scholarly journals pH/Thermo-Responsive Grafted Alginate-Based SiO2 Hybrid Nanocarrier/Hydrogel Drug Delivery Systems

Polymers ◽  
2021 ◽  
Vol 13 (8) ◽  
pp. 1228
Author(s):  
Nikolaos Theodorakis ◽  
Sofia-Falia Saravanou ◽  
Nikoleta-Paraskevi Kouli ◽  
Zacharoula Iatridi ◽  
Constantinos Tsitsilianis
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Release Kinetics ◽  
Ph Dependence ◽  
Sol Gel ◽  
Hybrid Nanoparticles ◽  
Random Copolymers ◽  
Layer By Layer ◽  
Degree Of Ionization ◽  
Hydrogel Composite

We report the preparation of mesoporous silica nanoparticles covered by layer by layer (LbL) oppositely charged weak polyelectrolytes, comprising poly(allylamine hydrochloride) (PAH) and a sodium alginate, highly grafted by N-isopropylacrylamide/N-tert-butylacrylamide random copolymers, NaALG-g-P(NIPAM90-co-NtBAM10) (NaALG-g). Thanks to the pH dependence of the degree of ionization of the polyelectrolytes and the LCST-type thermosensitivity of the grafting chains of the NaALG-g, the as-prepared hybrid nanoparticles (hNP) exhibit pH/thermo-responsive drug delivery capabilities. The release kinetics of rhodamine B (RB, model drug) can be controlled by the number of PAH/NaALG-g bilayers and more importantly by the environmental conditions, namely, pH and temperature. As observed, the increase of pH and/or temperature accelerates the RB release under sink conditions. The same NaALG-g was used as gelator to fabricate a hNP@NaALG-g hydrogel composite. This formulation forms a viscous solution at room temperature, and it is transformed to a self-assembling hydrogel (sol-gel transition) upon heating at physiological temperature provided that its Tgel was regulated at 30.7 °C, by the NtBAM hydrophobic monomer incorporation in the side chains. It exhibits excellent injectability thanks to its combined thermo- and shear-responsiveness. The hNP@NaALG-g hydrogel composite, encapsulating hNP covered with one bilayer, exhibited pH-responsive sustainable drug delivery. The presented highly tunable drug delivery system (DDS) (hNP and/or composite hydrogel) might be useful for biomedical potential applications.

Intrinsically Fluorescent Silica Nanocontainers: A Promising Theranostic Platform

2013 ◽  
Vol 19 (5) ◽  
pp. 1216-1221 ◽  
Author(s):  
Ana S. Rodrigues ◽  
Tânia Ribeiro ◽  
Fábio Fernandes ◽  
José Paulo S. Farinha ◽  
Carlos Baleizão
Keyword(s):  
Electron Microscopy ◽  
Drug Delivery ◽  
Mesoporous Silica Nanoparticles ◽  
Sol Gel ◽  
Mesoporous Structure ◽  
Hek293 Cells ◽  
Hybrid Nanoparticles ◽  
Fluorescent Properties ◽  
Template Removal ◽  
Transmission Electron

AbstractIn this paper we describe the preparation of fluorescent mesoporous silica nanoparticles (MSNs) for traceable drug delivery systems. The nanoparticles were prepared following a sol–gel procedure, incorporating a modified perylenediimide dye in the silica structure. Transmission electron microscopy and scanning electron microscopy show that the nanoparticles are monodispersed, with a spheroid shape and a raspberry-type surface morphology. The hybrid MSNs are robust, maintaining the mesoporous structure after template removal, with a pore diameter above 2 nm. A polymer shell was synthesized from the external surface of the hybrid nanoparticles by atom transfer radical polymerization, showing temperature-switchable collapsed/expanded conformation control. The fluorescent properties of the perylenediimide dye incorporated in the MSN pore walls are intact, and internalization in HEK293 cells shows that the nanoparticles are efficiently dispersed in the cytosol. These results show that the mesoporous fluorescent hybrid nanoparticles are an excellent platform for development of a traceable drug delivery system.

scholarly journals pH-Responsive Release of Ruthenium Metallotherapeutics from Mesoporous Silica-Based Nanocarriers

