scholarly journals Fat, Sugar or Gut Microbiota in Reducing Cardiometabolic Risk: Does Diet Type Really Matter?

Nutrients ◽  
2021 ◽  
Vol 13 (2) ◽  
pp. 639
Author(s):  
Katarzyna Nabrdalik ◽  
Katarzyna Krzyżak ◽  
Weronika Hajzler ◽  
Karolina Drożdż ◽  
Hanna Kwiendacz ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Gut Microbiota ◽  
Cardiometabolic Risk ◽  
Saturated Fat ◽  
Lifestyle Changes ◽  
Dietary Guidelines ◽  
Factors Affecting ◽  
Cardiometabolic Diseases ◽  
Low Carbohydrate Diet

The incidence of cardiometabolic diseases, such as obesity, diabetes, and cardiovascular diseases, is constantly rising. Successful lifestyle changes may limit their incidence, which is why researchers focus on the role of nutrition in this context. The outcomes of studies carried out in past decades have influenced dietary guidelines, which primarily recommend reducing saturated fat as a therapeutic approach for cardiovascular disease prevention, while limiting the role of sugar due to its harmful effects. On the other hand, a low-carbohydrate diet (LCD) as a method of treatment remains controversial. A number of studies on the effect of LCDs on patients with type 2 diabetes mellitus proved that it is a safe and effective method of dietary management. As for the risk of cardiovascular diseases, the source of carbohydrates and fats corresponds with the mortality rate and protective effect of plant-derived components. Additionally, some recent studies have focused on the gut microbiota in relation to cardiometabolic diseases and diet as one of the leading factors affecting microbiota composition. Unfortunately, there is still no precise answer to the question of which a single nutrient plays the most important role in reducing cardiometabolic risk, and this review article presents the current state of the knowledge in this field.

scholarly journals Impact of Gut Microbiota on the Risk of Cardiometabolic Diseases Development

2021 ◽  
Vol 17 (5) ◽  
pp. 743-751
Author(s):  
L. E. Vasilyeva ◽  
O. M. Drapkina
Keyword(s):  
Cardiovascular Diseases ◽  
Gut Microbiota ◽  
Intestinal Microbiota ◽  
Lifestyle Changes ◽  
Obese People ◽  
Cardiometabolic Diseases ◽  
The World ◽  
Prevalence Of Obesity ◽  
Treatment Of Obesity ◽  
The Relationship

Obesity is a multifactorial disease that leads to excessive adipose tissue accumulation, mainly visceral fat. Importance and prevalence of obesity has increased significantly in recent decades all over the world. Until now, the pandemic of obesity has been associated more to lifestyle changes: excessive eating and low physical activity. In recent years, special attention has been paid to studying of composition and functions of intestinal microbiota as major factor in development of obesity and related comorbidities, such as hypertension, cardiac ischemia, heart failure and others. It is proved that gut microbiota affects extraction, accumulation and consumption of energy derived from food, lipid metabolism and immune response. It is also revealed that composition of the microbiota is different in thin and obese people. Thus, study of the relationship between intestinal microbiota composition and risk factors for cardiovascular diseases, in particular obesity, is an actual task. The purpose of this review is analyzing of literature about assessment of relationship between composition and functions of intestinal microbiota in the diagnostics, prevention and treatment of obesity and cardiovascular diseases.

scholarly journals The Emerging Role of Gut Microbiota in Cardiovascular Diseases

2021 ◽  
Author(s):  
Dilip Kumar ◽  
Sanjeev S. Mukherjee ◽  
Rabin Chakraborty ◽  
Rana Rathod Roy ◽  
Arindam Pandey ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Gut Microbiota

A Comprehensive View on Cardiovascular Diseases (CVDs): Genetics, Risk Factors & Preventions

2021 ◽  
Vol 5 (1) ◽  
pp. 38-61
Author(s):  
Saaim Asif ◽  
Maaz Khan ◽  
Muhammad Waqar Arshad
Keyword(s):  
Risk Factors ◽  
Cardiovascular Diseases ◽  
Healthy Lifestyle ◽  
Saturated Fat ◽  
Vascular Diseases ◽  
Model Organisms ◽  
Balanced Diet ◽  
Diet And Exercise ◽  
Healthy Lifestyle Interventions

Cardiovascular Diseases (CVDs) are one of the foremost causes of deaths across the world. This review aims to evaluate the genetics and risk factors involved in CVDs and to assess the preventive measures which can be taken for diminishing the chances of developing CVDs. The goal of this review is to provide researchers and clinicians dealing with vascular disorders with a compendium of data about the genetic causes, risk factors, and preventive strategies to combat the development of CVDs. We searched online databases including PubMed for peer-reviewed scientific papers, case studies and review articles related to CVDs, emphasizing on the role of genetics and risk factors like diabetes, hypertension, smoking, alcohol consumption, obesity, age & gender in the progression of CVDs, and reviewing the role of diet and exercise in the prevention of CVDs. Managing the risk factors involved in CVDs is the most essential step for the inhibition of vascular diseases. Healthy lifestyle interventions consisting of a well-balanced diet and physical activity are very critical for the prevention of CVDs. Trials carried out on model organisms have indicated a direct link between diet and exercise on cardiovascular conditions. Strategies involved in the treatment of vascular diseases should also include low-fat diet plans like consumption of whole grains, fruits, vegetables, yogurts and avoiding high-saturated fat-containing foods with the addition of performing moderate aerobic exercises including cycling, swimming, hiking, and running to eliminate the root of the problem.

