scholarly journals Cosmetic Applications of Bee Venom

Toxins ◽  
2021 ◽  
Vol 13 (11) ◽  
pp. 810
Author(s):  
Aida A. Abd El-Wahed ◽  
Shaden A. M. Khalifa ◽  
Mohamed H. Elashal ◽  
Syed G. Musharraf ◽  
Aamer Saeed ◽  
...  
Keyword(s):  
Wound Healing ◽  
Atopic Dermatitis ◽  
Skin Diseases ◽  
Acne Vulgaris ◽  
Bee Venom ◽  
Skin Reactions ◽  
Immunological Responses ◽  
Therapeutic Uses ◽  
Therapeutic Choice ◽  
Different Cultures

Bee venom (BV) is a typical toxin secreted by stingers of honeybee workers. BV and BV therapy have long been attractive to different cultures, with extensive studies during recent decades. Nowadays, BV is applied to combat several skin diseases, such as atopic dermatitis, acne vulgaris, alopecia, vitiligo, and psoriasis. BV is used extensively in topical preparations as cosmetics and used as dressing for wound healing, as well as in facemasks. Nevertheless, the safety of BV as a therapeutic choice has always been a concern due to the immune system reaction in some people due to BV use. The documented unfavorable impact is explained by the fact that the skin reactions to BV might expand to excessive immunological responses, including anaphylaxis, that typically resolve over numerous days. This review aims to address bee venom therapeutic uses in skin cosmetics.

scholarly journals PSYCHOSOCIAL IMPACT OF COMMON SKIN DISORDERS – A REVIEW STUDY

2021 ◽  
Vol 9 (7) ◽  
pp. 1452-1456
Author(s):  
Manish Choudhari ◽  
Nikita Jamadari ◽  
Naresh Jain
Keyword(s):  
Quality Of Life ◽  
Atopic Dermatitis ◽  
Skin Disease ◽  
Skin Diseases ◽  
Fungal Infections ◽  
Acne Vulgaris ◽  
Well Being ◽  
Psychosocial Impact ◽  
Common Skin

Objective - To increase awareness of the psychosocial impact of Kushtha, Visarpa, Mukhadushika, Sheetpitta, Udarda and Kotha in Ayurveda and Acne vulgaris, Urticaria, Various types of fungal infections, Atopic dermatitis, Psoriasis etc. in modern point of view. Quality Of Evidence - A literature review was based on a MEDLINE search (1966 to 2000). Selected articles from the dermatologic and psychiatric literature, as well as other relevant medical journals, were reviewed and used as the basis for discussion of how skin disease affects patients’ lives and of appropriate management. Message - Dermatologic problems hurt patients’ quality of life. skin disease can produce stress, anxiety, anger, depression, low self-esteem, embarrassment, and other psychological, personal, professional and social life problems that affect patients’ lives in ways comparable to arthritis or other disabling illnesses, as well as showing a bidirectional relationship between skin disease and psychological distress. This review focuses on the effects of five common skin diseases seen by family physicians- Acne, Urticaria, Various types of fungal infections, Atopic dermatitis and Psoriasis. Conclusion - How skin disease affects psychosocial well-being is un- derappreciated. Increased understanding of the psychiatric comorbidity associated with skin disease and a biopsy- chosocial approach to management will ultimately improve patients’ lives. Keywords: Skin disease, Psychosocial Impact, Quality of life.

scholarly journals Ceramides: Where do we stand?

2021 ◽  
Vol 1 ◽  
pp. 44
Author(s):  
Nidhi Yadav ◽  
Bhushan Madke ◽  
Anupam Das
Keyword(s):  
Atopic Dermatitis ◽  
Barrier Function ◽  
Skin Diseases ◽  
Acne Vulgaris ◽  
Skin Aging ◽  
Skin Disorders ◽  
Healthy Skin ◽  
Epidermal Barrier ◽  
Inflammatory Dermatoses ◽  
Integral Component

Ceramides are an integral component of the epidermal barrier system. Alterations in ceramides levels are associated with various inflammatory dermatoses such as psoriasis, atopic dermatitis, ichthyosis, Gaucher’s disease, acne vulgaris, and skin aging. Various formulations containing ceramides have been developed so that exogenous ceramides can repair the barrier function. Herein, the authors have provided an overview of the basic anatomy, structure, functioning, and importance of ceramides and their role in healthy skin and various skin disorders. In addition, the authors review conventional and newer technologies for delivery of ceramides in various skin diseases.

