scholarly journals Clinical Significance of Pleural Effusion in Mycoplasma pneumoniae Pneumonia in Children

Pathogens ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 1075
Author(s):  
Seo-Hee Kim ◽  
Eun Lee ◽  
Eun-Song Song ◽  
Yun-Young Lee
Keyword(s):  
Pleural Effusion ◽  
Clinical Significance ◽  
Mycoplasma Pneumoniae ◽  
Clinical Laboratory ◽  
Clinical Course ◽  
Severe Pneumonia ◽  
Poor Response ◽  
Tertiary Hospital ◽  
Reactive Protein ◽  
Poor Treatment

The clinical significance of pleural effusion in Mycoplasma pneumoniae (MP) pneumonia in children has not yet been elucidated. Herein, we investigated the clinical implications of pleural effusion in children with MP pneumonia. Overall, 150 children with MP pneumonia transferred to a tertiary hospital were enrolled in this study. Information on their clinical, laboratory, and radiological features was retrospectively obtained from medical chart reviews. In total, 24 (16.0%) children had pleural effusion at the time of admission. The duration of fever and length of hospitalization were significantly longer in the pleural effusion group than in the non-pleural effusion group. A significantly higher proportion of individuals in the pleural effusion group had a poor response to stepwise treatment for MP pneumonia. The mean C-reactive protein, lactate dehydrogenase, and aspartate aminotransferase levels were significantly higher in the pleural effusion group than in the non-pleural effusion group at admission. The prevalence of severe pneumonia, defined on the basis of the extent of pneumonic lesions on chest radiography, was higher in the pleural effusion group than in the non-pleural effusion group. However, there was no significant intergroup difference in the proportion of macrolide-resistant MP cases or respiratory viral coinfections. The presence of pleural effusion in children with MP pneumonia indicated a more severe clinical course and poor treatment response. The results of the present study would help in the creation of a therapeutic plan and prediction of the clinical course of MP pneumonia in children.

scholarly journals Predictive Factors of the Responses to Treatment of Mycoplasma pneumoniae Pneumonia

2021 ◽  
Vol 10 (6) ◽  
pp. 1154
Author(s):  
Eun Lee ◽  
Yun Young Lee
Keyword(s):  
Pleural Effusion ◽  
Mycoplasma Pneumoniae ◽  
Predictive Factors ◽  
Respiratory Virus ◽  
Clinical Laboratory ◽  
Poor Response ◽  
Response To Treatment ◽  
Slow Response ◽  
Response Group ◽  
Time Of Admission

The prevalence of refractory Mycoplasma pneumoniae (MP) pneumonia is increasing. The present study aimed to identify the predictive factors of responses to treatment of MP pneumonia in children. A total of 149 children were diagnosed with MP pneumonia, of whom 56 were included in the good response group, 75 children in the slow response group, and 18 children in no response or progression group. Data on the clinical, laboratory, and radiologic features were retrospectively obtained through medical chart reviews. The severity of pneumonia, based on the extent of pneumonic lesions on chest x-ray (adjusted odds ratio (aOR), 10.573; 95% confidence intervals (CIs), 2.303−48.543), and lactate dehydrogenase (LDH) levels (aOR, 1.002; 95% CIs, 1.000–1.004) at the time of admission were associated with slow response to treatment of MP pneumonia. Pleural effusion (aOR, 5.127; 95% CIs, 1.404–18.727), respiratory virus co-infection (aOR, 4.354; 95% CIs, 1.374–13.800), and higher LDH levels (aOR, 1.005; 95% CIs, 1.002–1.007) as well as MP-specific IgM titer (aOR, 1.309; 95% CIs, 1.095–1.564) were associated with no response or progression of MP pneumonia. The area under the curve for the prediction of no or poor response in MP pneumonia using pleural effusion, respiratory virus co-infection, LDH levels, and MP-specific IgM titer at the time of admission was 0.8547. This study identified the predictive factors of responses to treatment of MP pneumonia in children, which would be helpful in establishing a therapeutic plan and predicting the clinical course of MP pneumonia in children.

scholarly journals Lymphopenia predicted illness severity and recovery in patients with COVID-19: A single-center, retrospective study

PLoS ONE ◽  
2020 ◽  
Vol 15 (11) ◽  
pp. e0241659
Author(s):  
Jiheng Liu ◽  
Heng Li ◽  
Ming Luo ◽  
Jiyang Liu ◽  
Lingzhen Wu ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Retrospective Study ◽  
Clinical Laboratory ◽  
Tertiary Hospital ◽  
Outcome Data ◽  
Single Center ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Prolonged Duration ◽  
Duration Of Hospitalization

