scholarly journals Effect of Gut Microbial Enterotypes on the Association between Habitual Dietary Fiber Intake and Insulin Resistance Markers in Mexican Children and Adults

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 3892
Author(s):  
Jennifer N. Martinez-Medina ◽  
Regina Flores-Lopez ◽  
Blanca E. López-Contreras ◽  
Hugo Villamil-Ramirez ◽  
Daniela Guzman-Muñoz ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Dietary Fiber ◽  
Short Chain Fatty Acids ◽  
Cross Sectional Study ◽  
Metabolic Phenotype ◽  
Cross Sectional ◽  
16S Sequencing ◽  
Metabolic Traits ◽  
Dietary Fiber Intake ◽  
Fatty Acids Profile

Dietary fiber (DF) is a major substrate for the gut microbiota that contributes to metabolic health. Recent studies have shown that diet–metabolic phenotype effect might be related to individual gut microbial profiles or enterotypes. Thus, the aim of this study was to examine whether microbial enterotypes modify the association between DF intake and metabolic traits. This cross-sectional study included 204 children (6–12 years old) and 75 adults (18–60 years old). Habitual DF intake was estimated with a Food Frequency Questionnaire and biochemical, clinical and anthropometric data were obtained. Gut microbiota was assessed through 16S sequencing and participants were stratified by enterotypes. Correlations adjusting for age and sex were performed to test the associations between dietary fiber components intake and metabolic traits. In children and adults from the Prevotella enterotype, a nominal negative correlation of hemicellulose intake with insulin and HOMA-IR levels was observed (p < 0.05), while in individuals of the other enterotypes, these associations were not observed. Interestingly, the latter effect was not related to the fecal short-chain-fatty acids profile. Our results contribute to understanding the enterotype influence on the diet–phenotype interaction, which ultimate could provide evidence for their use as potential biomarkers for future precision nutrition strategies.

scholarly journals Gut microbiota link dietary fiber intake and short-chain fatty acid metabolism with eating behavior

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Evelyn Medawar ◽  
Sven-Bastiaan Haange ◽  
Ulrike Rolle-Kampczyk ◽  
Beatrice Engelmann ◽  
Arne Dietrich ◽  
...  
Keyword(s):  
Dietary Fiber ◽  
Eating Behavior ◽  
Weight Status ◽  
Treatment Success ◽  
Short Chain Fatty Acids ◽  
Short Chain ◽  
Fiber Intake ◽  
Cross Sectional ◽  
Dietary Fiber Intake ◽  
And Control

AbstractThe gut microbiome has been speculated to modulate feeding behavior through multiple factors, including short-chain fatty acids (SCFA). Evidence on this relationship in humans is however lacking. We aimed to explore if specific bacterial genera relate to eating behavior, diet, and SCFA in adults. Moreover, we tested whether eating-related microbiota relate to treatment success in patients after Roux-en-Y gastric bypass (RYGB). Anthropometrics, dietary fiber intake, eating behavior, 16S-rRNA-derived microbiota, and fecal and serum SCFA were correlated in young overweight adults (n = 27 (9 F), 21–36 years, BMI 25–31 kg/m2). Correlated genera were compared in RYGB (n = 23 (16 F), 41–70 years, BMI 25–62 kg/m2) and control patients (n = 17 (11 F), 26–69 years, BMI 25–48 kg/m2). In young adults, 7 bacteria genera, i.e., Alistipes, Blautia, Clostridiales cluster XVIII, Gemmiger, Roseburia, Ruminococcus, and Streptococcus, correlated with healthier eating behavior, while 5 genera, i.e., Clostridiales cluster IV and XIVb, Collinsella, Fusicatenibacter, and Parabacteroides, correlated with unhealthier eating (all | r | > 0.4, FDR-corrected p < 0.05). Some of these genera including Parabacteroides related to fiber intake and SCFA, and to weight status and treatment response in overweight/obese patients. In this exploratory analysis, specific bacterial genera, particularly Parabacteroides, were associated with weight status and eating behavior in two small, independent and well-characterized cross-sectional samples. These preliminary findings suggest two groups of presumably beneficial and unfavorable genera that relate to eating behavior and weight status, and indicate that dietary fiber and SCFA metabolism may modify these relationships. Larger interventional studies are needed to distinguish correlation from causation.