scholarly journals Multilineage-differentiating stress-enduring cells alleviate atopic dermatitis-associated behaviors in mice

2021 ◽  
Vol 12 (1) ◽  
Author(s):  
WenDi Fei ◽  
JunLin Wu ◽  
MengDie Gao ◽  
Qian Wang ◽  
Ya Yu Zhao ◽  
...  
Keyword(s):  
Wound Healing ◽  
Atopic Dermatitis ◽  
Stem Cell ◽  
Skin Diseases ◽  
Quantitative Polymerase Chain Reaction ◽  
Inflammatory Factors ◽  
Inflammatory Skin Diseases ◽  
Cell Injection ◽  
Muse Cells

Abstract Background Pruritus is a recurring, long-lasting skin disease with few effective treatments. Many patients have unsatisfactory responses to currently available antipruritic treatments, and effective therapeutics are urgently needed to relieve symptoms. A previous study reported that mesenchymal stem cell (MSC)-mediated immune regulation could be used to treat skin inflammatory diseases. Multilineage-differentiating stress-enduring (Muse) cells are a new type of pluripotent stem cell that may also have the potential to treat inflammatory skin diseases. Methods Muse cells were isolated from human bone marrow-derived MSCs (BMSCs) via the 8-h longterm trypsin incubation (LTT) method. Repeated use of 2,4-dinitrofluorobenzene (DNFB) induced atopic dermatitis (AD) in a mouse model. Immunofluorescence, behavior recording, and image analysis were used to evaluate the therapeutic effect of subcutaneous Muse cell injection. Real-time quantitative polymerase chain reaction (qPCR) was used to measure the expression of inflammatory factors. In vitro, wound healing and cell proliferation experiments were used to examine the effect of Muse cell supernatant on keratinocytes. Results Our results showed that subcutaneous injection of Muse cells after AD model induction significantly alleviated scratching behavior in mice. The evaluation of dermatitis and photos of damaged skin on the back of the neck revealed that Muse cells reduced dermatitis, playing an active role in healing the damaged skin. The activation of spinal glial cells and scratching behavior were also reduced by Muse cell injection. In addition, we also showed that the expression levels of the inflammatory factors interleukin (IL)-6, IL-17α, and IL-33 in both the spinal cord and skin were suppressed by Muse cells. Furthermore, Muse cells not only exerted anti-inflammatory effects on lipopolysaccharide (LPS)-induced human HaCat cells but also promoted wound healing and keratinocyte proliferation. Conclusions In vivo, Muse cells could alleviate scratching symptoms, reduce epidermal inflammation, and promote wound healing. In vitro, Muse cells could also promote the migration and proliferation of keratinocytes. In summary, Muse cells may become a new therapeutic agent for the treatment of AD.

scholarly journals ALLERGIC SKIN DISEASES AND SPORT

2012 ◽  
Vol 9 (5) ◽  
pp. 17-25
Author(s):  
N V Shartanova ◽  
O G Elisyutina ◽  
E S Fedenko ◽  
N I Ilina
Keyword(s):  
Physical Activity ◽  
Atopic Dermatitis ◽  
Skin Diseases ◽  
Elite Athletes ◽  
Skin Reactions ◽  
Immunological Mechanisms ◽  
Allergic Skin

According to various authors up to 25% of athletes suffer from allergies. In this review, we are talking about allergodermatoses. Various immunological mechanisms are underlying of skin reactions in elite athletes. Interesting facts about anaphylaxis, associated with physical activity and consumption of some food as well as about contact and atopic dermatitis are presented.

scholarly journals Potential Therapeutic Applications of Bee Venom on Skin Disease and Its Mechanisms: A Literature Review

Toxins ◽  
2019 ◽  
Vol 11 (7) ◽  
pp. 374 ◽  
Author(s):  
Haejoong Kim ◽  
Soo-Yeon Park ◽  
Gihyun Lee
Keyword(s):  
Atopic Dermatitis ◽  
Skin Disease ◽  
Skin Diseases ◽  
Inflammatory Diseases ◽  
Bee Venom ◽  
Antimicrobial Drugs ◽  
Therapeutic Applications ◽  
Anticancer Effects ◽  
Life Threatening ◽  
Infectious Skin Diseases

