scholarly journals Development of Chitosan/Silver Sulfadiazine/Zeolite Composite Films for Wound Dressing

Pharmaceutics ◽  
2019 ◽  
Vol 11 (10) ◽  
pp. 535 ◽  
Author(s):  
Hissae Yassue-Cordeiro ◽  
Zandonai ◽  
Pereira Genesi ◽  
Santos Lopes ◽  
Sanchez-Lopez ◽  
...  
Keyword(s):  
Sustained Release ◽  
Composite Films ◽  
Safety Evaluation ◽  
Chitosan Film ◽  
Silver Sulfadiazine ◽  
Wound Dressings ◽  
Xrd Diffraction ◽  
Diffraction Patterns ◽  
Zeolite Composite

Biopolymeric films with silver sulfadiazine (AgSD) are proposed as an alternative to the occlusive AgSD-containing creams and gauzes, which are commonly used in the treatment of conventional burns. While the recognized cytotoxicity of AgSD has been reported to compromise its use as an antimicrobial drug in pharmaceuticals, this limitation can be overcome by developing sustained-release formulations. Microporous materials as zeolites can be used as drug delivery systems for sustained release of AgSD. The purpose of this work was the development and characterization of chitosan/zeolite composite films to be used as wound dressings. Zeolite was impregnated with AgSD before the production of the composite films. The physicochemical properties of zeolites and the films were evaluated, as well as the antimicrobial activity of the polymeric films and the cytotoxicity of the films in fibroblasts Balb 3T3/c. Impregnated zeolite exhibited changes in FTIR spectra and XRD diffraction patterns, in comparison to non-impregnated composites, which corroborate the results obtained with EDX-SEM. The pure chitosan film was compact and without noticeable defects and macropores, while the film with zeolite was opaquer, more rigid, and efficient against Candida albicans and some gram-negative bacteria. The safety evaluation showed that although the AgSD films present cytotoxicity, they could be used in a concentration-dependent fashion.

scholarly journals Synthesis and Characterization of Polyvinyl Alcohol-Gum Arabic Polymer Blend Membranes

2019 ◽  
Vol 32 (1) ◽  
pp. 111-114
Author(s):  
Larny Mary J ayan ◽  
S. Karthikeyan ◽  
D. Joice Sheeba ◽  
G.R. Angel ◽  
E.V. Kripa ◽  
...  
Keyword(s):  
Polymer Blend ◽  
Gum Arabic ◽  
Poly Vinyl Alcohol ◽  
Natural Polymer ◽  
New Class ◽  
Xrd Diffraction ◽  
Solution Casting Method ◽  
Diffraction Patterns ◽  
Blend Polymer

Membranes of poly(vinyl alcohol) (PVA), gum arabic (GA) homopolymer and their blends of six different compositions (w/w) were prepared using solution casting method. Mixing of synthetic polymer e.g., PVA and natural polymer e.g., gum arabic can give a new class of polymer blend with better mechanical properties and biocompatibility than those of single components. The structural, optical and conductivity studies of these prepared membranes were examined by XRD, FTIR, UV and EIS. The XRD diffraction patterns for the polymer blend samples showed that they are more amorphous in nature as compared to pure PVA and pure gum arabic. The FTIR analysis of the samples gave information about various functional groups present in the samples. The energy band gap of various samples were obtained from UV-visible analysis. The conductivity of polymer membrane was analyzed by electronics impedance spectroscopy (EIS). Addition of natural polymer gum arabic has resulted slight increase in the conductivity of blend polymer.

Structure and Electrical Properties of ZnO Nanoparticles Blend with POT-DBSA

2020 ◽  
Vol 1002 ◽  
pp. 114-122
Author(s):  
Dalal K. Thbayh ◽  
Rawnaq A. Talib ◽  
Dalal N. Ahilfi ◽  
Tahseen A. Alaridhee ◽  
Kareema M. Ziadan
Keyword(s):  
Zno Nanoparticles ◽  
In Situ Polymerization ◽  
Composite Films ◽  
Dodecylbenzene Sulfonate ◽  
Thin Film Layer ◽  
Film Layer ◽  
Layer Contact ◽  
Diffraction Patterns

