Paradoxical Enhancement of Spatial Learning Induced by Right Hippocampal Lesion in Rats

Migraine is a multifactorial neurovascular syndrome characterized by typical headache attacks that occur with internal and external triggering factors in individuals with genetic susceptibility. It affects more than 12% of the general population. The aim of the present study is to compare the morphometric measurements of the determined white matter structures with the control group to investigate whether there is a structural difference in white matter structures in female patients with migraine. The width of the internal capsule parts (anterior limb, posterior limb and genu) and genu angle was evaluated through MRI. Corpus callosum related measurements were determined in the sagittal section. It was manually traced following its edge on the midsagittal slice of T1 images, where its structure appeared most remarkable. The right and left internal capsule related measurements were compared with migraine and control groups. Except the genu angle, there were statistically significant difference between all measurements and widths in the migraine group were greater than controls. No significant difference was found between the corpus callosum related measurements in the comparison of both groups. Internal capsule consists of several essential white matter fiber bundles of the brain, and is strongly connected between a range of cortical and subcortical anatomical structures. It has a crucial importance for brain functions and it can be affected by a variety of pathologies. The corpus callosum is the main fiber tract connecting two hemispheres with extensive connections and is topographically organized. It has been investigated in several neurodegenerative diseases as a marker for cortical pathology. Knowing the white matter structure in migraine patients, determining its prevalence, and its correlation with the severity, type and duration of migraine can give an idea to clinicians.

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MORPHOMETRIC ANALYSIS OF THE WHITE MATTER STRUCTURES IN FEMALE MIGRAINE PATIENTS

Journal of Scientific Perspectives ◽

10.26900/jsp.5.1.06 ◽

2021 ◽

pp. 71-79

Author(s):

Ozan TURAMANLAR ◽

Hilal GÜZEL ◽

Hayri DEMİRBAŞ ◽

Furkan KAYA ◽

Abdülkadir BİLİR ◽

...

Keyword(s):

White Matter ◽

Corpus Callosum ◽

Structural Difference ◽

Internal Capsule ◽

Control Group ◽

Posterior Limb ◽

Brain Functions ◽

Significant Difference ◽

Strongly Connected ◽

The Right

Migraine is a multifactorial neurovascular syndrome characterized by typical headache attacks that occur with internal and external triggering factors in individuals with genetic susceptibility. It affects more than 12% of the general population. The aim of the present study is to compare the morphometric measurements of the determined white matter structures with the control group to investigate whether there is a structural difference in white matter structures in female patients with migraine. The width of the internal capsule parts (anterior limb, posterior limb and genu) and genu angle was evaluated through MRI. Corpus callosum related measurements were determined in the sagittal section. It was manually traced following its edge on the midsagittal slice of T1 images, where its structure appeared most remarkable. The right and left internal capsule related measurements were compared with migraine and control groups. Except the genu angle, there were statistically significant difference between all measurements and widths in the migraine group were greater than controls. No significant difference was found between the corpus callosum related measurements in the comparison of both groups. Internal capsule consists of several essential white matter fiber bundles of the brain, and is strongly connected between a range of cortical and subcortical anatomical structures. It has a crucial importance for brain functions and it can be affected by a variety of pathologies. The corpus callosum is the main fiber tract connecting two hemispheres with extensive connections and is topographically organized. It has been investigated in several neurodegenerative diseases as a marker for cortical pathology. Knowing the white matter structure in migraine patients, determining its prevalence, and its correlation with the severity, type and duration of migraine can give an idea to clinicians.

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Suicidal Ideation and Self-Determination in Institutionalized Elderly

Crisis ◽

10.1027//0227-5910.22.1.15 ◽

2001 ◽

Vol 22 (1) ◽

pp. 15-19 ◽

Cited By ~ 9

Author(s):

Andrée Fortin ◽

Sylvie Lapierre ◽

Jacques Baillargeon ◽

Réal Labelle ◽

Micheline Dubé ◽

...

Keyword(s):

Self Determination ◽

Current Debate ◽

Elderly Persons ◽

Rational Suicide ◽

Institutionalized Elderly ◽

Significant Difference ◽

Social Subscale ◽

Civil Status ◽

The Right ◽

Taking Action

The right to self-determination is central to the current debate on rational suicide in old age. The goal of this exploratory study was to assess the presence of self-determination in suicidal institutionalized elderly persons. Eleven elderly persons with serious suicidal ideations were matched according to age, sex, and civil status with 11 nonsuicidal persons. The results indicated that suicidal persons did not differ from nonsuicidal persons in level of self-determination. There was, however, a significant difference between groups on the social subscale. Suicidal elderly persons did not seem to take others into account when making a decision or taking action. The results are discussed from a suicide-prevention perspective.

