scholarly journals Comparison of the Effects of Different Food-Grade Emulsifiers on the Properties and Stability of a Casein-Maltodextrin-Soybean Oil Compound Emulsion

Molecules ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 458 ◽  
Author(s):  
Yuan Liu ◽  
Zhen-Cheng Wei ◽  
Yuan-Yuan Deng ◽  
Hao Dong ◽  
Yan Zhang ◽  
...  
Keyword(s):  
Particle Size ◽  
Zeta Potential ◽  
Soybean Oil ◽  
Activity Index ◽  
Average Particle Size ◽  
The Other ◽  
Average Particle ◽  
Emulsifying Activity ◽  
Food Grade ◽  
Hydrophilic Lipophilic Balance

The improvement of food-grade emulsifiers in the properties and stability of complex emulsion has attracted much interest. In this study, the effects of six food-grade emulsifiers with a hydrophilic–lipophilic balance (HLB) range of 3.4–8.0 on a casein-maltodextrin-soybean oil compound emulsion were investigated by centrifugal precipitation rate (CPR), emulsifying activity index (EAI), microrheological properties, zeta potential, average particle size, and Turbiscan stability index (TSI). The optimal amounts of added succinylated monoglyceride (SMG) and polyglycerol fatty acid ester were 0.0025% and 0.1% (w/w), respectively, while that of the other four emulsifiers was 0.2% (w/w), according to the CPR. Thereinto, the SMG-stabilized emulsion exhibited the highest emulsifying activity and the lowest viscosity value and possessed the highest stability over 14 days of storage, which was indicated by the lowest TSI value and the smallest change in delta backscattering signal, relative to those of the other groups. Moreover, the emulsion stabilized by SMG displayed better emulsion stability than the control under a range of pH (6.0–8.0) and calcium ion concentrations (0–10 mM), which was attributed to the increased zeta potential value and the decreased average particle size of droplets with the addition of SMG. The present study provides a basic understanding for SMG improving the properties and stability of the complex emulsion.

Preparation and characterization of natural quercetin-based Mongolia Medicine SenDeng-4 nanoemulsion (N-QUE-NE) and its antibacterial activity..

2020 ◽  
Vol 18 ◽  
Author(s):  
Yanfang Zhang ◽  
Rina Du ◽  
Pengwei Zhao ◽  
Sha Lu ◽  
Rina Wu ◽  
...  
Keyword(s):  
Particle Size ◽  
Antibacterial Activity ◽  
Zeta Potential ◽  
High Speed ◽  
Antibacterial Effect ◽  
Average Particle Size ◽  
Antagonistic Effect ◽  
Dilution Method ◽  
Average Particle

Background: Quercetin is the main active ingredient of Xanthoceras sorbifolia Bunge. Traditional compatibility theory of traditional Chinese medicine has typically reported a synergistic interaction among multiple components, while the synergistic effects of nanoemulsion have not been fully clarified. Objective: To study preparation and characterization of quercetin-based Mongolia Medicine Sendeng-4 nanoemulsion (NQUE-NE) and its antibacterial activity and mechanisms. Methods: The morphology of the nanoemulsion was observed by transmission electron microscopy (TEM), and the zeta potential, polydispersity index (PDI), and particle size distribution were determined by the nanometer particle size analyze. The stability of nanoemulsion was investigated by light test, high speed centrifugal test and storage experiment at different temperature. The combined bacteriostatic effect of N-QUE-NE was studied in vitro by double-dilution method and checkerboard dilution method. Results: The appearance of N-QUE-NE was pale yellow, clear and transparent. The nanoemulsion particles were spherical and uniformly distributed under TEM. The PDI was 0.052, the average particle size was 19.6nm, and the Zeta potential was -0.2mV. When quercetin nanoemulsion (QUE-NE) was used in combination with tannin nanoemulsion (TAN-NE) and toosendanin nanoemulsion (TOO-NE), it exhibited a synergistic antibacterial effect. However, the combination of QUE-NE and geniposide nanoemulsion (GEN-NE) exhibited an antagonistic effect. It was revealed that the antibacterial effect was in order of quercetin-tannin-toosendanin nanoemulsion (QUE-TAN-TOO-NE) ＞ quercetin-tannin nanoemulsion (QUE-TANNE) ＞ QUE-NE ＞ quercetin-tannin-toosendanin-geniposide nanoemulsion (QUE-TAN-TOO-GEN-NE). Conclusion: This study explored the preparation and efficacy of N-QUE-NE, and the results showed that quercetin, tannin and toosendanin had satisfactory synergistic antibacterial effects. The antagonistic effect of quercetin and geniposide in nanoemulsion indicated that it is not beneficial to the antibacterial effect of Sendeng-4, and further research needs to be conducted to clarify its antibacterial effect.

