Evaluation of the Physicochemical and Antibacterial Properties of Experimental Adhesives Doped with Lithium Niobate

The aim of the present study was to formulate dental adhesives with different concentrations of LiNbO3 and to evaluate their physicochemical and antibacterial properties. A dental adhesive was formulated using methacrylate monomers and photoinitiators and used as a control filler-free group. Subsequently, three experimental adhesives doped with LiNbO3 at different concentrations (1 wt.%, 2 wt.%, and 5 wt.%) were also formulated. All the experimental adhesives were assessed to evaluate the degree of conversion (DC), softening in solvent, immediate and long-term microtensile bond-strength (μ-TBS), radiopacity, ultimate tensile strength, and antibacterial activity. The incorporation of 1 wt.% of LiNbO3 had no negative effect on the DC of the adhesive resin compared to the control group (p > 0.05). We observed a decrease in the percentage of softening in solvent in the group LiNbO3 at 1 wt.% (p < 0.05). The addition of LiNbO3 increased the radiopacity at a concentration above 2 wt.%, and there was also an increase in cohesive strength (p < 0.05). The immediate μ-TBS increased for LiNbO3 at 5 wt.% (p < 0.05), and there was no statistical difference for the other groups compared to the control (p > 0.05). After six months, the group with 5 wt.% still presented the highest μ-TBS (p < 0.05). The adhesives showed no antimicrobial activity (p > 0.05). LiNbO3 was successfully incorporated in dental adhesives, increasing the radiopacity and their resistance to degradation. Although LiNbO3 offered no antibacterial properties, the reliability of LiNbO3 incorporation in the adhesive encourages new tests to better investigate the antimicrobial action of LiNbO3 through temperature variation.

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Effectiveness of Riboflavin and Rose Bengal Photosensitizer Modified Adhesive Resin for Orthodontic Bonding

Pharmaceuticals ◽

10.3390/ph14010048 ◽

2021 ◽

Vol 14 (1) ◽

pp. 48

Author(s):

Ali Alqerban

Keyword(s):

Mtt Assay ◽

Rose Bengal ◽

Antibacterial Properties ◽

Homogenization Method ◽

Tooth Surface ◽

Control Group ◽

Adhesive Resin ◽

Adhesive Remnant Index ◽

Significant Difference ◽

Sem Imaging

This study aimed to evaluate the effect of riboflavin (RF) and rose Bengal (RB) photosensitizer modified adhesive resin on the degree of conversion (DC), and antimicrobial capacity after bonded to tooth surface. Different concentrations of RB and RF were prepared by homogenization method. An ultraviolet light source A (UVA) (375 nm wavelength, 3 mW/cm2 power) was used for 30 min irradiation.FTIR was performed for control and test adhesives to analyze the DC. Antibacterial testing was performed using the MTT assay. Metal brackets were bonded using the modified adhesives and subjected for SEM examination. The surfaces of teeth and metal brackets were examined at ×10 magnification for assessing adhesive remnant index (ARI) after PDT, 24 h and thermocycling. For DC, control group, 0.1% RB and RF after PDT showed the highest value. SEM imaging indicated lowest growth of Streptococcus mutans over 0.5% of RB-PDT and RF-PDT as compared to the control group. The MTT assay outcomes reported that the activity of S. mutans substantially decreased with the addition of a high amount of either RB or RF (p < 0.01). Mean ARI scores showed a significant difference between all groups. This study concluded that 0.1% of either RB or RF after PDT can be used for bonding orthodontic brackets to the tooth surface with substantial antibacterial properties.

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Long-term release of chlorhexidine from dental adhesive resin system using human serum albumin nanoparticles

Polymer Bulletin ◽

10.1007/s00289-014-1099-0 ◽

2014 ◽

Vol 71 (4) ◽

pp. 875-886 ◽

Cited By ~ 7

Author(s):

Hyun-Jin Kim ◽

Tae-Yub Kwon ◽

Kyo-Han Kim ◽

Soon-Taek Kwon ◽

Dae-Hyun Cho ◽

...

