scholarly journals Designing Magnetic NanoMOFs for Biomedicine: Current Trends and Applications

2020 ◽  
Vol 6 (3) ◽  
pp. 39
Author(s):  
Mariangela Oggianu ◽  
Noemi Monni ◽  
Valentina Mameli ◽  
Carla Cannas ◽  
Suchithra Ashoka Sahadevan ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Magnetic Properties ◽  
Metal Organic Frameworks ◽  
High Porosity ◽  
Targeted Chemotherapy ◽  
Clinical Use ◽  
Crucial Step ◽  
Current Trends ◽  
Metal Organic ◽  
Shape Of Particles

Metal–organic frameworks (MOFs) have shown a great potential in biomedicine due to their promising applications in different fields, including drug delivery, thermometry, theranostics etc. In this context, the development of magnetic sub-micrometric or nanometric MOFs through miniaturization approaches of magnetic MOFs up to the nanoscale still represents a crucial step to fabricate biomedical probes, especially in the field of theranostic nanomedicine. Miniaturization processes have to be properly designed to tailor the size and shape of particles and to retain magnetic properties and high porosity in the same material, fundamental prerequisites to develop smart nanocarriers integrating simultaneously therapeutic and contrast agents for targeted chemotherapy or other specific clinical use. An overview of current trends on the design of magnetic nanoMOFs in the field of biomedicine, with particular emphasis on theranostics and bioimaging, is herein envisioned.

Chiral Nanoporous Metal-Organic Frameworks with High Porosity as Materials for Drug Delivery

2011 ◽  
Vol 23 (47) ◽  
pp. 5629-5632 ◽  
Author(s):  
Chun-Yi Sun ◽  
Chao Qin ◽  
Chun-Gang Wang ◽  
Zhong-Min Su ◽  
Shuang Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Metal Organic Frameworks ◽  
High Porosity ◽  
Nanoporous Metal ◽  
Metal Organic

scholarly journals Synthesis of a novel ternary ZIF-8/GO/MgFe2O4 nanocomposite and its application in drug delivery

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Saleheh Sanaei-Rad ◽  
Mohammad Ali Ghasemzadeh ◽  
Seyyed Mohammad Hossein Razavian
Keyword(s):  
Drug Delivery ◽  
Graphene Oxide ◽  
Metal Organic Frameworks ◽  
Diffusion Method ◽  
High Porosity ◽  
X Ray ◽  
X Ray Crystallography ◽  
Pure Graphite ◽  
Antibiotic Drug ◽  
Metal Organic

AbstractIn recent year, metal–organic frameworks (MOFs) have been displayed to be a category of promising drug delivery systems because of their crystalline structure, the potential of further functionality, and high porosity. In this research, graphene oxide was synthesized from pure graphite via hummer method and then MgFe2O4 nanoparticles was incorporated into the synthesized ZIF-8 metal–organic frameworks which followed with loading on the surfaces of graphene oxide. In continue, tetracycline as an antibiotic drug was loaded on the surfaces and the cavities of the prepared nanocomposite. The outcomes of this research revealed that 90% of the tetracycline was loaded on the synthesized ZIF-8/GO/MgFe2O4 nanostructure. Next, drug release was done at pH: 5 and pH: 7.4 within 3 days, resulting about 88% and 92% release of the tetracycline, respectively. With using different spectroscopic methods like X-ray crystallography (XRD), scanning electron microscope (SEM), energy-dispersive X-ray spectroscopy (EDX/Mapping), Fourier transform infrared (FTIR), thermalgravimetric analysis (TGA), and Brunauer–Emmett–Teller (BET), the structure of synthesized materials was confirmed. Furthermore, the antibiotic activity of tetracycline trapped into the ZIF-8/GO/MgFe2O4 was evaluated by agar-well diffusion method on both gram-positive (Staphylococcus aureus) and gram-negative (Escherichia coli) bacteria, which showed good antibacterial results.

scholarly journals Biomedical Applications of Metal−Organic Frameworks for Disease Diagnosis and Drug Delivery: A Review

Nanomaterials ◽  
2022 ◽  
Vol 12 (2) ◽  
pp. 277
Author(s):  
Miral Al Sharabati ◽  
Rana Sabouni ◽  
Ghaleb A. Husseini
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Chemical Engineering ◽  
Metal Organic Frameworks ◽  
Disease Diagnosis ◽  
Inorganic Materials ◽  
Synthesis Methods ◽  
High Porosity ◽  
Wide Range ◽  
Metal Organic

Metal−organic frameworks (MOFs) are a novel class of porous hybrid organic−inorganic materials that have attracted increasing attention over the past decade. MOFs can be used in chemical engineering, materials science, and chemistry applications. Recently, these structures have been thoroughly studied as promising platforms for biomedical applications. Due to their unique physical and chemical properties, they are regarded as promising candidates for disease diagnosis and drug delivery. Their well-defined structure, high porosity, tunable frameworks, wide range of pore shapes, ultrahigh surface area, relatively low toxicity, and easy chemical functionalization have made them the focus of extensive research. This review highlights the up-to-date progress of MOFs as potential platforms for disease diagnosis and drug delivery for a wide range of diseases such as cancer, diabetes, neurological disorders, and ocular diseases. A brief description of the synthesis methods of MOFs is first presented. Various examples of MOF-based sensors and DDSs are introduced for the different diseases. Finally, the challenges and perspectives are discussed to provide context for the future development of MOFs as efficient platforms for disease diagnosis and drug delivery systems.