Formulation and Evaluation of Polymeric Nanoparticles of an Antiviral Drug for Gastroretention

2012 ◽  
Vol 4 (4) ◽  
pp. 1557-1562 ◽  
Author(s):  
Ankit Anand Kharia ◽  
A K Singhai ◽  
R Verma
Keyword(s):  
Particle Size ◽  
Zeta Potential ◽  
Average Particle Size ◽  
Chlorinated Solvents ◽  
Entrapment Efficiency ◽  
The Body ◽  
Hydrophilic Polymers ◽  
Polydispersity Index ◽  
Average Particle ◽  
Loading Efficiency

The aim of present study was to formulate and evaluate nanoparticles of acyclovir by using different hydrophilic polymers. Acyclovir was selected as a suitable drug for gastro-retentive nanoparticles due to its short half life, low bioavailability, high frequency of administration, and narrow absorption window in stomach and upper part of GIT. The nano-precipitation method was used to prepare nanoparticles so as to avoid both chlorinated solvents and surfactants to prevent their toxic effect on the body. Nanoparticles of acyclovir were prepared by using hydrophilic polymers such as bovine serum albumin, chitosan, and gelatin. The prepared formulations were then characterized for particle size, polydispersity index, zeta potential, loading efficiency, encapsulation efficiency and drug-excipient compatibility. The prepared nanoparticulate formulations of acyclovir with different polymers in 1:1 ratio have shown particle size in the range of 250.12-743.07 nm, polydispersity index (PDI) in the range of 0.681-1.0, zeta potential in the range of -14.2 to +33.2 mV, loading efficiency in the range of 8.74-17.54%, and entrapment efficiency in the range of 55.7%-74.2%. Nanoparticulate formulation prepared with chitosan in 1:1 ratio showed satisfactory results i.e. average particle size 312.04 nm, polydispersity index 0.681, zeta potential 33.2 mV, loading efficiency 17.54%, and entrapment efficiency 73.4%. FTIR study concluded that no major interaction occurred between the drug and polymers used in the present study.  

Search for Candidate Exogenous Material on Bennu using MapCam and PolyCam Images

2020 ◽  
Author(s):  
Humberto Campins ◽  
Eri Tatsumi ◽  
Marcel Popescu ◽  
Juan Rizos ◽  
Amy Simon ◽  
...  
Keyword(s):  
Particle Size ◽  
Average Particle Size ◽  
The Other ◽  
Average Particle ◽  
X Band ◽  
Initial Comparison ◽  
Different Origin ◽  
Reflectance Peak ◽  
Basaltic Material