The outbreak of SARS-CoV-2 began in December 2019 and rapidly became a pandemic. The present study investigated the significance of lymphopenia on disease severity. A total of 115 patients with confirmed COVID-19 from a tertiary hospital in Changsha, China, were enrolled. Clinical, laboratory, treatment and outcome data were gathered and compared between patients with and without lymphopenia. The median age was 42 years (1–75). Fifty-four patients (47.0%) of the 115 patients had lymphopenia on admission. More patients in the lymphopenia group had hypertension (30.8% vs. 10.0%, P = 0.006) and coronary heart disease (3.6% vs. 0%, P = 0.029) than in the nonlymphopenia group, and more patients with leukopenia (48.1% vs 14.8%, P<0.001) and eosinopenia (92.6% vs 54.1%, P<0.001) were observed. Lymphopenia was also correlated with severity grades of pneumonia (P<0.001) and C-reactive protein (CRP) level (P = 0.0014). Lymphopenia was associated with a prolonged duration of hospitalization (17.0 days vs. 14.0 days, P = 0.002). Lymphocyte recovery appeared the earliest, prior to CRP and chest radiographs, in severe cases, which suggests its predictive value for disease improvement. Our results demonstrated the clinical significance of lymphopenia for predicting the severity of and recovery from COVID-19, which emphasizes the need to dynamically monitor lymphocyte count.

scholarly journals Spondylodiscitis: evaluation of patients in a tertiary hospital

2014 ◽  
Vol 8 (10) ◽  
pp. 1272-1276 ◽  
Author(s):  
Safak Kaya ◽  
Serdar Ercan ◽  
Sehmuz Kaya ◽  
Ulas Aktas ◽  
Kagan Kamasak ◽  
...  
Keyword(s):  
Clinical Laboratory ◽  
Complete Blood Count ◽  
Tertiary Hospital ◽  
Clinical Findings ◽  
Low Back ◽  
Reactive Protein ◽  
Laboratory Investigations ◽  
Magnetic Resonance Imaging Mri ◽  
Radiological Methods ◽  
Shed Light

Introduction: Spondylodiscitis (SD) is an uncommon but important infection. The aim of this work was to study the risk factors, bacteriological features, clinical, laboratory and radiological findings of SD, and to shed light on the initial treatment. Methodology: A total of 107 patients who underwent treatment for SD were evaluated. The diagnosis of SD was defined by clinical findings, complete blood count, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR), serum tube agglutination (STA) test, Ziehl-Neelsen staining, culture, histopathology, and radiological methods such as magnetic resonance imaging (MRI) and computed tomography (CT) scans. Results: Of the 107 cases, ranging between 17 to 83 years of age, 64 (59.8%) were male. Twenty-seven (25.2%) patients had diabetes mellitus. Laboratory investigations revealed elevated CRP in 70 (65%) patients, elevated ESR in 65 (61%) patients, and elevated white blood cell (WBC) counts in 41 (38.3%) patients. Thirty-six (33.6%) patients were identified as having brucellar SD, and 5 (4.7%) patients were identified as having tuberculous SD. A total of 66 (61.6%) patients were determined to have pyogenic SD. The most frequently isolated microorganism was Staphylococcus aureus. Antibiotic therapy was given intravenously to all pyogenic SD patients. Conclusions: The incidence of SD has increased as a result of the higher life expectancy of older patients with chronic debilitating diseases and the increase of spinal surgical procedures. In patients with low back pain, SD should be considered as a diagnosis. For effective treatment, it is important to determine the etiology of the disease.

scholarly journals Bacteriological Characteristics of COVID-19 Patients Nosocomially Co-infected at a Designated Hospital: A Retrospective Study

2020 ◽  
Author(s):  
Jing Yu ◽  
Lei Nie ◽  
Xia Zhou ◽  
Dongde Wu ◽  
Jian Chen ◽  
...  
Keyword(s):  
Clinical Laboratory ◽  
White Blood Cells ◽  
Laboratory Data ◽  
Critical Factor ◽  
Severe Pneumonia ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Extensive Drug Resistance ◽  
Causative Agents ◽  
Secondary Bacterial Pneumonia