Keyword(s):

Human Serum Albumin ◽

Serum Albumin ◽

Human Serum ◽

Resin System ◽

Adhesive Resin ◽

Dental Adhesive ◽

Albumin Nanoparticles

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A Propensity Score Cohort Study on the Long-Term Safety and Efficacy of Sleeve Gastrectomy in Patients Older Than Age 60

Journal of Obesity ◽

10.1155/2020/8783260 ◽

2020 ◽

Vol 2020 ◽

pp. 1-6

Author(s):

Judith Molero ◽

Romina Olbeyra ◽

Josep Vidal ◽

Ferran Torres ◽

Silvia Cañizares ◽

...

Keyword(s):

Statistical Difference ◽

Control Group ◽

Normal Range ◽

Inverse Probability ◽

The Past ◽

Obese Subjects ◽

Similar Body

Background. Bariatric surgery (BS) in older obese subjects (>60 years of age) has risen in the past decade and will continue to rise in the coming years due to ageing of the population. Aim. To evaluate the short- (12 months) and long-term (60 months) results of laparoscopic sleeve gastroscopy (LSG) in patients older than age 60. Methods. We performed a retrospective review of patients prospectively included in a database from January 2007 to December 2013. All patients >60 [older group (OG)] who had undergone LSG were included. The control group (CG) included patients aged 50 to 59 years who had undergone LSG during the same period. Results. 116 (8.4 % of total surgery) and 145 patients were included in the OG and CG, respectively. BS in patients >60 years increased from 2.4% in 2003 to 14% in the last 2 years of the study. After inverse probability of treatment weighting (IPTW) analysis, all absolute standardized differences were <0.15. A 60-month follow-up was attained in 90% of patients in the OG and 74% in the CG. There were no significant differences in postoperative complications between the two groups. At 12 and 60 months after LSG, both groups achieved a similar body mass index. There was no statistical difference in the percentage of resolution of type 2 diabetes, hypertension, dyslipidemia, and SAHS between the two groups. In both groups, all the nutritional parameters evaluated remained within the normal range throughout the study. Conclusions. LSG provides acceptable outcomes and is safe in older adults indicating that age should not be a limitation to perform BS in this population.

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Long-term effect of chlorhexidine on the dentin microtensile bond strength of conventional and self-adhesive resin cements: A two-year in vitro study

International Journal of Adhesion and Adhesives ◽

10.1016/j.ijadhadh.2014.02.001 ◽

2014 ◽

Vol 50 ◽

pp. 228-234 ◽

Cited By ~ 2

Author(s):

Thiago Henrique Scarabello Stape ◽

Murilo de Sousa Menezes ◽

Flávio Henrique Baggio Aguiar ◽

Paulo Sérgio Quagliatto ◽

Carlos José Soares ◽

...

Keyword(s):

Bond Strength ◽

In Vitro Study ◽

Term Effect ◽

Vitro Study ◽

Microtensile Bond Strength ◽

Resin Cements ◽

Adhesive Resin ◽

Long Term Effect

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Effects of Hydroxychloroquine on Proteinuria in IgA Nephropathy: A Systematic Review and Meta-Analysis

BioMed Research International ◽

10.1155/2021/9171715 ◽

2021 ◽

Vol 2021 ◽

pp. 1-9

Author(s):

Jialing Zhang ◽

Xiangxue Lu ◽

Jianan Feng ◽

Han Li ◽

Shixiang Wang

Keyword(s):