<p><strong>Introduction:</strong> Exogenous material has been reported on asteroids (101955) Bennu and (162173) Ryugu.  The albedo, color, and spectra of six bright boulders on Bennu show that they are distinct from the rest of Bennu’s comparatively dark surface and are likely basaltic material from asteroid (4) Vesta (DellaGiustina et al. 2019; 2020).  Bright boulders identified on asteroid (162173) Ryugu show absorptions near 1 µm but not near 2 µm, suggesting olivine-rich anhydrous silicates (Tatsumi et al., 2019; 2020).</p><p><strong>Methods: </strong>In this work, we used images of Bennu obtained by the MapCam and PolyCam instruments (Rizk et al. 2018; Golish et al. 2020) on NASA’s OSIRIS-REx spacecraft (Lauretta et al. 2017) to search for more potentially exogeneous material on the surface of Bennu.  </p><p><strong>Results: </strong>We identified approximately 50 bright boulders on Bennu with significant x-band (0.85 µm) absorptions, including the six bright boulders previously described in DellaGiustina et al. (2020).  These bright boulders are distributed across Bennu’s surface, concentrated in terrains with larger than average particle size.  The boulders exhibit three main morphologies (homogeneous, heterogenous, and breccia) and three spectral types (reflectance peak at 0.55 µm, flat, and reflectance peak at 0.7 µm). There is some correlation between the morphology and the spectra. More specifically, three of the four boulders with reflectance peaks at 0.55 µm are in the breccia category and one is in the heterogeneous category, whereas all the boulders with reflectance peaking at 0.7 µm fall in the homogeneous and heterogenous categories. Bright boulders with reflectance peaking at 0.55 µm have lower normal albedo than the other two spectral groups, suggesting a different composition and possibly a different origin. An initial comparison with Ryugu (Tatsumi et al. 2019) indicates that Bennu is more abundant in possible exogeneous material.  </p><p><strong>Discussion: </strong>Further analysis of MapCam and PolyCam images has revealed a wider diversity of potentially exogenous lithologies on Bennu, expanding on the findings of DellaGiustina et al. (2020).  We continue our study of this diversity of material on Bennu’s surface to constrain the asteroid’s origin, evolution, and collisional history (e.g., Ballouz et al. 2020).</p><p><strong>References: </strong>DellaGiustina D. et al. (2019) Nat. Astron. 3, 341-351. DellaGiustina D. et al. (2020) Nat. Astron, in revision. Lauretta D. S. et al. (2017) Space Sci. Rev. 212, 925–984. Tatsumi E. et al. (2019) LPI Contribution No. 2132, id.1753. Rizk B. et al. (2018) Space Sci. Rev. 214, 26. Golish D.R. et al. (2020) Space Sci. Rev. 216, 12. Ballouz R.-L. et al. 2020, EPSC abstract.</p>

Effect of Poly(Vinyl Pyrrolidone) on Dispersing Carbon Black Particles

2013 ◽  
Vol 796 ◽  
pp. 432-436
Author(s):  
Xia Yuan
Keyword(s):  
Particle Size ◽  
Zeta Potential ◽  
Carbon Black ◽  
Ultrasonic Method ◽  
Aqueous Media ◽  
Average Particle Size ◽  
Sodium Dodecyl ◽  
Vinyl Pyrrolidone ◽  
Average Particle ◽  
Poly Vinyl Pyrrolidone

The effects of poly (vinyl pyrrolidone)(PVP) on dispersing carbon black (CB) particles were investigated by measuring Z-average particle size, Zeta potential and centrifugal stability of CB dispersions. Addition of PVP in a dispersing medium significantly reduces the size of suspended CB particles, especially in water. The dispersing efficiency of PVP was found to have been enhanced by adding an anionic surfactant, sodium methylenedinaphthalene disulphonate (NNO) in the aqueous media. The particle size of CB dispersed with PVP and NNO was 175.7 nm, significantly smaller than that dispersed with PVP and sodium dodecyl sulfate (SDS). The performance of PVP-encapsulated CB particles and that of PVP-adsorbed CB particles were also compared. The particle size and Zeta potential of PVP-encapsulated CB particles were similar to those of PVP-adsorbed CB particles using ultrasonic method, but the centrifugal stability of PVP-encapsulated CB dispersions was significantly improved. The relative absorbency of PVP/CB dispersions was increased from 42.0% to 63.7%. However, the PVP-encapsulated layer can be destroyed by prolonged ultrasonic treatment because the ultrasound over a long period of time can not only break up the flocculation bridge in the crosslinking matrix of PVP, but also flake off the PVP shells on the surface of CB particles.

