scholarly journals Physical Activity, Cardiorespiratory Fitness, and the Metabolic Syndrome

Nutrients ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 1652 ◽  
Author(s):  
Jonathan Myers ◽  
Peter Kokkinos ◽  
Eric Nyelin
Keyword(s):  
Physical Activity ◽  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Cost Effective ◽  
Professional Organizations ◽  
Physically Active ◽  
Physical Activity Interventions ◽  
The Metabolic Syndrome ◽  
Current Article ◽  
The Impact

Both observational and interventional studies suggest an important role for physical activity and higher fitness in mitigating the metabolic syndrome. Each component of the metabolic syndrome is, to a certain extent, favorably influenced by interventions that include physical activity. Given that the prevalence of the metabolic syndrome and its individual components (particularly obesity and insulin resistance) has increased significantly in recent decades, guidelines from various professional organizations have called for greater efforts to reduce the incidence of this condition and its components. While physical activity interventions that lead to improved fitness cannot be expected to normalize insulin resistance, lipid disorders, or obesity, the combined effect of increasing activity on these risk markers, an improvement in fitness, or both, has been shown to have a major impact on health outcomes related to the metabolic syndrome. Exercise therapy is a cost-effective intervention to both prevent and mitigate the impact of the metabolic syndrome, but it remains underutilized. In the current article, an overview of the effects of physical activity and higher fitness on the metabolic syndrome is provided, along with a discussion of the mechanisms underlying the benefits of being more fit or more physically active in the prevention and treatment of the metabolic syndrome.

Metabolic Syndrome, a Cardiovascular Disease Risk Factor: Role of Adipocytokines and Impact of Diet and Physical Activity

2004 ◽  
Vol 29 (6) ◽  
pp. 808-829 ◽  
Author(s):  
Lindsay E. Robinson ◽  
Terry E. Graham
Keyword(s):  
Physical Activity ◽  
Insulin Resistance ◽  
Cardiovascular Disease ◽  
Metabolic Syndrome ◽  
Adipose Tissue ◽  
The Metabolic Syndrome ◽  
Key Words Insulin ◽  
Diet And Physical Activity ◽  
The Impact

The metabolic syndrome comprises an array of cardiovascular disease (CVD) risk factors such as abdominal obesity, dyslipidemia, hypertension, and glucose intolerance. Insulin resistance and/or increased abdominal (visceral) obesity have been suggested as potential etiological factors. More recently, increasing evidence has associated insulin resistance and subclinical inflammation involving cytokines derived from adipose tissue, or adipocytokines. Despite the fact that precise mechanisms have yet to be established, there is a significant role for both diet and physical activity to improve the many factors associated with the metabolic syndrome, including modulation of various adipocytokines. Although both diet and physical activity have been studied for their ability to modify cytokines in more traditional inflammatory conditions, such as rheumatoid arthritis, they have been less studied in relation to inflammation as an underlying cause of the metabolic syndrome and/or CVD. A more thorough understanding of the clustering of metabolic abnormalities and their underlying etiology will help to define diet and physical activity guidelines for preventing and treating the metabolic syndrome, an important aspect of CVD prevention. This paper will address potential underlying causes of the metabolic syndrome, with a focus on the putative mechanistic role of adipocytokines, and will discuss the impact of diet and physical activity on the metabolic syndrome. Key words: insulin resistance syndrome, obesity, adipose tissue, skeletal muscle, cytokines, TNF-α, IL-6, PAI-1, inflammation, nutrition, exercise

scholarly journals Effect of Exercise on Intestinal Microbium and Insulin Resistance in Person with Metabolic Syndrome

2020 ◽  
Vol 5 (5) ◽  
pp. 324-331
Author(s):  
O. O. Hurenko ◽  
◽  
S. B. Drozdovska
Keyword(s):  
Physical Activity ◽  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Intestinal Microbiota ◽  
Intestinal Microbiome ◽  
Microbial Composition ◽  
The Metabolic Syndrome ◽  
Inflammatory Status ◽  
Physical Exercises ◽  
The Impact