scholarly journals Sources of Dietary Fiber Are Differently Associated with Prevalence of Depression

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2813
Author(s):  
Chong-Su Kim ◽  
Seohyeon Byeon ◽  
Dong-Mi Shin
Keyword(s):  
Dietary Fiber ◽  
Cross Sectional Study ◽  
Fiber Intake ◽  
Cross Sectional ◽  
Korean Adults ◽  
Dietary Fiber Intake ◽  
Health And Nutrition ◽  
Patient Health ◽  
Study Population ◽  
Specific Source

Dietary fiber has been actively studied for its profound impacts on mental health by affecting the gut–brain axis communication. However, the association between dietary fiber intake and depression has been inconsistent, partly due to the lack of consideration of the fiber source. Therefore, this study aimed to examine the association between various sources of dietary fiber and depression in Korean adults through a nationwide cross-sectional study. The study population was a total of 2960 adults between 19 and 64 years of age who participated in the Korean National Health and Nutrition Examination Survey (KNHANES, 2012–2016). Dietary fiber intake from each fiber subtype (crude, cereal, vegetable, fruit, seaweed, and mushroom) was calculated using the Food Frequency Questionnaire (FFQ). Depression prevalence was assessed using a Patient Health Questionnaire (PHQ-9) and self-reported clinical diagnosis by a physician. We found that seaweed (odds ratio (OR) = 0.38; 95% confidence interval (CI): 0.20–0.72; p < 0.05) and mushroom fiber intake (OR = 0.18; 95% CI: 0.01–0.37; p < 0.05) were inversely associated with depressive symptoms assessed using the PHQ-9 parameters. Moreover, seaweed fiber intake was inversely associated with clinical depression diagnosed by a physician (OR = 0.45; 95% CI: 0.23–0.88; p < 0.05). This was the first study to find that higher intakes of seaweed and mushroom fiber were associated with a lower likelihood of depression in a representative cohort of Korean adults, indicating that the specific source of dietary fiber may be an important dietary factor in modulating depression.

scholarly journals Association of dietary fiber intake with metabolic syndrome among adult cancer survivors: a population-based cross-sectional study

2021 ◽  
Vol 11 (1) ◽  
Author(s):  
Kyuwoong Kim ◽  
Yoonjung Chang
Keyword(s):  
Metabolic Syndrome ◽  
Cancer Survivors ◽  
Dietary Fiber ◽  
Population Based ◽  
Cross Sectional Study ◽  
Fiber Intake ◽  
Sectional Study ◽  
Cross Sectional ◽  
Dietary Fiber Intake ◽  
Adult Cancer Survivors

AbstractNutrient intake for adult cancer survivors is of clinical importance for managing metabolic health. Whether dietary fiber intake is associated with metabolic syndrome (MetS) or not in adult cancer survivors is uncertain. We aim to investigate the association between dietary fiber intake and MetS in adult cancer survivors using a population-based cross-sectional study. A study sample of 1301 adult cancer survivors aged more than 20 years from the sixth and seventh Korea Nutrition Examination Survey (KNHANES) from 2013 to 2018 was identified. Odds ratio (OR) and 95% confidence intervals (95% CI) were estimated from multiple logistic regression adjusted for sociodemographic factors, health behavior, and nutritional status. Among 1,301 adult cancer survivors identified from the KNHANES 2013–2018, the mean dietary fiber intake was 28.1 g/day (standard error, 0.54). Compared to the first quintile of dietary fiber intake, the adjusted ORs and 95% CIs for MetS in the second, third, fourth, and fifth quintiles of dietary fiber intake were 0.84 (0.27–2.61), 0.77 (0.16–3.74), 0.55 (0.14–2.22), and 0.26 (0.05–1.39), respectively (p value for trend = 0.0007). Our findings suggest that high dietary fiber intake is marginally associated with reduced odds of MetS in adult cancer survivors.

