobial PP mesh devices were prepared using citric acid as a bio-based and green cross-linking agent. The inert PP mesh fibers were surface activated using O2 plasma treatment at low pressure. Then, chitosan of different molecular weights (low and medium weight) were cross-linked with O2 plasma activated surfaces using citric acid. Scanning electron microscopy (SEM), energy dispersive X-ray (EDX) spectroscopy, and Fourier transform infrared (FTIR) spectroscopy confirmed that chitosan was cross-linked with O2 plasma-treated PP mesh surfaces and formed a thin layer of chitosan and levofloxacin HCl on the PP mesh surfaces. Moreover, antimicrobial properties of chitosan and levofloxacin HCl-coated PP meshes were investigated using an agar plate release method. The coated PP meshes demonstrated excellent antimicrobial inhibition zone up to 10 mm. Thus, modified PP meshes demonstrated sustained antimicrobial properties for six continuous days against Staphylococcus aureus (SA) and Escherichia coli (EC) bacteria.

scholarly journals Preparation of antibacterial polypropylene grafted acrylic acid and immobilized silver nanoparticles by γ-irradiation method

2018 ◽  
Vol 14 (4) ◽  
pp. 699-704
Author(s):  
Dang Hoang Viet ◽  
Duong Hoa Xo ◽  
Le Quang Luan
Keyword(s):  
Silver Nanoparticles ◽  
Acrylic Acid ◽  
Mammalian Cells ◽  
Antibacterial Properties ◽  
Antimicrobial Properties ◽  
Inhibition Zone ◽  
Γ Irradiation ◽  
E Coli ◽  
Γ Rays

Silver nanoparticles (AgNPs) are now being widely used as antibacterial agents due to their strong bactericidal properties and low toxicity on mammalian cells. In this study, γ-rays irradiation method was used to synthesize AgNPs from silver nitrate (AgNO3) solution and to graft acrylic acid (AAc) onto porous polypropylene (PP). Porous PP grafted with AAc (PP-g-AAc) was then immobilized with AgNPs for preparing the antimicrobial materials (PP-g-AAc/AgNPs). The results demonstrated that the grafting yield of AAc onto PP increased by the increasing of irradiation dose as well as AAc concentration. The PP-g-AAc samples with grafting degrees from 1.2 to 29.8% were immobilized with AgNPs (d ~ 10 nm, 500 ppm) to obtain antimicrobial properties. The immobilized Ag contents were from 132 to 392 ppm and corresponded to the PP-g-AAc samples at grafting degrees from 1.2 to 29.8%. The in vitro antibacterial properties of PP-g-AAc/AgNPs materials on E. coli were evaluated and the results indicated that the bactericidal efficiency (η) increased by the increase of Ag contents in the tested materials. The germicidal activities against E. coli of PP-g-AAc/AgNPs containing 363 ppm Ag were found to be nearly 100% after treating in 30 min. In addition, the inhibition zone of this PP-g-AAc/AgNPs on E. coli was also found up to 28 mm in diameter. Thus, γ-rays radiation demonstrated a strong capability in grafting functional groups (AAc) onto porous PP. Furthermore, the porous PP grafted with AAc and immobilized with AgNPs might potentially be used for elimination of bacteria in water filtering.

scholarly journals Polydopamine-Inspired Surface Modification of Polypropylene Hernia Mesh Devices via Cold Oxygen Plasma: Antibacterial and Drug Release Properties

Coatings ◽  
2019 ◽  
Vol 9 (3) ◽  
pp. 164 ◽  
Author(s):  
Xiakeer Saitaer ◽  
Noor Sanbhal ◽  
Yansha Qiao ◽  
Yan Li ◽  
Jing Gao ◽  
...  
Keyword(s):  
Drug Release ◽  
Plasma Treatment ◽  
Oxygen Plasma ◽  
Antimicrobial Property ◽  
Antimicrobial Properties ◽  
Major Complication ◽  
Inhibition Zone ◽  
Repair Process ◽  
Hernia Surgery ◽  
Maximum Inhibition

Mesh infection is a major complication of hernia surgery after polypropylene (PP) mesh implantation. Modifying the PP mesh with antibacterial drugs is an effective way to reduce the chance of infection, but the hydrophobic characteristic of PP fibers has obstructed the drug adhesion. Therefore, to prepare antimicrobial PP mesh with a stable drug coating layer and to slow the drug release property during the hernia repair process has a great practical meaning. In this work, PP meshes were coated by bio-inspired polydopamine (PDA), which can load and release levofloxacin. PP meshes were activated with cold oxygen plasma and then plasma activated PP fibers were coated with PDA. The PDA coated meshes were further soaked in levofloxacin. The levofloxacin loaded PP meshes demonstrate excellent antimicrobial properties for 6 days and the drug release has lasted for at least 24 h. Moreover, a control PP mesh sample without plasma treatment was also prepared, after coating with PDA and loading levofloxacin. The antimicrobial property was sustained only for two days. The maximum inhibition zone of PDA coated meshes with and without plasma treatment was 12.5 and 9 mm, respectively. On all accounts, the modification strategy can facilely lead to long-term property of infection prevention.

