scholarly journals Effects of Peanut Protein Supplementation on Resistance Training Adaptations in Younger Adults

Nutrients ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 3981
Author(s):  
Casey L. Sexton ◽  
Morgan A. Smith ◽  
Kristen S. Smith ◽  
Shelby C. Osburn ◽  
Joshua S. Godwin ◽  
...  
Keyword(s):  
Resistance Training ◽  
Repeated Measures ◽  
Vastus Lateralis ◽  
Protein Supplementation ◽  
Peanut Protein ◽  
Whole Body ◽  
Training Experience ◽  
Tissue Mass ◽  
Training Adaptations ◽  
Dependent Samples

Protein supplementation is a commonly employed strategy to enhance resistance training adaptations. However, little research to date has examined if peanut protein supplementation is effective in this regard. Thus, we sought to determine if peanut protein supplementation (PP; 75 total g/d of powder providing 30 g/d protein, >9.2 g/d essential amino acids, ~315 kcal/d) affected resistance training adaptations in college-aged adults. Forty-seven college-aged adults (n = 34 females, n = 13 males) with minimal prior training experience were randomly assigned to a PP group (n = 18 females, n = 5 males) or a non-supplement group (CTL; n = 16 females, n = 8 males) (ClinicalTrials.gov trial registration NCT04707963; registered 13 January 2021). Body composition and strength variables were obtained prior to the intervention (PRE). Participants then completed 10 weeks of full-body resistance training (twice weekly) and PP participants consumed their supplement daily. POST measures were obtained 72 h following the last training bout and were identical to PRE testing measures. Muscle biopsies were also obtained at PRE, 24 h following the first exercise bout, and at POST. The first two biopsy time points were used to determine myofibrillar protein synthesis (MyoPS) rates in response to a naïve training bout with or without PP, and the PRE and POST biopsies were used to determine muscle fiber adaptations in females only. Dependent variables were analyzed in males and females separately using two-way (supplement × time) repeated measures ANOVAs, unless otherwise stated. The 24-h integrated MyoPS response to the first naïve training bout was similar between PP and CTL participants (dependent samples t-test p = 0.759 for females, p = 0.912 for males). For males, the only significant supplement × time interactions were for DXA-derived fat mass (interaction p = 0.034) and knee extensor peak torque (interaction p = 0.010); these variables significantly increased in the CTL group (p < 0.05), but not the PP group. For females, no significant supplement × time interactions existed, although interactions for whole body lean tissue mass (p = 0.088) and vastus lateralis thickness (p = 0.099) approached significance and magnitude increases in these characteristics favored the PP versus CTL group. In summary, this is the second study to determine the effects of PP supplementation on resistance training adaptations. While PP supplementation did not significantly enhance training adaptations, the aforementioned trends in females, the limited n-size in males, and this being the second PP supplementation study warrant more research to determine if different PP dosing strategies are more effective than the current approach.

scholarly journals Effects of High-Volume versus High-Load Resistance Training on Skeletal Muscle Growth and Molecular Adaptations

2021 ◽  
Author(s):  
Christopher Vann ◽  
Casey Sexton ◽  
Shelby Osburn ◽  
Morgan Smith ◽  
Cody Haun ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Protein Synthesis ◽  
Resistance Training ◽  
Repeated Measures ◽  
Vastus Lateralis ◽  
Peak Torque ◽  
Training Experience ◽  
Leg Extension ◽  
Sarcoplasmic Protein ◽  
Dependent Samples

Aim: We evaluated the effects of higher-load (HL) versus (lower-load) higher-volume (HV) resistance training on skeletal muscle hypertrophy, strength, and muscle-level molecular markers. Methods: Trained men (n=15, age: 23+/-3 y; training experience: 7+/-3 y) performed unilateral lower body training for 6 weeks (3x weekly), where single legs were assigned to HV and HL paradigms. Vastus lateralis (VL) biopsies were obtained prior to study initiation (PRE) as well as 3 days (POST) and 10 days following the last bout (POSTPR). Body composition and strength tests were performed at each testing session, and biochemical assays were performed on muscle tissue after study completion. Two-way within subjects repeated measures ANOVAs were performed on all dependent variables except tracer data, which was compared using dependent samples t-tests. Results: A significant (p<0.05) interaction existed for unilateral leg extension 1RM (HV<HL at POST and POSTPR). Six-week integrated sarcoplasmic protein synthesis (iSarcoPS) rates were higher in the HV versus HL leg, while no difference between legs existed for integrated myofibrillar protein synthesis rates. Main time effects existed for unilateral leg press strength (PRE<POST and POSTPR), knee extensor peak torque (PRE and POST<POSTPR), dual-energy x-ray absorptiometry (DXA)-derived upper leg lean mass (PRE<POST and POSTPR), ultrasound-derived VL thickness (PRE and POSTPR<POST), sarcoplasmic protein concentrations (POST and POSTPR<PRE), and tropomyosin and troponin protein abundances (POST and POSTPR<PRE). Conclusions: With the exception of differences in leg extensor strength and iSarcoPS between legs, our data suggest that short-term (6 weeks) HV and HL training elicit similar hypertrophic, strength, and molecular-level adaptations.

