scholarly journals Nutritional Modulation of the Immune Response Mediated by Nucleotides in Canine Leishmaniosis

2021 ◽  
Vol 9 (12) ◽  
pp. 2601
Author(s):  
Sergi Segarra

Leishmaniasis is an emerging, uncontrolled, and neglected zoonotic disease. Climate change is contributing to its ongoing global expansion. The dog is the main reservoir; hence the importance of implementing effective treatment, prevention, and control measures in this animal species to protect public health. However, although the standard treatment for canine leishmaniosis (CanL) is effective, it does not provide full parasitological clearance, and side effects and drug resistance have been described. The host’s immune system plays a key role in the establishment and evolution of leishmaniasis. Dietary nucleotides modulate the immune response and, given their reported efficacy and safety in sick and clinically healthy Leishmania-infected dogs and because they represent a sustainable option with no associated side effects or resistance, they could be included within the prevention, treatment, and control strategies for leishmaniasis. This article briefly summarizes the scientific literature on CanL management, including unresolved issues, and reviews the scientific evidence on immunomodulatory effects of dietary nucleotides in different animal species. It also proposes a CanL management algorithm, including nucleotides. It is concluded that nutritional modulation of the immune response with nucleotides can contribute to better management of leishmaniasis following a One Health approach, especially in the COVID-19 era.

2014 ◽  
Vol 641-642 ◽  
pp. 853-859
Author(s):  
Wei Wang ◽  
Hui Zhao ◽  
Guan Xing Wang ◽  
Hua Zhen Zhou

Traffic noise is a major source of noise pollution in the urban environment, including road traffic noise and rail traffic noise, which has become one of the domestic large and medium cities in environmental issues to be solved. This paper analyzes the status of the Beijing traffic noise pollution and control strategies, and a typical apartment block selected as a case, analyzes its noise pollution elements, severity, time distribution, and draws a noise map of the plane area and a dormitory building in the noise conditions typical time. Last we discussed and gave the method based on noise control measures.


2020 ◽  
Vol 18 (2) ◽  
pp. 53-66
Author(s):  
N. Lawal ◽  
A.B. Onoja

Coronaviridae is a family of RNA viruses responsible for two previous epidemics of viral pneumonia and related illnesses: Severe Acute Respiratory Syndrome in 2002 and Middle East Respiratory Syndrome in 2012. The current COVID-19 pandemic is caused by a new member of the family Coronaviridae, named SARS-CoV-2 which emerged in December, 2019 in Wuhan, China. Infected persons present with severe respiratory illness including pneumonia. There have been reports of confirmed cases in different animal species that became infected with SARS-CoV-2, suggesting possible reverse zoonosis. In this review, we discussed the origin, biology, genome organization, replication and virus entry into host cells, immune mechanisms, epidemiological trends, prevention and control strategies employed in combating the threat posed by the COVID-19 pandemic. Keywords: COVID-19, Epidemiological trend, Pandemic, SARS-CoV-2


2020 ◽  
Vol 9 (1) ◽  
Author(s):  
Olushayo Oluseun Olu ◽  
Joy Luba Lomole Waya ◽  
Sylvester Maleghemi ◽  
John Rumunu ◽  
David Ameh ◽  
...  

Abstract The ongoing pandemic of the coronavirus disease 2019 has spread rapidly to all countries of the world. Africa is particularly predisposed to an escalation of the pandemic and its negative impact given its weak economy and health systems. In addition, inadequate access to the social determinants of health such as water and sanitation and socio-cultural attributes may constrain the implementation of critical preventive measures such as hand washing and social distancing on the continent. Given these facts, the continent needs to focus on targeted and high impact prevention and control strategies and interventions which could break the chain of transmission quickly. We conclude that the available body of scientific evidence on the coronavirus disease 2019 holds the key to the development of such strategies and interventions. Going forward, we recommend that the African research community should scale up research to provide scientific evidence for a better characterization of the epidemiology, transmission dynamics, prevention and control of the virus on the continent.