scholarly journals Gut Microbiota Mediates High-Fiber Diet Alleviation of Maternal Obesity-Induced Cognitive and Social Deficits in Offspring

2020 ◽  
Author(s):  
Xiaoning Liu ◽  
Xiang Li ◽  
Bing Xia ◽  
Xin Jin ◽  
Zhenhua Zeng ◽  
...  
Keyword(s):  
Maternal Obesity ◽  
Short Chain Fatty Acids ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
High Fiber ◽  
Dietary Fiber Intake ◽  
Effective Interventions ◽  
Fiber Diet ◽  
High Fiber Diet ◽  
Underlying Mechanisms

SUMMARYMaternal obesity has been reported to be related to the neurodevelopmental disorders in offspring. However, the underlying mechanisms and effective interventions remain unclear. Here, a cross-sectional study on 778 children aged 7-14 years in two cities of China indicates that the maternal obesity is highly associated with the poorer cognition and sociality of their children. Moreover, we also find that the maternal obesity in mice disrupts the behavior and the gut microbiome in the offspring, which are alleviated by a high-fiber diet in either dams or offspring. Co-housing and feces microbiota transplantation experiments reveal a causal relationship between the reshaped microbiota and the behavioral changes. Moreover, treatment of the microbiota-derived short-chain fatty acids exhibits a similar beneficial effect on alleviating the behavioral deficits in offspring. Together, our study purports the microbiota-metabolites-brain axis as a mechanism, and high-dietary fiber intake is a promising intervention against maternal obesity-induced cognitive and social dysfunctions.

scholarly journals Dietary Fiber, Genetic Variations of Gut Microbiota-derived Short-chain Fatty Acids, and Bone Health in UK Biobank

2020 ◽  
Vol 106 (1) ◽  
pp. 201-210
Author(s):  
Tao Zhou ◽  
Mengying Wang ◽  
Hao Ma ◽  
Xiang Li ◽  
Yoriko Heianza ◽  
...  
Keyword(s):  
Fatty Acids ◽  
Gut Microbiota ◽  
Dietary Fiber ◽  
Bone Health ◽  
Short Chain Fatty Acids ◽  
Fiber Intake ◽  
Uk Biobank ◽  
Dietary Fiber Intake ◽  
Heel Ultrasound ◽  
Genetically Determined

Abstract Context Dietary fiber intake may relate to bone health. Objective To investigate whether dietary fiber intake is associated with bone mineral density (BMD), and the modification effect of genetic variations related to gut microbiota-derived short-chain fatty acids (SCFAs). Design The associations of dietary fiber intake with estimated BMD derived from heel ultrasound and fractures were assessed in 224 630 and 384 134 participants from the UK Biobank. Setting UK Biobank. Main Outcome Measures Estimated BMD derived from heel ultrasound Results Higher dietary fiber intake (per standard deviation) was significantly associated with higher heel-BMD (β [standard error] = 0.0047 [0.0003], P = 1.10 × 10–54). Similarly significant associations were observed for all the fiber subtypes including cereal, fruit (dried and raw), and vegetable (cooked and raw) (all P &lt; .05). A positive association was found in both women and men but more marked among men except for dietary fiber in cooked vegetables (all Pinteraction &lt; .05). A protective association was found between dietary fiber intake and hip fracture (hazard ratio, 95% confidence interval: 0.94, 0.89-0.99; P = 3.0 × 10–2). In addition, the association between dietary fiber and heel BMD was modified by genetically determined SCFA propionate production (Pinteraction = 5.1 × 10–3). The protective association between dietary fiber and heel BMD was more pronounced among participants with lower genetically determined propionate production. Conclusions Our results indicate that greater intakes of total dietary fiber and subtypes from various food sources are associated with higher heel-BMD. Participants with lower genetically determined propionate production may benefit more from taking more dietary fiber.