Skin is larger than any other organ in humans. Like other organs, various bacterial, viral, and inflammatory diseases, as well as cancer, affect the skin. Skin diseases like acne, atopic dermatitis, and psoriasis often reduce the quality of life seriously. Therefore, effective treatment of skin disorders is important despite them not being life-threatening. Conventional medicines for skin diseases include corticosteroids and antimicrobial drugs, which are effective in treating many inflammatory and infectious skin diseases; however, there are growing concerns about the side effects of these therapies, especially during long-term use in relapsing or intractable diseases. Hence, many researchers are trying to develop alternative treatments, especially from natural sources, to resolve these limitations. Bee venom (BV) is an attractive candidate because many experimental and clinical reports show that BV exhibits anti-inflammatory, anti-apoptotic, anti-fibrotic, antibacterial, antiviral, antifungal, and anticancer effects. Here, we review the therapeutic applications of BV in skin diseases, including acne, alopecia, atopic dermatitis, melanoma, morphea, photoaging, psoriasis, wounds, wrinkles, and vitiligo. Moreover, we explore the therapeutic mechanisms of BV in the treatment of skin diseases and cytotoxic effects of BV on skin disease-causing pathogens, including bacteria, fungi and viruses.

scholarly journals Redox Imbalance in T Cell-Mediated Skin Diseases

2010 ◽  
Vol 2010 ◽  
pp. 1-9 ◽  
Author(s):  
Saveria Pastore ◽  
Liudmila Korkina
Keyword(s):  
Oxidative Stress ◽  
Atopic Dermatitis ◽  
Contact Dermatitis ◽  
Skin Diseases ◽  
Redox Balance ◽  
Inflammatory Disorder ◽  
Chronic Inflammatory Disorder ◽  
Physical Chemical ◽  
Chemical Oxidants ◽  
Beneficial Outcome

The skin is permanently exposed to physical, chemical, and biological aggression by the environment. In addition, acute and chronic inflammatory events taking place in the skin are accompanied by abnormal release of pro-oxidative mediators. In this paper, we will briefly overview the homeostatic systems active in the skin to maintain the redox balance and also to counteract abnormal oxidative stress. We will concentrate on the evidence that a local and/or systemic redox dysregulation accompanies the chronic inflammatory disorder events associated to psoriasis, contact dermatitis, and atopic dermatitis. We will also discuss the fact that several well-established treatments for the therapy of chronic inflammatory skin disorders are based on the application of strong physical or chemical oxidants onto the skin, indicating that, in selected conditions, a further increase of the oxidative imbalance may lead to a beneficial outcome.

scholarly journals Treatment of acne and acne-related scarring with fixed combination clindamycin phosphate and benzoyl peroxide gel (1.2%/3.75%) and tretinoin gel microsphere 0.06% in an Asian American transgender female

2020 ◽  
Vol 8 ◽  
pp. 2050313X2098403
Author(s):  
Edidiong CN Kaminska
Keyword(s):  
Benzoyl Peroxide ◽  
Asian American ◽  
Skin Diseases ◽  
Fixed Combination ◽  
Acne Vulgaris ◽  
Topical Therapy ◽  
The United States ◽  
Clindamycin Phosphate ◽  
Common Skin ◽  
Group Post

Acne vulgaris is one of the most common skin diseases in the United States and can affect any gender or ethnic group. Post-inflammatory hyperpigmentation (PIH) and scarring from acne can have a negative psychosocial impact on patients. Skin of color patients are particularly prone to PIH, as the dark marks left from acne may take several months to resolve, far after the acne has cleared. Here, we report a case of moderate acne with associated scarring in a transgender, Asian American female who was successfully treated with fixed combination topical therapy with clindamycin phosphate and benzoyl peroxide gel 1.2%/3.75% and tretinoin gel microsphere 0.06%.

scholarly journals Gomisin M2 Ameliorates Atopic Dermatitis-like Skin Lesions via Inhibition of STAT1 and NF-κB Activation in 2,4-Dinitrochlorobenzene/Dermatophagoides farinae Extract-Induced BALB/c Mice

Molecules ◽  
2021 ◽  
Vol 26 (15) ◽  
pp. 4409
Author(s):  
Jinjoo Kang ◽  
Soyoung Lee ◽  
Namkyung Kim ◽  
Hima Dhakal ◽  
Taeg-Kyu Kwon ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Oral Administration ◽  
Skin Diseases ◽  
Nuclear Translocation ◽  
Skin Lesions ◽  
Biologically Active ◽  
Therapeutic Effects ◽  
Dermatophagoides Farinae ◽  
Tnf Α ◽  
Ifn Γ