In this study, we report on a successful preparation nanocomposites poly (o-toluidine) (POT) doping with dodecylbenzene sulfonate acid (DBSA)/ ZnO by in-situ polymerization of (o-toluidine) monomer using ZnO nanoparticles (the weight ratios OT/ZnO: 1/5%, 1/10%, 1/15%). The composite films have been prepared by using the casting method on different substrate depending on the type of measurement. The surface morphology properties of the prepared samples were studied by the field emission scanning electron microscopy (FESEM). The results of FESEM indicate that ZnO nanoparticles were successfully embedded in the POT via chemical interactions between ZnO and (O-toluidine) monomer and the EDX spectrum showed the presence of element Zn in POT-DBSA/ZnO composites. The crystal structure was measured by x-ray directional and its pattern revealed the presence of ZnO in dopant polymer, in the diffraction patterns of POT-DBSA. The intensity of the peaks was increased as the amount of ZnO nanoparticles increased in POT-DBSA. The typical rectifying behaviour indicated that the formation of a diode observes by the I–V characterization of POT-DBSA/ZnO composites at thin film layer with top Al thin layer contact.

Design and characterization of chitosan/zeolite composite films — Effect of zeolite type and zeolite dose on the film properties

2016 ◽  
Vol 60 ◽  
pp. 246-254 ◽  
Author(s):  
Gustavo P. Barbosa ◽  
Henrique S. Debone ◽  
Patrícia Severino ◽  
Eliana B. Souto ◽  
Classius F. da Silva
Keyword(s):  
Composite Films ◽  
Film Properties ◽  
Zeolite Type ◽  
Zeolite Composite

scholarly journals Characterization of sustained-release chitosan film loaded with rutin-β-cyclodextrin complex and glucoamylase

2019 ◽  
Vol 57 (2) ◽  
pp. 734-744
Author(s):  
Lijun Jiang ◽  
Jinhuan Zong ◽  
Chengye Ma ◽  
Shanfeng Chen ◽  
Hongjun Li ◽  
...  
Keyword(s):  
Sustained Release ◽  
Chitosan Film ◽  
Cyclodextrin Complex

scholarly journals Development and Characterization of Novel Active Chitosan Films Containing Fennel and Peppermint Essential Oils

Coatings ◽  
2020 ◽  
Vol 10 (10) ◽  
pp. 936 ◽  
Author(s):  
Ting Liu ◽  
Jingfan Wang ◽  
Fumin Chi ◽  
Zhankun Tan ◽  
Liu Liu
Keyword(s):  
Essential Oil ◽  
Composite Films ◽  
Environmental Scanning Electron Microscopy ◽  
Chitosan Film ◽  
Environmental Scanning ◽  
The Novel ◽  
Scanning Calorimetry ◽  
Chitosan Films ◽  
Water Swelling

The effects of fennel essential oil (FEO) and peppermint essential oil (PEO) on chitosan-based films were evaluated in this study. The results showed that the addition of FEO and PEO slightly increased the density and thickness, while significantly decreasing the moisture content, water swelling, and solubility properties. The color values (L, a, b, ΔE and whiteness index (WI)) of the composite films containing FEO and PEO changed obviously with a tendency toward yellowness, which was beneficial in resisting food decomposition caused by ultraviolet light. The differential scanning calorimetry (DSC) and fourier-transform-infrared (FTIR) results indicated that the addition of FEO and PEO affected the structure of the chitosan films, while the interaction between the chitosan and polyphenols in FEO and PEO established new hydrogen bonds and improved the thermal stability. The environmental scanning electron microscopy (ESEM) illustrated that the surfaces of the composite films containing FEO and PEO were smooth, but the cross-section was rougher than in pure chitosan film. Furthermore, the composite films containing FEO and PEO exhibited prominent antioxidant activity. In short, the novel active chitosan-based films with incorporated FEO and PEO present broad application prospects in fresh-cut meat or vegetable packaging.

