scholarly journals The Development of High-Quality Multispecies Probiotic Formulations: From Bench to Market

Nutrients ◽  
2020 ◽  
Vol 12 (8) ◽  
pp. 2453
Author(s):  
Lukas Grumet ◽  
Yorick Tromp ◽  
Verena Stiegelbauer
Keyword(s):  
Product Development ◽  
Functional Properties ◽  
Health Care Professionals ◽  
Manufacturing Process ◽  
Current Knowledge ◽  
Health Benefit ◽  
Human Consumption ◽  
High Quality ◽  
Quality Properties ◽  
Beneficial Effects

Probiotics are live microorganisms that, when administered in adequate amounts, confer a health benefit on the host. To date, there is an increasing number of commercially available products containing probiotics on the market. Probiotics have been recommended by health care professionals for reasons ranging from their long-term immunomodulatory effects to proven benefits in the management of different health conditions. For probiotic products, there are several important aspects that determine the success rate of the development from bench to market. The aim of this review is to explore how the current knowledge on microbe–microbe and host–microbe interactions can be used to develop high-quality, evidence-based probiotic formulations, specifically probiotic dietary supplements, with a focus on the selection of safe strains with relevant functional properties. In addition, we will highlight aspects of the probiotic manufacturing process that need to be considered during the product development and the subsequent manufacturing process to guarantee consistent efficacy of a probiotic product. For each high-quality probiotic formulation, it is important to screen multiple strains, and select only those strains that show relevant functional properties and that can be considered safe for human consumption. In addition, it is imperative that attention is paid to the product development and manufacturing process, and that safety and quality properties are monitored. Importantly, the beneficial effects of probiotics should be evaluated in product efficacy studies and post-marketing surveys in order to demonstrate their clinical efficacy. All these aspects need to be evaluated and validated during the development of a successful high-quality and ready-to-market probiotic.

scholarly journals Fish–derived proteins and their potential to improve human health

2019 ◽  
Vol 77 (8) ◽  
pp. 572-583 ◽  
Author(s):  
Hanna Fjeldheim Dale ◽  
Lise Madsen ◽  
Gülen Arslan Lied
Keyword(s):  
Animal Studies ◽  
Current Knowledge ◽  
Metabolic Health ◽  
Amino Acid Sequences ◽  
Metabolic Effects ◽  
Human Consumption ◽  
Beneficial Effects ◽  
Lean Fish ◽  
Animal Trials ◽  
Fish Proteins

Abstract Emerging evidence from studies evaluating the effect of lean fish consumption in humans suggests that proteins from fish have several beneficial metabolic effects. Rest, or waste, material from the fishing industry contains high-quality proteins, and utilization of this material offers novel possibilities for the development of protein-containing products that might be beneficial for human consumption. Fish-derived peptides containing bioactive amino acid sequences suggested to beneficially influence pathways involved in body composition, hypertension, lipid profile, and regulation of glucose metabolism are of particular interest, although the results of published studies are conflicting. This review aims to summarize current knowledge from animal studies and clinical interventions in humans evaluating the effects of lean fish, fish proteins, and fish-derived peptides on outcomes related to metabolic health. Fish proteins have a high content of taurine, and animal trials suggest that taurine mediates some of the beneficial effects observed thus far, although the mechanisms by which fish peptides exert their action are not yet elucidated. At this time, the literature is inconsistent, and there is insufficient mechanistic evidence to support a beneficial effect of fish-derived peptides on metabolic health.

scholarly journals Probiotic Delivery through Non-Dairy Plant-Based Food Matrices

Agriculture ◽  
2021 ◽  
Vol 11 (7) ◽  
pp. 599
Author(s):  
D. M. D. Rasika ◽  
Janak K. Vidanarachchi ◽  
Selma F. Luiz ◽  
Denise Rosane Perdomo Azeredo ◽  
Adriano G. Cruz ◽  
...  
Keyword(s):  
Functional Properties ◽  
Dairy Products ◽  
Microbiological Quality ◽  
Health Benefit ◽  
Food Products ◽  
Quality Characteristics ◽  
Dairy Plant ◽  
Food Matrices ◽  
Probiotic Food ◽  
Probiotic Delivery

Probiotics are live microorganisms which, when administered in adequate amounts, confer a health benefit on the host. Traditionally, dairy products are the major and most popular probiotic carriers. At present, there is a growing demand for non-dairy probiotic products. Both fermented and non-fermented non-dairy plant-based food products are becoming highly appealing to both dairy and non-dairy consumers worldwide. Non-dairy plant-based food matrices such as fruits, vegetables, plant-based milk, cereals, and legumes have been used successfully in producing probiotic products with the minimum recommended viable probiotic numbers at the time of consumption. However, due to the exclusion of dairy, whether these food matrices can enhance the functional properties of probiotics such as gastrointestinal survival and immune-enhancing effects needs a thorough investigation. Hence, this review focuses on some of the popular non-dairy plant-based probiotic food products and their microbiological quality characteristics in terms of maintaining probiotic viability during product storage. Their gastrointestinal tolerance in these products, other functional properties, and product qualities have also been briefly discussed.