Pharmaceutics ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 460
Author(s):  
Minja Mladenović ◽  
Ibrahim Morgan ◽  
Nebojša Ilić ◽  
Mohamad Saoud ◽  
Marija V. Pergal ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Inductively Coupled Plasma ◽  
Drug Delivery Systems ◽  
Mesoporous Silica Nanoparticles ◽  
Release Kinetics ◽  
Delivery Systems ◽  
Emission Spectrometry ◽  
Ph Responsive

Ruthenium complexes are attracting interest in cancer treatment due to their potent cytotoxic activity. However, as their high toxicity may also affect healthy tissues, efficient and selective drug delivery systems to tumour tissues are needed. Our study focuses on the construction of such drug delivery systems for the delivery of cytotoxic Ru(II) complexes upon exposure to a weakly acidic environment of tumours. As nanocarriers, mesoporous silica nanoparticles (MSN) are utilized, whose surface is functionalized with two types of ligands, (2-thienylmethyl)hydrazine hydrochloride (H1) and (5,6-dimethylthieno[2,3-d]pyrimidin-4-yl)hydrazine (H2), which were attached to MSN through a pH-responsive hydrazone linkage. Further coordination to ruthenium(II) center yielded two types of nanomaterials MSN-H1[Ru] and MSN-H2[Ru]. Spectrophotometric measurements of the drug release kinetics at different pH (5.0, 6.0 and 7.4) confirm the enhanced release of Ru(II) complexes at lower pH values, which is further supported by inductively coupled plasma optical emission spectrometry (ICP-OES) measurements. Furthermore, the cytotoxicity effect of the released metallotherapeutics is evaluated in vitro on metastatic B16F1 melanoma cells and enhanced cancer cell-killing efficacy is demonstrated upon exposure of the nanomaterials to weakly acidic conditions. The obtained results showcase the promising capabilities of the designed MSN nanocarriers for the pH-responsive delivery of metallotherapeutics and targeted treatment of cancer.

scholarly journals Versatile Layer-By-Layer Highly Stable Multilayer Films: Study of the Loading and Release of FITC-Labeled Short Peptide in the Drug Delivery Field

Materials ◽  
2019 ◽  
Vol 12 (8) ◽  
pp. 1206 ◽  
Author(s):  
Kun Nie ◽  
Xiang Yu ◽  
Navnita Kumar ◽  
Yihe Zhang
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Multilayer Films ◽  
Layer By Layer ◽  
Guest Molecules ◽  
Potential Applications ◽  
Spatio Temporal ◽  
Release Speed

A viable short FITC-peptide immobilization is the most essential step in the fabrication of multilayer films based on FITC-peptide. These functional multilayer films have potential applications in drug delivery, medical therapy, and so forth. These FITC-peptides films needed to be handled with a lot of care and precision due to their sensitive nature. In this study, a general immobilization method is reported for the purpose of stabilizing various kinds of peptides at the interfacial regions. Utilizing Mesoporous silica nanoparticles can help in the preservation of these FITC-peptides by embedding themselves into these covalently cross-linked multilayers. This basic outlook of the multilayer films is potent enough and could be reused as a positive substrate. The spatio-temporal retention property of peptides can be modulated by varying the number of capping layers. The release speed of guest molecules such as tyrosine within FITC-peptide or/and adamantane (Ad)-in short peptides could also be fine-tuned by the specific arrangements of the multilayers of mesoporous silica nanoparticles (MSNs) and hyaluronic acid- cyclodextrin (HA-CD) multilayer films.

Sol-gel processing of drug delivery materials and release kinetics

2005 ◽  
Vol 16 (3) ◽  
pp. 261-265 ◽  
Author(s):  
F. De Gaetano ◽  
L. Ambrosio ◽  
M. G. Raucci ◽  
A. Marotta ◽  
M. Catauro
Keyword(s):  
Drug Delivery ◽  
Release Kinetics ◽  
Sol Gel ◽  
Gel Processing

scholarly journals Study on adenosine loading capacity of porous nanosilica for application in drug delivery

