scholarly journals Krill Oil Has Different Effects on the Plasma Lipidome Compared with Fish Oil Following 30 Days of Supplementation in Healthy Women: A Randomized Controlled and Crossover Study

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2804
Author(s):  
Hyunsin H. Sung ◽  
Andrew J. Sinclair ◽  
Kevin Huynh ◽  
Adam A. T. Smith ◽  
Natalie A. Mellett ◽  
...  
Keyword(s):  
Fish Oil ◽  
Area Under The Curve ◽  
Krill Oil ◽  
Omega 3 ◽  
Lipidomic Analysis ◽  
Randomized Controlled ◽  
Healthy Women ◽  
Lipid Molecular Species ◽  
Long Chain

This is a follow-up of our previous postprandial study and it focused on the plasma lipidomic responses to 30 days of krill oil (KO) versus fish oil (FO) supplementations in healthy women. Eleven women (aged 18–50 years) consumed KO or FO for 30 days in a randomized, cross-over study, with at least a four-week washout period between supplementations. The daily supplements provided 1.27 g/day of long-chain (LC) omega-3 polyunsaturated fatty acids (PUFA) from KO (containing 0.76 g eicosapentaenoic acid (EPA), 0.42 g docosahexaenoic acid (DHA)) and 1.44 g/day from FO (containing 0.79 g EPA, 0.47 g DHA). Fasting plasma samples at days 0, 15, and 30 were analyzed using gas chromatography and liquid chromatography electrospray ionisation-tandem mass spectrometry. KO resulted in a significantly greater relative area under the curve (relAUC) for plasma EPA after 30 days. Lipidomic analysis showed that 26 of 43 lipid molecular species had a significantly greater relAUC in the KO group, while 17/43 showed a significantly lower relAUC compared with the FO group. More than 38% of the lipids species which increased more following KO contained omega-3 PUFA, while where FO was greater than KO, only 12% contained omega-3 PUFA. These data show that KO and FO do not have equivalent effects on the plasma lipidome.

scholarly journals Association of the Omega-3 Index with Incident Prostate Cancer with Updated Meta-Analysis: The Cooper Center Longitudinal Study

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 384
Author(s):  
Stephen W. Farrell ◽  
Laura F. DeFina ◽  
Nathan L. Tintle ◽  
David Leonard ◽  
Kenneth H. Cooper ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Proportional Hazards ◽  
Meta Analysis ◽  
Continuous Variable ◽  
Omega 3 ◽  
Proportional Hazards Regression ◽  
Time To Diagnosis ◽  
Docosahexaenoic Acids ◽  
Long Chain

Background: The association between long-chain omega-3 polyunsaturated fatty acids (n-3 PUFA) and prostate cancer (PC) remains unclear. Methods: We compared incident PC rates as a function of the Omega-3 Index [O3I, erythrocyte eicosapentaenoic and docosahexaenoic acids (EPA + DHA)] in 5607 men (40–80 years of age) seen at the Cooper Clinic who were free of PC at baseline. The average follow-up was 5.1 ± 2.8 years until censoring or reporting a new PC diagnosis. Proportional hazards regression was used to model the linear association between baseline O3I and the age-adjusted time to diagnosis. A meta-analysis of n-3 PUFA biomarker-based studies and incident PC was updated with the present findings. Results: A total of 116 cases of incident PC were identified. When O3I was examined as a continuous variable, the age-adjusted hazard ratio (HR) (95% CI) was 0.98 (0.89, 1.07; p = 0.25) for each 1% increment in the O3I. The updated meta-analysis with 10 biomarker-based studies found no significant relationship between EPA or DHA levels and risk for PC. Conclusions: We find no evidence in this study nor in a meta-analysis of similar studies that consuming n-3 PUFA-rich fish or using fish oil supplements affects the risk of PC.

scholarly journals Non-dietary factors associated with n-3 long-chain PUFA levels in humans – a systematic literature review

2019 ◽  
Vol 121 (7) ◽  
pp. 793-808 ◽  
Author(s):  
Renate H. M. de Groot ◽  
Rebecca Emmett ◽  
Barbara J. Meyer
Keyword(s):  
Physical Activity ◽  
Literature Review ◽  
Fish Oil ◽  
Systematic Literature Review ◽  
Dietary Factors ◽  
Krill Oil ◽  
Chain Pufa ◽  
Epa And Dha ◽  
Modifiable Factors ◽  
Long Chain

AbstractNumerous health benefits are attributed to the n-3 long-chain PUFA (n-3 LCPUFA); EPA and DHA. A systematic literature review was conducted to investigate factors, other than diet, that are associated with the n-3 LCPUFA levels. The inclusion criteria were papers written in English, carried out in adult non-pregnant humans, n-3 LCPUFA measured in blood or tissue, data from cross-sectional studies, or baseline data from intervention studies. The search revealed 5076 unique articles of which seventy were included in the qualitative synthesis. Three main groups of factors potentially associated with n-3 LCPUFA levels were identified: (1) unmodifiable factors (sex, genetics, age), (2) modifiable factors (body size, physical activity, alcohol, smoking) and (3) bioavailability factors (chemically bound form of supplements, krill oil v. fish oil, and conversion of plant-derived α-linolenic acid (ALA) to n-3 LCPUFA). Results showed that factors positively associated with n-3 LCPUFA levels were age, female sex (women younger than 50 years), wine consumption and the TAG form. Factors negatively associated with n-3 LCPUFA levels were genetics, BMI (if erythrocyte EPA and DHA levels are <5·6 %) and smoking. The evidence for girth, physical activity and krill oil v. fish oil associated with n-3 LCPUFA levels is inconclusive. There is also evidence that higher ALA consumption leads to increased levels of EPA but not DHA. In conclusion, sex, age, BMI, alcohol consumption, smoking and the form of n-3 LCPUFA are all factors that need to be taken into account in n-3 LCPUFA research.

scholarly journals Successful high‐level accumulation of fish oil omega‐3 long‐chain polyunsaturated fatty acids in a transgenic oilseed crop

2013 ◽  
Vol 77 (2) ◽  
pp. 198-208 ◽  
Author(s):  
Noemi Ruiz‐Lopez ◽  
Richard P. Haslam ◽  
Johnathan A. Napier ◽  
Olga Sayanova
Keyword(s):  
Fatty Acids ◽  
Polyunsaturated Fatty Acids ◽  
Fish Oil ◽  
Oilseed Crop ◽  
Omega 3 ◽  
High Level ◽  
Long Chain
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