scholarly journals Current Insights on Antifungal Therapy: Novel Nanotechnology Approaches for Drug Delivery Systems and New Drugs from Natural Sources

2020 ◽  
Vol 13 (9) ◽  
pp. 248
Author(s):  
Filipa Sousa ◽  
Domingos Ferreira ◽  
Salette Reis ◽  
Paulo Costa
Keyword(s):  
Drug Delivery ◽  
Antifungal Therapy ◽  
Drug Delivery Systems ◽  
Fungal Infections ◽  
Delivery Systems ◽  
New Drugs ◽  
Public Health Issue ◽  
Cellular Targets ◽  
Antifungal Potential ◽  
Emerging Fungal Infections

The high incidence of fungal infections has become a worrisome public health issue, having been aggravated by an increase in host predisposition factors. Despite all the drugs available on the market to treat these diseases, their efficiency is questionable, and their side effects cannot be neglected. Bearing that in mind, it is of upmost importance to synthetize new and innovative carriers for these medicines not only to fight emerging fungal infections but also to avert the increase in drug-resistant strains. Although it has revealed to be a difficult job, new nano-based drug delivery systems and even new cellular targets and compounds with antifungal potential are now being investigated. This article will provide a summary of the state-of-the-art strategies that have been studied in order to improve antifungal therapy and reduce adverse effects of conventional drugs. The bidirectional relationship between Mycology and Nanotechnology will be also explained. Furthermore, the article will focus on new compounds from the marine environment which have a proven antifungal potential and may act as platforms to discover drug-like characteristics, highlighting the challenges of the translation of these natural compounds into the clinical pipeline.

scholarly journals Nano Drug Delivery Platforms for Dental Application: Infection Control and TMJ Management—A Review

Polymers ◽  
2021 ◽  
Vol 13 (23) ◽  
pp. 4175
Author(s):  
Abhishek Lal ◽  
Mohammad Khursheed Alam ◽  
Naseer Ahmed ◽  
Afsheen Maqsood ◽  
Ruba K. Al-Qaisi ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Temporomandibular Joint ◽  
Drug Delivery Systems ◽  
Viral Infections ◽  
Fungal Infections ◽  
Delivery Systems ◽  
Temporomandibular Joint Disorders ◽  
Oral Infections ◽  
Limited Effectiveness ◽  
Nano Drug Delivery

The oral cavity is an intricate environment subjected to various chemical, physical, and thermal injuries. The effectiveness of the local and systemically administered drugs is limited mainly due to their toxicities and poor oral bioavailability that leads to the limited effectiveness of the drugs in the target tissues. To address these issues, nanoparticle drug delivery systems based on metals, liposomes, polymeric particles, and core shells have been developed in recent years. Nano drug delivery systems have applications in the treatment of patients suffering from temporomandibular joint disorders such as preventing degeneration of cartilage in patients suffering from rheumatoid arthritis and osteoarthritis and alleviating the pain along with it. The antibacterial dental applications of nano-drug delivery systems such as silver and copper-based nanoparticles include these agents used to arrest dental caries, multiple steps in root canal treatment, and patients suffering from periodontitis. Nanoparticles have been used in adjunct with antifungals to treat oral fungal infections such as candida albicans in denture wearers. Acyclovir being the most commonly used antiviral has been used in combination with nanoparticles against an array of viral infections such as the herpes simplex virus. Nanoparticles based combination agents offer more favorable drug release in a controlled manner along with efficient delivery at the site of action. This review presents an updated overview of the recently developed nanoparticles delivery systems for the management of temporomandibular joint disorders along with the treatment of different oral infections.

