scholarly journals Field-Effect Sensors Using Biomaterials for Chemical Sensing

Sensors ◽  
2021 ◽  
Vol 21 (23) ◽  
pp. 7874
Author(s):  
Chunsheng Wu ◽  
Ping Zhu ◽  
Yage Liu ◽  
Liping Du ◽  
Ping Wang
Keyword(s):  
Chemical Sensing ◽  
Field Effect ◽  
High Sensitivity ◽  
Research Field ◽  
Chemical Substances ◽  
Natural Systems ◽  
Sensing Systems ◽  
Potential Applications ◽  
Functional Biomaterials ◽  
Light Addressable Potentiometric Sensor

After millions of years of evolution, biological chemical sensing systems (i.e., olfactory and taste systems) have become very powerful natural systems which show extreme high performances in detecting and discriminating various chemical substances. Creating field-effect sensors using biomaterials that are able to detect specific target chemical substances with high sensitivity would have broad applications in many areas, ranging from biomedicine and environments to the food industry, but this has proved extremely challenging. Over decades of intense research, field-effect sensors using biomaterials for chemical sensing have achieved significant progress and have shown promising prospects and potential applications. This review will summarize the most recent advances in the development of field-effect sensors using biomaterials for chemical sensing with an emphasis on those using functional biomaterials as sensing elements such as olfactory and taste cells and receptors. Firstly, unique principles and approaches for the development of these field-effect sensors using biomaterials will be introduced. Then, the major types of field-effect sensors using biomaterials will be presented, which includes field-effect transistor (FET), light-addressable potentiometric sensor (LAPS), and capacitive electrolyte–insulator–semiconductor (EIS) sensors. Finally, the current limitations, main challenges and future trends of field-effect sensors using biomaterials for chemical sensing will be proposed and discussed.

scholarly journals Immunomodulatory Nanomedicine for the Treatment of Atherosclerosis

2021 ◽  
Vol 10 (14) ◽  
pp. 3185
Author(s):  
Linsey J. F. Peters ◽  
Alexander Jans ◽  
Matthias Bartneck ◽  
Emiel P. C. van der Vorst
Keyword(s):  
Cell Proliferation ◽  
Drug Carriers ◽  
Research Field ◽  
General Introduction ◽  
Cellular Receptors ◽  
Cellular Processes ◽  
Potential Applications ◽  
Current Therapies ◽  
Based Medicine ◽  
Physiological Systems

Atherosclerosis is the main underlying cause of cardiovascular diseases (CVDs), which remain the number one contributor to mortality worldwide. Although current therapies can slow down disease progression, no treatment is available that can fully cure or reverse atherosclerosis. Nanomedicine, which is the application of nanotechnology in medicine, is an emerging field in the treatment of many pathologies, including CVDs. It enables the production of drugs that interact with cellular receptors, and allows for controlling cellular processes after entering these cells. Nanomedicine aims to repair, control and monitor biological and physiological systems via nanoparticles (NPs), which have been shown to be efficient drug carriers. In this review we will, after a general introduction, highlight the advantages and limitations of the use of such nano-based medicine, the potential applications and targeting strategies via NPs. For example, we will provide a detailed discussion on NPs that can target relevant cellular receptors, such as integrins, or cellular processes related to atherogenesis, such as vascular smooth muscle cell proliferation. Furthermore, we will underline the (ongoing) clinical trials focusing on NPs in CVDs, which might bring new insights into this research field.

scholarly journals Capacitive Field-effect (bio-)chemical Sensors Based on Nanocrystalline Diamond Films

2009 ◽  
Vol 1203 ◽  
Author(s):  
Matthias Bäcker ◽  
Arshak Poghossian ◽  
Maryam H. Abouzar ◽  
Sylvia Wenmackers ◽  
Stoffel D. Janssens ◽  
...  
Keyword(s):  
Thin Films ◽  
Field Effect ◽  
High Sensitivity ◽  
Ph Sensitive ◽  
Nanocrystalline Diamond ◽  
Penicillin G ◽  
Layer By Layer ◽  
Label Free ◽  
High Coverage ◽  
Layer Adsorption

