scholarly journals Interactive Effects of Maternal Vitamin D Status and Socio-Economic Status on the Risk of Spontaneous Abortion: Evidence from Henan Province, China

Nutrients ◽  
2022 ◽  
Vol 14 (2) ◽  
pp. 291
Author(s):  
Shiqi Lin ◽  
Yuan Zhang ◽  
Lifang Jiang ◽  
Jiajia Li ◽  
Jian Chai ◽  
...  
Keyword(s):  
Vitamin D ◽  
Vitamin D Deficiency ◽  
Spontaneous Abortion ◽  
Economic Status ◽  
Interactive Effects ◽  
Low Ses ◽  
Vitamin D Status ◽  
Maternal Vitamin ◽  
Socio Economic Status ◽  
Maternal Vitamin D Status

Background: Maternal vitamin D deficiency might generate adverse reproductive outcomes, and socio-economic inequalities in micronutrient-related diseases have often been found. This study aimed to explore the interactive effects of maternal vitamin D status and socio-economic status (SES) on risk of spontaneous abortion. Methods: A population-based case–control study was conducted including 293 women with spontaneous abortion and 498 control women in December 2009 and January, 2010 in Henan Province, China. Information on pregnancy outcomes, maternal demographic, lifestyle and exposure factors and blood samples were collected at the same time. Vitamin D deficiency was defined as 25(OH)D < 20 ng/mL. SES index was constructed with principal component analysis by aggregating women’s and their husbands’ education level and occupation, and household income and expenditure. Interactive effects were assessed on a multiplicative scale with ratio of the odds ratio (ROR). Results: Compared to those with high SES and vitamin D sufficiency, women with vitamin D deficiency and low SES index had an increased risk of spontaneous abortion (aOR: 1.99; 95% CI: 1.23–3.23). The ROR was 2.06 (95% CI: 1.04–4.10), indicating a significant positive multiplicative interaction. Conclusions: Maternal low SES may strengthen the effect of vitamin D deficiency exposure on spontaneous abortion risk in this Chinese population.

scholarly journals Vitamin D Deficiency in Mexican Pregnant Women: Is Supplementation with ≤400 IU/day Enough?

Nutrients ◽  
2020 ◽  
Vol 12 (9) ◽  
pp. 2517
Author(s):  
Otilia Perichart-Perera ◽  
Carla Patricia González-Leyva ◽  
Isabel González-Ludlow ◽  
Maricruz Tolentino-Dolores ◽  
Mario Solis-Paredes ◽  
...  
Keyword(s):  
Vitamin D ◽  
Pregnant Women ◽  
Vitamin D Deficiency ◽  
Vitamin D3 ◽  
Mexican Women ◽  
Vitamin D Status ◽  
Third Trimester ◽  
Maternal Vitamin ◽  
The Third ◽  
Maternal Vitamin D Status

Controversy remains surrounding vitamin D routine supplementation in healthy pregnancy, and the doses are unclear. The aim of this study was to describe maternal vitamin D status throughout pregnancy in a group of Mexican women and evaluate the effect of frequently prescribed doses of vitamin D3 on longitudinal 25-OH-D concentrations, adjusting for obesity, season, and other factors. We conducted a cohort study (Instituto Nacional de Perinatología-INPer) (2017–2020)) of healthy pregnant women without complications. Pregestational overweight/obesity (body mass index ≥ 25), vitamin D3 supplementation (prescribed by physician; 0–250, 250–400, and >400 IU/day), and serum 25-OH-D concentrations (ELISA) were evaluated in each trimester of pregnancy. Vitamin D deficiency or insufficiency was computed (<20 and <30 ng/mL, respectively). We studied 141 adult women; 58.5% had pregestational obesity or overweight. In the first trimester, 45.8% of the women were supplemented with vitamin D3; 51.4% had vitamin D insufficiency and 37.3%, deficiency. In the third trimester, 75.4% of the women were supplemented, and 20% of them still had deficiency. The final general mixed linear model showed that 25-OH-D significantly increased throughout pregnancy (p < 0.001); the highest increase was observed in the third trimester in women with doses >400 IU/day of vitamin D3 (+4 ng/mL, 95% CI: 1.72–8.11 ng/mL). In winter/autumn, 25-OH-D concentrations were also lower (p ≤ 0.05). In this group of pregnant Mexican women, the prevalence of vitamin D deficiency and insufficiency was high. A higher increase in 25-OH-D concentrations during pregnancy was observed when the women were supplemented with >400 IU/day. Common supplementation doses of 250–400 IU/day were insufficient for achieving an adequate maternal vitamin D status.

scholarly journals Impact of maternal vitamin D status during pregnancy on the prevalence of neonatal vitamin D deficiency

2013 ◽  
Vol 5 (1) ◽  
pp. 6 ◽  
Author(s):  
Yasser F. Aly ◽  
Mohamed A. El Koumi ◽  
Rehab N. Abd El Rahman
Keyword(s):  
Vitamin D ◽  
Pregnant Women ◽  
Vitamin D Deficiency ◽  
Later Life ◽  
Serum Levels ◽  
Vitamin D Status ◽  
Maternal Vitamin ◽  
Vitamin D Levels ◽  
Maternal Vitamin D Status