Recent Trends in Antifungal Agents: A Reference to Formulation, Characterization and Applications

2019 ◽  
Vol 9 (3) ◽  
pp. 199-210
Author(s):  
Kajal Pawar ◽  
Rutuja Gadhave ◽  
Swati Waydande ◽  
Pravin Pawar
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Antifungal Agents ◽  
Fungal Infections ◽  
Delivery Systems ◽  
General Information ◽  
Colloidal System ◽  
Eukaryotic Organisms ◽  
In Situ Gelling ◽  
Novel Drug

Background & Objectives: Fungi are the heterotrophic eukaryotic organisms which are useful as they causes the biodegradation. There are still some harmful species like yeasts, molds and dermatophytes which cause the infections. As the fungi are eukaryotics, they do not respond to the antibiotic therapy due to the limitations associated with the traditional antibiotic therapies. There are several antifungal agents introduced to treat such infections. These antifungal agents posses severe problems like drug resistance and toxicity due to the higher dose which comprises the need for newer alternatives over conventional dosage forms. Novel drug delivery systems proved to be a better approach to enhance the effectiveness of the antifungals and enhance patient compliance by reducing the adverse effect. Discussion: This review focused on the general information about fungal infections, types and mechanism of action of antifungal agents and overview of formulation approaches such as vesicular system, colloidal system, nanoparticulate system and in situ gelling which are often studied for antifungal treatments. Conclusion: We concluded that the novel drug delivery systems are the essential techniques for delivering the antifungal agents to their target site with desired concentration. Moreover, the researchers focused on these novel drug deliveries which mainly concentrate on controlling & sustaining the release of antifungal agents.

scholarly journals Role of Novel Drug Delivery Systems in Bioavailability Enhancement: At A Glance

2016 ◽  
Vol 6 (1) ◽  
Author(s):  
Mehta Abhinav ◽  
Jain Neha ◽  
Grobler Anne ◽  
Vandana Bharti
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Systemic Circulation ◽  
Delivery Systems ◽  
New Drugs ◽  
Target Tissue ◽  
Drug Bioavailability ◽  
Bioavailability Enhancement ◽  
Advantages And Disadvantages ◽  
Novel Drug

Novel drug delivery systems (NDDS) are one of the most strategies which enable to overcome the problems related to drug bioavailability. It is the rate and extent to which a drug becomes available to the target tissue after its administration. Most of the new drugs used today have poor bioavailability and are required to be administered at higher doses because only a small fraction of the administered dose is absorbed in the systemic circulation and able to reach the target site. This results in the wastage of major amount of drug and lead to adverse effects. Pharmaceutical technology mainly focuses on enhancing the solubility and permeability of drugs with lower bioavailability. Nanotechnology is the concept used in NDDS that enables a weight reduction of drug particles accompanied by an increase in stability and improved functionality. Various approaches such as nanosuspensions, liposomes, niosomes, nanoemulsions, cubosomes, solid lipid nanoparticles (SLN), nanostructured lipid carriers (NLC), cyclodextrins, phytosome etc., are used for the enhancement of bioavailability. The present review focuses on the different approaches used for bioavailability enhancement along with their advantages and disadvantages.

scholarly journals A Comprehensive Map of FDA-Approved Pharmaceutical Products

Pharmaceutics ◽  
2018 ◽  
Vol 10 (4) ◽  
pp. 263 ◽  
Author(s):  
Hao Zhong ◽  
Ging Chan ◽  
Yuanjia Hu ◽  
Hao Hu ◽  
Defang Ouyang
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Generic Drugs ◽  
Pharmaceutical Products ◽  
Delivery Systems ◽  
Market Potential ◽  
New Drugs ◽  
Drug Candidates ◽  
Four Quadrant ◽  
Novel Drug

With the increasing research and development (R&D) difficulty of new molecular entities (NMEs), novel drug delivery systems (DDSs) are attracting widespread attention. This review investigated the current distribution of Food and Drug Administration (FDA)-approved pharmaceutical products and evaluated the technical barrier for the entry of generic drugs and highlighted the success and failure of advanced drug delivery systems. According to the ratio of generic to new drugs and the four-quadrant classification scheme for evaluating the commercialization potential of DDSs, the results showed that the traditional dosage forms (e.g., conventional tablets, capsules and injections) with a lower technology barrier were easier to reproduce, while advanced drug delivery systems (e.g., inhalations and nanomedicines) with highly technical barriers had less competition and greater market potential. Our study provides a comprehensive insight into FDA-approved products and deep analysis of the technical barriers for advanced drug delivery systems. In the future, the R&D of new molecular entities may combine advanced delivery technologies to make drug candidates into more therapeutically effective formulations.