Influence of Fineness on Activity Index of Blast Furnace Slag with Different SiO2/Al2O3

2015 ◽  
Vol 814 ◽  
pp. 579-582
Author(s):  
Su Ping Cui ◽  
Ling Ling Liu ◽  
Ya Li Wang ◽  
Hui Wang ◽  
Shi Jie Dong
Keyword(s):  
Particle Size ◽  
Blast Furnace ◽  
Blast Furnace Slag ◽  
Activity Index ◽  
Average Particle Size ◽  
Particle Size Analysis ◽  
Size Analysis ◽  
Average Particle ◽  
Furnace Slag ◽  
Activity Indices

Granulated blast furnace slag (GBFS) is a by-product of ironmaking and widely used in the cement and concrete. GBFS samples with different ratio of SiO2/Al2O3 were prepared under the laboratory conditions and ground by the agate ball mill at different times. Then they were characterized by laser particle size analysis (LPSA), scanning electron microscopy (SEM), Bertrand surface method and mechanical testing. It was found that the activity index of GBFS clearly increased with the decrease of the GBFS particle size. In the case of the average particle size about 32μm, the activity indices were irregular with the increase of SiO2/Al2O3 ratio, whereas for the average particle size about 11μm, the activity indices decreased with the increase of SiO2/Al2O3 ratio.

scholarly journals Effect of the Dispersion State in Y5O4F7 Suspension on YOF Coating Deposited by Suspension Plasma Spray

Coatings ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 831
Author(s):  
Seungjun Lee ◽  
Jaehoo Lee ◽  
Nongmoon Hwang
Keyword(s):  
Particle Size ◽  
Light Scattering ◽  
Dynamic Light Scattering ◽  
Zeta Potential ◽  
Average Particle Size ◽  
Average Particle ◽  
Electrophoretic Light Scattering ◽  
Electrosteric Stabilization ◽  
Dispersion State ◽  
Yttrium Oxyfluoride

The stable Y5O4F7 suspension for dense yttrium oxyfluoride (YOF) coating by suspension plasma spraying (SPS) was developed. Electrostatically and electrosterically stabilized aqueous Y5O4F7 suspensions were prepared and compared with a commercially available Y5O4F7 suspension without dispersant. The wettability and dispersibility of the Y5O4F7 suspensions were evaluated in terms of the zeta potential, average particle size, and size distribution with electrophoretic light scattering (ELS) and dynamic light scattering (DLS). The viscosity was measured and the sedimentation was tested to examine the fluidity and stability of the Y5O4F7 suspensions. When electrostatic (BYK-154) and electrosteric (BYK-199) dispersants were added to the Y5O4F7 suspension, the isoelectric point (IEP) of Y5O4F7 particles in the suspension shifted to lower pH. The zeta potential of both of electrostatically and electrosterically stabilized Y5O4F7 suspensions were higher than ±40 mV at pH of 8.6, respectively, which were much higher than of the Y5O4F7 suspension without dispersant. Meanwhile, the average particle size of the electrosterically stabilized Y5O4F7 suspension was much smaller than that of the electrostatically stabilized one. The electrosteric stabilization had a great effect on improving the wettability and dispersibility of the Y5O4F7 suspension. The coating rate of the electrosterically stabilized Y5O4F7 suspension was the highest among the three tested suspensions. In addition, the YOF coating deposited with the electrosterically stabilized Y5O4F7 suspension had the highest hardness and the lowest porosity.

scholarly journals BIO-NANOPARTICLES: GREEN SYNTHESIS OF GOLD NANOPARTICLES AND ASSESSMENT OF BIOLOGICAL EVALUATION

2019 ◽  
pp. 133-138
Author(s):  
RATIH DYAH PERTIWI ◽  
SUWALDI ◽  
ERNA PRAWITA SETYOWATI ◽  
RONNY MARTIEN
Keyword(s):  
Particle Size ◽  
Gold Nanoparticles ◽  
Zeta Potential ◽  
Absorption Spectra ◽  
Biological Activities ◽  
Average Particle Size ◽  
Antioxidant Properties ◽  
Biological Evaluation ◽  
Nano Particles ◽  
Average Particle