2021 ◽  
Author(s):  
S.D. Audarya ◽  
D. Chhabra ◽  
R. Sharda ◽  
R. Gangil ◽  
R. Sikrodia ◽  
...  

Mastitis is an inflammation of mammary glands that is prevalent in dairy bovines. It causes a significant proportion of economic losses to the dairy farmers in India. Cattle and buffalo farming contribute significantly to the economy of the state. Various infectious agents such as bacteria, fungi, and algae may cause mastitis. Hence, it is essential to understand the etiological agents and predisposing factors that lead to mastitis in susceptible bovine populations in Madhya Pradesh state so that appropriate prevention and control strategies can be implemented. In this chapter, epidemiology, diagnosis, prevention, and control measures of mastitis in general and in India, the state of Madhya Pradesh, in particular, will be presented.


Author(s):  
Xiang-Sha Kong ◽  
Feng Liu ◽  
Hai-Bo Wang ◽  
Rui-Feng Yang ◽  
Dong-Bo Chen ◽  
...  

AbstractAt the end of 2019, an outbreak of unknown pathogen pneumonia occurred in China, then it was named corona virus disease 2019 (COVID-19). With the rapid spread of COVID-19, a series of strict prevention and control measures were implemented to cut the spread of the epidemic. Influenza as a respiratory tract infection disease as COVID-19 might also be controlled. To assess the effects, we used the total passenger numbers sent in mainland China from 2018 to 2020 and the daily number of railway passenger (DNRP) flow in 2020 during Spring Festival travel rush to reflect the population movement and further to analyze newly and cumulative confirmed COVID-19 and influenza. We found that with implementing the series measures on COVID-19, not only COVID-19, but also influenza mitigated in China. The prevention and control measures for COVID-19 might be used in controlling respiratory tract diseases, and reducing the national health economic burden. When other countries issue measures on COVID-19 and influenza, they should consider adopting more aggressive epidemic prevention and control strategies.


2021 ◽  
Author(s):  
Lequan Min

AbstractTo date, over 130 million people on infected with COVID-19. It causes more 2.8 millions deaths. This paper introduces a symptomatic-asymptomatic-recoverer-dead differential equation model (SARDDE). It gives the conditions of the asymptotical stability on the disease-free equilibrium of SARDDE. It proposes the necessary conditions of disease spreading for the SARDDE. Based on the reported data of the first and the second COVID-19 epidemics in Beijing and simulations, it determines the parameters of SARDDE, respectively. Numerical simulations of SARDDE describe well the outcomes of current symptomatic and asymptomatic individuals, recovered symptomatic and asymptomatic individuals, and died individuals, respectively. The numerical simulations suggest that both symptomatic and asymptomatic individuals cause lesser asymptomatic spread than symptomatic spread; blocking rate of about 90% cannot prevent the spread of the COVID19 epidemic in Beijing; the strict prevention and control strategies implemented by Beijing government is not only very effective but also completely necessary. The numerical simulations suggest also that using the data from the beginning to the day after about two weeks at the turning point can estimate well or approximately the following outcomes of the two COVID-19 academics, respectively. It is expected that the research can provide better understanding, explaining, and dominating for epidemic spreads, prevention and control measures.


EDIS ◽  
2008 ◽  
Vol 2008 (5) ◽  
Author(s):  
Allen Morris ◽  
Ron Muraro

FE712, a 7-page illustrated article by Allen Morris and Ron Muraro, explores the profitability of various types of control measures now being practiced in the citrus industry. Published by the UF Department of Food and Resource Economics, June 2008.