Systematic Review ◽

Iga Nephropathy ◽

Therapeutic Effect ◽

Statistical Difference ◽

Meta Analysis ◽

Immunosuppressive Agents ◽

Control Group ◽

Percentage Reduction ◽

And Control

Introduction. The present meta-analysis was to explore the efficacy of hydroxychloroquine (HCQ) in IgA nephropathy patients in terms of proteinuria. Method. We systematically searched PubMed and Embase for studies that compared HCQ and other treatments to reduce proteinuria in patients with IgA nephropathy up to June 2021. Mean ± SD of percentage change and level of proteinuria was calculated. Results. A total of 5 studies with 587 participants were included. IgA nephropathy patients who received HCQ were at a lower level of mean proteinuria at 6 months. However, there was no statistical difference between HCQ and control group considering percentage reduction in proteinuria. The long-term therapeutic effect of HCQ might be inferior to HCQ and renin-angiotensin-aldosterone system inhibition. Conclusion. HCQ might play a role in the reduction of proteinuria in IgA nephropathy patients. The addition of HCQ to other immunosuppressive agents should be clarified further.

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Short- and Long-Term Dentin Bond Strength of Bioactive Glass-Modified Dental Adhesives

Nanomaterials ◽

10.3390/nano11081894 ◽

2021 ◽

Vol 11 (8) ◽

pp. 1894

Author(s):

Ramona Oltramare ◽

Matej Par ◽

Dirk Mohn ◽

Daniel B. Wiedemeier ◽

Thomas Attin ◽

...

Keyword(s):

Bond Strength ◽

Bioactive Glass ◽

Control Group ◽

Long Term Effects ◽

Control Groups ◽

Dental Adhesives ◽

Etch And Rinse ◽

Short And Long Term ◽

Self Etch

This study investigated the short- and long-term effects of dental adhesives doped with nano-sized bioactive glass 45S5 (BAG) on the resin–dentin interfacial bond strength. Two etch-and-rinse adhesives (Adper Scotchbond Multi-Purpose (ASB) and Solobond Plus (SB)) and one self-etch adhesive (Clearfil SE Bond (CF)) were doped with different concentrations of BAG (5, 10, and 20 wt%). The unmodified (0 wt% BAG) commercial adhesives served as control groups. Dentin of 120 molars (n = 10 per group) was treated with the different adhesives, followed by buildups with a conventional composite restorative material. From each tooth, 14 sticks were prepared for micro-tensile bond strength (µTBS) testing. The sticks were stored in simulated body fluid at 37 °C and tested after 24 h or six months for µTBS and failure mode. Data were analyzed using Kruskal–Wallis tests in combination with post-hoc Conover-tests and Wilcoxon signed-rank tests at a level of significance of a = 0.05. After 24 h and six months, both etch-and-rinse adhesives with a low BAG content (up to 10 wt% for ASB and 5 wt% for SB) showed similar µTBSs as their respective control groups (0 wt% BAG). CF showed a significant decrease in µTBS even after addition of 5 wt% BAG. At a high concentration of added BAG (20 wt%), all three adhesives showed a significant decrease in µTBS compared to the unmodified controls. The CF control group showed significantly lower µTBS after 6 months of storage than after 24 h. In contrast, the µTBS of all CF groups modified with BAG was unaffected by aging. In conclusion, the tested etch-and-rinse adhesives can be modified with up to 5 wt% (SB), or 10 wt% (ASB) of BAG without reducing their short- and long-term dentin bond strength. Moreover, the addition of nano-sized BAG may prevent long-term bond strength deterioration of a self-etch adhesive.

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Physicochemical Effects of Niobic Acid Addition Into Dental Adhesives

Frontiers in Materials ◽

10.3389/fmats.2020.601078 ◽

2021 ◽

Vol 7 ◽

Author(s):

Isadora Martini Garcia ◽

Vicente Castelo Branco Leitune ◽

Gabrielade Souza Balbinot ◽

AbdulRahman A. Balhaddad ◽

Mary Anne S. Melo ◽

...