scholarly journals Probiotics in Pediatrics. A Review and Practical Guide

Nutrients ◽  
2021 ◽  
Vol 13 (7) ◽  
pp. 2176
Author(s):  
Leontien Depoorter ◽  
Yvan Vandenplas
Keyword(s):  
Health Benefit ◽  
Beneficial Effects ◽  
Treatment Regimens ◽  
Clostridioides Difficile ◽  
Nosocomial Diarrhea ◽  
Infectious Gastroenteritis ◽  
Study Heterogeneity ◽  
Probiotic Strains ◽  
Prophylactic Use ◽  
Meta Analyses

The potential benefit of the administration of probiotics in children has been studied in many settings globally. Probiotics products contain viable micro-organisms that confer a health benefit on the host. Beneficial effects of selected probiotic strains for the management or prevention of selected pediatric conditions have been demonstrated. The purpose of this paper is to provide an overview of current available evidence on the efficacy of specific probiotics in selected conditions to guide pediatricians in decision-making on the therapeutic or prophylactic use of probiotic strains in children. Evidence to support the use of certain probiotics in selected pediatric conditions is often available. In addition, the administration of probiotics is associated with a low risk of adverse events and is generally well tolerated. The best documented efficacy of certain probiotics is for treatment of infectious gastroenteritis, and prevention of antibiotic-associated, Clostridioides difficile-associated and nosocomial diarrhea. Unfortunately, due to study heterogeneity and in some cases high risk of bias in published studies, a broad consensus is lacking for specific probiotic strains, doses and treatment regimens for some pediatric indications. The current available evidence thus limits the systematic administration of probiotics. The most recent meta-analyses and reviews highlight the need for more well-designed, properly powered, strain-specific and dedicated-dose response studies.

scholarly journals Dietary supplementation with Bifidobacterium lactis NCC2818 from weaning reduces local immunoglobulin production in lymphoid-associated tissues but increases systemic antibodies in healthy neonates

2013 ◽  
Vol 110 (7) ◽  
pp. 1243-1252 ◽  
Author(s):  
Marie C. Lewis ◽  
Dilip V. Patel ◽  
Jenni Fowler ◽  
Swantje Duncker ◽  
Adrian W. Zuercher ◽  
...  
Keyword(s):  
Immune System ◽  
Health Benefit ◽  
Dietary Supplementation ◽  
Nutritional Intervention ◽  
Dietary Interventions ◽  
Probiotic Supplementation ◽  
Human Infants ◽  
Bifidobacterium Lactis ◽  
Beneficial Effects ◽  
Mucosal Tissues

Weaning is associated with a major shift in the microbial community of the intestine, and this instability may make it more acquiescent than the adult microbiota to long-term changes. Modulation achieved through dietary interventions may have potentially beneficial effects on the developing immune system, which is driven primarily by the microbiota. The specific aim of the present study was to determine whether immune development could be modified by dietary supplementation with the human probiotic Bifidobacterium lactis NCC2818 in a tractable model of weaning in infants. Piglets were reared by their mothers before being weaned onto a solid diet supplemented with B. lactis NCC2818, while sibling controls did not receive supplementation. Probiotic supplementation resulted in a reduction in IgA (P< 0·0005) and IgM (P< 0·009) production by mucosal tissues but had no effect on IgG production (P>0·05). Probiotic-supplemented pigs had more mast cells than unsupplemented littermates (P< 0·0001), although numbers in both groups were low. In addition, the supplemented piglets made stronger serum IgG responses to fed and injected antigens (P< 0·05). The present findings are consistent with B. lactis NCC2818 reducing intestinal permeability induced by weaning, and suggest that the piglet is a valuable intermediate between rodent models and human infants. The results also strongly suggest that measures of the effect of probiotic supplementation on the immune system need to be interpreted carefully as proxy measures of health benefit. However, they are useful in developing an understanding of the mechanism of action of probiotic strains, an important factor in predicting favourable health outcomes of nutritional intervention.