PHYTOCHEMICAL INVESTIGATION AND ANTIMICROBIAL PROPERTIES OF DIOSCOREA BULBIFERA TUBER

2017 ◽  
Vol 10 (12) ◽  
pp. 317
Author(s):  
Dahiya P
Keyword(s):  
Antimicrobial Properties ◽  
Inhibition Zone ◽  
Multidrug Resistant ◽  
Diffusion Method ◽  
Phytochemical Analysis ◽  
Phytochemical Investigation ◽  
Dioscorea Bulbifera ◽  
Acinetobacter Sp ◽  
Almost All

  Objective: The inhibitory properties of successive extracts from Dioscorea bulbifera (Dioscoreaceae) tubers have been evaluated for the presence of phytochemical constituents and antimicrobial efficacy against multidrug-resistant (MDR) clinical isolates was evaluated.Methods: The tuber of D. bulbifera was oven dried and extracted successively with n-hexane, chloroform, methanol, ethanol, and water. The antimicrobial potential of successive extracts against MDR isolates was studied by agar well-diffusion method. Qualitative phytochemical analysis was performed.Results: Qualitative phytochemical analysis demonstrated the presence of steroids, flavonoids, cardiac glycosides, saponins, and reducing sugars in almost all the extracts tested. Anthraquinones, phlobatanins, and tannins were not reported in any extracts tested. The in vitro antimicrobial activity of various solvents and water extracts of D. bulbifera was further investigated against ten MDR bacteria and three fungi, respectively. Aqueous and chloroform extracts were found to be more potent being capable of exerting significant inhibitory activities against the majority of the isolates such as Escherichia coli, Acinetobacter sp., Salmonella paratyphi, Klebsiella pneumoniae, and Candida albicans. The highest inhibitory activity was observed for K. pneumoniae with wide inhibition zone diameters (17 ± 0.15 mm), followed by E. coli 1(13 ± 0.11) mm, and Acinetobacter sp. (11 ± 0.12).Conclusion: Based on the present study, the extracts of D. bulbifera tubers have shown excellent activity against MDR microbial cultures tested. Further study is recommended for clinical evaluation, of the efficacy of crude extract in herbal medicine that can serve as a base for the development of novel potent drugs and phytomedicines.

scholarly journals The PHYTOCHEMICALS, ANTIOXIDANT AND ANTIMICROBIAL PROPERTIES OF Senna alata AND Senna tora LEAF EXTRACTS AGAINST BACTERIAL STRAINS CAUSING SKIN INFECTIONS

2019 ◽  
Vol 2 (1) ◽  
pp. 19
Author(s):  
Murni Halim
Keyword(s):  
Leaf Extract ◽  
Antimicrobial Properties ◽  
Inhibition Zone ◽  
Antimicrobial Activities ◽  
Diffusion Method ◽  
Bacterial Strains ◽  
Leaf Extracts ◽  
Natural Drugs ◽  
Senna Alata

A study was carried out to screen for phytochemical constituents and assess the antioxidant and antimicrobial activities of Senna alata and Senna tora leaf extracts. The leaves were first dried at room temperature and 50°C in an oven prior to solvent extraction using ethanol and methanol. The in-vitro qualitative assays showed that both S. alata and S. tora leaf extracts contained bioactive and secondary metabolites components such as tannins, steroids, saponin, terpenoids, glycosides, flavonoids and phenols. The antioxidant activity and capacity test were carried out by conducting free radical of 2,2-diphenyl-1-picrylhydrazyl (DPPH) scavenging activity and Ferric reduction antioxidant plasma (FRAP) assays. Both assays showed S. tora leaf extract has higher antioxidant capacity than S. alata leaf extract. The efficacy of these leaf extracts were tested against skin pathogens through agar well diffusion method. S. alata extract showed an inhibition zone (1.15 – 1.59 mm) against Pseudomonas aeruginosa while S. tora extracts exhibited a strong antimicrobial activity against S. epidermidis (inhibition zone of 12 – 16.94 mm) followed by P. aeruginosa (inhibition zone of 1 – 1.59 mm). Nonetheless, no inhibition zone was observed for S. aureus by both leaf extracts. The phytochemicals and antioxidant constituents as well as inhibitory potential on skin pathogens possessed by S. alata and S. tora leave highlighted their potential utilization in the development of natural drugs or cosmetics to treat skin related diseases or infections.