scholarly journals The effects of resistance training with or without peanut protein supplementation on skeletal muscle and strength adaptations in older individuals

2020 ◽  
Author(s):  
Donald A. Lamb ◽  
Johnathon H. Moore ◽  
Morgan A. Smith ◽  
Christopher G. Vann ◽  
Shelby C. Osburn ◽  
...  
Keyword(s):  
Resistance Training ◽  
Deuterium Oxide ◽  
Vastus Lateralis ◽  
Adult Population ◽  
Quantitative Computed Tomography ◽  
Group Versus ◽  
Protein Supplementation ◽  
Peanut Protein ◽  
Older Individuals ◽  
Post Intervention

Abstract Several studies suggest resistance training (RT) while supplementing with various protein supplements can enhance strength and muscle mass in older individuals. However, to date, no study has examined the effects of RT with a peanut protein powder (PP) supplement on these outcomes. Herein, 39 older, untrained individuals (n=17 female, n=22 male; age=58.6±8.0 years; body mass index =28.7±5.8) completed a 6-week (n=22) or 10-week (n=17) RT program, where full-body training was implemented twice weekly (ClinicalTrials.gov trial registration NCT04015479; registered July 11, 2019). Participants in each program were randomly assigned to consume either a PP supplement once per day (75 total g powder providing 30 g protein, >9.2 g essential amino acids, ~315 kcal; n=20) or no supplement (CTL; n=19). Right leg vastus lateralis (VL) muscle biopsies were obtained prior to and 24 hours following the first training bout in all participants to assess the change in myofibrillar protein synthetic rates (MyoPS) as measured via the deuterium-oxide (D2O) tracer method. Pre- and Post-intervention testing in all participants was conducted using dual energy x-ray absorptiometry (DXA), VL ultrasound imaging, a peripheral quantitative computed tomography (pQCT) scan at the mid-thigh, and right leg isokinetic dynamometer assessments. Integrated MyoPS rates over a 24-hour period were not significantly different (p<0.05) between supplement groups following the first training bout. Regarding chronic changes, there were no significant supplement-by-time interactions in DXA-derived fat mass, lean soft tissue mass or percent body fat between supplementation groups. There was, however, a significant increase in VL thickness in PP versus CTL participants when the 6- and 10-week cohorts were pooled (interaction p=0.041). There was also a significant increase in knee flexion torque in the 10-week PP group versus the CTL group (interaction p=0.032). In conclusion, a higher-protein, defatted peanut powder supplement in combination with RT positively affects select markers of muscle hypertrophy and strength in an untrained, older adult population. Moreover, subanalyses indicated that gender did not play a role in these adaptations.

scholarly journals The effects of resistance training with or without peanut protein supplementation on skeletal muscle and strength adaptations in older individuals

2020 ◽  
Vol 17 (1) ◽  
Author(s):  
Donald A. Lamb ◽  
Johnathon H. Moore ◽  
Morgan A. Smith ◽  
Christopher G. Vann ◽  
Shelby C. Osburn ◽  
...  
Keyword(s):  
Resistance Training ◽  
Deuterium Oxide ◽  
Vastus Lateralis ◽  
Adult Population ◽  
Quantitative Computed Tomography ◽  
Group Versus ◽  
Protein Supplementation ◽  
Peanut Protein ◽  
Older Individuals ◽  
Post Intervention

