Omega-3-Fettsäuren bei Krebserkrankungen

Cancer Treatment ◽

Scoping Review ◽

Clinical Evidence ◽

Omega 3 ◽

Newell M et al. N-3 long-chain polyunsaturated fatty acids, eicosapentaenoic and docosahexaenoic acid, and the role of supplementation during cancer treatment: A scoping review of current clinical evidence. Cancers (Basel) 2021; 13: 1206. doi: 10.3390/cancers13061206

The role of omega-3 long-chain polyunsaturated fatty acids in health and disease of the retina

Progress in Retinal and Eye Research ◽

10.1016/j.preteyeres.2004.06.002 ◽

2005 ◽

Vol 24 (1) ◽

pp. 87-138 ◽

Cited By ~ 463

Author(s):

John Paul SanGiovanni ◽

Emily Y. Chew

Keyword(s):

Fatty Acids ◽

Omega 3 ◽

Health And Disease ◽

A Scoping Review of Interactions between Omega-3 Long-Chain Polyunsaturated Fatty Acids and Genetic Variation in Relation to Cancer Risk

Nutrients ◽

10.3390/nu12061647 ◽

2020 ◽

Vol 12 (6) ◽

pp. 1647

Author(s):

Karin Yurko-Mauro ◽

Mary Van Elswyk ◽

Lynn Teo

Keyword(s):

Prostate Cancer ◽

Fatty Acids ◽

Cancer Risk ◽

Scoping Review ◽

Genetic Variants ◽

Prostate Cancer Risk ◽

Lymphocytic Leukemia ◽

Omega 3 ◽

This scoping review examines the interaction of docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) and genetic variants of various types of cancers. A comprehensive search was performed to identify controlled and observational studies conducted through August 2017. Eighteen unique studies were included: breast cancer (n = 2), gastric cancer (n = 1), exocrine pancreatic cancer (n = 1), chronic lymphocytic leukemia (n = 1), prostate cancer (n = 7) and colorectal cancer (n = 6). An additional 13 studies that focused on fish intake or at-risk populations were summarized to increase readers’ understanding of the topic based on this review, DHA and EPA interact with certain genetic variants to decrease breast, colorectal and prostate cancer risk, although data was limited and identified polymorphisms were heterogeneous. The evidence to date demonstrates that omega-3 long-chain polyunsaturated fatty acids (n-3 LC-PUFA) may decrease cancer risk by affecting genetic variants of inflammatory pathways, oxidative stress and tumor apoptosis. Collectively, data supports the notion that once a genetic variant is identified, the benefits of a targeted, personalized therapeutic regimen that includes DHA and/or EPA should be considered.

An Ω-3 fatty acid-deficient diet during gestation induces depressive-like behavior in rats: the role of the hypothalamo–pituitary–adrenal (HPA) system

Food & Function ◽

10.1039/c7fo01714f ◽

2018 ◽

Vol 9 (6) ◽

pp. 3481-3488 ◽

Cited By ~ 8

Author(s):

Mimi Tang ◽

Yiping Liu ◽

Lu Wang ◽

Huande Li ◽

Hualin Cai ◽

...

Keyword(s):

Fatty Acids ◽

Fatty Acid ◽

Docosahexaenoic Acid ◽

Postpartum Depression ◽

Omega 3 ◽

Deficient Diet ◽

System P

Low intake of omega-3 (Ω-3) polyunsaturated fatty acids (PUFAs) especially docosahexaenoic acid (DHA) is associated with postpartum depression.

Role of Dietary Long-Chain Polyunsaturated Fatty Acids in Infant Allergies and Respiratory Diseases

Clinical and Developmental Immunology ◽

10.1155/2012/730568 ◽

2012 ◽

Vol 2012 ◽

pp. 1-8 ◽

Cited By ~ 16

Author(s):

Lynette P. Shek ◽

Mary Foong-Fong Chong ◽

Jia Yi Lim ◽

Shu-E Soh ◽

Yap-Seng Chong

Keyword(s):

Fatty Acids ◽

Respiratory Diseases ◽

Maternal Nutrition ◽

Immunoglobulin E ◽

Protective Role ◽

Omega 3 ◽

Long Term Effects ◽

Maternal nutrition has critical effects on the developing structures and functions of the fetus. Malnutrition during pregnancy can result in low birth weight and small for gestational age babies, increase risk for infection, and impact the immune system. Long-chain polyunsaturated fatty acids (PUFAs) have been reported to have immunomodulatory effects. Decreased consumption of omega-6 PUFAs, in favor of more anti-inflammatory omega-3 PUFAs in modern diets, has demonstrated the potential protective role of omega-3 PUFAs in allergic and respiratory diseases. In this paper, we examine the role of PUFAs consumption during pregnancy and early childhood and its influence on allergy and respiratory diseases. PUFAs act via several mechanisms to modulate immune function. Omega-3 PUFAs may alter the T helper (Th) cell balance by inhibiting cytokine production which in turn inhibits immunoglobulin E synthesis and Th type 2 cell differentiation. PUFAs may further modify cellular membrane, induce eicosanoid metabolism, and alter gene expression. These studies indicate the benefits of omega-3 PUFAs supplementation. Nevertheless, further investigations are warranted to assess the long-term effects of omega-3 PUFAs in preventing other immune-mediated diseases, as well as its effects on the later immunodefense and health status during early growth and development.

Elovl2 Is Required for Robust Visual Function in Zebrafish

Cells ◽

10.3390/cells9122583 ◽

2020 ◽

Vol 9 (12) ◽

pp. 2583

Author(s):

Manish Dasyani ◽

Fangyuan Gao ◽

Qianlan Xu ◽

Donald Van Fossan ◽

Ellis Zhang ◽

...

Keyword(s):

Fatty Acids ◽

Omega 3 ◽

Retina Development ◽

Omega 6 ◽

Motor Reflex ◽

And Function ◽

Omega-3 and omega-6 polyunsaturated fatty acids (PUFAs) play critical roles in membrane stability and cell signaling within the retina. ELOVL2 (Elongation of Very Long Chain Fatty Acids-Like 2), an elongase involved in the synthesis of long chain polyunsaturated fatty acids (LC-PUFAs), has recently been implicated in regulating aging in the mammalian retina. In this work, we characterize the expression and function of elovl2 in the retina development in embryonic zebrafish. Whole mount in situ hybridization shows elovl2 is expressed in the Muller glia in embryonic and adult zebrafish. Lipidomics analysis of elovl2 crispants whole embryos at day 2 and eyes at day 7 demonstrated significant changes in lipids composition, especially on the level of lipids containing docosahexaenoic acid (DHA). Histological analysis of zebrafish lacking elovl2 revealed increased retinal thickness compared to controls at day 7 without gross disruptions of the retinal architecture. Finally, elovl2 crispants showed differences in the visual motor reflex light off (VMR-OFF) at day 7 compared to controls. In sum, inactivation of elovl2 in zebrafish embryos caused changes in lipid composition and in visual behavior, further confirming the important role of LC-PUFAs in healthy vision.