scholarly journals A REVIEW ON NANOSPONGES A REVIEW ON NANOSPONGES: A BOON TO TARGETED DRUG DELIVERY FOR ANTICANCER DRUG

2019 ◽  
pp. 1-7
Author(s):  
NIKITA SEHGAL ◽  
VISHAL GUPTA N ◽  
SANDEEP KANNA
Keyword(s):  
Drug Delivery ◽  
Health Care ◽  
Cancer Treatment ◽  
Drug Delivery Systems ◽  
Water Solubility ◽  
Delivery Systems ◽  
New Drugs ◽  
Stimuli Responsive ◽  
Drug Bioavailability ◽  
Conventional Drug

In recent decades, the rise in the investigation of new drugs had made health-care system expensive compared to conventional drug delivery systems and techniques. The present drug delivery systems have become highly productive and are growing fast. Majority of the anticancer agent has low water solubility resulting in multistep synthetic routes that require higher selectivity and specificity that can cause difficulty in the development of the formulation. Nanosponges (NSs) are branched cyclodextrin (CD) polymeric systems which have proven to be a boon in the pharmaceutical and biomedical fields. Different kinds of NSs based on different types of CDs and crosslinkers are used for developing of new drug formulations from the past few years for various applications in health care. Nanotechnology has overcome the issues regarding the drug solubility, stability, and other parameters and has attained success in achieving of sustained release, increased activity, improved permeability, delivery of nucleoprotein, the stimuli-responsive release of the drug, and improved drug bioavailability. There is a huge eruption of research on NSs for cancer treatment. Multiple anticancer moieties have been developed, taking into account the pharmacological and physicochemical perspective of the drug to develop a NS formulation. Our target in this review is to catch an efficient and far-reaching NSs for malignancy cancer treatment announced until now. This survey will give a perfect stage for providing details for researchers taking a shot at using new polymers for improving the treatment of the disease using nanotechnology. The present article provides details regarding antineoplastic molecules and provides ideas on CD-based NSs specifically using curcumin, tamoxifen, resveratrol, quercetin, oxygen-NSs, temozolomide, doxorubicin, and 5-fluorouracil (5-FU), and erlotinib (ETB) glutathione.

scholarly journals An Insight to Nanostructured Lipid Carrier System

2020 ◽  
Vol 10 (6-s) ◽  
pp. 173-182
Author(s):  
G. Rajalakshmi ◽  
C.K. Dhanapal ◽  
R. Sundhararajan
Keyword(s):  
Drug Delivery ◽  
Drug Therapy ◽  
Drug Delivery Systems ◽  
New Technologies ◽  
Delivery Systems ◽  
Structured Lipid ◽  
New Drugs ◽  
Nanostructured Lipid Carrier ◽  
Conventional Drug ◽  
Nano Drug Delivery

In pharmaceutical field, many drugs are being invented to combat the existing new diseases. The winds of change in the drug scenario are blowing forcefully worldwide. The emergence of new technologies provides an unique opportunities to exploit novel approaches in drug delivery. A shift from conventional drug delivery to novel drug delivery is noticed as shift from conventional drug delivery suffers from various drawbacks, But these new mighty compounds in drug therapy solely are not sufficient to meet the today’s need. There is an urgent need for the smart technology, as the drugs available suffer from serious problems like poor solubility and poor bioavailability. Most of the drugs that are available therapeutically comes under BCS class II ie, poorly soluble and high lipophilc. To assure progress in drug therapy, the development of new drugs merely is not sufficient. Issues arising in delivery of new drugs should also be addressed. Thus there is an emergent need to improve the bioavailability of these drugs, the only remedy or boon for such drugs is the discovery of some smart technologies which can improve the bioavailability of these drugs. Nano drug delivery systems are the one such universal approach which fulfills the lacuna, which exists in conventional drug delivery systems. These Nano drug delivery systems, improves the pharmacokinetic profiles of many drugs. In 1980 K. Eric Drexler developed and popularized the concept of nanotechnology. In this review a deep insight on Nano structured lipid carriers is discussed elaborating its birth, significant qualities compared to other colloidal systems, its structure, characteristics, preparation and application are spotted. Key words: BCS class, Lipophilic, Nano technology, Nano structured lipid carrier.