Metabolic syndrome is a cluster of cardiometabolic risk factors. They include obesity, dyslipidemia, hypertension, and insulin resistance. Central obesity and resistance to insulin, in particular, are recognized as causative factors, which form the development of metabolic syndrome. Metabolic syndrome is a progressive and genetically determined condition. The result of its progression is that carbohydrate, lipid and purine metabolism break down. The intestinal microbiome has a significant role in the pathogenesis of metabolic syndrome. One of the methods of influencing the micribiotic composition is the physical activity. The human intestinal microbiome is a complex ecosystem consisting not only of microorganisms, but also including bacteria, archaea, fungi and viruses. Biodiversity and the overall composition of the microbiota play a crucial role in maintaining normal homeostasis in the human body. With the recent advent of the possibility of studying the intestinal microbiome, the impact on its taxonomic composition and metabolism through exercise is the subject of scientific interest. Recent studies showed that the intestinal microbiota was directly involved in the formation of the metabolic syndrome. The function of the microbiome is just as important as the function of the "metabolic organs" that affect energy homeostasis and control body weight. In addition, changes in the intestinal microbiotic composition lead to increased intestinal permeability, endotoxemia, which plays a role in the development of chronic inflammation in the host, contributing to the development of metabolic syndrome and related chronic metabolic diseases. Intestinal microbiota in its own right is injected into the development of systemic inflammation in obesity, such a rank, inappropriate insertions in development or regression of insulin resistance, and hyperglycemia in metabolic syndrome. Physical activity can affect not only the composition of the microbial composition, but also the metabolic activity of the intestinal microbiome. The health-improving effect of physical exercises is connected with their ability to change the composition of an intestinal microbiota. Studies involving professional athletes and a specially selected control group indicated that athletes had a lower pro-inflammatory status and a high degree of bacterial diversity. Due to this, there is a positive dynamics of improving carbohydrate metabolism and the impact on the course of pathological processes associated with the metabolic syndrome, through the introduction of regular physical activity. Conclusion. The literature review presents data on the metabolic syndrome, its pathogenesis and components of the spectrum of development of metabolic disorders. We also analyzed material on influence of gut microbiota on development of metabolic disturbances and inreraction of structure of a microbiotic composition with physical exercises

scholarly journals Exercise Induced Adipokine Changes and the Metabolic Syndrome

2014 ◽  
Vol 2014 ◽  
pp. 1-16 ◽  
Author(s):  
Saeid Golbidi ◽  
Ismail Laher
Keyword(s):  
Physical Activity ◽  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Adipose Tissue ◽  
The Body ◽  
Beneficial Effects ◽  
The Metabolic Syndrome ◽  
Before And After ◽  
Inflammatory State ◽  
Exercise Induced

The lack of adequate physical activity and obesity created a worldwide pandemic. Obesity is characterized by the deposition of adipose tissue in various parts of the body; it is now evident that adipose tissue also acts as an endocrine organ capable of secreting many cytokines that are though to be involved in the pathophysiology of obesity, insulin resistance, and metabolic syndrome. Adipokines, or adipose tissue-derived proteins, play a pivotal role in this scenario. Increased secretion of proinflammatory adipokines leads to a chronic inflammatory state that is accompanied by insulin resistance and glucose intolerance. Lifestyle change in terms of increased physical activity and exercise is the best nonpharmacological treatment for obesity since these can reduce insulin resistance, counteract the inflammatory state, and improve the lipid profile. There is growing evidence that exercise exerts its beneficial effects partly through alterations in the adipokine profile; that is, exercise increases secretion of anti-inflammatory adipokines and reduces proinflammatory cytokines. In this paper we briefly describe the pathophysiologic role of four important adipokines (adiponectin, leptin, TNF-α, and IL-6) in the metabolic syndrome and review some of the clinical trials that monitored these adipokines as a clinical outcome before and after exercise.

