scholarly journals Stimuli-Responsive Micelles with Detachable Poly(2-ethyl-2-oxazoline) Shell Based on Amphiphilic Polyurethane for Improved Intracellular Delivery of Doxorubicin

Polymers ◽  
2020 ◽  
Vol 12 (11) ◽  
pp. 2642
Author(s):  
Kang Xu ◽  
Xiaojun Liu ◽  
Leran Bu ◽  
Hena Zhang ◽  
Caihong Zhu ◽  
...  
Keyword(s):  
Disulfide Bonds ◽  
Biomedical Applications ◽  
Fluorescent Microscopy ◽  
Controlled Drug Delivery ◽  
Release Profile ◽  
C6 Cells ◽  
Stimuli Responsive ◽  
Trimethylene Carbonate ◽  
Ph Responsive ◽  
Drug Release Profile

Polyurethanes (PUs) have various biomedical applications including controlled drug delivery. However, the incompletely release of drug at tumor sites limits the efficiency of these drug loaded polyurethane micelles. Here we report a novel polymer poly(2-ethyl-2-oxazoline)-SS-polyurethane-SS-poly(2-ethyl-2-oxazoline) triblock polyurethane (PEtOz-PU(PTMCSS)-PEtOz). The hydrophilic pH-responsive poly(2-ethyl-2-oxazoline) was used as an end-block to introduce pH responsiveness, and the hydrophobic PU middle-block was easily synthesized by the reaction of poly (trimethylene carbonate) diol containing disulfide bonds (PTMC-SS-PTMC diol) and bis (2-isocyanatoethyl) disulfide (CDI). PEtOz-PU(PTMCSS)-PEtOz could self-assemble to form micelles (176 nm). The drug release profile of PEtOz-PU(PTMCSS)-PEtOz micelles loaded with Doxorubicin (DOX) was studied in the presence of acetate buffer (10 mM, pH 5.0) and 10 mM dithiothreitol (DTT). The results showed that under this environment, DOX-loaded polyurethane micelles could release DOX faster and more thoroughly, about 97% of the DOX was released from the DOX-loaded PEtOz-PU(PTMCSS)-PEtOz micelle. In addition, fluorescent microscopy and cell viability assays validated that the DOX-loaded polyurethane micelle strongly inhibits the growth of C6 cells, suggesting their potential as a new nanomedicine against cancer.

Biopolymer Encapsulation of CdTe Quantum Dot for In Vitro Controlled Drug Delivery Release of 6-Mercaptopurine

2012 ◽  
Vol 584 ◽  
pp. 258-262 ◽  
Author(s):  
Sundarrajan Parani ◽  
Baddireddi Subhadra Lakshmi ◽  
Kanniyan Pandian
Keyword(s):  
Drug Delivery ◽  
Folic Acid ◽  
Quantum Dot ◽  
Drug Carrier ◽  
Controlled Drug Delivery ◽  
Release Profile ◽  
Drug Release Profile ◽  
The Stability ◽  
Cdte Quantum Dot

Alginate biopolymer stabilized CdTe quantum dot (QD) was prepared and it was encapsulated with folic acid conjugated chitosan for controlled drug delivery of anticancer drug 6-mercaptopurine (6-MP). In addition to alginate, chitosan enhances the stability of QD. Also, in addition to chitosan, alginate binds to the drug leading to enhance the loading efficiency of the resulting drug carrier. The drug release profile of the carrier was investigated by in-vitro. The present study has shown that this drug carrier is feasible for drug delivery and will be important beneficiary for cancer therapy.

scholarly journals Microencapsulation for controlled drug delivery: a comprehensive review

2013 ◽  
Vol 1 (1) ◽  
pp. 48-54 ◽  
Author(s):  
AK Gupta ◽  
BK Dey
Keyword(s):  
Technical College ◽  
Review Paper ◽  
Controlled Drug Delivery ◽  
Release Profile ◽  
Scientific Journals ◽  
Drug Release Profile ◽  
Medical Treatments ◽  
Factors Affecting ◽  
Advantages And Disadvantages ◽  
General Aspects

Microencapsulation is described as a process of enclosing micron sized particles of solids or droplets of liquids or gasses in an inert shell, which in turn isolates and protects them from the external environment as well as control the drug release profile. Microencapsulated particle is having diameter between 3 [-] 800µm which differ them from other technologies such as nanotechnology and macroparticle in their morphology and internal structure. This review paper will address the background of microencapsulation technology, commonly used microencapsulation methods with its advantages and disadvantages and its applications in pharmaceutical field. This article also gives an overview on the general aspects and recent advances in drug-loaded microparticles to improve the efficiency of various medical treatments. The review paper will also address about the other factors affecting microencapsulation and its limitation. The article will also discuss about various findings described in the published scientific journals and patent literatures. Based on the existing results and authors’ reflection, this review gives rise to reasoning and suggested choices of process parameters and microencapsulation procedure.  DOI: http://dx.doi.org/10.3126/stcj.v1i1.8660  Sunsari Technical College Journal Vol.1(1) 2012 48-54