The extracts of Schisandra chinensis (Turcz.) Baill. (Schisandraceae) have various therapeutic effects, including inflammation and allergy. In this study, gomisin M2 (GM2) was isolated from S. chinensis and its beneficial effects were assessed against atopic dermatitis (AD). We evaluated the therapeutic effects of GM2 on 2,4-dinitrochlorobenzene (DNCB) and Dermatophagoides farinae extract (DFE)-induced AD-like skin lesions with BALB/c mice ears and within the tumor necrosis factor (TNF)-α and interferon (IFN)-γ-stimulated keratinocytes. The oral administration of GM2 resulted in reduced epidermal and dermal thickness, infiltration of tissue eosinophils, mast cells, and helper T cells in AD-like lesions. GM2 suppressed the expression of IL-1β, IL-4, IL-5, IL-6, IL-12a, and TSLP in ear tissue and the expression of IFN-γ, IL-4, and IL-17A in auricular lymph nodes. GM2 also inhibited STAT1 and NF-κB phosphorylation in DNCB/DFE-induced AD-like lesions. The oral administration of GM2 reduced levels of IgE (DFE-specific and total) and IgG2a in the mice sera, as well as protein levels of IL-4, IL-6, and TSLP in ear tissues. In TNF-α/IFN-γ-stimulated keratinocytes, GM2 significantly inhibited IL-1β, IL-6, CXCL8, and CCL22 through the suppression of STAT1 phosphorylation and the nuclear translocation of NF-κB. Taken together, these results indicate that GM2 is a biologically active compound that exhibits inhibitory effects on skin inflammation and suggests that GM2 might serve as a remedy in inflammatory skin diseases, specifically on AD.

scholarly journals Ubiquitous Overexpression of Chromatin Remodeling Factor SRG3 Exacerbates Atopic Dermatitis in NC/Nga Mice by Enhancing Th2 Immune Responses

2021 ◽  
Vol 22 (4) ◽  
pp. 1553
Author(s):  
Sung Won Lee ◽  
Hyun Jung Park ◽  
Jungmin Jeon ◽  
Yun Hoo Park ◽  
Tae-Cheol Kim ◽  
...  
Keyword(s):  
Atopic Dermatitis ◽  
Mast Cells ◽  
Immune Responses ◽  
Chromatin Remodeling ◽  
Skin Diseases ◽  
Immunoglobulin E ◽  
Critical Role ◽  
Interleukin 4 ◽  
Inflammatory Skin Diseases ◽  
Immune Disorder

The SWItch (SWI)3-related gene (SRG3) product, a SWI/Sucrose Non-Fermenting (SNF) chromatin remodeling subunit, plays a critical role in regulating immune responses. We have previously shown that ubiquitous SRG3 overexpression attenuates the progression of Th1/Th17-mediated experimental autoimmune encephalomyelitis. However, it is unclear whether SRG3 overexpression can affect the pathogenesis of inflammatory skin diseases such as atopic dermatitis (AD), a Th2-type immune disorder. Thus, to elucidate the effects of SRG3 overexpression in AD development, we bred NC/Nga (NC) mice with transgenic mice where SRG3 expression is driven by the β-actin promoter (SRG3β-actin mice). We found that SRG3β-actin NC mice exhibit increased AD development (e.g., a higher clinical score, immunoglobulin E (IgE) hyperproduction, and an increased number of infiltrated mast cells and basophils in skin lesions) compared with wild-type NC mice. Moreover, the severity of AD pathogenesis in SRG3β-actin NC mice correlated with expansion of interleukin 4 (IL4)-producing basophils and mast cells, and M2 macrophages. Furthermore, this accelerated AD development is strongly associated with Treg cell suppression. Collectively, our results have identified that modulation of SRG3 function can be applied as one of the options to control AD pathogenesis.

Polyvinyl Alcohol/Chitosan Composite Hydrogels with Sustained Release of Traditional Tibetan Medicine for Promoting Chronic Diabetic Wound Healing

2021 ◽  
Author(s):  
Xingyu Chen ◽  
Zuxin Wang ◽  
Shan Gao ◽  
Wanlin Zhang ◽  
Hanwen Gong ◽  
...  
Keyword(s):  
Wound Healing ◽  
Polyvinyl Alcohol ◽  
Sustained Release ◽  
Skin Diseases ◽  
Tibetan Medicine ◽  
Diabetic Wound ◽  
Composite Hydrogels ◽  
Diabetic Wound Healing ◽  
Traditional Tibetan Medicine ◽  
Chitosan Composite

The Tibetan eighteen flavor dangshen pills (TEP) are composed of 18 traditional Tibetan medicines, which are commonly used in the treatment of skin diseases in the Tibetan medicine system. They...

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