scholarly journals Gut Microbiota Profile and Its Association with Clinical Variables and Dietary Intake in Overweight/Obese and Lean Subjects: A Cross-Sectional Study

Nutrients ◽  
2021 ◽  
Vol 13 (6) ◽  
pp. 2032
Author(s):  
Judit Companys ◽  
Maria José Gosalbes ◽  
Laura Pla-Pagà ◽  
Lorena Calderón-Pérez ◽  
Elisabet Llauradó ◽  
...  
Keyword(s):  
Gut Microbiota ◽  
Dietary Intake ◽  
Saturated Fatty Acids ◽  
Cross Sectional Study ◽  
Sectional Study ◽  
Anthropometric Parameters ◽  
Cross Sectional ◽  
Negatively Associated ◽  
Clinical Variables ◽  
Obese Subjects

We aimed to differentiate gut microbiota composition of overweight/obese and lean subjects and to determine its association with clinical variables and dietary intake. A cross-sectional study was performed with 96 overweight/obese subjects and 32 lean subjects. Anthropometric parameters were positively associated with Collinsella aerofaciens, Dorea formicigenerans and Dorea longicatena, which had higher abundance the overweight/obese subjects. Moreover, different genera of Lachnospiraceae were negatively associated with body fat, LDL and total cholesterol. Saturated fatty acids (SFAs) were negatively associated with the genus Intestinimonas, a biomarker of the overweight/obese group, whereas SFAs were positively associated with Roseburia, a biomarker for the lean group. In conclusion, Dorea formicigenerans, Dorea longicatena and Collinsella aerofaciens could be considered obesity biomarkers, Lachnospiraceae is associated with lipid cardiovascular risk factors. SFAs exhibited opposite association profiles with butyrate-producing bacteria depending on the BMI. Thus, the relationship between diet and microbiota opens new tools for the management of obesity.

scholarly journals Altered Gut Microbiota in Irritable Bowel Syndrome and Its Association with Food Components

2021 ◽  
Vol 11 (1) ◽  
pp. 35
Author(s):  
Zahra A. Barandouzi ◽  
Joochul Lee ◽  
Kendra Maas ◽  
Angela R. Starkweather ◽  
Xiaomei S. Cong
Keyword(s):  
Irritable Bowel Syndrome ◽  
Gut Microbiota ◽  
Alpha Diversity ◽  
Diversity Indices ◽  
Cross Sectional Study ◽  
Caffeine Intake ◽  
Caffeine Consumption ◽  
Cross Sectional ◽  
Food Components ◽  
Irritable Bowel

The interplay between diet and gut microbiota has gained interest as a potential contributor in pathophysiology of irritable bowel syndrome (IBS). The purpose of this study was to compare food components and gut microbiota patterns between IBS patients and healthy controls (HC) as well as to explore the associations of food components and microbiota profiles. A cross-sectional study was conducted with 80 young adults with IBS and 21 HC recruited. The food frequency questionnaire was used to measure food components. Fecal samples were collected and profiled by 16S rRNA Illumina sequencing. Food components were similar in both IBS and HC groups, except in caffeine consumption. Higher alpha diversity indices and altered gut microbiota were observed in IBS compared to the HC. A negative correlation existed between total observed species and caffeine intake in the HC, and a positive correlation between alpha diversity indices and dietary fiber in the IBS group. Higher alpha diversity and gut microbiota alteration were found in IBS people who consumed caffeine more than 400 mg/d. Moreover, high microbial diversity and alteration of gut microbiota composition in IBS people with high caffeine consumption may be a clue toward the effects of caffeine on the gut microbiome pattern, which warrants further study.

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