2020 ◽  
Vol 5 (1) ◽  
pp. first
Author(s):  
Dat Ngoc Xuan Mai ◽  
Lua Thi Xuan Danh ◽  
Huy Dinh Minh Dang ◽  
Ha Van Nguyen ◽  
Hanh Thi Kieu Ta ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Surface Area ◽  
Mesoporous Silica Nanoparticles ◽  
Sol Gel ◽  
Material Structure ◽  
Loading Capacity ◽  
Release Process ◽  
Adenosine Concentration ◽  
Ft Ir ◽  
Mcm 41

Mesoporous silica nanoparticles (MSNs) are used as drug delivery materials because of their outstanding features such as large surface area, easy synthesis and high biocompability. In this study, inorganic mesoporous nanosilica material, MCM-41, was synthesized by sol-gel hydrothermal method using tetraethyl orthosilicate precursor (TEOS). The material structure and composition were analyzed by X-ray power diffraction (P-XRD), N2 adsorption isotherm, thermalgravimetric analysis (TGA) and Fourier-transform infrared spectroscopy (FT-IR). Its morphology was examined by scanning electron microscopy (SEM) and transmission electron microscope (TEM). The results showed that synthesized MCM-41 has a spherical shape, homogeneous with an average size of 100 nm. The specific surface area is 845 m2 g􀀀1, the pore size is approximately 35 Å. It has high thermal stability until 800oC. FT-IR result showed the formation of the Si-O-Si bond in the structure. The adenosine loading capacity of MCM-41 was investigated based on the influence of loading factors including adenosine concentration, time, solvent, and temperature. The kinetics and thermodynamics of the adsorption processes were also studied. The adenosine loading ability on MCM-41 is significant high, approximately 1699 mg g􀀀1. The kinetic and thermodynamic results showed that the drug adsorbed of MCM-41 occurred with fast rate and spontaneously. Moreover, the release profile of adenosine proved that the drug release process occurred quickly which is suitable for application in acute disease treatment.

Mesoporous Silica Nanoparticles as a Prospective and Promising Approach for Drug Delivery and Biomedical Applications

2019 ◽  
Vol 19 (4) ◽  
pp. 285-295 ◽  
Author(s):  
Xiaohui Pu ◽  
Jia Li ◽  
Peng Qiao ◽  
Mengmeng Li ◽  
Haiyan Wang ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Biomedical Applications ◽  
Mesoporous Silica Nanoparticles ◽  
Release Kinetics ◽  
Drug Loading ◽  
Synthetic Methods ◽  
Pubmed Database ◽  
Modified Surface

Background: With the development of nanotechnology, nanocarrier has widely been applied in such fields as drug delivery, diagnostic and medical imaging and engineering in recent years. Among all of the available nanocarriers, mesoporous silica nanoparticles (MSNs) have become a hot issue because of their unique properties, such as large surface area and voidage, tunable drug loading capacity and release kinetics, good biosafety and easily modified surface. Objective: We described the most recent progress in silica-assisted drug delivery and biomedical applications according to different types of Cargo in order to allow researchers to quickly learn about the advance in this field. Methods: Information has been collected from the recently published literature available mainly through Title or Abstract search in SpringerLink and PubMed database. Special emphasis is on the literature available during 2008-2017. Results: In this review, the major research advances of MSNs on the drug delivery and biomedical applications were summarized. The significant advantages of MSNs have also been listed. It was found that the several significant challenges need to be addressed and investigated to further advance the applications of these structurally defined nanomaterials. Conclusion: Through approaching this review, the researchers can be aware of many new synthetic methods, smart designs proposed in the recent year and remaining questions of MSNs at present.

scholarly journals Sterically Stabilised Polymeric Mesoporous Silica Nanoparticles Improve Doxorubicin Efficiency: Tailored Cancer Therapy

Molecules ◽  
2020 ◽  
Vol 25 (3) ◽  
pp. 742 ◽  
Author(s):  
Thashini Moodley ◽  
Moganavelli Singh
Keyword(s):  
Drug Delivery ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Mesoporous Silica Nanoparticles ◽  
Release Kinetics ◽  
Drug Delivery Vehicles ◽  
Biological Compatibility ◽  
Delivery Vehicles ◽  
Efficient Loading ◽  
Kinetics Of