Manipulating the Gut Microbiota to Manage Obesity

2018 ◽  
Vol 24 (8) ◽  
pp. 6198-6202
Author(s):  
Anthony Paulo Sunjaya ◽  
Angela Felicia Sunjaya ◽  
Meilani Kumala
Keyword(s):  
Gut Microbiota ◽  
Low Cost ◽  
Lifestyle Changes ◽  
Gut Permeability ◽  
Great Role ◽  
Diet Modification ◽  
Food Biotechnology ◽  
Microbial Strain

Obesity has currently become a worldwide epidemic. Currently, lifestyle changes, pharmacotherapy and bariatric surgery remains the only available armamentarium. However, lifestyle changes and pharmacotherapy resulted in variable outcomes and are often unsustainable. On the other hand, advances in metagenomics and food biotechnology has reported the important role of gut microbiota in the complex pathophysiology of obesity and its possible role in treating it. This review aims to discuss the potential of manipulating gut microbiota to tackle obesity. Articles were obtained through Pubmed, Science Direct, Google Scholar, High Wire and Elsevier Clinical Key using the keywords “obesity AND gut microbiota or synonyms.” Various studies have shown the interactions between gut microbiota, gut permeability and the immune system as a mechanism that links diet, obesity and its comorbidities. There are currently several reported methods of manipulating gut microbiota namely, though probiotics, prebiotics, synbiotics and diet modification with varying outcomes based on the microbial strain affected and used. Studies have also proposed manipulating gut microbiota as a way to prevent and manage obesity en-mass. Conclusions: Gut microbiota plays a great role in maintaining body’s energy balance. Manipulating gut microbiota has great potential to become a low cost and effective treatment for obesity and its prevention with minimal side effects for long-term use. The various forms of prebiotics, probiotics and synbiotics currently available would be able to increase patient’s compliance and easiness in distribution. Better management of obesity would lead to a reduction in many comorbidities including heart disease, stroke and diabetes.

scholarly journals Implication of Gut Microbiota in Cardiovascular Diseases

2020 ◽  
Vol 2020 ◽  
pp. 1-14
Author(s):  
Wenyi Zhou ◽  
Yiyu Cheng ◽  
Ping Zhu ◽  
M. I. Nasser ◽  
Xueyan Zhang ◽  
...  
Keyword(s):  
Cell Death ◽  
Cardiovascular Diseases ◽  
Programmed Cell Death ◽  
Gut Microbiota ◽  
Intestinal Flora ◽  
Short Chain Fatty Acids ◽  
Secondary Bile Acid ◽  
Cardiac Disorders ◽  
The Relationship

Emerging evidence has identified the association between gut microbiota and various diseases, including cardiovascular diseases (CVDs). Altered intestinal flora composition has been described in detail in CVDs, such as hypertension, atherosclerosis, myocardial infarction, heart failure, and arrhythmia. In contrast, the importance of fermentation metabolites, such as trimethylamine N-oxide (TMAO), short-chain fatty acids (SCFAs), and secondary bile acid (BA), has also been implicated in CVD development, prevention, treatment, and prognosis. The potential mechanisms are conventionally thought to involve immune regulation, host energy metabolism, and oxidative stress. However, numerous types of programmed cell death, including apoptosis, autophagy, pyroptosis, ferroptosis, and clockophagy, also serve as a key link in microbiome-host cross talk. In this review, we introduced and summarized the results from recent studies dealing with the relationship between gut microbiota and cardiac disorders, highlighting the role of programmed cell death. We hope to shed light on microbiota-targeted therapeutic strategies in CVD management.

Pivotal Role Of The Interaction Between Herbal Medicines And Gut Microbiota On Disease Treatment

2020 ◽  
Vol 21 ◽  
Author(s):  
Tingting Zhao ◽  
Zhe Wang ◽  
Zhilong Liu ◽  
Youhua Xu
Keyword(s):  
Cardiovascular Diseases ◽  
Gut Microbiota ◽  
Neurodegenerative Diseases ◽  
Disease Progression ◽  
Herbal Medicines ◽  
Underlying Mechanism ◽  
Disease Treatment ◽  
Endocrine Diseases ◽  
Health And Disease

