scholarly journals Evaluating the Anticarcinogenic Activity of Surface Modified/Functionalized Nanochitosan: The Emerging Trends and Endeavors

Polymers ◽  
2021 ◽  
Vol 13 (18) ◽  
pp. 3138
Author(s):  
Jae-Wook Oh ◽  
Juhyun Shin ◽  
Sechul Chun ◽  
Manikandan Muthu ◽  
Judy Gopal
Keyword(s):  
Biomedical Applications ◽  
Chitosan Nanoparticles ◽  
Future Perspective ◽  
Modified Chitosan ◽  
Scientific Curiosity ◽  
Emerging Trends ◽  
Attractive Option ◽  
Marine Food ◽  
Surface Modified ◽  
The Ideal

Chitosan begins its humble journey from marine food shell wastes and ends up as a versatile nutraceutical. This review focuses on briefly discussing the antioxidant activity of chitosan and retrospecting the accomplishments of chitosan nanoparticles as an anticarcinogen. The various modified/functionalized/encapsulated chitosan nanoparticles and nanoforms have been listed and their biomedical deliverables presented. The anticancer accomplishments of chitosan and its modified composites have been reviewed and presented. The future of surface modified chitosan and the lacunae in the current research focus have been discussed as future perspective. This review puts forth the urge to expand the scientific curiosity towards attempting a variety of functionalization and surface modifications to chitosan. There are few well known modifications and functionalization that benefit biomedical applications that have been proven for other systems. Being a biodegradable, biocompatible polymer, chitosan-based nanomaterials are an attractive option for medical applications. Therefore, maximizing expansion of its bioactive properties are explored. The need for applying the ideal functionalization that will significantly promote the anticancer contributions of chitosan nanomaterials has also been stressed.

Glycyrrhizin surface-modified chitosan nanoparticles for hepatocyte-targeted delivery

2008 ◽  
Vol 359 (1-2) ◽  
pp. 247-253 ◽  
Author(s):  
Aihua Lin ◽  
Yiming Liu ◽  
Yu Huang ◽  
Jingbo Sun ◽  
Zhifeng Wu ◽  
...  
Keyword(s):  
Targeted Delivery ◽  
Chitosan Nanoparticles ◽  
Modified Chitosan ◽  
Surface Modified

Intranasal dexmedetomidine: the ideal drug for sedation in the pediatric echo lab?

2021 ◽  
pp. 1-5
Author(s):  
David E Saudek ◽  
Deborah Walbergh ◽  
Peter Bartz ◽  
Sara Shreve ◽  
Amy Schaal ◽  
...  
Keyword(s):  
Heart Rate ◽  
Heart Disease ◽  
Chart Review ◽  
Chloral Hydrate ◽  
Vital Signs ◽  
Cyanotic Heart Disease ◽  
Historical Cohort ◽  
Safety And Efficacy ◽  
Attractive Option ◽  
The Ideal

Abstract Background: Intranasal dexmedetomidine is an attractive option for procedural sedation in pediatrics due to ease of administration and its relatively short half-life. This study sought to compare the safety and efficacy of intranasal dexmedetomidine to a historical cohort of pediatric patients sedated using chloral hydrate in a pediatric echo lab. Methods: Chart review was performed to compare patients sedated between September, 2017 and October, 2019 using chloral hydrate and intranasal dexmedetomidine. Vital signs, time to sedation, duration of sedation, need for second dose of medication, rate of failed sedation, and impact on vital signs were compared between groups. Subgroup analysis was performed for those with complex and cyanotic heart disease. Results: Chloral hydrate was used in 356 patients and intranasal dexmedetomidine in 376. Patient age, complexity of heart disease, and duration of sedation were similar. Rates of failed sedation were very low and similar. Average heart rate and minimum heart rate were lower for those receiving intranasal dexmedetomidine than chloral hydrate. Impact on vital signs was similar for those with complex and cyanotic heart disease. No adverse events occurred in either group. Conclusions: Sedation with intranasal dexmedetomidine is comparable to chloral hydrate in regards to safety and efficacy for children requiring echocardiography. Consistent with the mechanism of action, patients receiving intranasal dexmedetomidine have a lower heart rate without morbidity.

scholarly journals Characterization of Epigallocatechin-Gallate-Grafted Chitosan Nanoparticles and Evaluation of Their Antibacterial and Antioxidant Potential

Polymers ◽  
2021 ◽  
Vol 13 (9) ◽  
pp. 1375
Author(s):  
María J. Moreno-Vásquez ◽  
Maribel Plascencia-Jatomea ◽  
Saúl Sánchez-Valdes ◽  
Judith C. Tanori-Córdova ◽  
Francisco J. Castillo-Yañez ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Food Packaging ◽  
Inhibitory Concentration ◽  
Antioxidant Activities ◽  
Bacterial Species ◽  
Chitosan Nanoparticles ◽  
Epigallocatechin Gallate ◽  
Antioxidant Power ◽  
Ferric Reducing Antioxidant Power