Objective: The design like bio-nano particles are beneficial over chemical and physical composition due to the eco-friendly and lower-cost synthesis of nanoparticles. The current study was purposed for the biosynthesis of gold nanoparticles (GNPs) and their antioxidant evaluation. Methods: Aqua extract of Muntingia calabura, Linn was applied for the synthesis of GNPs and confirmed by UV visible and ATR-Fourier Transform Infra-Red (ATR-FTIR) spectroscopy. Transmission Electron Microscope and Particle Size Analyser were used for the shape zeta potential and determination of size. Antioxidant activity was examined by DPPH (1,1 diphenyl-2-picryl-hydrazyl) radical scavenging method. Results: The result showed that UV–vis absorption spectra of H Au Cl4 at 290 nm while absorption spectra of biosynthesis gold nanoparticles at 540 nm. The forming of nanoparticles were spherical, having an average particle size of 88 nm, and the result of zeta potential was 9.5 mV. Analysis of ATR-FTIR revealed the possible involvement of phytochemical constituents in gold nanoparticles of aqua extract. Green synthesized nanoparticles showed enhanced antioxidant properties. Conclusion: Green synthesized GNPs showed enhanced biological activities. Present results also support the benefit of using the biosynthesis method for the production of gold nanoparticles that have the potential of antioxidant and biology activities.

scholarly journals Improving the Intercellular Uptake and Osteogenic Potency of Calcium Phosphate via Nanocomplexation with the RALA Peptide

Nanomaterials ◽  
2020 ◽  
Vol 10 (12) ◽  
pp. 2442
Author(s):  
Michelle O’Doherty ◽  
Eoghan J. Mulholland ◽  
Philip Chambers ◽  
Sreekanth Pentlavalli ◽  
Monika Ziminska ◽  
...  
Keyword(s):  
Particle Size ◽  
Calcium Phosphate ◽  
Zeta Potential ◽  
Average Particle Size ◽  
Average Particle ◽  
Type I ◽  
Amphipathic Peptide ◽  
Matrix Deposition ◽  
Post Transfection ◽  
Osteogenic Response

Calcium phosphate-base materials (e.g., alpha tri-calcium phosphate (α–TCP)) have been shown to promote osteogenic differentiation of stem/progenitor cells, enhance osteoblast osteogenic activity and mediate in vivo bone tissue formation. However, variable particle size and hydrophilicity of the calcium phosphate result in an extremely low bioavailability. Therefore, an effective delivery system is required that can encapsulate the calcium phosphate, improve cellular entry and, consequently, elicit a potent osteogenic response in osteoblasts. In this study, collagenous matrix deposition and extracellular matrix mineralization of osteoblast lineage cells were assessed to investigate osteogenesis following intracellular delivery of α-TCP nanoparticles. The nanoparticles were formed via condensation with a novel, cationic 30 mer amphipathic peptide (RALA). Nanoparticles prepared at a mass ratio of 5:1 demonstrated an average particle size of 43 nm with a zeta potential of +26 mV. The average particle size and zeta potential remained stable for up to 28 days at room temperature and across a range of temperatures (4–37 °C). Cell viability decreased 24 h post-transfection following RALA/α-TCP nanoparticle treatment; however, recovery ensued by Day 7. Immunocytochemistry staining for Type I collagen up to Day 21 post-transfection with RALA/α-TCP nanoparticles (NPs) in MG-63 cells exhibited a significant enhancement in collagen expression and deposition compared to an untreated control. Furthermore, in porcine mesenchymal stem cells (pMSCs), there was enhanced mineralization compared to α–TCP alone. Taken together these data demonstrate that internalization of RALA/α-TCP NPs elicits a potent osteogenic response in both MG-63 and pMSCs.

scholarly journals High-Pressure Homogenization Pre-Treatment Improved Functional Properties of Oyster Protein Isolate Hydrolysates