AbstractSeveral studies suggest resistance training (RT) while supplementing with various protein supplements can enhance strength and muscle mass in older individuals. However, to date, no study has examined the effects of RT with a peanut protein powder (PP) supplement on these outcomes. Herein, 39 older, untrained individuals (n = 17 female, n = 22 male; age = 58.6 ± 8.0 years; body mass index =28.7 ± 5.8) completed a 6-week (n = 22) or 10-week (n = 17) RT program, where full-body training was implemented twice weekly (ClinicalTrials.gov trial registration NCT04015479; registered July 11, 2019). Participants in each program were randomly assigned to consume either a PP supplement once per day (75 total g powder providing 30 g protein, > 9.2 g essential amino acids, ~ 315 kcal; n = 20) or no supplement (CTL; n = 19). Right leg vastus lateralis (VL) muscle biopsies were obtained prior to and 24 h following the first training bout in all participants to assess the change in myofibrillar protein synthetic rates (MyoPS) as measured via the deuterium-oxide (D2O) tracer method. Pre- and Post-intervention testing in all participants was conducted using dual energy x-ray absorptiometry (DXA), VL ultrasound imaging, a peripheral quantitative computed tomography (pQCT) scan at the mid-thigh, and right leg isokinetic dynamometer assessments. Integrated MyoPS rates over a 24-h period were not significantly different (p < 0.05) between supplement groups following the first training bout. Regarding chronic changes, there were no significant supplement-by-time interactions in DXA-derived fat mass, lean soft tissue mass or percent body fat between supplementation groups. There was, however, a significant increase in VL thickness in PP versus CTL participants when the 6- and 10-week cohorts were pooled (interaction p = 0.041). There was also a significant increase in knee flexion torque in the 10-week PP group versus the CTL group (interaction p = 0.032). In conclusion, a higher-protein, defatted peanut powder supplement in combination with RT positively affects select markers of muscle hypertrophy and strength in an untrained, older adult population. Moreover, subanalyses indicated that gender did not play a role in these adaptations.

Muscle strength and hypertrophy occur independently of protein supplementation during short-term resistance training in untrained men

2015 ◽  
Vol 40 (8) ◽  
pp. 797-802 ◽  
Author(s):  
Carleigh H. Boone ◽  
Jeffrey R. Stout ◽  
Kyle S. Beyer ◽  
David H. Fukuda ◽  
Jay R. Hoffman
Keyword(s):  
Resistance Training ◽  
Muscle Strength ◽  
Repeated Measures ◽  
Vastus Lateralis ◽  
Protein Supplementation ◽  
Muscle Size ◽  
Short Term ◽  
Cross Sectional ◽  
Muscle Morphology ◽  
Leg Extension

Short-term resistance training has consistently demonstrated gains in muscular strength, but not hypertrophy. Post-resistance training protein ingestion is posited to augment the acute anabolic stimulus, thus potentially accelerating changes in muscle size and strength. The purpose of this investigation was to examine the effects of 4 weeks of resistance training with protein supplementation on strength and muscle morphology changes in untrained men. Participants (mean ± SD; N = 18; age, 22.0 ± 2.5 years; body mass index, 25.1 ± 5.4 kg·m−2) were randomly assigned to a resistance training + protein group (n = 9; whey (17 g) + colostrum (3 g) + leucine (2 g)) or a resistance training + placebo group (n = 9). One-repetition maximum (1RM) strength in the leg press (LP) and leg extension (LE) exercises, maximal isometric knee extensor strength (MVIC), and muscle morphology (thickness (MT), cross-sectional area (CSA), pennation angle) of the dominant rectus femoris (RF) and vastus lateralis (VL) was assessed before and after training. Participants performed LP and LE exercises (3 × 8–10; at 80% 1RM) 3 days/week for 4 weeks. Data were analyzed using 2-way ANOVA with repeated measures. Four weeks of resistance training resulted in significant increases in LP (p < 0.001), LE (p < 0.001), MVIC (p < 0.001), RF MT (p < 0.001), RF CSA (p < 0.001), VL MT (p < 0.001), and VL CSA (p < 0.001). No between-group differences were observed. Although nutrition can significantly affect training adaptations, these results suggest that short-term resistance training augments muscle strength and size in previously untrained men with no additive benefit from postexercise protein supplementation.