Physical activity and the metabolic syndrome in Canada

2006 ◽  
Vol 31 (1) ◽  
pp. 40-47 ◽  
Author(s):  
Susan E Brien ◽  
Peter T Katzmarzyk
Keyword(s):  
Physical Activity ◽  
Metabolic Syndrome ◽  
Health Surveys ◽  
Lifestyle Changes ◽  
Heart Health ◽  
Physically Active ◽  
The Metabolic Syndrome ◽  
Strenuous Activity ◽  
Therapeutic Lifestyle Changes ◽  
The Relationship

The metabolic syndrome (MetS) is a cluster of risk factors that predispose individuals to cardiovascular disease. Therapeutic lifestyle changes, including increased physical activity, are recommended for the prevention and treatment of MetS. The purpose of this study was to examine the relationship between physical activity and MetS in Canada. The sample included 6406 men and 6475 women aged 18-64 y who were participants in the Canadian Heart Health Surveys (1986-1992). MetS was classified using criteria modified from the US National Cholesterol Education Program. Participants were deemed physically active if they were active at least once each week for at least 30 min, engaging in strenuous activity some of the time. The relationship between physical activity and MetS was assessed using logistic regression, with age, smoking, alcohol consumption, and income adequacy as covariates. A total of 14.4% of Canadians had MetS and 33.6% were physically active. The odds ratio for MetS was 0.73 (95% confidence interval (CI): 0.54-0.98; p < 0.05) for physically active vs. physically inactive participants. The corresponding odds ratios were 0.45 (95% CI: 0.29-0.69; p < 0.001) and 0.67 (95% CI: 0.44-1.02; p = 0.06) for men and women, respectively. In summary, physical activity was associated with lower odds of MetS, particularly in men. Further research is required to determine the effectiveness of physical activity in the treatment of MetS.Key words: metabolic syndrome, physical activity, Canadian Heart Health Surveys.

scholarly journals Electronic Cigarette Use and Metabolic Syndrome Development: A Critical Review

Toxics ◽  
2020 ◽  
Vol 8 (4) ◽  
pp. 105
Author(s):  
Ilona Górna ◽  
Marta Napierala ◽  
Ewa Florek
Keyword(s):  
Insulin Resistance ◽  
Blood Pressure ◽  
Metabolic Syndrome ◽  
Arterial Blood Pressure ◽  
Abdominal Obesity ◽  
Critical Review ◽  
Lifestyle Modifications ◽  
The Metabolic Syndrome ◽  
Arterial Blood ◽  
The Impact

The metabolic syndrome is a combination of several metabolic disorders, such as cardiovascular disease, atherosclerosis, and type 2 diabetes. Lifestyle modifications, including quitting smoking, are recommended to reduce the risk of metabolic syndrome and its associated complications. Not much research has been conducted in the field of e-cigarettes and the risk of metabolic syndrome. Furthermore, taking into account the influence of e-cigarettes vaping on the individual components of metabolic syndrome, i.e, abdominal obesity, insulin resistance, dyslipidemia and elevated arterial blood pressure, the results are also ambiguous. This article is a review and summary of existing reports on the impact of e-cigarettes on the development of metabolic syndrome as well as its individual components. A critical review for English language articles published until 30 June 2020 was made, using a PubMed (including MEDLINE), Cochrane, CINAHL Plus, and Web of Science data. The current research indicated that e-cigarettes use does not affect the development of insulin resistance, but could influence the level of glucose and pre-diabetic state development. The lipid of profile an increase in the TG level was reported, while the influence on the level of concentration of total cholesterol, LDL fraction, and HDL fraction differed. In most cases, e-cigarettes use increased the risk of developing abdominal obesity or higher arterial blood pressure. Further research is required to provide more evidence on this topic.

scholarly journals The Polycystic Ovary Syndrome and the Metabolic Syndrome: A Possible Chronobiotic-Cytoprotective Adjuvant Therapy

2018 ◽  
Vol 2018 ◽  
pp. 1-12 ◽  
Author(s):  
Eduardo Spinedi ◽  
Daniel P. Cardinali
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Adipose Tissue ◽  
Polycystic Ovary Syndrome ◽  
White Adipose Tissue ◽  
Polycystic Ovary ◽  
Ovary Syndrome ◽  
The Metabolic Syndrome ◽  
Obstructive Sleep ◽  
The Impact

