scholarly journals Adverse Effects on Work and Daily Life Interference among Healthcare Workers after the First and Second ChAdOx1 and BNT162b2 COVID-19 Vaccine Doses

Vaccines ◽  
2021 ◽  
Vol 9 (8) ◽  
pp. 926
Author(s):  
Chulyong Park ◽  
Joon Sakong ◽  
Seongmin Jo ◽  
Minkeun Kim ◽  
Kiook Baek
Keyword(s):  
General Population ◽  
Adverse Effects ◽  
Healthcare Workers ◽  
Daily Life ◽  
Vaccine Dose ◽  
Multivariate Model ◽  
Factors Associated ◽  
Vaccine Type ◽  
Interaction Term ◽  
Numeric Scale

In this study, we assessed the adverse effects and the work and daily life interference associated with each dose of the ChAdOx1 and BNT162b2 COVID-19 vaccines. Questionnaires were distributed to workers after they received both doses; only those who worked the day after receiving the vaccine were included in the analysis. Overall, 368 ChAdOx1-vaccinated and 27 BNT162b2-vaccinated participants were included. Among the ChAdOx1-vaccinated participants, the incidence of adverse effects was significantly lower after the second dose than after the first dose. Among the BNT162b2-vaccinated participants, however, no differences in adverse effects or work and daily life interference were found between the doses. After the first and second dose, the numeric scale score (0–10) for interference with work was 3.9 ± 2.9 and 1.6 ± 1.9 for the ChAdOx1 and 3.2 ± 2.5 and 3.6 ± 3.0 for the BNT162b2 vaccine, respectively. A similar trend was observed for interference with daily life. Factors associated with work and daily life interference in the multivariate model were age, vaccine dose (first or second), and the interaction term of vaccine type and dose. These results could be used to inform the general population of the adverse effects associated with these vaccinations.

scholarly journals Impact of prior SARS-CoV-2 infection on post-vaccination SARS-CoV-2 spike IgG antibodies in a longitudinal cohort of healthcare workers

2021 ◽  
Author(s):  
Diana Zhong ◽  
Shaoming Xiao ◽  
Amanda K Debes ◽  
Emily R Egbert ◽  
Patrizio Caturegli ◽  
...  
Keyword(s):  
Serum Sample ◽  
Healthcare Workers ◽  
Natural Infection ◽  
Vaccine Dose ◽  
Igg Antibodies ◽  
Linear Regression Models ◽  
Post Vaccination ◽  
Longitudinal Cohort ◽  
Vaccine Type ◽  
Antibody Levels

Waning serum antibodies against SARS-CoV-2 have sparked discussions about long-term immunity and need for vaccine boosters. We examined SARS-CoV-2 spike IgG antibodies in a longitudinal cohort, comparing antibody decay in individuals who received an mRNA SARS-CoV-2 vaccine, with and without prior SARS-CoV-2 infection. We completed a longitudinal cohort of healthcare workers (HWs) between June 2020 and September 2021. HWs were included if they had a serum sample collected after SARS-CoV-2 infection and/or a serum sample collected ≥ 14 days after second dose of an mRNA SARS-CoV-2 vaccine. Linear regression models adjusting for vaccine type, age, and sex were used to compare post-vaccination antibody levels between 1) HWs with and without prior SARS-CoV-2 infection and 2) HWs with prior SARS-CoV-2 infection ≤ 90 days and > 90 days prior to first vaccine. Serum was collected from 98 HWs after SARS-CoV-2 infection and before vaccine, and 1960 HWs ≥ 14 days following second vaccine dose. Serum spike antibody levels were higher after vaccination than after natural infection. Compared to SARS-CoV-2 naïve individuals, those with prior infection maintained higher post-vaccination mean spike IgG values at 1, 3, and 6 months, after adjusting for age, sex, and vaccine type. Individuals with PCR-confirmed infection > 90 days before vaccination had higher post-vaccination antibody levels than individuals infected ≤ 90 days before vaccination. Individuals with three exposures to spike protein maintain the highest antibody levels particularly when first and second exposures were greater than 90 days apart. A booster dose provides a third exposure and may similarly induce a more durable antibody response.

scholarly journals Effectiveness of BNT162b2 and ChAdOx1 Vaccines against Symptomatic COVID-19 among Healthcare Workers in Kuwait: A Retrospective Cohort Study

Healthcare ◽  
2021 ◽  
Vol 9 (12) ◽  
pp. 1692
Author(s):  
Walid Q. Alali ◽  
Lamiaa A. Ali ◽  
Mohammad AlSeaidan ◽  
Mohammad Al-Rashidi
Keyword(s):  
Healthcare Workers ◽  
Cox Regression ◽  
Vaccine Coverage ◽  
Age Groups ◽  
Vaccine Dose ◽  
Factors Associated ◽  
Executive Staff ◽  
Hazard Ratios ◽  
Younger Age ◽  
Secondary Hospital

