Simulation Study on Performance Optimization of Magnetic Nanoparticles DC Thermometry Model

Magnetic nanoparticles (MNPs) can work as temperature sensors to realize temperature measurement due to the excellent temperature sensitivity of their magnetization. This paper mainly reports on a performance optimization method of MNPs DC thermometry model. Firstly, by exploring the influencing factors of MNPs magnetization temperature sensitivity, it is found that the optimal excitation of the magnetic field to make the temperature sensitivity of MNPs reach their optimal value is, approximately, inversely proportional to the particle size of MNPs. Then, the temperature sensitivity of MNP magnetization is modulated by adding appropriate DC bias magnetic field in the original triangular wave excitation field, to optimize the original DC thermometry model based on MNP magnetization. The simulation results show that the temperature measurement performance of small-size MNPs can be significantly improved. In short, this paper optimizes the temperature measurement performance of the original DC thermometry model based on MNP magnetization and provides a new application idea for temperature measurement of small-size MNPs.

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In Vitro Evaluation of Capturing and Dissolving the Clot by Magnetic Nanoparticles Carrying a Thrombolytic Agents Instead of Temporary Inferior Vena Cava (IVC) Filter

Journal of Biomedical Nanotechnology ◽

10.1166/jbn.2020.29941623 ◽

2020 ◽

Vol 16 (11) ◽

pp. 1623-1632

Author(s):

Abbas Moghanizadeh ◽

Fakhreddin Ashrafizadeh ◽

Jaleh Varshousaz ◽

Mahshid Kharaziha

Keyword(s):

Magnetic Field ◽

Magnetic Nanoparticles ◽

Vena Cava ◽

Simple Method ◽

Thrombolytic Agents ◽

Blood Clots ◽

Life Threatening ◽

The Magnetic Field ◽

Different Levels

This study aims to evaluate the efficiency of a novel in vitro technique in clot capturing and dissolving them by applying magnetic force on magnetic nanoparticles (MNP) carrying thrombolytic agents. It is a quick and simple method to protect patients from a life-threatening pulmonary embolism in an emergency to provide time for the medical team. To analyze the in vitro efficiency of nano-magnetic capturing and dissolving of clots (NCDC), different levels of process parameter including strength magnetic field (0.1, 0.2 and 0.3 T) and fluid flow rate (2.5, 5 and 7 l/min) are exposed to different blood clots sizes from 5 × 10 to 20 × 10 mm2 (length × diameter), in an in vitro flow model. The results show that by increasing the parameters to their maximum values, it is possible to immobilize 100% of the clots and dissolve around 61.4% of clots weight. In addition, the clot-dissolving is directly proportional to the magnetic field strength. NCDC is an efficient technique in immobilizing and dissolving the clots and its efficiency depends on process parameters especially the magnetic field.

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Remote manipulation of magnetic nanoparticles using magnetic field gradient to promote cancer cell death

10.1101/317115 ◽

2018 ◽

Author(s):

Mahendran Subramanian ◽

Arkadiusz Miaskowski ◽

Stuart Iain Jenkins ◽

Jenson Lim ◽

Jon Dobson

Keyword(s):