Polycystic ovary syndrome is a highly frequent reproductive-endocrine disorder affecting up to 8–10% of women worldwide at reproductive age. Although its etiology is not fully understood, evidence suggests that insulin resistance, with or without compensatory hyperinsulinemia, and hyperandrogenism are very common features of the polycystic ovary syndrome phenotype. Dysfunctional white adipose tissue has been identified as a major contributing factor for insulin resistance in polycystic ovary syndrome. Environmental (e.g., chronodisruption) and genetic/epigenetic factors may also play relevant roles in syndrome development. Overweight and/or obesity are very common in women with polycystic ovary syndrome, thus suggesting that some polycystic ovary syndrome and metabolic syndrome female phenotypes share common characteristics. Sleep disturbances have been reported to double in women with PCOS and obstructive sleep apnea is a common feature in polycystic ovary syndrome patients. Maturation of the luteinizing hormone-releasing hormone secretion pattern in girls in puberty is closely related to changes in the sleep-wake cycle and could have relevance in the pathogenesis of polycystic ovary syndrome. This review article focuses on two main issues in the polycystic ovary syndrome-metabolic syndrome phenotype development: (a) the impact of androgen excess on white adipose tissue function and (b) the possible efficacy of adjuvant melatonin therapy to improve the chronobiologic profile in polycystic ovary syndrome-metabolic syndrome individuals. Genetic variants in melatonin receptor have been linked to increased risk of developing polycystic ovary syndrome, to impairments in insulin secretion, and to increased fasting glucose levels. Melatonin therapy may protect against several metabolic syndrome comorbidities in polycystic ovary syndrome and could be applied from the initial phases of patients’ treatment.

scholarly journals Fatty acids and the metabolic syndrome

2005 ◽  
Vol 64 (1) ◽  
pp. 23-29 ◽  
Author(s):  
Helen M. Roche
Keyword(s):  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Fatty Acids ◽  
Health Effects ◽  
Aetiological Factor ◽  
Dietary Therapy ◽  
Adverse Health Effects ◽  
Adverse Health ◽  
The Metabolic Syndrome ◽  
The Impact

The metabolic syndrome is a very common condition, characterised by insulin resistance, dyslipidaemia, abdominal obesity and hypertension, that is associated with a high risk of type 2 diabetes mellitus (T2DM) and CVD. Obesity is a key aetiological factor in the development of the metabolic syndrome. In light of the increasing prevalence of obesity, there is a high requirement to reduce the impact of the adverse health effects associated with the metabolic syndrome. The aetiological role of nutrient-derived metabolic stressors, in particular fatty acids, in the development of obesity and the metabolic syndrome is explored. Also, the evidence that pro-inflammatory stressors may predispose to obesity-induced insulin resistance is reviewed. The present paper explores the concept that reducing the impact of metabolic and inflammatory stressors may reduce the adverse health effects of obesity and slow the progression towards the metabolic syndrome and T2DM. Evidence from human dietary intervention studies that have investigated the potential therapeutic effects of dietary fatty acid modification is explored. The present review highlights the requirement to take account of genetic background, within the context of nutrient regulation of gene expression and individual responsiveness to dietary therapy. This approach will further the understanding of the interaction between fatty acids in the pathogenesis and progression of the metabolic syndrome.

scholarly journals Provision of healthy school meals does not affect the metabolic syndrome score in 8–11-year-old children, but reduces cardiometabolic risk markers despite increasing waist circumference

2014 ◽  
Vol 112 (11) ◽  
pp. 1826-1836 ◽  
Author(s):  
Camilla T. Damsgaard ◽  
Stine-Mathilde Dalskov ◽  
Rikke P. Laursen ◽  
Christian Ritz ◽  
Mads F. Hjorth ◽  
...  
Keyword(s):  
Physical Activity ◽  
Insulin Resistance ◽  
Metabolic Syndrome ◽  
Body Composition ◽  
Waist Circumference ◽  
Control Diet ◽  
Hdl Cholesterol ◽  
School Meals ◽  
The Metabolic Syndrome ◽  
Cardiometabolic Markers