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Individual Differences and Hemispheric Asymmetry While Processing Emotional Words

Journal of Individual Differences ◽

10.1027/1614-0001/a000137 ◽

2014 ◽

Vol 35 (3) ◽

pp. 137-143 ◽

Cited By ~ 1

Author(s):

Lindsay M. Niccolai ◽

Thomas Holtgraves

Keyword(s):

Individual Differences ◽

Hemispheric Asymmetry ◽

Past Research ◽

Decision Task ◽

Depression And Anxiety ◽

Hemispheric Differences ◽

Affective Valence ◽

Emotional Words ◽

Emotion Words ◽

The Right

This research examined differences in the perception of emotion words as a function of individual differences in subclinical levels of depression and anxiety. Participants completed measures of depression and anxiety and performed a lexical decision task for words varying in affective valence (but equated for arousal) that were presented briefly to the right or left visual field. Participants with a lower level of depression demonstrated hemispheric asymmetry with a bias toward words presented to the left hemisphere, but participants with a higher level of depression displayed no hemispheric differences. Participants with a lower level of depression also demonstrated a bias toward positive words, a pattern that did not occur for participants with a higher level of depression. A similar pattern occurred for anxiety. Overall, this study demonstrates how variability in levels of depression and anxiety can influence the perception of emotion words, with patterns that are consistent with past research.

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DeVega versus ring annuloplasty in severe functional tricuspid insufficiency and their impact on the right ventricle

The Egyptian Cardiothoracic Surgeon ◽

10.35810/ects.v1i4.89 ◽

2019 ◽

Vol 1 (4) ◽

pp. 133-139

Author(s):

Yasser Hamdy ◽

Mohammed Mahmoud Mostafa ◽

Ahmed Elminshawy

Keyword(s):

Right Ventricular ◽

Tricuspid Valve ◽

Tricuspid Regurgitation ◽

Early Postoperative Period ◽

Tricuspid Valve Repair ◽

Ring Annuloplasty ◽

Significant Difference ◽

Group A ◽

Group B ◽

The Right

Background: Functional tricuspid valve regurgitation secondary to left-sided valve disease is common. DeVega repair is simple, but residual regurgitation with subsequent impairment of the right ventricular function is a concern. This study aims to compare tricuspid valve repair using DeVega vs. ring annuloplasty and their impact on the right ventricle in the early postoperative period and after six months. Methods: This is a prospective cohort study of 51 patients with rheumatic heart disease who underwent tricuspid valve repair for secondary severe tricuspid regurgitation. Patients were divided into two groups: group A; DeVega repair (n=34) and group B; ring annuloplasty repair (n=17). Patients were assessed clinically and by echocardiography before discharge and after six months for the degree of tricuspid regurgitation, right ventricular diameter and tricuspid annular plane systolic excursion (TAPSE). Results: Preoperative echocardiographic assessment showed no difference in left ventricular end-systolic diameter, end-diastolic diameter, ejection fraction and right ventricular diameter, however; group A had significantly better preoperative right ventricular function measured by TAPSE (1.96 ± 0.27 vs1.75 ± 0.31 cm; p=0.02). Group B had significantly longer cardiopulmonary bypass time (127.65 ± 13.56 vs. 111.74 ± 18.74 minutes; p= 0.003) and ischemic time (99.06 ± 11.80 vs. 87.15 ± 16.01 minutes; p= 0.009). Pre-discharge, there was no statistically significant difference in the degree of tricuspid regurgitation, but the right ventricular diameter was significantly lower in group B (2.66 ± 0.41 and 2.40 ± 0.48 cm; p=0.049). After six months of follow up, the degree of tricuspid regurgitation (p= 0.029) and the right ventricular diameter were significantly lower in the ring annuloplasty group (2.56 ± 0.39 and 2.29 ± 0.44 cm; p=0.029). Although there was a statistically significant difference in preoperative TAPSE, this difference disappeared after six months. Conclusion: Both DeVega and ring annuloplasty techniques were effective in the early postoperative period, ring annuloplasty was associated with lesser residual regurgitation and better right ventricular remodeling in severe functional tricuspid regurgitation than DeVega procedure after 6-months of follow up.

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POS0586 RHEUMATOID ARTHRITIS IS AN INFLAMMATORY DISEASE WITH A HIGH CARDIOVASCULAR RISK

Annals of the Rheumatic Diseases ◽

10.1136/annrheumdis-2021-eular.4080 ◽

2021 ◽

Vol 80 (Suppl 1) ◽

pp. 526.1-526

Author(s):

L. Nacef ◽

H. Riahi ◽

Y. Mabrouk ◽

H. Ferjani ◽

K. Maatallah ◽

...