Maternal vitamin D deficiency is not uncommon. The lack of vitamin D during pregnancy may result in poor fetal growth and altered neonatal development that may persist into later life. Recognition of risk factors and early detection of vitamin D deficiency during pregnancy is important in order to prevent neonatal vitamin D deficiency and related complications. The aim of the current study is to assess the effect of maternal vitamin D status on the neonatal vitamin D stores. A total of 92 pregnant women at the end of the 3rd trimester and their newborns were recruited from Al Khafji Joint Operation Hospital, Saudi Arabia, during the year 2011. Maternal and cord blood samples were taken for determination of serum levels of circulating 25-hydroxyvitamin D3 [25(OH)D3] concentration, serum calcium (Ca++), phosphorus (PO4) and alkaline phosphatase (ALP). Compared with pregnant women with adequate vitamin D levels, women deficient in vitamin D had infants with vitamin D deficiency (X±SD 33.44±18.33 nmol/L <em>vs</em> 55.39±17.37 nmol/L, P=0.01). Maternal and neonatal serum 25(OH)D3 levels showed a positive correlation with serum Ca++ and negative correlation with serum PO4 and ALP. Neonatal 25(OH)D was related to maternal 3rd trimester levels (r=0.89, P=0.01). The newborn serum 25(OH)D3 concentrations rely on maternal vitamin D status. Poor maternal vitamin D status may adversely affect neonatal vitamin D status and, consequently, calcium homeostasis.

Maternal Vitamin D Status and Development of Asthma and Allergy in Early Childhood

2015 ◽  
Vol 15 (11) ◽  
pp. 900-912 ◽  
Author(s):  
Anna Papadopoulou ◽  
Evangelia Bountouvi ◽  
Vasiliki Papaevaggelou ◽  
Kostas Priftis
Keyword(s):  
Vitamin D ◽  
Early Childhood ◽  
Vitamin D Status ◽  
Maternal Vitamin ◽  
Asthma And Allergy ◽  
Maternal Vitamin D Status

scholarly journals Low maternal vitamin D status and fetal bone development: Cohort study

2009 ◽  
Vol 25 (1) ◽  
pp. 14-19 ◽  
Author(s):  
Pamela Mahon ◽  
Nicholas Harvey ◽  
Sarah Crozier ◽  
Hazel Inskip ◽  
Sian Robinson ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cohort Study ◽  
Bone Development ◽  
Vitamin D Status ◽  
Maternal Vitamin ◽  
Fetal Bone ◽  
Maternal Vitamin D Status

scholarly journals Maternal Vitamin D Status and Risk of Gestational Diabetes: a Meta-Analysis

2018 ◽  
Vol 45 (1) ◽  
pp. 291-300 ◽  
Author(s):  
Lingmin Hu ◽  
Yue Zhang ◽  
Xing Wang ◽  
Lianghui You ◽  
Pengfei Xu ◽  
...  
Keyword(s):  
Vitamin D ◽  
Gestational Diabetes ◽  
Observational Studies ◽  
Meta Analysis ◽  
Vitamin D Insufficiency ◽  
Significant Heterogeneity ◽  
Vitamin D Status ◽  
Maternal Vitamin ◽  
Increased Risk ◽  
Maternal Vitamin D Status

Background/Aims: Whether maternal vitamin D deficiency is associated with gestational diabetes remains controversial. This meta-analysis aimed to systematically evaluate published evidence on the association between maternal vitamin D status and the risk of gestational diabetes. Methods: We retrieved relevant articles from the PubMed, Medline and Embase databases up to May 2017 for observational studies investigating the association between vitamin D status and the risk of gestational diabetes. Odds ratios (OR) or risk ratios (RR) from individual studies were pooled using the fixed and random effect models. Results: The meta-analysis of 29 observational studies included 28,982 participants, of which 4,634 were diagnosed with gestational diabetes, and showed that maternal vitamin D insufficiency was associated with a significantly increased risk of gestational diabetes by 39% (pooled OR = 1.39, 95%CI = 1.20-1.60) with moderate heterogeneity (I2 = 50.2%; P = 0.001). Moreover, the 25(OH)D level was significantly lower in gestational diabetes cases than in controls with a pooled effect of -4.79 nmol/L (95% CI = -6.43, -3.15). Significant heterogeneity was also detected (I2 = 65.0%, P < 0.001). Further subgroup analysis indicated that this association was also evident in most subpopulations. Conclusion: This meta-analysis indicated a significant association between vitamin D insufficiency and increased risk of gestational diabetes. Further well-designed large-scale clinical trials are essential to verify this association.

scholarly journals Maternal vitamin D status in pregnancy: a critical appraisal of current analytical data on maternal and neonatal outcomes

HORMONES ◽  
2015 ◽  
pp. 224-231 ◽  
Author(s):  
Spyridon Karras ◽  
Panagiotis Anagnostis ◽  
Andrea Petroczi ◽  
Cedric Annweiler ◽  
Declan Naughton ◽  
...  
Keyword(s):  
Vitamin D ◽  
Critical Appraisal ◽  
Analytical Data ◽  
Neonatal Outcomes ◽  
Vitamin D Status ◽  
Maternal Vitamin ◽  
Maternal And Neonatal Outcomes ◽  
Maternal Vitamin D Status ◽  
In Pregnancy

Maternal Vitamin D Status During Pregnancy and Bone Mass in Offspring at 20 Years of Age: A Prospective Cohort Study

2014 ◽  
Vol 29 (5) ◽  
pp. 1088-1095 ◽  
Author(s):  
Kun Zhu ◽  
Andrew JO Whitehouse ◽  
Prue H Hart ◽  
Merci Kusel ◽  
Jenny Mountain ◽  
...  
Keyword(s):  
Vitamin D ◽  
Cohort Study ◽  
Bone Mass ◽  
Prospective Cohort Study ◽  
Prospective Cohort ◽  
Vitamin D Status ◽  
Maternal Vitamin ◽  
Maternal Vitamin D Status
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