Magnetic Field ◽

Magnetic Nanoparticles ◽

Field Gradient ◽

Biomedical Applications ◽

Magnetic Field Gradient ◽

Field Source ◽

Remote Manipulation ◽

Cancer Cell Death ◽

The Magnetic Field

AbstractThe manipulation of magnetic nanoparticles (MNPs) using an external magnetic field, has been demonstrated to be useful in various biomedical applications. Some techniques have evolved utilizing this non-invasive external stimulus but the scientific community widely adopts few, and there is an excellent potential for more novel methods. The primary focus of this study is on understanding the manipulation of MNPs by a time-varying static magnetic field and how this can be used, at different frequencies and displacement, to manipulate cellular function. Here we explore, using numerical modeling, the physical mechanism which underlies this kind of manipulation, and we discuss potential improvements which would enhance such manipulation with its use in biomedical applications, i.e., increasing the MNP response by improving the field parameters. From our observations and other related studies, we infer that such manipulation depends mostly on the magnetic field gradient, the magnetic susceptibility and size of the MNPs, the magnet array oscillating frequency, the viscosity of the medium surrounding MNPs, and the distance between the magnetic field source and the MNPs. Additionally, we demonstrate cytotoxicity in neuroblastoma (SH-SY5Y) and hepatocellular carcinoma (HepG2) cells in vitro. This was induced by incubation with MNPs, followed by exposure to a magnetic field gradient, physically oscillating at various frequencies and displacement amplitudes. Even though this technique reliably produces MNP endocytosis and/or cytotoxicity, a better biophysical understanding is required to develop the mechanism used for this precision manipulation of MNPs, in vitro.

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BIREFRINGENCE AND MAGNETO-OPTICAL PROPERTIES IN OLEIC ACID COATED Fe3O4 NANOPARTICLES: APPLICATION FOR OPTICAL SWITCH

International Journal of Nanoscience ◽

10.1142/s0219581x11008289 ◽

2011 ◽

Vol 10 (03) ◽

pp. 515-520 ◽

Cited By ~ 14

Author(s):

SI-HUA XIA ◽

JUN WANG ◽

ZHANG-XIAN LU ◽

FEIYAN ZHANG

Keyword(s):

Magnetic Field ◽

Optical Properties ◽

Oleic Acid ◽

Magnetic Nanoparticles ◽

Magnetic Nanoparticle ◽

Optical Switch ◽

Colloidal Suspension ◽

Experimental Parameters ◽

Nanoparticle Chains ◽

The Magnetic Field

We report magneto-optical properties in a kerosene colloidal suspension of oleic acid coated Fe3O4 nanoparticles (~14 nm). The magnetic colloids (fluids) show birefringence under a magnetic field. Systematical studies of the on–off switch times upon application of the on–off magnetic field with varied experimental parameters indicate that the switch response time depends strongly on the strength of the magnetic field and the concentration of the magnetic nanoparticles in the fluid. The data can be explained in terms of the formation of magnetic nanoparticle chains under a magnetic field. The important magneto-optical properties of the magnetic fluids allow us to design a tunable optical switch.

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Targeting Magnetic Nanoparticles in High Magnetic Fields for Drug Delivery Purposes

MRS Proceedings ◽

10.1557/proc-820-o3.8 ◽

2004 ◽

Vol 820 ◽

Cited By ~ 3

Author(s):

Ramazan Asmatulu ◽

Richard.O. Claus ◽

Judy S. Riffle ◽

Michael Zalich

Keyword(s):

Magnetic Field ◽

Drug Delivery ◽

Magnetic Nanoparticles ◽

Magnetic Fields ◽

Magnetic Particles ◽

Guidance System ◽

Test Results ◽

Test Parameters ◽

Magnetic Guidance ◽

The Magnetic Field

AbstractBiodegradable magnetic nanoparticles were synthesized using Poly(L-Lactic Acid) and magnetite nanoparticles (∼14 nm) at different dosages, and then these nanaoparticles (nanocomposites) and pure magnetic particles were targeted in external magnetic fields by changing the test parameters. The magnetic field test results showed that magnetic saturation, fluid speed, magnetic field distance and particle size were extremely effective for a magnetic guidance system that is needed for an effective drug delivery approach. Thus, it is assumed that such nanoparticles can carry drugs (chemotherapy) to be able to cure cancer tumors as well as many other diseases.

