scholarly journals Retrieval of High Added Value Natural Bioactive Coumarins from Mandarin Juice-Making Industrial Byproduct

Molecules ◽  
2021 ◽  
Vol 26 (24) ◽  
pp. 7527
Author(s):  
Eleni D. Myrtsi ◽  
Apostolis Angelis ◽  
Sofia D. Koulocheri ◽  
Sofia Mitakou ◽  
Serkos A. Haroutounian
Keyword(s):  
High Performance ◽  
Industrial Process ◽  
Pilot Scale ◽  
Added Value ◽  
Volatile Fraction ◽  
Citrus Reticulata ◽  
Reduced Pressure ◽  
Mild Conditions ◽  
Current Value ◽  
Cold Pressed

Cold pressed essential oil (CPEO) of mandarin (Citrus reticulata Blanco), a by-product of the juice-making industrial process known to contain large amounts of polymethoxyflavones, was exploited for its content in high added value natural coumarins. The study herein afforded a method referring to the evaporation of CPEO volatile fraction under mild conditions (reduced pressure and temperature below 35 °C) as azeotrope with isopropanol. This allowed the isolation of high added value coumarins from the non-volatile fragment using preparative High Performance Liquid Chromatography (HPLC). Pilot-scale application of this procedure afforded for each kg of CPEO processed the following natural bioactive coumarins in chemically pure forms: heraclenol (38–55 mg), 8-gerayloxypsoralen (35–51 mg), auraptene (22–33 mg), and bergamottin (14–19 mg). The structures of coumarins were verified by Nuclear Magnetic Resonance (NMR) spectroscopy and HPLC co-injection with authentic standards. Thus, the low market value mandarin CPEO with current value of 17 to 22 EUR/kg can be valorized through the production of four highly bioactive natural compounds worth 3479 to 5057 EUR/kg, indicating the great potentials of this methodology in the terms of the circular economy.

scholarly journals Implementation of green extraction and isolation methodologies for the recovery of bioactive compounds from olive-growing products and by-products

2014 ◽  
Author(s):  
Νικόλαος Ξυνός
Keyword(s):  
Subcritical Water ◽  
Pilot Scale ◽  
Biological Properties ◽  
Added Value ◽  
Green Extraction ◽  
Kernel Oil ◽  
Olive Kernel ◽  
Table Olive ◽  
Phd Thesis ◽  
By Products

The experimental work of this PhD thesis has been scheduled on a three-axis base. Theaims that were set, they concerned the optimal exploitation of four different by-products of the table olive, olive oil and olive kernel oil industries, for the recovery of specific highadded-value compounds with well-known biological properties. Those natural productswere desired either in the form of enriched fractions or pure compounds. The prerequisitewas to utilize as eco-friendly technologies as possible for extraction and purification and tooptimize the processes in laboratory as well as in pilot scale. Thus, trustworthy estimationof industrial feasibility is provided. The main technologies that were implicated for therecovery of the target compounds are: Supercritical fluid extraction Pressurized liquid (and subcritical water) extraction Liquid/liquid extraction Adsorption resin technology Centrifugal Partition ChromatographyThe by-products that were the subject of the tracing/ extraction/ enrichment/identification/ quantification on studies for this PhD thesis were the following: Olive leaves (by-products of the pruning of the trees and of the olive fruit harvest) Olive mill pomace waste (biphasic process) Table olive process wastewater (by-product of the debittering process for theproduction of table olives) Olive kernel oil deodorization distillates (by-product of the refining process for theproduction of olive kernel oil from olive pomace)The natural compounds that were targeted for their recovery, enrichment and isolation dueto their well-established (and still under research) biological properties and theirapplication in pharmaceutical, phytotherapeutical, nutraceutical, cosmetic andcosmeceutical industries were respectively: Oleuropein Hydroxytyrosol SqualeneIn all cases, not only biomarkers’ content but also the overall chemical profile of theextracts was studied. The applied scientific interest of this work was that novel green extraction technologies and combinatorial processes as well as experimental design wereimplemented in lab and pilot scale for the exploitation of certain by-products that occur invery large quantities every year as a result of the agricultural/ industrial processing of theolive tree, with the aim of recovering high added value natural products.