Uji Ekstrak Bawang Bombay sebagai Anti Bakteri Gram Positif Staphylococcus aureus dengan Metode Difusi Cakram

2012 ◽  
Vol 12 (2) ◽  
pp. 68
Author(s):  
Wuryanti Wuryanti ◽  
Nies Suci Mulyani ◽  
Mukhammad Asy'ari ◽  
Purbowatiningrum Ria Sarjono
Keyword(s):  
Allium Cepa ◽  
Human Life ◽  
Antimicrobial Property ◽  
Antimicrobial Properties ◽  
Living Organism ◽  
Inhibition Zone ◽  
Antimicrobial Test ◽  
Allium Cepa L ◽  
Paper Disc

Microbe is a microscopic living organism which is closely linked to human life. One of pathogenic microorganisms such as Staphylococcus aureu,. may cause diseases. Sulfure of several plants are bioactive as antimicrobial. The properties of sulfure in Allium cepa L leads to an assumption that it has antimicrobial properties. Therefore, this study involved the antimicrobial test. The determination steps of antimicrobial Allium cepa L extract consisted of the Allium cepa L extract preparation, microbial regeneration and antimicrobial test. The antibacterial determination were performed by paper disc method. Based on the research data, determination of antimicrobial Allium cepa L extract resulted in inhibition zone area showed that the extract owned antimicrobial property.

scholarly journals Effects Of Environmental Factors On The Dispersion Behavior Of Iron Oxide In Aqueous Solutions With Poly Acrylic Acid

2015 ◽  
Vol 60 (2) ◽  
pp. 1561-1564
Author(s):  
E.-H. Lee ◽  
K.-M. Kim ◽  
W.-Y. Maeng ◽  
D.-H. Hur
Keyword(s):  
Molecular Weight ◽  
Acrylic Acid ◽  
High Molecular Weight ◽  
Low Molecular Weight ◽  
Solution Ph ◽  
Molecular Weights ◽  
Aqueous Suspensions ◽  
Magnetite Particles ◽  
The Stability ◽  
Poly Acrylic Acid

Abstract After preparing aqueous suspensions from magnetite particles with a poly-acrylic acid, we investigated the effects of several experimental parameters. We characterized the stability of the suspensions using visual inspection, sedimentation, adsorption, and thermal stability of the dispersant. The dispersion stability is affected by the solution pH, the concentrations of magnetite particles, the molecular weight, the concentration of the dispersants, and the temperature. The stability of the suspensions increased as the concentration of the dispersant and the temperature increased. In terms of the molecular weights of the dispersant, the suspensions with dispersant of low-molecular weight (1800) were more stable than those of high-molecular weight (250000) at room temperature. However, at high temperature the suspensions with high-molecular weight showed stability. The adsorption efficiency of the dispersant was very low. The dispersant of high-molecular weight showed a higher thermal integrity than that of low-molecular weight. From this work, we obtained the optimum conditions for stable aqueous suspensions of magnetite particles.

Well-defined amphiphilic polymethylene-b-poly(acrylic acid) diblock copolymers: New synthetic strategy and their self-assembly

2012 ◽  
Vol 50 (17) ◽  
pp. 3641-3647 ◽  
Author(s):  
Hui-Chao Lu ◽  
Yang Xue ◽  
Qiao-Ling Zhao ◽  
Jin Huang ◽  
Shen-Gang Xu ◽  
...  
Keyword(s):  
Acrylic Acid ◽  
Self Assembly ◽  
Diblock Copolymers ◽  
Synthetic Strategy ◽  
Poly Acrylic Acid

scholarly journals Antibacterial activity of chitosan and the interpolyelectrolyte complexes of poly(acrylic acid)-chitosan

2010 ◽  
Vol 53 (3) ◽  
pp. 623-628 ◽  
Author(s):  
Hortensia Ortega-Ortiz ◽  
Baltazar Gutiérrez-Rodríguez ◽  
Gregorio Cadenas-Pliego ◽  
Luis Ibarra Jimenez
Keyword(s):  
Antibacterial Activity ◽  
Acrylic Acid ◽  
Antimicrobial Agents ◽  
Water Soluble ◽  
Amino Groups ◽  
Molecular Weights ◽  
Carboxylic Acid Groups ◽  
Microbial Inhibition ◽  
Interpolyelectrolyte Complexes ◽  
Poly Acrylic Acid

The antimicrobial activity of chitosan and water soluble interpolyelectrolyte complexes of poly(acrylic acid)-chitosan was studied. Chitosans of two different molecular weights were tested at different concentration for 0.5 to 5 g·L-1 as antimicrobial agents against P. aeruginosa and P. oleovorans. In both cases, the best microbial inhibition was obtained with the concentration of 5 g·L-1. However, the interpolyelectrolyte complexes of poly(acrylic acid)-chitosan with composition φ =2 produced higher antibacterial activity than the two chitosans at the concentration of 0.5 g·L-1. The NPEC2 complex was more effective than chitosans. This could be attributed to the number of moles of the amino groups of chitosan and the carboxylic acid groups of the interpolyelectrolyte complexes poly(acrylic acid).

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