New Drugs and Drug Delivery Systems in the year 2000

1984 ◽  
Vol 24 (9) ◽  
pp. 44-46 ◽  
Author(s):  
William A. Check
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
New Drugs ◽  
Year 2000

scholarly journals Applications of Nanosized-Lipid-Based Drug Delivery Systems in Wound Care

2021 ◽  
Vol 11 (11) ◽  
pp. 4915
Author(s):  
Andreea-Mariana Matei ◽  
Constantin Caruntu ◽  
Mircea Tampa ◽  
Simona Roxana Georgescu ◽  
Clara Matei ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Wound Healing ◽  
Drug Delivery Systems ◽  
Wound Care ◽  
Drug Loading ◽  
Healing Process ◽  
Lipid Nanoparticles ◽  
Delivery Systems ◽  
Public Health Issue ◽  
Impaired Wound Healing

Impaired wound healing is an encumbering public health issue that increases the demand for developing new therapies in order to minimize health costs and enhance treatment efficacy. Available conventional therapies are still unable to maximize their potential in penetrating the skin at the target site and accelerating the healing process. Nanotechnology exhibits an excellent opportunity to enrich currently available medical treatments, enhance standard care and manage wounds. It is a promising approach, able to address issues such as the permeability and bioavailability of drugs with reduced stability or low water solubility. This paper focuses on nanosized-lipid-based drug delivery systems, describing their numerous applications in managing skin wounds. We also highlight the relationship between the physicochemical characteristics of nanosized, lipid-based drug delivery systems and their impact on the wound-healing process. Different types of nanosized-lipid-based drug delivery systems, such as vesicular systems and lipid nanoparticles, demonstrated better applicability and enhanced skin penetration in wound healing therapy compared with conventional treatments. Moreover, an improved chemically and physically stable drug delivery system, with increased drug loading capacity and enhanced bioavailability, has been shown in drugs encapsulated in lipid nanoparticles. Their applications in wound care show potential for overcoming impediments, such as the inadequate bioavailability of active agents with low solubility. Future research in nanosized-lipid-based drug delivery systems will allow the achievement of increased bioavailability and better control of drug release, providing the clinician with more effective therapies for wound care.

New drugs and drug-delivery systems in the year 2000

1984 ◽  
Vol 41 (8) ◽  
pp. 1536-1547
Author(s):  
William A. Check
Keyword(s):  
Drug Delivery ◽  
Drug Delivery Systems ◽  
Delivery Systems ◽  
New Drugs ◽  
Year 2000

scholarly journals General Approach to Drug Delivery Systems (DDS)

Bionatura ◽  
2019 ◽  
Vol 02 (Bionatura Conference Serie) ◽  
Author(s):  
Danna Belén Castillo ◽  
Hortensia M. Rodriguez
Keyword(s):  
Drug Delivery ◽  
Side Effects ◽  
Drug Delivery Systems ◽  
High Specificity ◽  
Delivery Systems ◽  
New Drugs ◽  
Cancer Treatments ◽  
Chemical Conjugation ◽  
Macromolecular Systems ◽  
Important Approach

The field of drug discovery drives to find out efficient, selective, stable and biocompatible new drugs. The purpose of drug delivery systems (DDS) is to reduce the side effects that treatments usually cause to mitigate some diseases, especially cancer. Cancer treatments are usually so strong and invasive that they end up weakening the patient, so the cure became as dangerous as the disease. That is the reason that DDS try to maximize the effectiveness of the drugs administered by wanting them to reach specifically to the area affected by the disease (High specificity). In this regard, the fruitfully use of liposome-, erythrocytes-, nanoparticles- or antibodies-based therapies became a choice for the treatment of a huge range of diseases, due to the biocompatibility that these macromolecular systems present. In the last five years, a broad range of DDS have been developed, and some of them, specifically four ADC´s are approved by the FDA and commercializing. In this work, we summarized the most important approach to DDS obtained through chemical conjugation, highlighting ADC´s like the most promising controlled release systems.

Sign in / Sign up

Export Citation Format

Share Document