The fruition, commercialisation and clinical application combining nano-engineering, nanomedicine and material science for utilisation in drug delivery is becoming a reality. The successful integration of nanomaterial in nanotherapeutics requires their critical development to ensure physiological and biological compatibility. Mesoporous silica nanoparticles (MSNs) are attractive nanocarriers due to their biodegradable, biocompatible, and relative malleable porous frameworks that can be functionalized for enhanced targeting and delivery in a variety of disease models. The optimal formulation of an MSN with polyethylene glycol (2% and 5%) and chitosan was undertaken, to produce sterically stabilized, hydrophilic MSNs, capable of efficient loading and delivery of the hydrophobic anti-neoplastic drug, doxorubicin (DOX). The pH-sensitive release kinetics of DOX, together with the anticancer, apoptosis and cell-cycle activities of DOX-loaded MSNs in selected cancer cell lines were evaluated. MSNs of 36–60 nm in size, with a pore diameter of 9.8 nm, and a cumulative surface area of 710.36 m2/g were produced. The 2% pegylated MSN formulation (PCMSN) had the highest DOX loading capacity (0.98 mgdox/mgmsn), and a sustained release profile over 72 h. Pegylated-drug nanoconjugates were effective at a concentration range between 20–50 μg/mL, inducing apoptosis in cancer cells, and affirming their potential as effective drug delivery vehicles.

scholarly journals Development of Bioadhesive Chitosan Superporous Hydrogel Composite Particles Based Intestinal Drug Delivery System

2013 ◽  
Vol 2013 ◽  
pp. 1-10 ◽  
Author(s):  
Hitesh Chavda ◽  
Ishan Modhia ◽  
Anant Mehta ◽  
Rupal Patel ◽  
Chhagan Patel
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Drug Delivery System ◽  
Delivery System ◽  
Drug Transport ◽  
Release Kinetics ◽  
Hydrogel Composite ◽  
Intestinal Delivery ◽  
Superporous Hydrogel

Bioadhesive superporous hydrogel composite (SPHC) particles were developed for an intestinal delivery of metoprolol succinate and characterized for density, porosity, swelling, morphology, and bioadhesion studies. Chitosan and HPMC were used as bioadhesive and release retardant polymers, respectively. A 32full factorial design was applied to optimize the concentration of chitosan and HPMC. The drug loaded bioadhesive SPHC particles were filled in capsule, and the capsule was coated with cellulose acetate phthalate and evaluated for drug content,in vitrodrug release, and stability studies. To ascertain the drug release kinetics, the drug release profiles were fitted for mathematical models. The prepared system remains bioadhesive up to eight hours in intestine and showed Hixson-Crowell release with anomalous nonfickian type of drug transport. The application of SPHC polymer particles as a biomaterial carrier opens a new insight into bioadhesive drug delivery system and could be a future platform for other molecules for intestinal delivery.

Layer-by-layer coated lipid–polymer hybrid nanoparticles designed for use in anticancer drug delivery

2014 ◽  
Vol 102 ◽  
pp. 653-661 ◽  
Author(s):  
Thiruganesh Ramasamy ◽  
Tuan Hiep Tran ◽  
Ju Yeon Choi ◽  
Hyuk Jun Cho ◽  
Jeong Hwan Kim ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Anticancer Drug ◽  
Hybrid Nanoparticles ◽  
Layer By Layer ◽  
Anticancer Drug Delivery ◽  
Polymer Hybrid

scholarly journals Mesoporous silica–chondroitin sulphate hybrid nanoparticles for targeted and bio-responsive drug delivery

2015 ◽  
Vol 39 (3) ◽  
pp. 1754-1760 ◽  
Author(s):  
Krishna Radhakrishnan ◽  
Jasaswini Tripathy ◽  
Akshay Datey ◽  
Dipshikha Chakravortty ◽  
Ashok M. Raichur
Keyword(s):  
Drug Delivery ◽  
Drug Release ◽  
Mesoporous Silica ◽  
Silica Nanoparticles ◽  
Cancer Cells ◽  
Chondroitin Sulphate ◽  
Mesoporous Silica Nanoparticles ◽  
Hybrid Nanoparticles ◽  
Intracellular Degradation

A polysaccharide based gatekeeper is attached to seal the nanopores of drug mesoporous silica nanoparticles, which facilitates uptake by cancer cells and undergoes intracellular degradation to initiate drug release.

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