Background: Estimating vaccine effectiveness (VE) against severe, acute respiratory syndrome coronavirus 2 (SARS-CoV-2) among healthcare workers (HCWs) is necessary to demonstrate protection from the disease. Between 24 December 2020 and 15 June 2021, we determined the factors associated with vaccine coverage and estimated VE against SARS-CoV-2 infection in HCWs at a secondary hospital in Kuwait. Methods: We extracted sociodemographic, occupational, SARS-CoV-2 infection, and vaccination data for eligible HCWs from the hospital records. Vaccine coverage percentages were cross-tabulated with the HCW factors. Cox regression was used to estimate hazard ratios in vaccinated versus unvaccinated. Results: 3246 HCWs were included in the analysis, of which 82.1% received at least one vaccine dose (50.4% only one dose of ChAdOx1, 3.3% only one dose of BNT162b2, and 28.3% two doses of BNT162b2). However, 17.9% of HCWs were unvaccinated. A significantly lower vaccination coverage was reported amongst female HCWs, younger age group (20–30 years), and administrative/executive staff. The adjusted VE of fully vaccinated HCWs was 94.5% (95% CI = 89.4–97.2%), while it was 75.4% (95% CI = 67.2–81.6%) and 91.4% (95% CI = 65.1–97.9%) in partially vaccinated for ChAdOx1 and BNT162b2, respectively. Conclusions: BNT162b2 and ChAdOx1 vaccines prevented most symptomatic infections in HCWs across age groups, nationalities, and occupations.

scholarly journals COVID-VAC: The second global study of COVID-19 vaccine acceptance

2021 ◽  
Author(s):  
Jeffrey Lazarus ◽  
Katarzyna Wyka ◽  
Trenton White ◽  
Camila Picchio ◽  
Kenneth Rabin ◽  
...  
Keyword(s):  
Personal Experience ◽  
Healthcare Workers ◽  
Disease Risk ◽  
School Attendance ◽  
Vaccine Dose ◽  
Vaccine Acceptance ◽  
Perceived Safety ◽  
Factors Associated ◽  
One Year

Abstract This one-year follow-up study investigated COVID-19 vaccine acceptance in 23 countries. In June 2021, 75.2% of respondents reported to accept the vaccine, of which 49% had received at least one vaccine dose and 51% were willing to get it once available to them. Factors associated with COVID-19 vaccine acceptance include perceived safety and trust in science, as measured by a novel COVID-VAC score, and personal experience with COVID-19. Males, healthcare workers, well-to-do people, those with university degrees, and those whose physician recommended vaccination were more likely to accept it. Trust in governmental ability to address COVID-19 was weakly associated with vaccine acceptance. Respondents strongly supported vaccination to travel internationally, but weakly supported vaccinating children for school attendance. Hesitancy rates remain high in LMICs. Health policymakers should aggressively communicate vaccination need and inform accurately about efficacy and safety compared to disease risk, and healthcare workers need a greater vaccine communications role.

scholarly journals SARS-CoV-2 Ig G among Healthcare Workers and the General Population

Pathogens ◽  
2021 ◽  
Vol 10 (4) ◽  
pp. 465
Author(s):  
Gregorio P. Milani ◽  
Mario G. Bianchetti ◽  
Giuseppe Togni ◽  
Andreas W. Schoenenberger ◽  
Franco Muggli
Keyword(s):  
General Population ◽  
Healthcare Workers ◽  
Geographical Area ◽  
Healthcare Personnel ◽  
Protein Subunit ◽  
Positive Serology ◽  
Seroprevalence Data ◽  
And Gender ◽  
Few Data ◽  
Ig G