Abstract Background: Bacterial co-infection in patients infected with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a critical factor that increases the complexity and treatment of coronavirus disease 2019 (COVID-19). Methods: We collected the clinical laboratory data of 1799 patients with confirmed COVID-19 who were admitted to Jinyintan Hospital in Wuhan, China, between January 1 to April 26, 2020. The bacterial co-infection along with disease progression was analyzed. Other inflammatory markers, including C-reactive protein (CRP), white blood cells (WBC), lymphocytes (L), neutrocytes (N), interleukin-6 (IL-6), and procalcitonin (PCT), were assessed to estimate the progression of COVID-19. Results: We found that 191 of the 1799 (10.62%) patients had bacterial co-infection. The most prevalent causative agents for bacterial co-infection were Klebsiella pneumoniae (91 cases, 5.06%) and Acinetobacter baumannii (66 cases, 3.67%). The most patients with bacterial co-infection showed extensive drug-resistance. The outcomes of patients with bacterial co-infection were worse than those of patients without bacterial co-infection.Conclusions: Secondary bacterial pneumonia during virus infection is a major risk factor for high mortality resulting from severe pneumonia caused by COVID-19.

scholarly journals Chlamydia pneumoniae and Mycoplasma pneumoniae pneumonia: comparison of clinical, epidemiological characteristics and laboratory profiles

2005 ◽  
Vol 134 (3) ◽  
pp. 548-555 ◽  
Author(s):  
I. PULJIZ ◽  
I. KUZMAN ◽  
O. DAKOVIC-RODE ◽  
N. SCHÖNWALD ◽  
B. MISE
Keyword(s):  
Pleural Effusion ◽  
Mycoplasma Pneumoniae ◽  
Aspartate Aminotransferase ◽  
Chlamydia Pneumoniae ◽  
Clinical Findings ◽  
Community Acquired Pneumonia ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Epidemiological Characteristics ◽  
Mycoplasma Pneumoniae Pneumonia

The purpose of our retrospective 3-year study was to analyse and compare clinical and epidemiological characteristics in hospitalized patients older than 6 years with community-acquired pneumonia (CAP) caused by Chlamydia pneumoniae (87 patients) and Mycoplasma pneumoniae (147 patients). C. pneumoniae and M. pneumoniae infection was confirmed by serology. C. pneumoniae patients were older (42·12 vs. 24·64 years), and were less likely to have a cough, rhinitis, and hoarseness (P<0·001). C. pneumoniae patients had higher levels of C-reactive protein (CRP), and aspartate aminotransferase (AST) than M. pneumoniae patients (P<0·001). Pleural effusion was recorded more frequently in patients with M. pneumoniae (8·84 vs. 3·37%). There were no characteristic epidemiological and clinical findings that would distinguish CAP caused by M. pneumoniae from C. pneumoniae. However, some factors are indicative for C. pneumoniae such as older age, lack of cough, rhinitis, hoarseness, and higher value of CRP, and AST.

INFLAMMATORY MARKERS IN THE DIAGNOSIS OF COMPLICATED ACUTE APPENDICITIS

2021 ◽  
Vol 108 (Supplement_3) ◽  
Author(s):  
J Michi Campos ◽  
M Merayo Álvarez ◽  
L García González ◽  
B Carrasco Aguilera ◽  
J L Rodicio Miravalles ◽  
...  
Keyword(s):  
Inflammatory Markers ◽  
Clinical Laboratory ◽  
Complete Blood Count ◽  
Area Under The Curve ◽  
Tertiary Hospital ◽  
Complicated Appendicitis ◽  
Neutrophil Lymphocyte Ratio ◽  
Reactive Protein ◽  
Surgical Emergencies ◽  
Relationship Of

Abstract INTRODUCTION Appendicitis constitutes one of the most frequent surgical emergencies. New inflammatory markers such as the neutrophil-lymphocyte ratio (NLR) have recently emerged, which are added to others such as leukocyte count and C-reactive protein (CRP), and whose role in the diagnosis of appendicitis remains unclear. MATERIAL AND METHODS We conducted an observational, descriptive, longitudinal and retrospective study of 484 adults appendectomized between April 2017 and May 2019 in a tertiary hospital. Sociodemographic, clinical, laboratory, imaging and surgical variables were collected. RESULTS 32.2% of appendicitis were complicated. All patients had a complete blood count and basic biochemistry (98.5% with CRP). Complicated appendicitis had a mean of 14538 leukocytes, 12.4 CRP and 8.7 NLR, and uncomplicated appendicitis had 14667 leukocytes, 5 CRP and 10.7 NLR. When analyzing the relationship of inflammatory markers with the existence or not of complicated appendicitis, CRP yielded an area under the curve (AUC) of 73.1% (95% CI: 0.684-0.779, p &lt; 0.01), while leukocytes and NLR had 52.6% and 55.9%. The CRP cut-off point was determined to be 3.5 which presented a higher discriminative power to predict complicated appendicitis, with a sensitivity and specificity of 70.1% and 65.3% respectively. CONCLUSIONS Of the inflammatory markers studied, only CRP proved to be a valid parameter to help differentiate preoperatively those appendicitis uncomplicated from complicated appendicitis.