scholarly journals Homogeneous Catalyzed Valorization of Furanics: A Sustainable Bridge to Fuels and Chemicals

Catalysts ◽  
2021 ◽  
Vol 11 (11) ◽  
pp. 1371
Author(s):  
Rosa Padilla ◽  
Sakhitha Koranchalil ◽  
Martin Nielsen
Keyword(s):  
Homogeneous Catalysis ◽  
High Performance ◽  
Sustainable Production ◽  
Biomass Valorization ◽  
Complex Chemical ◽  
Mild Conditions ◽  
High Performance Polymers ◽  
Organometallic Catalysis ◽  
The Future ◽  
Fuels And Chemicals

The development of efficient biomass valorization is imperative for the future sustainable production of chemicals and fuels. Particularly, the last decade has witnessed the development of a plethora of effective and selective transformations of bio-based furanics using homogeneous organometallic catalysis under mild conditions. In this review, we describe some of the advances regarding the conversion of target furanics into value chemicals, monomers for high-performance polymers and materials, and pharmaceutical key intermediates using homogeneous catalysis. Finally, the incorporation of furanic skeletons into complex chemical architectures by multifunctionalization routes is also described.

scholarly journals Automating multistep flow synthesis: approach and challenges in integrating chemistry, machines and logic

2017 ◽  
Vol 13 ◽  
pp. 960-987 ◽  
Author(s):  
Chinmay A Shukla ◽  
Amol A Kulkarni
Keyword(s):  
Industrial Process ◽  
Pilot Scale ◽  
Laboratory Scale ◽  
Flow Synthesis ◽  
Multistep Synthesis ◽  
Synthesis Strategy ◽  
Line Separation ◽  
Synthesis Approach ◽  
Scale Of Operation

The implementation of automation in the multistep flow synthesis is essential for transforming laboratory-scale chemistry into a reliable industrial process. In this review, we briefly introduce the role of automation based on its application in synthesis viz. auto sampling and inline monitoring, optimization and process control. Subsequently, we have critically reviewed a few multistep flow synthesis and suggested a possible control strategy to be implemented so that it helps to reliably transfer the laboratory-scale synthesis strategy to a pilot scale at its optimum conditions. Due to the vast literature in multistep synthesis, we have classified the literature and have identified the case studies based on few criteria viz. type of reaction, heating methods, processes involving in-line separation units, telescopic synthesis, processes involving in-line quenching and process with the smallest time scale of operation. This classification will cover the broader range in the multistep synthesis literature.

scholarly journals Beneficial Regulatory Effects of Polymethoxyflavone—Rich Fraction from Ougan (Citrus reticulata cv. Suavissima) Fruit on Gut Microbiota and Identification of Its Intestinal Metabolites in Mice

Antioxidants ◽  
2020 ◽  
Vol 9 (9) ◽  
pp. 831
Author(s):  
Jiebiao Chen ◽  
Yue Wang ◽  
Tailin Zhu ◽  
Sijia Yang ◽  
Jinping Cao ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
High Performance ◽  
Citrus Fruit ◽  
Intestinal Content ◽  
Citrus Reticulata ◽  
Citrus Fruits ◽  
Human Gut ◽  
16S Ribosomal Dna ◽  
Regulatory Effects ◽  
Main Components

Polymethoxyflavones (PMFs) are special flavonoids in citrus fruits that have been suggested to be beneficial to human health. However, whether PMFs in citrus fruit alter human gut microbiota is not well understood. The aim of the present study was to investigate the effects of PMF-rich fraction from Ougan (Citrus reticulata cv. Suavissima) on gut microbiota and evaluate the intestinal metabolic profile of PMFs in Institute of Cancer Research mice. The main components of the PMF-rich fraction were nobiletin, tangeretin, and 5-demethylnobiletin. The composition of the gut microbiota was analyzed using 16S ribosomal DNA sequencing. The results showed that after oral administration, the composition of mice gut microbiota was significantly altered. The relative abundance of two probiotics, Lactobacillus and Bifidobacterium, were found to increase significantly. A total of 21 metabolites of PMFs were detected in mice intestinal content by high performance liquid chromatography electrospray ionization tandem mass spectrometry, and they were generated through demethylation, demethoxylation, hydroxylation, and glucuronidation. Our results provided evidence that PMFs have potential beneficial regulatory effects on gut microbiota that in turn metabolize PMFs, which warrants further investigation in human clinical trials.