Effect of Whey and Soy Protein Supplementation Combined with Resistance Training in Young Adults

2006 ◽  
Vol 16 (3) ◽  
pp. 233-244 ◽  
Author(s):  
Darren G. Candow ◽  
Natalie C. Burke ◽  
T. Smith-Palmer ◽  
Darren G. Burke
Keyword(s):  
Young Adults ◽  
Resistance Training ◽  
Whey Protein ◽  
Body Mass ◽  
Soy Protein ◽  
Protein Supplementation ◽  
Protein Catabolism ◽  
Lean Tissue ◽  
Tissue Mass ◽  
Lean Tissue Mass

The purpose was to compare changes in lean tissue mass, strength, and myof-brillar protein catabolism resulting from combining whey protein or soy protein with resistance training. Twenty-seven untrained healthy subjects (18 female, 9 male) age 18 to 35 y were randomly assigned (double blind) to supplement with whey protein (W; 1.2 g/kg body mass whey protein + 0.3 g/kg body mass sucrose power, N = 9: 6 female, 3 male), soy protein (S; 1.2 g/kg body mass soy protein + 0.3 g/kg body mass sucrose powder, N = 9: 6 female, 3 male) or placebo (P; 1.2 g/kg body mass maltodextrine + 0.3 g/kg body mass sucrose powder, N = 9: 6 female, 3 male) for 6 wk. Before and after training, measurements were taken for lean tissue mass (dual energy X-ray absorptiometry), strength (1-RM for bench press and hack squat), and an indicator of myofbrillar protein catabolism (urinary 3-methylhistidine). Results showed that protein supplementation during resistance training, independent of source, increased lean tissue mass and strength over isocaloric placebo and resistance training (P < 0.05). We conclude that young adults who supplement with protein during a structured resistance training program experience minimal beneficial effects in lean tissue mass and strength.

scholarly journals Transfer of Dry-Land Resistance Training Modalities to Swimming Performance

2020 ◽  
Vol 74 (1) ◽  
pp. 195-203
Author(s):  
Jerzy Sadowski ◽  
Andrzej Mastalerz ◽  
Wilhelm Gromisz
Keyword(s):  
Resistance Training ◽  
Repeated Measures ◽  
Swimming Performance ◽  
Swimming Velocity ◽  
Training Experience ◽  
Dry Land ◽  
Significance Level ◽  
Training Interventions ◽  
And Control ◽  
Training Modalities

Abstract A great number of studies focusing on the effects of dry-land resistance training interventions on swimming performance remain inconclusive. It is suggested that transferability of dry-land strength gains to swimming performance appear when dry-land resistance training programs are swim-specific. The main aim of this study was to compare the effects of specific dry-land resistance training on an ergometer with traditional dry-land exercises, and to determine how much of the resistance training effects were transferred to specific swimming conditions. The study included a group of 26 youth competitive male swimmers (age 15.7 ± 0.5 years, height 174.6 ± 6.6 cm, weight 68.4 ± 8.2 kg, training experience 5.8±0.7 years) of regional level. They were randomly allocated to one of two groups: experimental (E) and control (T). Both groups were involved in a 12-week dry-land resistance training concentrated on increasing muscular strength and power output of the upper limbs. Group E used a specialized ergometer (JBA – Zbigniew Staniak), while group T performed traditional resistance exercises. The program consisted of 10 sets of 30 s of exercise with 30 s rest intervals between each set. A two-way repeated measures ANOVA with Tukey HSD post hoc comparisons was used to determine if any significant differences existed between training groups across pretest and posttest conditions. The significance level was set at p ≤ 0.05. Dry-land resistance training modalities were the only differences in training between both groups. Our findings show that rates of transfer are much higher in group E than in group T, which resulted in a significant increase in swimming velocity (by 4.32%, p<0.001; ES=1.23, and 2.78%, p<0.003, ES=0.31, respectively).

scholarly journals The Effects of the Movement Tempo on the One-Repetition Maximum Bench Press Results

2020 ◽  
Vol 72 (1) ◽  
pp. 151-159 ◽  
Author(s):  
Michal Wilk ◽  
Artur Golas ◽  
Piotr Zmijewski ◽  
Michal Krzysztofik ◽  
Aleksandra Filip ◽  
...  
Keyword(s):  
Resistance Training ◽  
Repeated Measures ◽  
Bench Press ◽  
Trial And Error ◽  
Training Experience ◽  
Test Procedures ◽  
Test Protocol ◽  
Repetition Maximum ◽  
One Year ◽  
The One