Keyword(s):

Rheumatoid Arthritis ◽

Risk Factors ◽

Cardiovascular Risk ◽

Carotid Artery ◽

Internal Carotid ◽

Subclinical Atherosclerosis ◽

External Carotid ◽

Significant Difference ◽

The Mean ◽

The Right

Background:Hypertension, diabetes, and dyslipidemia are traditional risk factors of cardiac events. Carotid ultrasonography is an available way to detect subclinical atherosclerosis.Objectives:This study aimed to compare the intima-media thickness in RA patients based on their personal cardiovascular (CV) history of hypertension (hypertension), diabetes, and dyslipidemia.Methods:The present study is a prospective study conducted on Tunisian RA patients in the rheumatology department of Mohamed Kassab University Hospital (March and December 2020). The characteristics of the patients and those of the disease were collected.The high-resolution B-mode carotid US measured the IMT, according to American Society of Echocardiography guidelines. The carotid bulb below its bifurcation and the internal and external carotid arteries were evaluated bilaterally with grayscale, spectral, and color Doppler ultrasonography using proprietary software for carotid artery measurements. IMT was measured using the two inner layers of the common carotid artery, and an increased IMT was defined as ≥0.9 mm. A Framingham score was calculated to predict the cardiovascular risk at 10-year.Results:Forty-seven patients were collected, 78.7% of whom were women. The mean age was 52.5 ±11.06 [32-76]. The rheumatoid factor (RF) was positive in 57.8% of cases, and anti-citrullinated peptide antibodies (ACPA) were positive in 62.2% of cases. RA was erosive in 81.6% of cases. Hypertension (hypertension) was present in 14.9% of patients, diabetes in 12.8% of patients, and dyslipidemia in 12.8% of patients. Nine patients were active smokers. The mean IMT in the left common carotid (LCC) was 0.069 ±0.015, in the left internal carotid (LIC) was 0.069 ±0.015, in the left external carotid (LEC) was 0.060 ±0.023. The mean IMT was 0.068 ±0.01 in the right common carotid (RCC), 0.062 ±0.02 in the right internal carotid (RIC), and 0.060 ±0.016 in the right external carotid (REC). The IMT was significantly higher in the left common carotid (LCC) in patients with hypertension (p=0.025). There was no significant difference in the other ultrasound sites (LIC, LEC, RCC, RIC, and REC) according to the presence or absence of hypertension. The IMT was also significantly increased in patients with diabetes at LCC (p=0.017) and RIC (p=0.025). There was no significant difference in the IMT at different ultrasound sites between patients with and without dyslipidemia.Conclusion:Hypertension was significantly associated with the increase in IMT at the LCC level in RA patients. Diabetes had an impact on IMT in LCC and RIC. However, dyslipidemia did not affect the IMT at the different ultrasound sites.References:[1]S. Gunter and al. Arterial wave reflection and subclinical atherosclerosis in rheumatoid arthritis. Clinical and Experimental Rheumatology 2018; 36: Clinical E.xperimental.[2]Aslan and al. Assessment of local carotid stiffness in seronegative and seropositive rheumatoid arthritis. SCANDINAVIAN CARDIOVASCULAR JOURNAL, 2017.[3]Martin I. Wah-Suarez and al, Carotid ultrasound findings in rheumatoid arthritis and control subjects: A case-control study. Int J Rheum Dis. 2018;1–7.[4]Gobbic C and al. Marcadores subclínicos de aterosclerosis y factores de riesgo cardiovascular en artritis temprana. Subclinical markers of atherosclerosis and cardiovascular risk factors in early arthritis marcadores subclínicos de aterosclerose e fatores de risco cardiovascular na artrite precoce.Disclosure of Interests:None declared

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The Effect of Reflexology on Lactation in Women Who Had Cesarean Section: A Randomized Controlled Pilot Study

Complementary Medicine Research ◽

10.1159/000513924 ◽

2021 ◽

pp. 1-8

Author(s):

Sevde Aksu ◽

Pelin Palas Karaca

Keyword(s):