Obtaining High-Quality Blood Specimens for Downstream Applications: A Review of Current Knowledge and Best Practices

2018 ◽  
Vol 16 (6) ◽  
pp. 411-418 ◽  
Author(s):  
Qiyuan Li ◽  
Xian Wang ◽  
Xue Li ◽  
Xuheng He ◽  
Qian Wan ◽  
...  
Keyword(s):  
Best Practices ◽  
Current Knowledge ◽  
High Quality ◽  
Blood Specimens

Production of Metal Matrix Composite Using a Bottom Tapping Stir Casting Furnace

2015 ◽  
Vol 772 ◽  
pp. 263-267 ◽  
Author(s):  
Ramanathan Arunachalam ◽  
Majid Al-Maharbi ◽  
Yahya Al Kiyumi ◽  
Elyas Aal-Thani ◽  
Mohammed Al Mafraji
Keyword(s):  
Continuous Improvement ◽  
Manufacturing Process ◽  
Metal Matrix ◽  
Low Cost ◽  
Casting Process ◽  
Stir Casting ◽  
Matrix Composites ◽  
High Quality ◽  
Reinforcement Material ◽  
Low Cost Manufacturing

Metal matrix composites (MMC's) have attracted the attention of researchers for quite some time. In the last 15 years, many studies have been reported in this field of MMC production through various routes. The most commonly used process for producing MMC is stir casting process whereby the reinforcement material is incorporated into the molten metal by stirring. It is a relatively low cost manufacturing process that is capable of producing high quality MMC. However, the process is associated with issues such as attaining uniform distribution of particles, wettability between particles and porosity in the MMCs. Because of these challenges, there has been continuous improvement in the process as well as the design of the furnace. In this research, an innovatively designed bottom tapping furnace has been used to produce the MMCs and the produced sample is characterized.

scholarly journals The Clash of Microbiomes: From the Food Matrix to the Host Gut

2022 ◽  
Vol 10 (1) ◽  
pp. 116
Author(s):  
Despoina Eugenia Kiousi ◽  
Nikos Chorianopoulos ◽  
Chrysoula C. Tassou ◽  
Alex Galanis
Keyword(s):  
Raw Materials ◽  
Interdisciplinary Collaboration ◽  
Health Benefit ◽  
Potential Health ◽  
Empirical Observation ◽  
New Era ◽  
Host Interactions ◽  
Beneficial Effects ◽  
Organoleptic Characteristics

Food fermentation has led to the improvement of the safety characteristics of raw materials and the production of new foodstuffs with elevated organoleptic characteristics. The empirical observation that these products could have a potential health benefit has garnered the attention of the scientific community. Therefore, several studies have been conducted in animal and human hosts to decipher which of these products may have a beneficial outcome against specific ailments. However, despite the accumulating literature, a relatively small number of products have been authorized as ‘functional foods’ by regulatory bodies. Data inconsistency and lack of in-depth preclinical characterization of functional products could heavily contribute to this issue. Today, the increased availability of omics platforms and bioinformatic algorithms for comprehensive data analysis can aid in the systematic characterization of microbe–microbe, microbe–matrix, and microbe–host interactions, providing useful insights about the maximization of their beneficial effects. The incorporation of these platforms in food science remains a challenge; however, coordinated efforts and interdisciplinary collaboration could push the field toward the dawn of a new era.

scholarly journals Determination of Mercury, Methylmercury and Selenium Concentrations in Elasmobranch Meat: Fish Consumption Safety

2022 ◽  
Vol 19 (2) ◽  
pp. 788
Author(s):  
Arianna Storelli ◽  
Grazia Barone ◽  
Rita Garofalo ◽  
Antonio Busco ◽  
Maria Maddalena Storelli
Keyword(s):  
Total Mercury ◽  
Health Benefit ◽  
Absorption Spectrometry ◽  
Human Consumption ◽  
Apex Predators ◽  
Safety Level ◽  
Italian Market ◽  
Elasmobranch Fish ◽  
Rate Limit

This study measures total mercury (THg), methylmercury (MeHg) and selenium (Se) concentrations in elasmobranch fish from an Italian market with the aim of evaluating the risk-benefit associated with their consumption, using estimated weekly intake (EWI), permissible safety level (MeHgPSL), selenium health benefit value (HBVSe) and monthly consumption rate limit (CRmm) for each species. THg and Se were analysed by atomic absorption spectrometry, while MeHg was determined by HrGc/Ms. THg and MeHg concentrations ranged from 0.61 to 1.25 μg g−1 w.w. and from 0.57 to 0.97 μg g−1 w.w., respectively, whereas Se levels were 0.49–0.65 μg g−1 w.w. In most samples European Community limits for THg were surpassed, while for MeHg none of the fish had levels above the limit adopted by FAO/WHO. EWIs for THg and MeHg in many cases were above the provisional tolerable weekly intakes (PTWIs). MeHgPSL estimate showed that fish should contain approximately 50% of the concentration measured to avoid exceeding the PTWI. Nevertheless, the HBVSe index indicated that solely skates were safe for human consumption (HBVSe = 3.57–6.22). Our results highlight the importance of a constant monitoring of THg and MeHg level in fish, especially in apex predators, to avoid the risk of overexposure for consumers.

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