AbstractDifferent tempos of movement can be used during resistance training, but programming them is often a trial-and-error practice, as changing the speed at which the exercise is performed does not always correspond with the tempo at which the 1-repetition-maximum occurred. Therefore, the aim of this study was to determine the effect of different movement tempos during the bench press (BP) exercise on the one-repetition maximum (1RM) load. Ninety men (age = 25.8 ± 5.3 years, body mass = 80.2 ± 14.9 kg), with a minimum one year of resistance training experience took part in the study. Using a randomized crossover design, each participant completed the BP 1RM test with five different movement tempos: V/0/V/0, 2/0/V/0, 5/0/V/0, 8/0/V/0 and 10/0/V/0. Repeated measures ANOVA compared the differences between the 1RM at each tempo. The 1RM load was significantly greater during V/0/V/0 and 2/0/V/0 compared to 5/0/V/0, 8/0/V/0, and 10/0/V/0 (p < 0.01). Furthermore, the 1RM load was significantly greater during 5/0/V/0 compared to 8/0/V/0 and 10/0/V/0 (p < 0.01), but there were no differences between either V/0/V/0 and 2/0/V/0 (p = 0.92) or between 8/0/V/0 and 10/0/V/0 (p = 0.08). Therefore, different movement tempos used during training should be accompanied by their own tempo-specific 1RM testing, as slower eccentric phases significantly decrease maximal concentric performance. Furthermore, 1RM test procedures should include information about the movement tempo used during the test protocol. In addition, the standardization of the tempo should be taken into account in investigations that use the 1 RM test to assess the effects of any treatment on maximal muscle strength.

scholarly journals The Effects of Resistance Training With or Without Peanut Protein Supplementation on Skeletal Muscle and Strength Adaptations in Older Individuals

2020 ◽  
Author(s):  
Donald A. Lamb ◽  
Johnathon H. Moore ◽  
Morgan A. Smith ◽  
Christopher G. Vann ◽  
Shelby C. Osburn ◽  
...  
Keyword(s):  
Resistance Training ◽  
Deuterium Oxide ◽  
Vastus Lateralis ◽  
Adult Population ◽  
Quantitative Computed Tomography ◽  
Group Versus ◽  
Protein Supplementation ◽  
High Protein ◽  
Older Individuals ◽  
Positive Effects

Abstract Several studies suggest resistance training (RT) with protein supplementation has positive effects on strength and muscle mass in older individuals. However, to date, no study has examined the effects of RT with a high-protein, defatted peanut powder (PP) supplement on these markers. Herein, 39 older, untrained individuals (n=17 female, n=22 male; age=58.6±8.0 years; body mass index =28.7±5.8) completed a 6-week (n=22) or 10-week (n=17) RT program, where full-body training was implemented twice weekly (ClinicalTrials.gov trial registration NCT04015479; registered July 11, 2019). Participants in each program were randomly assigned to consume either a PP supplement once per day (35 g protein, 315 kcal; n=20) or no supplement (CTL; n=19). Right leg vastus lateralis (VL) muscle biopsies were obtained prior to and 24 hours following the first training bout in all participants to assess the change in myofibrillar protein synthetic rates (MyoPS) as measured via the deuterium-oxide (D2O) tracer method. Pre- and Post-intervention testing in all participants was conducted using dual energy x-ray absorptiometry (DXA), VL ultrasound imaging, a peripheral quantitative computed tomography (pQCT) scan at the mid-thigh, and right leg isokinetic dynamometer assessments. Integrated MyoPS rates over a 24-hour period were not significantly different (p<0.05) between supplement groups following the first training bout. Regarding chronic changes, there were no significant supplement-by-time interactions in DXA-derived fat mass, lean soft tissue mass or percent body fat between supplementation groups. There was, however, a significant increase in VL thickness in PP versus CTL participants when the 6- and 10-week cohorts were pooled (interaction p=0.041). There was also a significant increase in knee flexion torque in the 10-week PP group versus the CTL group (interaction p=0.032). In conclusion, a high-protein, defatted peanut powder supplement in combination with RT positively affects select markers of muscle hypertrophy and strength in an untrained, older adult population.