AbstractCapacitive field-effect electrolyte-diamond-insulator-semiconductor (EDIS) structures with O-terminated nanocrystalline diamond (NCD) as sensitive gate material have been realized and investigated for the detection of pH, penicillin concentration, and layer-by-layer adsorption of polyelectrolytes. The surface oxidizing procedure of NCD thin films as well as the seeding and NCD growth process on a Si-SiO2 substrate have been improved to provide high pH-sensitive, non-porous thin films without damage of the underlying SiO2 layer and with a high coverage of O-terminated sites. The NCD surface topography, roughness, and coverage of the surface groups have been characterized by SEM, AFM and XPS methods. The EDIS sensors with O-terminated NCD film treated in oxidizing boiling mixture for 45 min show a pH sensitivity of about 50 mV/pH. The pH-sensitive properties of the NCD have been used to develop an EDIS-based penicillin biosensor with high sensitivity (65-70 mV/decade in the concentration range of 0.25-2.5 mM penicillin G) and low detection limit (5 μM). The results of label-free electrical detection of layer-by-layer adsorption of charged polyelectrolytes are presented, too.

Identification of types of membrane injuries and cell death using whole cell-based proton-sensitive field-effect transistor systems

The Analyst ◽  
2017 ◽  
Vol 142 (18) ◽  
pp. 3451-3458 ◽  
Author(s):  
Yuki Imaizumi ◽  
Tatsuro Goda ◽  
Akira Matsumoto ◽  
Yuji Miyahara
Keyword(s):  
Cell Death ◽  
Mammalian Cells ◽  
Field Effect ◽  
Field Effect Transistor ◽  
Ph Sensing ◽  
Membrane Injury ◽  
Whole Cell ◽  
Sensing Systems ◽  
Effect Transistor ◽  
Chemical Stimuli

Membrane injury and apoptosis of mammalian cells by chemical stimuli were distinguished using ammonia-perfused continuous pH-sensing systems.

High-sensitivity detection of Concanavalin A using MoS2-based field effect transistor biosensor

2021 ◽  
Vol 54 (24) ◽  
pp. 245401
Author(s):  
Mingyang Ma ◽  
Lemeng Chao ◽  
Yuhang Zhao ◽  
Jiafeng Ding ◽  
Zhongchao Huang ◽  
...  
Keyword(s):  
Concanavalin A ◽  
Field Effect ◽  
Field Effect Transistor ◽  
High Sensitivity ◽  
Effect Transistor ◽  
High Sensitivity Detection ◽  
Sensitivity Detection

Electric field modulated ion-sieving effects of graphene oxide membranes

2021 ◽  
Vol 9 (1) ◽  
pp. 244-253
Author(s):  
Zhi Yi Leong ◽  
Zhaojun Han ◽  
Guangzhao Wang ◽  
Dong-Sheng Li ◽  
Shengyuan A. Yang ◽  
...  
Keyword(s):  
Graphene Oxide ◽  
Energy Storage ◽  
Water Treatment ◽  
Electric Field ◽  
Research Field ◽  
Selective Separation ◽  
Two Dimensional ◽  
Potential Applications ◽  
Oxide Membranes ◽  
Graphene Oxide Membranes

Precise and selective separation of ions using two-dimensional (2D) laminar membranes is a budding research field with potential applications in water treatment, desalination, sensing, biomimicry and energy storage.

The electronic applications of stable diradicaloids: present and future

2018 ◽  
Vol 6 (42) ◽  
pp. 11232-11242 ◽  
Author(s):  
Xiaoguang Hu ◽  
Wenxiang Wang ◽  
Dongsheng Wang ◽  
Yonghao Zheng
Keyword(s):  
Field Effect ◽  
High Performance ◽  
Field Effect Transistor ◽  
Logic Gates ◽  
Linear Optics ◽  
Non Linear Optics ◽  
Potential Applications ◽  
Future Potential ◽  
Effect Transistor ◽  
Organic Batteries

Diradicaloids are promising materials for organic electronics and nonlinear optics due to their unique optical, electronic and magnetic properties. High performance organic field-effect transistor and photodetector based on diradicaloids have been achieved. Future potential applications in organic batteries, memory, logic gates and non-linear optics are expected.

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