Pilot Study ◽

Cesarean Section ◽

Intervention Group ◽

Control Group ◽

Breast Pain ◽

Randomized Controlled ◽

Significant Difference ◽

The Right ◽

Documentation Tool ◽

And Control

Aim: The research was conducted as a randomized controlled pilot study to evaluate the effects of reflexology on lactation in mothers who delivered by cesarean section (CS). Methods: A single-blind randomized controlled experimental study was conducted with a total of 60 postpartum women in the reflexology application (n = 30) and control groups (n = 30). After the CS, the mothers in the control group were given approximately 3-h routine nursing care after recovering from the effects of anesthesia; the introductory information form was applied, and the Breastfeeding Charting System and Documentation Tool (LATCH) and visual analog scale (VAS) for the signs of the onset of lactation were implemented on the first and second days. Reflexology was applied to the women in the intervention group after an average of 3 h following the mother’s condition had become stable and she had recovered from the effects of anesthesia. Reflexology was applied a total of 20 min – 10 min for the right foot, 10 min for the left foot – twice a day with 8-h intervals on the first and second days after CS. After the last reflexology application, the LATCH and VAS for the signs of the onset of lactation were applied. Results: Of the women, 70% breastfed their babies within 60 min after delivery; 46.7% of the mothers received breastfeeding training and 81.7% needed support for breastfeeding after the CS. The LATCH breastfeeding scores of the women in the intervention group on both days were significantly higher compared to those of the women in the control group (p < 0.001). On the first day after the CS, apart from breast pain, there was no significant difference between the two groups in terms of breast heat and breast tension (p > 0.05). On the second day after the CS, apart from breast tension, there was no significant difference between the groups in terms of breast heat and breast pain (p < 0.05). In the study, women in the intervention group were found to have higher scores in terms of all three symptoms compared to the control group (p < 0.05). Conclusions: In the study, it was determined that LATCH scores and signs of the onset of breastfeeding increased in the mothers who received reflexology after CS.

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Frequency-Following Response (FFR) in Military Pilots

International Archives of Otorhinolaryngology ◽

10.1055/s-0040-1718525 ◽

2020 ◽

Author(s):

Graziela Maria Martins-Moreira ◽

Alessandra Spada Durante

Keyword(s):

Pure Tone Audiometry ◽

Control Group ◽

Study Group ◽

Aircraft Accidents ◽

Frequency Following Response ◽

Significant Difference ◽

Qualitative Variables ◽

Chi Squared ◽

The Right ◽

Military Pilots

Abstract Introduction Good hearing in pilots, including central auditory skills, is critical for flight safety and the prevention of aircraft accidents. Pure tone audiometry alone may not be enough to assess hearing in the members of this population who, in addition to high noise levels, routinely face speech recognition tasks in non-ideal conditions. Objective To characterize the frequency-following response (FFR) of a group of military pilots compared with a control group. Methods Twenty military pilots in the Study Group and 20 non-pilot military personnel, not exposed to noise in their work, in the Control Group, all with normal hearing, aged between 30 and 40 years old, completed a questionnaire to assess their hearing habits, and their FFRs were measured with a /da/ syllable (duration 40 milliseconds, speed 10.9/s), at 80 dB NA in the right ear. All procedures were approved by the ethical committee of the institution. Statistical analysis was performed using the t-Student or Mann-Whitney tests for quantitative variables, and the Fisher or chi-squared tests for qualitative variables, and a value of p < 0.05 was considered to be statistically significant. Results There was no significant difference between the groups regarding auditory habits. In the FFR, wave amplitudes A (p = 0.01) and C (p = 0.04) were significantly lower in the Study Group. Conclusion Working as a military pilot can be a crucial factor in determining an individual's typical FFR pattern, demonstrated in the present study by statistically significant reductions in the amplitudes of the A and C waves.

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In vivo exploration of synaptic projections in frontotemporal dementia

Scientific Reports ◽

10.1038/s41598-021-95499-1 ◽

2021 ◽

Vol 11 (1) ◽

Author(s):

Eric Salmon ◽

Mohamed Ali Bahri ◽

Alain Plenevaux ◽

Guillaume Becker ◽

Alain Seret ◽

...

Keyword(s):

Frontotemporal Dementia ◽

Input Function ◽

Parahippocampal Gyrus ◽

Exploratory Research ◽

Social Brain ◽

Synaptic Density ◽

Clinical Disorder ◽

Significant Difference ◽

The Right

AbstractThe purpose of this exploratory research is to provide data on synaptopathy in the behavioral variant of frontotemporal dementia (bvFTD). Twelve patients with probable bvFTD were compared to 12 control participants and 12 patients with Alzheimer’s disease (AD). Loss of synaptic projections was assessed with [18F]UCBH-PET. Total distribution volume was obtained with Logan method using carotid artery derived input function. Neuroimages were analyzed with SPM12. Verbal fluency, episodic memory and awareness of cognitive impairment were equally impaired in patients groups. Compared to controls, [18F]UCBH uptake tended to decrease in the right anterior parahippocampal gyrus of bvFTD patients. Loss of synaptic projections was observed in the right hippocampus of AD participants, but there was no significant difference in [18F]UCBH brain uptake between patients groups. Anosognosia for clinical disorder was correlated with synaptic density in the caudate nucleus and the anteromedial prefrontal cortex. This study suggests that synaptopathy in bvFTD targets the temporal social brain and self-referential processes.

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