scholarly journals Lymphopenia acted as an adverse factor for severity in patients with COVID-19: a single-centered, retrospective study

2020 ◽  
Author(s):  
Jiheng Liu ◽  
Heng Li ◽  
Ming Luo ◽  
Jiyang Liu ◽  
Lingzhen Wu ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Clinical Laboratory ◽  
Tertiary Hospital ◽  
Outcome Data ◽  
C Reactive Protein ◽  
Reactive Protein ◽  
Prolonged Duration ◽  
Duration Of Hospitalization ◽  
Severity Of The Disease ◽  
Adverse Factor

Abstract Purpose: The outbreak of SARS-CoV-2 began in December and rapidly caused a pandemic. To investigate the significance of lymphopenia for the severity of the disease, this study was performed.Methods: 115 patients confirmed COVID-19 from a tertiary hospital in Changsha, China were enrolled. The clinical, laboratory, treatment and outcome data were collected and compared between patients with lymphopenia or not.Results: The median age was 42 years (1-75). 54 patients (47.0%) of the patients had lymphopenia on admission. In the group of lymphopenia, more patients had hypertension (30.8% vs 10.0%, P=0.006) and coronary heart disease (3.6% vs 0%, P=0.029) and more patients with leucopenia (48.1% vs 14.8%, P<0.001) and eosinophilia (92.6% vs 54.1%, P<0.001) were observed. Lymphopenia was also correlated with severity grades of pneumonia (P<0.001) and C-reactive protein (CRP) level (P=0.0014). Lymphopenia was associated with a prolonged duration of hospitalization (17.0 days vs 14.0 days, P=0.002). Moreover, the recovery of lymphocyte appeared the earliest before CRP and chest radiographs in severe cases, suggesting its predictive value for disease improvement. Conclusion: Our results showed the clinical significance of lymphopenia for predicting the severity of COVID-19 and the recovery of the disease, emphasizing the need to monitor the lymphocyte count dynamically.

The Pattern of Ventricular Remodeling Influences the Level of Oxidative Stress in Heart Failure Patients

2017 ◽  
Vol 68 (7) ◽  
pp. 1506-1511
Author(s):  
Cerasela Mihaela Goidescu ◽  
Anca Daniela Farcas ◽  
Florin Petru Anton ◽  
Luminita Animarie Vida Simiti
Keyword(s):  
Oxidative Stress ◽  
Heart Failure ◽  
Ventricular Remodeling ◽  
Clinical Laboratory ◽  
Left Ventricular ◽  
Control Group ◽  
Reactive Protein ◽  
Lv Mass ◽  
Few Data

Oxidative stress (OS) is increased in chronic diseases, including cardiovascular (CV), but there are few data on its effects on the heart and vessels. The isoprostanes (IsoP) are bioactive compounds, with 8-iso-PGF25a being the most representative in vivo marker of OS. They correlate with the severity of heart failure (HF), but because data regarding OS levels in different types of HF are scarce, our study was aimed to evaluate it by assessing the urinary levels of 8-iso-PGF2aand its correlations with various biomarkers and parameters. Our prospective study included 53 consecutive patients with HF secondary to ischemic heart disease or dilative cardiomyopathy, divided according to the type of HF (acute, chronic decompensated or chronic compensated HF). The control group included 13 hypertensive patients, effectively treated. They underwent clinical, laboratory - serum NT-proBNP, creatinine, uric acid, lipids, C reactive protein (CRP) and urinary 8-iso-PGF2a and echocardiographic assessment. HF patients, regardless the type of HF, had higher 8-iso-PGF2a than controls (267.32pg/�mol vs. 19.82pg/�mol, p[0.001). The IsoP level was directly correlated with ejection fraction (EF) (r=-0.31, p=0.01) and NT-proBNP level (r=0.29, p=0.019). The relative wall thickness (RWT) was negatively correlated with IsoP (r=-0.55, p[0.001). Also 8-iso-PGF25a was higher by 213.59pg/�mol in the eccentric left ventricular (LV) hypertrophy subgroup comparing with the concentric subgroup (p=0.014), and the subgroups with severe mitral regurgitation (MR) and moderate/severe pulmonary hypertension (PAH) had the highest 8-iso-PGF2a levels. Male sex, severe MR, moderate/severe PAH, high LV mass and low RWT values were predictive for high OS level in HF patients.Eccentric cardiac remodeling, MR severity and PAH severity are independent predictors of OS in HF patients.

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