Single crystal to single crystal transformation of spin-crossover coordination polymers from 3D frameworks to 2D layers

2021 ◽  
Vol 9 (15) ◽  
pp. 5082-5087
Author(s):  
Yu Gong ◽  
Wang-Kang Han ◽  
Hui-Shu Lu ◽  
Qing-Tao Hu ◽  
Huan Tu ◽  
...  
Keyword(s):  
Magnetic Properties ◽  
Single Crystal ◽  
Coordination Polymers ◽  
Ligand Exchange ◽  
Spin Crossover ◽  
Metal Organic Frameworks ◽  
Crystal Transformation ◽  
Metal Organic

New Hofmann-type metal–organic frameworks display rare and complete ligand exchange induced single crystal to single crystal transformations from 3D frameworks to 2D layers, accompanied by magnetic properties transition from two-step SCO behavior to hysteretic SCO behavior.

Smart metal organic frameworks: Focus on cancer treatment

2021 ◽  
Author(s):  
Monir Falsafi ◽  
Amir Shokooh Saljooghi ◽  
Khalil Abnous ◽  
Seyed Mohammad Taghdisi ◽  
Mohammad Ramezani ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Treatment ◽  
Porous Materials ◽  
Metal Clusters ◽  
Metal Organic Frameworks ◽  
Controlled Systems ◽  
Metal Organic

Metal–organic frameworks (MOFs), as a prominent category of hybrid porous materials constructed from metal clusters or ions plus organic linkers, have been broadly employed as controlled systems of drug delivery...

scholarly journals Chitosan modified metal–organic frameworks as a promising carrier for oral drug delivery

RSC Advances ◽  
2020 ◽  
Vol 10 (73) ◽  
pp. 45130-45138
Author(s):  
Li Li ◽  
Shasha Han ◽  
Sengqun Zhao ◽  
Xurui Li ◽  
Bingmi Liu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Oral Administration ◽  
Drug Delivery System ◽  
Delivery System ◽  
Oral Drug Delivery ◽  
Metal Organic Frameworks ◽  
Oral Drug ◽  
Metal Organic

The drug delivery system of CS-MOF@5-FU was developed to achieve oral administration of 5-FU.

Lawsone Derived Zn (II) and Fe (III) Metal Organic Frameworks with pH Dependent Emission for Controlled Drug Delivery

2021 ◽  
Author(s):  
Sirajunnisa P ◽  
Liz Hannah George ◽  
Narayanapillai Manoj ◽  
Prathapan S ◽  
G.S. Sailaja
Keyword(s):  
Drug Delivery ◽  
Porous Structure ◽  
High Surface ◽  
Metal Organic Frameworks ◽  
High Surface Area ◽  
Controlled Drug Delivery ◽  
Sensing Applications ◽  
Porous Carriers ◽  
Metal Organic ◽  
Ph Dependent

Fluorescent biocompatible porous carriers have been investigated as suitable probes for drug delivery and sensing applications owing to their intrinsic fluorescence and high surface area originating from their porous structure...

scholarly journals Recent Bio-Advances in Metal-Organic Frameworks

Molecules ◽  
2020 ◽  
Vol 25 (6) ◽  
pp. 1291 ◽  
Author(s):  
Isobel Tibbetts ◽  
George Kostakis
Keyword(s):  
Drug Delivery ◽  
Inorganic Material ◽  
Metal Organic Frameworks ◽  
Gas Storage ◽  
Industrial Applications ◽  
Biologically Relevant ◽  
Bioinspired Materials ◽  
Synthesis Properties ◽  
Metal Organic

Metal-organic frameworks (MOFs) have found uses in adsorption, catalysis, gas storage and other industrial applications. Metal Biomolecule Frameworks (bioMOFs) represent an overlap between inorganic, material and medicinal sciences, utilising the porous frameworks for biologically relevant purposes. This review details advances in bioMOFs, looking at the synthesis, properties and applications of both bioinspired materials and MOFs used for bioapplications, such as drug delivery, imaging and catalysis, with a focus on examples from the last five years.

scholarly journals A novel route to size-controlled MIL-53(Fe) metal–organic frameworks for combined chemodynamic therapy and chemotherapy for cancer

RSC Advances ◽  
2021 ◽  
Vol 11 (18) ◽  
pp. 10540-10547
Author(s):  
Anxia Li ◽  
Xiaoxin Yang ◽  
Juan Chen
Keyword(s):  
Drug Delivery ◽  
Therapeutic Approach ◽  
Metal Organic Frameworks ◽  
Ionic Surfactant ◽  
Controlled Synthesis ◽  
New Approach ◽  
Metal Organic ◽  
Size Controlled

In this study, we reported a new approach for the size-controlled synthesis of uniform iron(iii)-based MIL-53 nanocrystals using the non-ionic surfactant PVP. A combinational therapeutic approach was presented for drug delivery and ROS therapy.

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