Synthesis and Characterization of CoMn2O4 Nanopowders by a Reverse Micelle Processing

2016 ◽  
Vol 868 ◽  
pp. 105-110
Author(s):  
Dong Sik Bae
Keyword(s):  
Reverse Micelle ◽  
Molar Ratio ◽  
Synthesis And Characterization ◽  
X Ray Diffraction ◽  
X Ray ◽  
Xrd Diffraction ◽  
Transmission Electron ◽  
Diffraction Patterns ◽  
Average Size

CoMn2O4 nanoparticles were synthesized by reverse micelle processing from the mixed precursor (consisting of Co (NO3)2 ·6H2O and MnCl2·4H2O). The CoMn2O4 was prepared by mixing the aqueous solution at a molar ratio of Co : Mn = 1 : 2. The synthesized powders were calcined at 600°C for 2h. The average size and distribution of synthesized powders were in the range of 10-20nm and narrow, respectively. The average size of the synthesized powders increased with increasing water to surfactant molar ratio. The XRD diffraction patterns show that the phase of CoMn2O4 was spinel (JCPDS no.77-0471). The synthesized and calcined powders were characterized by thermogravimetry-differential scanning calorimeter (TG-DSC), X-ray diffraction analysis (XRD) and transmission electron microscopy (TEM). The magnetic property of the powder was measured by Vibrating Sample Magneto-meter (VSM) at 298K. The effect of synthesis parameter, such as the molar ratio of water to surfactant, is discussed.

scholarly journals Fabrication and Characterization of Silk Fibroin/Curcumin Sustained-Release Film

Materials ◽  
2019 ◽  
Vol 12 (20) ◽  
pp. 3340 ◽  
Author(s):  
Xiaoning Zhang ◽  
Zhenyu Chen ◽  
Hong Bao ◽  
Jianwei Liang ◽  
Shui Xu ◽  
...  
Keyword(s):  
Sustained Release ◽  
Silk Fibroin ◽  
Gas Permeability ◽  
Transmission Rate ◽  
Chemical Properties ◽  
Wound Dressings ◽  
Fabrication And Characterization ◽  
Physical And Chemical ◽  
And Chemical Properties

In the present work, a sustained-release film composed of silk fibroin (SF), curcumin (Cur), glutaraldehyde (GA), and glycerol (Gly) was prepared successfully for wound dressings. Features relevant to wound dressings of SF/Gly/GA/Cur film were assessed. Physical and chemical properties of the fabricated materials were also characterized. The results showed that the prepared SF/Gly/GA/Cur film demonstrated a good sustained-release performance, flexibility, and gas permeability. In addition, it was found that the prepared SF/Gly/GA/Cur film possessed the capability to effectively inhibit the growth of bacteria and prevent bacterial penetration with a suitable water vapor transmission rate. Furthermore, the prepared composite film was non-cytotoxic, which makes it an ideal material for wound dressings.

The effect of nanocellulose on mechanical and physical properties of chitosan-based biocomposites

2021 ◽  
pp. 009524432110171
Author(s):  
Hamidreza Talebi ◽  
Faramarz Ashenai Ghasemi ◽  
Alireza Ashori
Keyword(s):  
Mechanical Properties ◽  
Tensile Strength ◽  
Storage Modulus ◽  
Composite Films ◽  
Chitosan Film ◽  
Wound Dressings ◽  
Nanocomposite Films ◽  
Homogeneous Distribution ◽  
Morphological Studies ◽  
Chitosan Films

The effect of two types of nanocellulose on the mechanical properties of chitosan (CH) film was examined in terms of elongation, tensile strength, and dynamic-mechanical properties such as tan δ and storage modulus. Chitosan films were reinforced by cellulose nanocrystal (CNC) and cellulose nanofiber (CNF) with different ratios. CH/CNC and CH/CNF nanocomposite films containing 0–7 wt.% nanofibers were produced by solution casting. A comparison between CNC and CNF was made based on their nanostructures and interfacial bonding with the CH matrix. For both CNC and CNF, reinforcing effects in nanocomposite polymer films were presented. The results demonstrated that nanocomposite films can increase mechanical properties; 7 wt.% CNF and CNC had the most increasing effect on the mechanical properties, raising the tensile strength of the chitosan film by 104% and 52%, respectively. Moreover, the values of CH/CNC and CH/CNF films showed higher storage modulus compared to the pure chitosan film. CNF shows higher modulus and strength compared with CNC at the same amount of fiber because of CNFs’ percolation networks and their larger aspect ratio. Morphological studies revealed the dispersion of CNC and CNF is in the contiguous matrix of chitosan with a homogeneous distribution without agglomeration. The results also illustrated that CNC and CNF can improve the water resistance of chitosan films. The mechanical properties of composite films were acceptable to use as artificial skin and wound dressings.

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