: With the recognition of the important role of gut microbiota in both health and disease progression, attempts to modulate its composition as well as its co-metabolism with the organism have attracted special attention. Abundant studies have demonstrated that dysfunction or imbalance of gut microbiota is closely with disease including endocrine diseases, neurodegenerative diseases, tumors, cardiovascular diseases, et al. Herbal medicines have been applied for preventing and treating disease worldwide for hundreds of years. Although the underlying mechanism seems to be complex, one of the important one is through modulating gut microbiota. In this review, co-metabolism between herbal medicines and microbiota, as well as the potential pathways are summarized from most recent published papers.

scholarly journals Role of Gut Microbiota in the Pathogenesis of Cardiovascular Diseases and Metabolic Syndrome

2018 ◽  
Vol 14 (4) ◽  
pp. 567-574 ◽  
Author(s):  
O. M. Drapkina ◽  
O. E. Shirobokikh
Keyword(s):  
Heart Failure ◽  
Metabolic Syndrome ◽  
Fatty Acids ◽  
Cardiovascular Diseases ◽  
Gut Microbiota ◽  
Bile Acids ◽  
G Protein ◽  
Short Chain Fatty Acids ◽  
Short Chain

The role of gut microbiota in the pathogenesis of cardiovascular diseases (CVD) and metabolic syndrome has attracted massive attention in the past decade. Accumulating evidence has revealed that the metabolic potential of gut microbiota can be identified as a contributing factor in the development of atherosclerosis, hypertension, heart failure, obesity, diabetes mellitus. The gut-host interaction occurs through many pathways including trimethylamine-N-oxide pathway (TMAO), short-chain fatty acids and second bile acids pathways. TMAO (the hepatic oxidation product of the microbial metabolite of trimethylamine) enhances platelet hyperreactivity and thrombosis risk and predicts major adverse cardiovascular events. Short-chain fatty acids and second bile acids, which are produced with the help of microbiota, can modulate host lipid metabolism as well as carbohydrate metabolism through several receptors such as G-protein-coupled receptors 41,43, farnesoid X-receptor, Takeda-G-protein-receptor-5. This way microbiota can impact host lipid levels, processes of weight gain, insulin sensitivity. Besides these metabolism-dependent pathways, there are some other pathways, which link microbiota and the pathogenesis of CVD. For example, lipopolysaccharide, the major component of the outer bacterial membrane, causes metabolic endotoxemia and low-grade systemic inflammation and contribute this way to obesity and progression of heart failure and atherosclerosis. This review aims to illustrate the complex interplay between microbiota, their metabolites, and the development and progression of CVD and metabolic syndrome. It is also discussed how modulating of gut microbiota composition and function through diet, prebiotics, probiotics and fecal microbiota transplantation can become a novel therapeutic and preventative target for CVD and metabolic syndrome. Many questions remain unresolved in this field and undoubtedly further studies are needed.

scholarly journals The Effective Role of Natural Product Berberine in Modulating Oxidative Stress and Inflammation Related Atherosclerosis: Novel Insights Into the Gut-Heart Axis Evidenced by Genetic Sequencing Analysis

2021 ◽  
Vol 12 ◽  
Author(s):  
Richard Y. Cao ◽  
Ying Zhang ◽  
Zhen Feng ◽  
Siyu Liu ◽  
Yifan Liu ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Gut Microbiota ◽  
Natural Product ◽  
Sequencing Analysis ◽  
Inflammatory Reactions ◽  
Genetic Sequencing ◽  
Effective Role ◽  
Underlying Mechanisms ◽  
Atherosclerotic Cardiovascular Diseases

The exacerbation of oxidative and inflammatory reactions has been involved in atherosclerotic cardiovascular diseases leading to morbidity and mortality worldwide. Discovering the underlying mechanisms and finding optimized curative approaches to control the global prevalence of cardiovascular diseases is needed. Growing evidence has demonstrated that gut microbiota is associated with the development of atherosclerosis, while berberine, a natural product exhibits antiatherogenic effects in clinical and pre-clinical studies, which implies a potential link between berberine and gut microbiota. In light of these novel discoveries, evidence of the role of berberine in modulating atherosclerosis with a specific focus on its interaction with gut microbiota is collected. This review synthesizes and summarizes antioxidant and anti-inflammatory effects of berberine on combating atherosclerosis experimentally and clinically, explores the interaction between berberine and intestinal microbiota comprehensively, and provides novel insights of berberine in managing atherosclerotic cardiovascular diseases via targeting the gut-heart axis mechanistically. The phenomenon of how berberine overcomes its weakness of poor bioavailability to conduct its antiatherogenic properties is also discussed and interpreted in this article. An in-depth understanding of this emerging area may contribute to identifying therapeutic potentials of medicinal plant and natural product derived pharmaceuticals for the prevention and treatment of atherosclerotic cardiovascular diseases in the future.

scholarly journals The role of gut microbiota in cardiovascular diseases

2018 ◽  
Vol 75 (2) ◽  
pp. 213-224
Author(s):  
Zinnet Şevval Aksoyalp ◽  
Cahit Nacitarhan
Keyword(s):  
Cardiovascular Diseases ◽  
Gut Microbiota
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