Keyword(s):

Mechanical Properties ◽

Tensile Strength ◽

Ultimate Tensile Strength ◽

Testing Machine ◽

Polymerization Rate ◽

Niobium Pentoxide ◽

Control Group ◽

Dental Adhesives ◽

Dental Adhesive ◽

Niobic Acid

The incorporation of metallic oxides in dental adhesives has been a strategy to confer improved radiopacity and physicochemical properties for polymers. Tailoring the structure of these fillers could contribute to their application in therapeutic strategies for dental restorations. The aim of this study was to evaluate the incorporation of niobic acid into experimental dental adhesives, and compare these adhesives to niobium pentoxide containing adhesives. A control group without Nb2O5·n H2O or Nb2O5 was also used for comparison. Niobium-based particles have been used as a feasible approach, mainly because of their bioactivity. In this study, hydrated niobium pentoxide, also called niobic acid (Nb2O5·n H2O), was incorporated into an experimental dental adhesive as a potential catalyst for monomer conversion. A base resin for dental adhesive was formulated with methacrylate monomers and photoinitiators. Two types of oxides were tested as filler for this adhesive: Nb2O5·n H2O or niobium pentoxide (Nb2O5). Both fillers were added separately into the experimental adhesive at 0, 2.5, 5, and 10 wt.%. One group without Nb2O5·n H2O or Nb2O5 (0 wt.% of filler addition) was used as a control group. The formulated materials were analyzed for radiopacity according to the ISO 4049 and used FTIR analysis to assess the degree of conversion (DC) and the maximum polymerization rate (RPmax). Mechanical properties were analyzed by ultimate tensile strength (UTS) in a testing machine. Softening in solvent was conducted by measuring Knoop microhardness before and after immersion of samples in ethanol. Normality of data was assessed with Shapiro-Wilk, and comparisons between factors were conducted with two-way ANOVA and Tukey at 5% of significance. Both fillers, Nb2O5 or Nb2O5·n H2O, increased the radiopacity of dental adhesives in comparison to the unfilled adhesive (p < 0.05). There were no differences among groups for the ultimate tensile strength (p > 0.05), and all groups containing Nb2O5 or Nb2O5·n H2O improved the resistance against softening in solvent (p < 0.05). The groups with 5 and 10 wt% addition of Nb2O5 showed decreased DC compared to the control group (p < 0.05), while the addition of Nb2O5·nH2O up to 10 wt% did not alter the DC (p > 0.05). The polymerization rate did not change among groups (p > 0.05). In conclusion, Nb2O5·n H2O is a promising filler to be incorporated into dental adhesives providing proper mechanical properties, improved resistance against solvents, and increased radiopacity, without changing the DC.

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The response of skin perfusion and of rheological and immunological variables to intravenous prostanoid administration in Raynaud’s phenomenon secondary to collagenosis

VASA ◽

10.1024/0301-1526.34.4.243 ◽

2005 ◽

Vol 34 (4) ◽

pp. 243-249 ◽

Cited By ~ 2

Author(s):

Drinda ◽

Neumann ◽

Pöhlmann ◽

Vogelsang ◽

Stein ◽

...

Keyword(s):

Laser Doppler Flowmetry ◽

Raynaud’S Phenomenon ◽

Raynaud's Phenomenon ◽

Plasma Viscosity ◽

Laser Doppler ◽

Erythrocyte Aggregation ◽

Control Group ◽

Long Term Effects ◽

Doppler Flowmetry

Background: Prostanoids are used in the treatment of Raynaud’s phenomenon and acral perfusion disorders secondary to collagenosis. In subjective terms, intravenous administration of these agents produces success in more than 50% of patients. The therapeutic outcome of clinical administration of alprostadil or iloprost may vary from individual to individual. Patients and methods: The following variables were analysed in a cross-over study in 27 patients with collagenosis and Raynaud’s phenomenon: plasma viscosity and erythrocyte aggregation (rheological variables), partial pressure of oxygen and laser Doppler flowmetry in the finger region, and lymphocyte phenotyping and interleukin (IL) determinations (immunological variables). Results: Laser Doppler flowmetry revealed significant differences between patients with secondary Raynaud’s phenomenon and a control group of 25 healthy subjects. Laser Doppler readings did not change significantly as a result of the treatments. Therapy with iloprost produced a reduction in IL-1beta, L-selectin (CD 62 L) and IL-6. Conclusion: The change in immunological variables due to iloprost may explain the long-term effects of prostaglandins in the treatment of Raynaud’s phenomenon. From our results it is not possible to infer any preference for iloprost or alprostadil.