Use of immobilised bacteria for the wastewater treatment – examples from the sugar industry

2006 ◽  
Vol 53 (3) ◽  
pp. 9-15 ◽  
Author(s):  
H.-J. Jördening ◽  
K. Hausmann ◽  
B. Demuth ◽  
M. Zastrutzki
Keyword(s):  
Wastewater Treatment ◽  
High Performance ◽  
Sugar Industry ◽  
Pilot Scale ◽  
Fluidized Bed Reactors ◽  
Reactor Volume ◽  
High Performance Systems ◽  
Pilot Scale Reactor ◽  
Nitrogen Elimination ◽  
Hydrolysis Of

This work focuses on the implementation of high performance systems to the wastewater treatment of sugar factories. For this purpose, systems with immobilised bacteria were studied. For the hydrolysis of organic matter and denitrification, fluidized bed reactors were used. The nitrification was studied with an airlift reactor system. Both hydrolysis and nitrogen elimination were investigated on laboratory and pilot scales in sugar factories. Although with porous materials higher biomass concentrations are attainable for the hydrolysis (up to 55 kg/m3), for economical reasons sand was used (22.5 kg/m3) for the pilot scale-study. With a pilot-scale reactor (volume 1 m3) the maximum sucrose conversion rate achieved with sand in the first campaign was 52 kg/(m3 d). For the nitrogen elimination on the pilot scale, a system with denitrification and nitrification was combined. The highest performance for the nitrification (reactor volume: 0.68 m3) with pumice as support material was 1.2 kg NH4-N/(m3 d), limiting the whole system. The denitrification rate (reactor volume: 0.12 m3) was four times higher (3.5–5 kg NO3-N/(m3 d). Rules of the modelling of the system are discussed.

scholarly journals Investigation of lab and pilot scale electric-pulse fragmentation systems for the recycling of ultra-high performance fibre-reinforced concrete

2018 ◽  
Vol 128 ◽  
pp. 187-194 ◽  
Author(s):  
Kathy Bru ◽  
Solène Touzé ◽  
Pascal Auger ◽  
Svatopluk Dobrusky ◽  
Jérôme Tierrie ◽  
...  
Keyword(s):  
Reinforced Concrete ◽  
High Performance ◽  
Electric Pulse ◽  
Pilot Scale ◽  
Fibre Reinforced Concrete ◽  
High Performance Fibre

scholarly journals High Performance Redox Initiating Systems Based on the Interaction of Silane with Metal Complexes: A Unique Platform for the Preparation of Composites

Molecules ◽  
2020 ◽  
Vol 25 (7) ◽  
pp. 1602
Author(s):  
Ahmad Arar ◽  
Haifaa Mokbel ◽  
Frédéric Dumur ◽  
Jacques Lalevée
Keyword(s):  
Metal Complexes ◽  
Aromatic Amines ◽  
High Performance ◽  
Room Temperature ◽  
Hazardous Substances ◽  
Gel Time ◽  
Chemical Mechanisms ◽  
Mild Conditions ◽  
Spin Resonance ◽  
Methacrylate Monomers

Currently, Redox Initiating Systems (RISs) of Free Radical Polymerization (FRP) are mainly based on the interaction of aromatic amines with peroxides (e.g., dibenzoyl peroxide (BPO)) that can be both toxic and unstable. In the present work, we aim to replace these hazardous substances in new RIS that can be peroxide-free and amine-free. Our redox two components (2K) initiating system is based on diphenylsilane (DPS) as reducing agent combined with different metal complexes (Mn(acac)2, Cu(AAEMA)2 or Fe(acac)3) as oxidizing agents. For the new proposed RIS, an excellent reactivity is found for the polymerization of benchmark methacrylate monomers under mild conditions (redox polymerization done under air and at room temperature); remarkably, it is also possible to finely control the gel time. Different techniques (optical pyrometry, Real-Time FTIR spectroscopy, Cyclic Voltammetry and Electron Spin Resonance (ESR)) were used to follow the polymerization processes but also to shed some light on the new redox chemical mechanisms.

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