Chitosan-Coated Vitis viniferaL Mediated Gold Nanoparticles for Controlled Released of Anticancer Drug Doxorubicin

2017 ◽  
Vol 7 (03) ◽  
Author(s):  
Pradipta Das ◽  
Subash Das ◽  
Niranjan Rout ◽  
Umesh Kumar Parida
Keyword(s):  
Breast Cancer ◽  
Gold Nanoparticles ◽  
Drug Release ◽  
Breast Cancer Treatment ◽  
Release Profile ◽  
Ph Responsive ◽  
Drug Release Profile ◽  
Uv Visible ◽  
Controlled Released

In this study, we developed encapsulating doxorubicin (DOX) drug loaded CS coated Vitis viniferaL mediated gold nanoparticles (V-AuNPs) [DOX loaded CS coated-V-AuNPs]. V-AuNPs were characterized by UV-Visible spectrophotometer, FTIR, XRD, TEM. The DOX-loaded CS coated-V-AuNPs was evaluated by particle size, surface charge, entrapment efficacy, and effect of pH in drug release profile. Additionally, drug entrapment efficacy (EE) was up to 56%; CS-DOX- V-AuNPs showed a pH-responsive drug release in vitro. The DOX release was nearly 84% at pH 5.4 and 67% at pH 7.4.The current work proves the potential of pharmacology that involves a fusion of advanced techniques from nanoscience to develop the biology and used in the fields of drug delivery, Bio Sensor Manufacturing, Medical therapy and the development of DOX-loaded CS coated-V-AuNPs nanoparticle for sustained, controlled release and may be useful for breast cancer treatment.

Tuning Drug Release Profile from Nanoporous Gold Thin Films

2013 ◽  
Vol 1569 ◽  
pp. 259-263
Author(s):  
Ozge Kurtulus ◽  
Erkin Seker
Keyword(s):  
High Surface ◽  
High Surface Area ◽  
Volume Ratio ◽  
Controlled Drug Delivery ◽  
Release Profile ◽  
Nanoporous Gold ◽  
Pore Morphology ◽  
Drug Release Profile ◽  
Promising Candidate ◽  
Microfabrication Techniques

ABSTRACTNanoporous gold (np-Au) with its high surface area to volume ratio, tunable pore morphology, ease of surface modification with well-studied thiol chemistry, as well as integration with conventional microfabrication techniques is a promising candidate for controlled drug delivery studies. While it has been demonstrated that np-Au can retain and release drugs, release mechanisms and governing parameters are unclear. This paper reports on the effect of film thickness and morphology on the molecular release from np-Au films.

scholarly journals Dual stimuli-responsive polyphosphazene-based molecular gates for controlled drug delivery in lung cancer cells

RSC Advances ◽  
2020 ◽  
Vol 10 (46) ◽  
pp. 27305-27314
Author(s):  
Yolanda Salinas ◽  
Michael Kneidinger ◽  
Cristina Fornaguera ◽  
Salvador Borrós ◽  
Oliver Brüggemann ◽  
...  
Keyword(s):  
Lung Cancer ◽  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica Nanoparticles ◽  
Controlled Drug Delivery ◽  
Controlled Drug Release ◽  
Stimuli Responsive ◽  
Ph Responsive ◽  
Bottle Brush ◽  
Molecular Gates

Bottle-brush polyphosphazenes as dual, thermosensitive and pH responsive gatekeepers for mesoporous silica nanoparticles, and their use in controlled drug release.

Emerging Biomedical Applications of Algal Polysaccharides

2019 ◽  
Vol 25 (11) ◽  
pp. 1335-1344 ◽  
Author(s):  
Maryam Rahmati ◽  
Zahra Alipanahi ◽  
Masoud Mozafari
Keyword(s):  
Drug Delivery ◽  
Biomedical Applications ◽  
Drug Delivery Systems ◽  
Antimicrobial Properties ◽  
Controlled Drug Delivery ◽  
Delivery Systems ◽  
Stimuli Responsive ◽  
Swelling Properties ◽  
Gelling Properties ◽  
Algal Polysaccharides