Effect of Acute Interset Foot Cooling on Lower Limb Strength Training Workout

2021 ◽  
Vol 16 (5) ◽  
pp. 682-687
Author(s):  
Zong-Yan Cai ◽  
Wen-Yi Wang ◽  
Yi-Ming Huang ◽  
Chih-Min Wu
Keyword(s):  
Repeated Measures ◽  
Perceived Exertion ◽  
Vastus Lateralis ◽  
Time Trial ◽  
Simple Main Effect ◽  
Rating Of Perceived Exertion ◽  
Training Experience ◽  
Leg Press ◽  
Lower Limb Strength ◽  
Main Effect

Purpose: The authors investigated the effect of foot cooling (FC) between sets in a leg press pyramid workout with resistance-trained participants. Methods: A total of 12 resistance-trained men (age = 21.8 [0.6] y; training experience = 1.7 [1] y) performed a pyramid workout, including 4 sets of 85% to 90% 1-repetition maximum leg press exercise to exhaustion with interset FC or noncooling in a repeated-measures crossover design separated by 5 days. The authors immersed the participants’ feet in 10°C water for 2.5 minutes between sets. Results: Two-way repeated-measures analysis of variance revealed that FC elicited significantly higher repetitions and electromyography (EMG) values of the vastus lateralis (simple main effect of condition) than did noncooling (P < .05) in the second (repetitions: 11 [3.5] vs 7.75 [3.2]; EMG: 63.4% [19.4%] vs 54.5% [18.4%]), third (repetitions: 8.9 [3.2] vs 6.4 [2.1]; EMG: 71.5% [17.4%] vs 60.6% [19.4%]), and fourth (repetitions: 7.5 [2.7] vs 5.1 [2.2]; EMG: 75.2% [19.6%] vs 59.3% [23.5%]) sets. The authors also detected a simple main effect of set in the FC and noncooling conditions on repetitions (P < .05) and in the FC condition on the vastus lateralis EMG values. Although the authors observed no time × trial interactions for the rating of perceived exertion, the authors observed main effects on the sets (7.7–9.6 vs 7.9–9.3, P < .05). Conclusions: Interset FC provides an ergogenic effect on a leg press pyramid workout and may offset fatigue, as indicated by higher repetitions and EMG response, without increasing perceived exertion.

scholarly journals Skeletal muscle oxidative function in vivo and ex vivo in athletes with marked hypertrophy from resistance training

2013 ◽  
Vol 114 (11) ◽  
pp. 1527-1535 ◽  
Author(s):  
Desy Salvadego ◽  
Rossana Domenis ◽  
Stefano Lazzer ◽  
Simone Porcelli ◽  
Jörn Rittweger ◽  
...  
Keyword(s):  
Skeletal Muscle ◽  
Resistance Training ◽  
Muscle Mass ◽  
Body Mass ◽  
Mitochondrial Respiration ◽  
Ex Vivo ◽  
Vastus Lateralis ◽  
Whole Body ◽  
Vastus Lateralis Muscle ◽  
Oxidative Function

Oxidative function during exercise was evaluated in 11 young athletes with marked skeletal muscle hypertrophy induced by long-term resistance training (RTA; body mass 102.6 ± 7.3 kg, mean ± SD) and 11 controls (CTRL; body mass 77.8 ± 6.0 kg). Pulmonary O2 uptake (V̇o2) and vastus lateralis muscle fractional O2 extraction (by near-infrared spectroscopy) were determined during an incremental cycle ergometer (CE) and one-leg knee-extension (KE) exercise. Mitochondrial respiration was evaluated ex vivo by high-resolution respirometry in permeabilized vastus lateralis fibers obtained by biopsy. Quadriceps femoris muscle cross-sectional area, volume (determined by magnetic resonance imaging), and strength were greater in RTA vs. CTRL (by ∼40%, ∼33%, and ∼20%, respectively). V̇o2peak during CE was higher in RTA vs. CTRL (4.05 ± 0.64 vs. 3.56 ± 0.30 l/min); no difference between groups was observed during KE. The O2 cost of CE exercise was not different between groups. When divided per muscle mass (for CE) or quadriceps muscle mass (for KE), V̇o2 peak was lower (by 15–20%) in RTA vs. CTRL. Vastus lateralis fractional O2 extraction was lower in RTA vs. CTRL at all work rates, during both CE and KE. RTA had higher ADP-stimulated mitochondrial respiration (56.7 ± 23.7 pmol O2·s−1·mg−1 ww) vs. CTRL (35.7 ± 10.2 pmol O2·s−1·mg−1 ww) and a tighter coupling of oxidative phosphorylation. In RTA, the greater muscle mass and maximal force and the enhanced mitochondrial respiration seem to compensate for the hypertrophy-induced impaired peripheral O2 diffusion. The net results are an enhanced whole body oxidative function at peak exercise and unchanged efficiency and O2 cost at submaximal exercise, despite a much greater body mass.

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