2021 ◽  
Vol 12 ◽  
Author(s):  
Zhiyi Wang ◽  
Biao Chen ◽  
Tong Zhang ◽  
Guohui Zhou ◽  
Xin Yang

Rice stripe mosaic disease (RSMD) is caused by the rice stripe mosaic virus (RSMV; genus Cytorhabdovirus, family Rhabdoviridae). In recent years, significant progress has been made in understanding several aspects of the disease, especially its geographical distribution, symptoms, vectors, gene functions, and control measures. Since RSMD was first detected in southern China in 2015, it has been found in more and more rice growing areas and has become one of the most important rice diseases in southern China. RSMV is transmitted by the leafhopper Recilia dorsalis in a persistent-propagative manner, inducing yellow stripes, a slight distortion of leaves, increased tillers, and empty grains in rice plants. The virus has a negative-sense single-strand RNA genome of about 12.7 kb that encodes seven proteins: N, P, P3, M, G, P6, and L. Several molecular and serological tests have been developed to detect RSMV in plants and insects. The disease cycle can be described as follows: RSMV and its vector overwinter in infected plants; viruliferous R. dorsalis adults transmit the virus to spring rice and lay eggs on the infected seedlings; the next generation of R. dorsalis propagate on infected seedlings, become viruliferous, disperse, and cause new disease outbreaks. Control measures include monitoring and accurate forecasting, selecting disease-resistant varieties, improving cultivation systems, covering rice seedling nurseries with insect-proof nets, and using pesticides rationally. Inappropriate cultivation systems, pesticide overuse, and climatic conditions contribute to epidemics by affecting the development of vector insects and their population dynamics.


2021 ◽  
Author(s):  
Lequan Min

To date, over 178 million people on infected with COVID-19. It causes more 3.8 millions deaths. Based on a previous symptomatic-asymptomatic-recoverer-dead differential equation model (SARDDE) and the clinic data of the first COVID-19 epidemic in Shanghai, this paper determines the parameters of SARDDE. Numerical simulations of SARDDE describe well the outcomes of current symptomatic individuals, recovered symptomatic individuals, and died individuals, respectively. The numerical simulations suggest that both symptomatic and asymptomatic individuals cause lesser asymptomatic spread than symptomatic spread; blocking rate of about 95.5\% cannot prevent the spread of the COVID19 epidemic in Shanghai. The strict prevention and control strategies implemented by Shanghai government is not only very effective but also completely necessary. The numerical simulations suggest also that using the data from the beginning to the day after about 19 days at the turning point can estimate well the following outcomes of the COVID-19 academic. It is expected that the research can provide better understanding, explaining, and dominating for epidemic spreads, prevention and control measures.


Author(s):  
Kuldeep Dhama ◽  
Shailesh Kumar Patel ◽  
Khan Sharun ◽  
Mamta Pathak ◽  
Ruchi Tiwari ◽  
...  

Coronavirus Disease 2019 (COVID-19), caused by SARS-CoV-2 (Severe Acute Respiratory Syndrome - Coronavirus-2) of the family Coronaviridae, appeared in Wuhan, Hubei province, China being its epicenter in December 2019. This disease was declared as posing Public Health International Emergency by World Health Organization on January 30, 2020, attained the status of a very high-risk category on February 29, and now having a pandemic status (March 11, 2020). COVID-19 has presently spread to more than 195 countries/territories while killing nearly 19,600 humans out of cumulative confirmed cases accounting to more than 430,000 within a short period of just a few weeks. The majority of deaths have been reported in Italy and China. Researchers worldwide are pacing with high efforts to counter the spread of this virus and to design effective vaccines and therapeutics/drugs. Few of the studies have shown the potential of animal-human interface and zoonotic links in the origin of SARS-CoV-2. Exploring the possible zoonosis and revealing the factors responsible for its initial transmission from animals to humans will pave ways to design and implement effective preventive and control strategies to counter COVID-19. The present review presents an overview of COVID-19 and the causative virus SARS-CoV-2, with particular emphasis on the role of animals and their jumping the cross-species barriers, experiences learned from SARS- and MERS-CoVs, zoonotic links, and spillover events, transmission to humans and rapid spread., highlighting in very brief the preventive and control measures along with a few of the recent research developments to counter this pandemic virus/disease.


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