Molecules ◽  
2018 ◽  
Vol 23 (12) ◽  
pp. 3344 ◽  
Author(s):  
Yue Cha ◽  
Fan Wu ◽  
Henan Zou ◽  
Xiaojie Shi ◽  
Yidi Zhao ◽  
...  
Keyword(s):  
Particle Size ◽  
High Pressure ◽  
Zeta Potential ◽  
Functional Properties ◽  
Potential Surface ◽  
Activity Index ◽  
Surface Hydrophobicity ◽  
High Pressure Homogenization ◽  
Emulsifying Activity ◽  
Pre Treatment

The effects of HPH (high-pressure homogenization) pre-treatment on the functional properties of OPIH (oyster protein isolates hydrolysates) were studied. Sodium dodecyl sulfate-polyacrylamide gel electrophoresis profiles, solubility, particle size distribution, zeta potential, surface hydrophobicity, emulsifying activity index and microstructure of emulsions were analyzed. Results indicated that HPH pre-treatment increased the accessibility of OPI to trypsin hydrolysis, resulting in decease in particle size, increase in solubility, absolute zeta potential, surface hydrophobicity and emulsifying activity index. In addition, HPH pre-treated OPIH emulsions became more uniform and the particle size of droplets decreased. These results revealed that HPH pre-treatment has the potential to modify the functional properties of OPIH.

scholarly journals Third-Generation Cephalosporin-Loaded Chitosan Used to Limit Microorganisms Resistance

Materials ◽  
2020 ◽  
Vol 13 (21) ◽  
pp. 4792
Author(s):  
Letiția Doina Duceac ◽  
Gabriela Calin ◽  
Lucian Eva ◽  
Constantin Marcu ◽  
Elena Roxana Bogdan Goroftei ◽  
...  
Keyword(s):  
Particle Size ◽  
Antibiotic Resistance ◽  
Zeta Potential ◽  
Average Particle Size ◽  
Chitosan Nanoparticles ◽  
World Health ◽  
Multi Drug Resistance ◽  
Prolonged Release ◽  
Average Particle ◽  
Gravimetric Analysis

From their discovery, antibiotics have significantly improved clinical treatments of infections, thus leading to diminishing morbidity and mortality in critical care patients, as well as surgical, transplant and other types of medical procedures. In contemporary medicine, a significant debate regarding the development of multi-drug resistance involves all types of pathogens, especially in acute care hospitals due to suboptimal or inappropriate therapy. The possibility of nanotechnology using nanoparticles as matrices to encapsulate a lot of active molecules should increase drug efficacy, limit adverse effects and be an alternative helping to combat antibiotic resistance. The major aim of this study was to obtain and to analyze physico-chemical features of chitosan used as a drug-delivery system in order to stop the antibiotic resistance of different pathogens. It is well known that World Health Organization stated that multidrug resistance is one of the most important health threats worldwide. In last few years, nano-medicine emerged as an improved therapy to combat antibiotic-resistant infections agents. This work relies on enhancement of the antimicrobial efficiency of ceftriaxone against gram(+) and gram(−) bacteria by antibiotic encapsulation into chitosan nanoparticles. Physicochemical features of ceftriaxone-loaded polymer nanoparticles were investigated by particle size distribution and zeta potential, Fourier-transform infrared spectroscopy (FTIR), Thermal Gravimetric Analysis (TG/TGA), Scanning Electron Microscopy (SEM) characteristics techniques. The obtained results revealed an average particle size of 250 nm and a zeta potential value of 38.5 mV. The release profile indicates an incipient drug deliverance of almost 15%, after 2 h of approximately 83%, followed by a slowed drug release up to 24 h. Characteristics peaks of chitosan were confirmed by FTIR spectra indicating a similar structure in the case of ceftriaxone-loaded chitosan nanoparticles. A good encapsulation of the antibiotic into chitosan nanoparticles was also provided by thermo-gravimetric analysis. Morphological characteristics shown by SEM micrographs exhibit spherical nanoparticles of 30–250 nm in size with agglomerated architectures. Chitosan, a natural polymer which is used to load different drugs, provides sustained and prolonged release of antibiotics at a specific target by possessing antimicrobial activity against gram(+) and gram(−) bacteria. In this research, ceftriaxone-loaded chitosan nanoparticles were investigated as a carrier in antibiotic delivery.

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