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Magnetic Assistance for Suppressing Cross-Reactions Between Biomolecules in Immunoassay

Volume 4: 12th International Conference on Advanced Vehicle and Tire Technologies; 4th International Conference on Micro- and Nanosystems ◽

10.1115/detc2010-28040 ◽

2010 ◽

Author(s):

Chin-Yih Hong ◽

Shieh-Yueh Yang ◽

Herng-Er Horng ◽

Hong-Chang Yang

Keyword(s):

Magnetic Field ◽

Magnetic Nanoparticles ◽

Centrifugal Force ◽

Applied Magnetic Field ◽

Cross Reactions ◽

Target Molecules ◽

The Cross ◽

Alternative Current ◽

The Magnetic Field ◽

Current Magnetic Field

A method involving the use of magnetic nanoparticles to suppress the cross-reactions in immunoassay is developed. Antibodies are coated onto magnetic nanoparticles. These antibodies bind with target and non-target molecules. Once an alternative-current magnetic field is applied, magnetic nanoparticles oscillate with the magnetic field. The target and non-target molecules attached onto magnetic nanoparticles via antibodies experience a centrifugal force, which is against the association between antibodies and target/non-target molecules. Theoretically, the centrifugal force is proportional to the square of the frequency of the applied magnetic field. Thus, the strength of the centrifugal force can be manipulated by changing the frequency of the applied magnetic field. By well controlling the frequency of applied magnetic field, the centrifugal force can be stronger than the binding between antibodies and non-target molecules, but still weaker than that of target molecules. Consequently, the binding between antibodies and non-target molecules is broken by the centrifugal force.

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Fe2Co2Nb2O9: a magnetoelectric honeycomb antiferromagnet

Journal of Materials Chemistry C ◽

10.1039/d1tc02950a ◽

2021 ◽

Author(s):

Antoine Maignan ◽

Christine Martin ◽

Elodie Tailleur ◽

Françoise Damay ◽

Maxim Mostovoy ◽

...

Keyword(s):

Magnetic Field ◽

Random Distribution ◽

Electric Polarization ◽

Microscopic Model ◽

Model Based ◽

The Magnetic Field

In Fe2Co2Nb2O9, magneto-electric ME poling induces below TN an electric polarization P whose magnitude increases with the magnetic field H. Large P values and steep P responses to H are explained by a microscopic model based on the random distribution of Fe and Co.

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Performance Optimization Method of Wireless Power Transfer System Based on Magnetic Field Editing

10.1109/aemcse51986.2021.00010 ◽

2021 ◽

Author(s):

Cheng Ming ◽

Luo Yanting ◽

Yang Yongmin ◽

Zhang Yingchun ◽

Xu Yingxiao

Keyword(s):

Magnetic Field ◽

Performance Optimization ◽

Wireless Power Transfer ◽

Optimization Method ◽

Transfer System ◽

Power Transfer ◽

Wireless Power ◽

Wireless Power Transfer System

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A Magnetically Actuated Drug Delivery System for Robotic Endoscopic Capsules

Journal of Medical Devices ◽

10.1115/1.4031811 ◽

2015 ◽

Vol 10 (1) ◽

Cited By ~ 7

Author(s):

Fredy Munoz ◽

Gursel Alici ◽

Weihua Li

Keyword(s):

Magnetic Field ◽

Drug Delivery ◽

Drug Delivery System ◽

Delivery System ◽

Optimization Method ◽

Analytical Models ◽

Magnetically Actuated ◽

Controlled Drug Delivery System ◽

The Magnetic Field ◽

Crank Mechanism

There is an increasing need to incorporate an actively controlled drug delivery system (DDS) into the next generation of capsule endoscopy in order to treat diseases in the gastrointestinal tract in a noninvasive way. Despite a number of attempts to magnetically actuate drug delivery mechanisms embedded in endoscopic capsules, longer operating distances and further miniaturization of on-board components are still drawbacks of such systems. In this paper, we propose an innovative magnetic system that consists of an array of magnets, which activates a DDS, based on an overly miniaturized slider–crank mechanism. We use analytical models to compare the magnetic fields generated by cylindrical and arc-shaped magnets. Our experimental results, which are in agreement with the analytical results, show that an optimally configured array of the magnets enhances the magnetic field and also the driving magnetic torque and subsequently, it imposes a high enough force on the piston of the DDS to expel a required dose of a drug out of a reservoir. We conclude that the proposed magnetic field optimization method is effective in establishing an active DDS that is designed to deliver drug profiles with accurate control of the release rate, release amount, and number of doses.

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