Nanoparticles based on chitosan modified with epigallocatechin gallate (EGCG) were synthetized by nanoprecipitation (EGCG-g-chitosan-P). Chitosan was modified by free-radical-induced grafting, which was verified by Fourier transform infrared (FTIR). Furthermore, the morphology, particle size, polydispersity index, and zeta potential of the nanoparticles were investigated. The grafting degree of EGCG, reactive oxygen species (ROS) production, antibacterial and antioxidant activities of EGCG-g-chitosan-P were evaluated and compared with those of pure EGCG and chitosan nanoparticles (Chitosan-P). FTIR results confirmed the modification of the chitosan with EGCG. The EGCG-g-chitosan-P showed spherical shapes and smoother surfaces than those of Chitosan-P. EGCG content of the grafted chitosan nanoparticles was 330 μg/g. Minimal inhibitory concentration (MIC) of EGCG-g-chitosan-P (15.6 μg/mL) was lower than Chitosan-P (31.2 μg/mL) and EGCG (500 μg/mL) against Pseudomonas fluorescens (p < 0.05). Additionally, EGCG-g-chitosan-P and Chitosan-P presented higher Staphylococcus aureus growth inhibition (100%) than EGCG at the lowest concentration tested. The nanoparticles produced an increase of ROS (p < 0.05) in both bacterial species assayed. Furthermore, EGCG-g-chitosan-P exhibited higher antioxidant activity than that of Chitosan-P (p < 0.05) in 2,2′-azino-bis (3-ethyl-benzothiazoline-6-sulfonic acid) (ABTS), 2,2-diphenyl-1-picrylhydrazyl radical (DPPH) and ferric-reducing antioxidant power assays. Based on the above results, EGCG-g-chitosan-P shows the potential for food packaging and biomedical applications.

scholarly journals Application of Magnetic Nano Particles and their Composites as Adsorbents for Waste Water Treatment: A Brief Review

2021 ◽  
pp. 246-278
Author(s):  
M. Dhiman
Keyword(s):  
Waste Water ◽  
Water Treatment ◽  
Waste Water Treatment ◽  
Nano Particles ◽  
Future Perspective ◽  
Isotherm Models ◽  
Water And Wastewater Treatment ◽  
The Future ◽  
Potential Applications ◽  
Surface Modified

The present review highlights the different types of nano ferrites and their surface modified composites as an alternative adsorbent in waste water treatment. In this review, the recent progresses and potential applications of SFNPs/SFNCs for the removal of organic and inorganic contaminants through adsorption routes are critically reviewed. There are number of water purification techniques but the adsorption is one of the simplest, effective and economical method for wastewater purification. Adsorption isotherm models, kinetic models, thermodynamic parameters and adsorption mechanism have also been discussed. The present article lists different type of adsorbents and reviews state-of-the-art of the removal of different pollutants from water. The efforts have been made to discuss the sources of contamination and toxicities of pollutants. The possible techniques of recovery and reuse, toxicity, research gaps and the future perspective of SFNPs are also discussed in brief. Based on this review, it is possible to conclude that SFNPs and their derivative composites have unlimited capacity in addressing array of problems encountered in water and wastewater treatment. The present study highlights the future areas of research for waste water treatment.

scholarly journals Using Chitosan or Chitosan Derivatives in Cancer Therapy

2021 ◽  
Vol 2 (4) ◽  
pp. 795-816
Author(s):  
Md Salman Shakil ◽  
Kazi Mustafa Mahmud ◽  
Mohammad Sayem ◽  
Mahruba Sultana Niloy ◽  
Sajal Kumar Halder ◽  
...  
Keyword(s):  
Drug Delivery ◽  
Cancer Therapy ◽  
Anticancer Agents ◽  
Chitosan Nanoparticles ◽  
Chemotherapeutic Drugs ◽  
Chitosan Derivatives ◽  
Drug Delivery Vehicles ◽  
Modified Chitosan ◽  
Therapeutic Benefits ◽  
Delivery Vehicles

Cancer is one of the major causes of death worldwide. Chemotherapeutic drugs have become a popular choice as anticancer agents. Despite the therapeutic benefits of chemotherapeutic drugs, patients often experience side effects and drug resistance. Biopolymers could be used to overcome some of the limitations of chemotherapeutic drugs, as well as be used either as anticancer agents or drug delivery vehicles. Chitosan is a biocompatible polymer derived from chitin. Chitosan, chitosan derivatives, or chitosan nanoparticles have shown their promise as an anticancer agent. Additionally, functionally modified chitosan can be used to deliver nucleic acids, chemotherapeutic drugs, and anticancer agents. More importantly, chitosan-based drug delivery systems improved the efficacy, potency, cytotoxicity, or biocompatibility of these anticancer agents. In this review, we will investigate the properties of chitosan and chemically tuned chitosan derivatives, and their application in cancer therapy.

Chitosan Nanoparticles: An Overview on Preparation, Characterization and Biomedical Applications

2021 ◽  
pp. 393-427
Author(s):  
Arundathi Mesa ◽  
Grace Sugandha Sowjanya Mythatha ◽  
Rathna Silviya Lodi ◽  
Sudheer Ravuri ◽  
Ramesh Balli
Keyword(s):  
Biomedical Applications ◽  
Chitosan Nanoparticles

scholarly journals Growing prospects of DNA nanomaterials in novel biomedical applications

RSC Advances ◽  
2019 ◽  
Vol 9 (29) ◽  
pp. 16479-16491 ◽  
Author(s):  
Zhiguang Suo ◽  
Jingqi Chen ◽  
Xialing Hou ◽  
Ziheng Hu ◽  
Feifei Xing ◽  
...  
Keyword(s):  
Biomedical Applications ◽  
Recent Progress ◽  
Logic Gates ◽  
Future Perspective ◽  
Molecular Logic ◽  
Molecular Logic Gates

Recent progress in DNA-based nanomaterials is summarized, ranging from applications in biosensors, biomedicine/imaging, and molecular logic gates to emerging nanomachines, as well as future perspective discussions.

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