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Acute and Chronic Changes in Platelet Volume and Count After Cardiopulmonary Bypass Induced Thrombocytopenia in Man

Thrombosis and Haemostasis ◽

10.1055/s-0038-1651061 ◽

1987 ◽

Vol 57 (01) ◽

pp. 55-58 ◽

Cited By ~ 37

Author(s):

J F Martin ◽

T D Daniel ◽

E A Trowbridge

Keyword(s):

Platelet Count ◽

Mean Platelet Volume ◽

Artery Bypass ◽

Bypass Graft ◽

Control Group ◽

Artery Bypass Graft ◽

Platelet Volume ◽

Young Males ◽

The Mean

SummaryPatients undergoing surgery for coronary artery bypass graft or heart valve replacement had their platelet count and mean volume measured pre-operatively, immediately post-operatively and serially for up to 48 days after the surgical procedure. The mean pre-operative platelet count of 1.95 ± 0.11 × 1011/1 (n = 26) fell significantly to 1.35 ± 0.09 × 1011/1 immediately post-operatively (p <0.001) (n = 22), without a significant alteration in the mean platelet volume. The average platelet count rose to a maximum of 5.07 ± 0.66 × 1011/1 between days 14 and 17 after surgery while the average mean platelet volume fell from preparative and post-operative values of 7.25 ± 0.14 and 7.20 ± 0.14 fl respectively to a minimum of 6.16 ± 0.16 fl by day 20. Seven patients were followed for 32 days or longer after the operation. By this time they had achieved steady state thrombopoiesis and their average platelet count was 2.44 ± 0.33 × 1011/1, significantly higher than the pre-operative value (p <0.05), while their average mean platelet volume was 6.63 ± 0.21 fl, significantly lower than before surgery (p <0.001). The pre-operative values for the platelet volume and counts of these patients were significantly different from a control group of 32 young males, while the chronic post-operative values were not. These long term changes in platelet volume and count may reflect changes in the thrombopoietic control system secondary to the corrective surgery.

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Infrastructure mortgage in Russia: Opportunities and prospects

Voprosy Ekonomiki ◽

10.32609/0042-8736-2019-2-114-133 ◽

2019 ◽

pp. 114-133

Author(s):

G. I. Idrisov ◽

Y. Yu. Ponomarev

Keyword(s):

Federal Government ◽

Public Debt ◽

Budget Deficit ◽

Expert Assessment ◽

Inflation Expectations ◽

Direct Impact ◽

Long Run ◽

Gdp Growth Rate ◽

Negative Effect

The article shows that depending on the goals pursued by the federal government and the available interbudgetary tools a different design of infrastructure mortgage is preferable. Three variants of such mortgage in Russia are proposed, each of which is better suited for certain types of projects and uses different forms of subsidies. According to our expert assessment the active use of infrastructure mortgage in Russia can increase the average annual GDP growth rate by 0.5 p. p. on the horizon of 5—7 years. In the long run the growth of infrastructure financing through the use of infrastructure mortgage could increase long-term economic growth by 0.9 p. p., which in 20—30 years can add 20—30% of GDP to the economy. However, the change in the structure of budget expenditures in the absence of an increase in the budget deficit and public debt will cause no direct impact on monetary policy. The increase in the deficit and the build-up of public debt will have a negative effect on inflation expectations, which will require monetary tightening for a longer time to stabilize them.

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