It is assumed that healthcare workers are at the highest risk to be infected by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, few data from healthcare workers who do not primarily take care of patients with SARS-CoV-2 infection support this assumption. We investigated the prevalence of immunoglobulin G (Ig G) against SARS-CoV-2 among healthcare workers who do not primarily take care of patients with SARS-CoV-2 infection and the general population in a well-defined geographical area. The first part of the study was conducted in May 2020 in Val Mesolcina (Southern Switzerland), a valley with ~8000 inhabitants. All healthcare workers were invited. All participants (n = 488) of the Swiss Longitudinal Cohort Study (SWICOS), a cohort representative of the general population, were also invited. Circulating Ig G against spike protein subunit 1 of SARS-CoV-2 were tested in each subject. Subjects with positive Ig G were tested again after 6 months. The condition of being a healthcare worker, rather than a part of the general population, was tested as a predictor of seroprevalence positivity by both simple and multiple (adjusted for age and sex) logistic regression. Eleven (2.6%) of the 423 SWICOS participants and 46 (16%) out of 289 healthcare workers were positive for antibodies against SARS-CoV-2. The seroprevalence OR was 7.01 (95% CI: 3.53–15.47) for healthcare workers as compared to SWICOS participants. After adjusting for age and gender, the seroprevalence OR was 5.13 (95% CI: 2.54–10.40). About three quarters of the subjects in the SWICOS (73%) and in healthcare (79%) group with a previous positive serology still presented positive Ig G against the SARS-CoV-2 after 6 months. The present seroprevalence data point out that the SARS-CoV-2 infection is seven times higher among healthcare workers than in the general population of Val Mesolcina. Efforts to effectively protect all the healthcare personnel are needed.

scholarly journals SARS-CoV-2 Seroprevalence among Healthcare Workers in General Hospitals and Clinics in Japan

2021 ◽  
Vol 18 (7) ◽  
pp. 3786
Author(s):  
Tatsuya Yoshihara ◽  
Kazuya Ito ◽  
Masayoshi Zaitsu ◽  
Eunhee Chung ◽  
Izumi Aoyagi ◽  
...  
Keyword(s):  
Public Health ◽  
Social Support ◽  
General Population ◽  
Severe Acute Respiratory Syndrome ◽  
Immunoglobulin G ◽  
Health Problem ◽  
Healthcare Workers ◽  
Public Health Problem ◽  
General Hospitals ◽  
Second Wave

Coronavirus disease 2019 (COVID-19) has become a serious public health problem worldwide. In general, healthcare workers are considered to be at higher risk of COVID-19 infection. However, the prevalence of COVID-19 among healthcare workers in Japan is not well characterized. In this study, we aimed to examine the seroprevalence of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) antibodies among 2160 healthcare workers in hospitals and clinics that are not designated to treat COVID-19 patients in Japan. The prevalence of SARS-CoV-2 immunoglobulin G was 1.2% in August and October 2020 (during and after the second wave of the pandemic in Japan), which is relatively higher than that in the general population in Japan (0.03–0.91%). Because of the higher risk of COVID-19 infection, healthcare workers should be the top priority for further social support and vaccination against SARS-CoV-2.

scholarly journals Psychosocial status during the prevalence of COVID-19 disease: the comparison between healthcare workers and general population

2021 ◽  
Author(s):  
Mohammad Ali Zakeri ◽  
Sayed Mortaza Hossini Rafsanjanipoor ◽  
Nadia Sedri ◽  
Mahmood Kahnooji ◽  
Mojtaba Sanji Rafsanjani ◽  
...  
Keyword(s):  
General Population ◽  
Healthcare Workers ◽  
Psychosocial Status

scholarly journals Real-World Acceptance of COVID-19 Vaccines among Healthcare Workers in Perinatal Medicine in China

Vaccines ◽  
2021 ◽  
Vol 9 (7) ◽  
pp. 704
Author(s):  
Biyun Xu ◽  
Xuelian Gao ◽  
Xinyue Zhang ◽  
Yali Hu ◽  
Huixia Yang ◽  
...  
Keyword(s):  
General Population ◽  
Real World ◽  
Healthcare Workers ◽  
Vaccine Safety ◽  
Vaccine Hesitancy ◽  
Present Survey ◽  
Perinatal Medicine ◽  
Vaccine Acceptance ◽  
Questionnaire Online ◽  
Convincing Data

Surveys showed that vaccine hesitancy may influence the acceptance of COVID-19 vaccines in healthcare workers (HCWs) and the general population. Currently, the actual acceptance of COVID-19 vaccination in HCWs has rarely been reported. In the present survey, we investigated the real-world acceptance of COVID-19 vaccination in HCWs in perinatal medicine during the first three-month period of vaccination in China and to identify the main reason for the decline of vaccination. HCWs (1087) who participated in a Chinese national symposium on perinatal medicine during 16–18 April 2021 were invited to answer a 27-question questionnaire online. A total of 1051 HCWs completed the questionnaire. Of them, 86.2% (906/1051) accepted the COVID-19 vaccination and 13.8% (145/1051) declined the vaccination. Because of the vaccine hesitancy, one-fourth of the vaccinated participants did not accept the vaccination until consulted with others or requested by employers. The main reason for the decline of vaccination in 145 unvaccinated HCWs was the concern about vaccine safety. The results indicate that vaccination request by employers may promote vaccine acceptance. More convincing data on the safety of COVID-19 vaccines appears to be important to increase the acceptance of vaccination.

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