Background: Over the past two decades, there have been substantial progress and a growing body of research on using natural polymeric biomaterials in emerging biomedical applications. Among different natural biopolymers, polysaccharides have gained considerable attraction among biomedical scientists and surgeons due to their biocompatibility, biodegradability, anti-inflammatory, and antimicrobial properties. In recent years, algalbased polysaccharides including agar, alginate, and carrageenan, have been broadly suggested for different biomedical applications. Methods: The aim of this paper is discussing various possible applications of algal-based polysaccharides in biomedical engineering particularly in controlled drug delivery systems. The main properties of each algal polysaccharide will be discussed, and particular drug delivery applications will be presented. Results: Algal polysaccharides can be detected in a group of photosynthetic unite as their key biomass constituents. They provide a range of variety in their size, shape, liquefaction, chemical stability, and crosslinking ability. In addition, algal polysaccharides have shown exceptional gelling properties including stimuli-responsive behavior, softness, and swelling properties. Conclusion: All the mentioned properties of alga polysaccharides lead to their successful usage in biomedical applications specially targeted and controlled drug delivery systems such as particles, capsules, and gels.

scholarly journals Strategy to design a smart photocleavable and pH sensitive chitosan based hydrogel through a novel crosslinker: a potential vehicle for controlled drug delivery

RSC Advances ◽  
2020 ◽  
Vol 10 (25) ◽  
pp. 14694-14704 ◽  
Author(s):  
Safiya Nisar ◽  
Ashiq Hussain Pandit ◽  
Li-Fang Wang ◽  
Sunita Rattan
Keyword(s):  
Drug Delivery ◽  
Controlled Drug Delivery ◽  
Ph Sensitive ◽  
Stimuli Responsive ◽  
Ph Responsive

We report the synthesis of a novel photocleavable crosslinker and its joining with amine-based polysachharides, viz. chitosan, resulting in the formation of a dual stimuli-responsive hydrogel having UV- and pH-responsive sites.

Biodegradable multi-blocked polyurethane micelles for intracellular drug delivery: the effect of disulfide location on the drug release profile

RSC Advances ◽  
2016 ◽  
Vol 6 (11) ◽  
pp. 9082-9089 ◽  
Author(s):  
Yongchao Yao ◽  
He Xu ◽  
Chang Liu ◽  
Yayuan Guan ◽  
Deqiu Xu ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Disulfide Bonds ◽  
Drug Carriers ◽  
Antitumor Drug ◽  
Release Profile ◽  
Drug Release Profile ◽  
Intracellular Drug Delivery

Polyurethane micelles with disulfide bonds positioned mainly either at the hydrophobic PCL junctions (PU-SS-C) or at the connections between the hydrophilic PEG and hydrophobic PCL blocks (PU-SS-I) were developed as a antitumor drug carriers.

Anticancer Nano Formulation of Imatinib with Chitosan Polymer

2019 ◽  
Vol 9 (01) ◽  
pp. 58-64
Author(s):  
Senthilnathan B ◽  
Billy Graham R ◽  
Chaarmila Sherin C ◽  
Vivekanandan K ◽  
Bhavya E
Keyword(s):  
Drug Release ◽  
Drug Targeting ◽  
Bone Marrow Failure ◽  
Lymphoblastic Leukemia ◽  
Release Profile ◽  
Nano Particles ◽  
Drug Release Profile ◽  
Study Results ◽  
Mast Cell Disease ◽  
Nano Formulation

Objective: Drug targeting is the capacity of the dosage form. In which the therapeutic agent acts specifically to desired site of action in the non-targeted tissue with the help of Nano particles is called as the drug targeting. IMATINIB is a used to treat cancer by chemo therapy. Cancers like chronic myeloid leukemia cancer (CML) and acute lymphoblastic leukemia cancer (ALL) and other specific types of gastrointestinal stromal cell tumor (GIST) systemic mast cell disease and Bone marrow failure disorder. It is administered by oral root. For ATP, Tyrosine kinase is act as a binding site. Methodology: The drug IMATINIB is loaded in the polymer chitosan, poly-(D) glucosamine is a bio compactible, bio degradable, nontoxic, antimicrobial and soluble in solvents. This preparation is done by emulsion-droplet coalescence method. Content of the Drug, Size of the particle and Zeta potential, Encapsulation efficiency and Drug release testing are described for this formulation in this study. Results: The Imatinib Nano particles were formulated and evaluated for its invitro drug release profile. Based on the invitro drug release profile of Imatinib nano particles formulation (INP1 – INP5) formulation INP3 was selected as the best formulation in which the particle size was 285.9nm. The invitro % drug release of INP3 formulation was 99.76 ± 0.82 and it was found to be the suitable formulation to manage the cancer. Conclusion: Hence it is concluded that the newly formulated controlled release nanoparticle drug delivery system of Imatinib may be idol and effective by allowing the drug to release continuously for 24 hrs.

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