scholarly journals Immunity in Light of Spinoza and Canguilhem

Philosophies ◽  
2020 ◽  
Vol 5 (4) ◽  
pp. 38
Author(s):  
Hidetaka Yakura

All living organisms are under stress imposed by their surrounding environments. They must adapt to their stressors to live and survive. At the forefront of this adaptation is a defense system called immunity. Immunity, as the most ancient cognitive apparatus with memory function, is present in all living organisms. In previous reports, minimal cognitive function was defined as a “biologized” concept—namely, perception of elements in a milieu, integration of perceived information, reaction according to integrated information, and memory of that experience. In this study, I aim to explore the essential feature of immunity by synthesizing scientific facts and “metaphysicalizing” them with logical reasoning. As a result of my analysis, I have realized the essential element in immunity: the capacity to preserve the existence of organisms by regulating their physiology and pathology. Having further analyzed immunity with special reference to the philosophy of Baruch Spinoza and George Canguilhem, conatus (“appetite”, to be precise) with normative activities is deeply embedded in immunity and may constitute its essential feature. Given that conatus and normativity imply mental elements, including the judgment of good and bad or health and disease, it is possible to conclude that the essential function of immunity includes cognition with normative connotations. This inclusive view encourages us to rethink the fundamental nature and philosophical implications of immunity from the cognitive perspective.

2020 ◽  
Vol 185 ◽  
pp. 01023
Author(s):  
Yuan An ◽  
Jianing Li ◽  
Cenyue Chen

The intermittence and uncertainty of wind power and photovoltaic power have hindered the large-scale development of both. Therefore, it is very necessary to properly configure energy storage devices in the wind-solar complementary power grid. For the hybrid energy storage system composed of storage battery and supercapacitor, the optimization model of hybrid energy storage capacity is established with the minimum comprehensive cost as the objective function and the energy saving and charging state as the constraints. A simulated annealing artificial fish school algorithm with memory function is proposed to solve the model. The results show that the hybrid energy storage system can greatly save costs and improve system economy.


Nano Energy ◽  
2021 ◽  
pp. 106569
Author(s):  
Yangbin Zhu ◽  
Yang Liu ◽  
Hailong Hu ◽  
Zhongwei Xu ◽  
Chaoxing Wu ◽  
...  

Author(s):  
Uldis Zupa ◽  

The implementation of the comprehensive national defense system in Latvia marks a new turning point in the relationship between the state and society – instead of being consumers of the security and defense provided by the state, every inhabitant of Latvia must become an active contributor to the natio-nal defense system. Thus, the society’s willingness to defend the state becomes an essential element in the successful implementation of the comprehensive state defense system. This article analyzes the different views of Latvian and Russian-speaking population on issues that affect the willingness to defend the state, as well as evaluates the role of intercultural communication for informing public and increasing the involvement in the comprehensive national defense system.


2001 ◽  
Vol 281 (1) ◽  
pp. E1-E7 ◽  
Author(s):  
Zimian Wang ◽  
F. Xavier Pi-Sunyer ◽  
Donald P. Kotler ◽  
Jack Wang ◽  
Richard N. Pierson ◽  
...  

Potassium is an essential element of living organisms that is found almost exclusively in the intracellular fluid compartment. The assumed constant ratio of total body potassium (TBK) to fat-free mass (FFM) is a cornerstone of the TBK method of estimating total body fat. Although the TBK-to-FFM (TBK/FFM) ratio has been assumed constant, a large range of individual and group values is recognized. The purpose of the present study was to undertake a comprehensive analysis of biological factors that cause variation in the TBK/FFM ratio. A theoretical TBK/FFM model was developed on the cellular body composition level. This physiological model includes six factors that combine to produce the observed TBK/FFM ratio. The ratio magnitude and range, as well as the differences in the TBK/FFM ratio between men and women and variation with growth, were examined with the proposed model. The ratio of extracellular water to intracellular water ( E/I) is the major factor leading to between-individual variation in the TBK/FFM ratio. The present study provides a conceptual framework for examining the separate TBK/FFM determinants and suggests important limitations of the TBK/FFM method used in estimating total body fat in humans and other mammals.


2019 ◽  
Vol 245 ◽  
pp. 461-467 ◽  
Author(s):  
Mariko Itoh ◽  
Hiroaki Hori ◽  
Mingming Lin ◽  
Madoka Niwa ◽  
Keiko Ino ◽  
...  

2011 ◽  
Vol 47 (3) ◽  
pp. 151-160 ◽  
Author(s):  
Jennifer L. McCown ◽  
Andrew J. Specht

Iron is an essential element for nearly all living organisms and disruption of iron homeostasis can lead to a number of clinical manifestations. Iron is used in the formation of both hemoglobin and myoglobin, as well as numerous enzyme systems of the body. Disorders of iron in the body include iron deficiency anemia, anemia of inflammatory disease, and iron overload. This article reviews normal iron metabolism, disease syndromes of iron imbalance, diagnostic testing, and treatment of either iron deficiency or excess. Recent advances in diagnosing iron deficiency using reticulocyte indices are reviewed.


2014 ◽  
pp. 43-47
Author(s):  
Judit Horváth ◽  
János Kátai

The research topic has timeliness, since the rational utilization and protection of the soil, besides the conservation of its diverse functions is part of the sustainable development. Research of the long-term experiments is esentially important, because it can model the term effects in the same place, under the same conditions. If we want to get accurate informations about the occured changes, way and danger of changes, we should track the resupply and effect of the mineral nutrients and the removed quantity of nutrients with the harvest. Nitrogen is an essential element for living organisms, it is present in the soil mainly in organic form. In general only only a low percentage of the total nitrogent content can be used directly by plants in the soil. This inorganic nitrogen is produced by the transformation of organic contents through mineralization processes and it get into the soil by the fertilization. The plants incorporote the mineral nitrogen into our bodies. This is how nitrogen turnover is realized when mineral forms become organic and organic forms become mineral. The purpose of our paper is to make a literature before our research.


Physiology ◽  
2006 ◽  
Vol 21 (2) ◽  
pp. 115-123 ◽  
Author(s):  
Adriana Donovan ◽  
Cindy N. Roy ◽  
Nancy C. Andrews

Iron is an essential element that is toxic when it accumulates in excess. Intricate regulatory mechanisms have evolved to maintain iron homeostasis within cells and between different tissues of complex organisms. This review discusses the proteins involved in iron transport and storage and their regulation in health and disease.


2021 ◽  
Vol 39 (1) ◽  
Author(s):  
Julie Y. Zhou ◽  
Brian A. Cobb

The surfaces of all living organisms and most secreted proteins share a common feature: They are glycosylated. As the outermost-facing molecules, glycans participate in nearly all immunological processes, including driving host-pathogen interactions, immunological recognition and activation, and differentiation between self and nonself through a complex array of pathways and mechanisms. These fundamental immunologic roles are further cast into sharp relief in inflammatory, autoimmune, and cancer disease states in which immune regulation goes awry. Here, we review the broad impact of glycans on the immune system and discuss the changes and clinical opportunities associated with the onset of immunologic disease. Expected final online publication date for the Annual Review of Immunology, Volume 39 is April 2021. Please see http://www.annualreviews.org/page/journal/pubdates for revised estimates.


2020 ◽  
Vol 4 (10) ◽  
pp. 2845-2862
Author(s):  
Zhiheng Zhu ◽  
Yunlong Guo ◽  
Yunqi Liu

Functional organic field-effect transistors (OFETs) have developed rapidly, especially OFETs with memory function. We make a comprehensive summary of the background, memory mechanism, structure construction and memory applications based on OFETs.


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