An increasing number of children are exhibiting features of the metabolic syndrome (MetS) including abdominal fatness, hypertension, adverse lipid profile and insulin resistance. Healthy eating practices during school hours may improve the cardiometabolic profile, but there is a lack of evidence. In the present study, the effect of provision of school meals rich in fish, vegetables and fibre on a MetS score (primary outcome) and on individual cardiometabolic markers and body composition (secondary outcomes) was investigated in 834 Danish school children. The study was carried out as a cluster-randomised, controlled, non-blinded, cross-over trial at nine schools. Children aged 8–11 years received freshly prepared school lunch and snacks or usual packed lunch from home (control) each for 3 months. Dietary intake, physical activity, cardiometabolic markers and body composition were measured at baseline and after each dietary period. The school meals did not affect the MetS score (P= 1·00). However, it was found that mean arterial pressure was reduced by 0·4 (95 % CI 0·0, 0·8) mmHg (P= 0·04), fasting total cholesterol concentrations by 0·05 (95 % CI 0·02, 0·08) mmol/l (P= 0·001), HDL-cholesterol concentrations by 0·02 (95 % CI 0·00, 0·03) mmol/l, TAG concentrations by 0·02 (95 % CI 0·00, 0·04) mmol/l (bothP< 0·05), and homeostasis model of assessment-insulin resistance by 0·10 (95 % CI 0·04, 0·16) points (P= 0·001) compared with the control diet in the intention-to-treat analyses. Waist circumference increased 0·5 (95 % CI 0·3, 0·7) cm (P< 0·001), but BMIz-score remained unaffected. Complete-case analyses and analyses adjusted for household educational level, pubertal status and physical activity confirmed the results. In conclusion, the school meals did not affect the MetS score in 8–11-year-olds, as small improvements in blood pressure, TAG concentrations and insulin resistance were counterbalanced by slight undesired effects on waist circumference and HDL-cholesterol concentrations.

scholarly journals Does Physical Activity Lower the Risk for Metabolic Syndrome: A Longitudinal Study of Physically Active Elderly Women

2020 ◽  
Author(s):  
Izabela Zając-Gawlak ◽  
Jana Pelclová ◽  
Dorota Groffik ◽  
Miroslava Pridalová ◽  
Agnieszka Nawrat-Szołtysik ◽  
...  
Keyword(s):  
Physical Activity ◽  
Metabolic Syndrome ◽  
Older Women ◽  
Elderly Women ◽  
Physically Active ◽  
The Metabolic Syndrome ◽  
The Mean ◽  
High Level ◽  
High Density Cholesterol ◽  
Mean Concentration

Abstract Background: There are few studies assessing the health of older women with respect to their physical activity. This study sought to determine whether changes in the physical activity of 59 women aged 60+ measured seven years apart and the risk of the participants developing the metabolic syndrome (MetS) were related to each other. Methods: The physical activity of the participants was measured using the accelerometers in 2009 and 2016. Their risk for the MetS was assessed as per the NCEP-ATP III criteria. Results: The number of steps the participants took daily increased between 2009 and 2016 from 10.944±3,560 to 11.652±4865. Women who maintained a high level of physical activity between the measurements, or increased it, had a significantly higher mean concentration of high-density cholesterol in 2016 (80.3 vs. 64.5 mg/dL and 79.2 vs. 66.9mg/dL, respectively). In the latter, a lower concentration of triglycerides (TG) (123.8 vs. 158.3mg/dL) was also observed. In 2016, only 7 women met 3 or more criteria for MetS compared with 24 in 2009; at the same time, the mean number of the MetS criteria met by a participant fell from 2.2±1.4 to 1.4±1.0.Conclusions: The number of MetS criteria that the participants met in 2016 was lower than in 2007, probably due to the high number of steps taken daily. Therefore, their risk of developing cardiovascular diseases was lower too.

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