Ulcerative colitis in the practice of a medical assistant

2020 ◽  
pp. 60-67
Author(s):  
Vsevolod Skvortsov
Keyword(s):  
Quality Of Life ◽  
Ulcerative Colitis ◽  
Age Groups ◽  
Clinical Manifestations ◽  
The Elderly ◽  
Long Duration ◽  
Rational Drug ◽  
Nonspecific Ulcerative Colitis ◽  
Severity Of The Disease

Ulcerative colitis (UC) is a chronic nonspecific inflammatory disease caused by immune disorders, mental disorders, genetics, and other factors. Its main clinical manifestations are accompanied by abdominal pain, diarrhea, bloody stools, weight loss, etc. A distinctive feature of nonspecific ulcerative colitis from Crohn's disease is its limitation by the large intestine, as well as the limited inflammation of the mucous membrane [1]. The disease affects various age groups from infants to the elderly, with a maximum incidence rate between the ages of 15 to 30 years and between 50 and 70 years. UC seriously affects human health and quality of life because of its long duration and repeated attacks, and also there is a risk of developing colorectal cancer. The disease violates the quality of life and leads to disability [2]. The article presents the causes of ulcerative colitis and describes the mechanisms for the development of pathological changes in the intestine. The principles of patient management, taking into account the severity of the disease, and the tactics of rational drug therapy are presented.

EFFECTS OF BIOLOGICAL THERAPY ON QUALITY OF LIFE AND PSYCHOEMOTIONAL STATUS OF PATIENTS WITH ULCERATIVE COLITIS

2021 ◽  
Vol 74 (10) ◽  
pp. 2610-2613
Author(s):  
Antonina V. Varvarynets
Keyword(s):  
Quality Of Life ◽  
Ulcerative Colitis ◽  
Biological Therapy ◽  
Old Patients ◽  
Group Iii ◽  
Group I ◽  
Sf 36 ◽  
Nonspecific Ulcerative Colitis ◽  
Social Introversion

The aim: To compare the effects of tofacitinib, adalimumab and budesonide on the quality of life and psychoemotional status of patients with moderate UC. Materials and methods: The study included 104 patients with moderately severe UC aged between 18 and 75 years old. Patients were divided into 3 groups. Group I consisted of patients with UC treated with budesonide 9 mg 1 g / d (BUD; n = 34). Group II – of patients receiving adalimumab at an initial dose of 160 mg and 80 mg at week 2, followed by maintenance dose of 40 mg weekly (ADA; n = 38) and group III, who received tofacitinib 10 mg 2p / d (TOF; n = 32). Evaluation of quality of life and psycho-emotional status of patients was performed using IBDQ, SF-36 and MMRI questionnaires. Results: According to the IBDQ-questionnaire, all groups after treatment had a statistically significant increase in their results: BUD (from 146,44 ± 2,23 to 151,36 ± 2,40), ADA (from 144,28 ± 3,10 to 172,36 ± 3,12), TOF (from 149,22 ± 2, 86 to 184.36 ± 2.88), respectively, p <0.05. Also, after treatment statistically significant changes were seen in patients of all groups in regards to the psychological and physical components of the SF-36 scale. Analysis of the personality profile using MMRI of all groups of patients showed a change in scales 2 (depression), 3 (hysteria), 5 (tenderness-femininity), 6 (paranoia) and 0 (social introversion), which significantly improved in the ADA and TOF groups. Conclusions: Tofacitinib and adalimumab in patients with nonspecific ulcerative colitis of moderate severity had a better effect on quality of life and psychoemotional status compared with budesonide treatment.

Performance and QOL after Geriatric Cochlear Implantation

2008 ◽  
Vol 139 (2_suppl) ◽  
pp. P57-P58
Author(s):  
Alexandros Georgolios ◽  
Kelley Melissa Dodson ◽  
Cristina Baldassari ◽  
Patrick G Maiberger ◽  
Aristides Sismanis
Keyword(s):  
Quality Of Life ◽  
Hearing Loss ◽  
Patient Satisfaction ◽  
Cochlear Implantation ◽  
Age Groups ◽  
The Elderly ◽  
Time Interval ◽  
Comorbid Conditions ◽  
Glasgow Benefit Inventory

Objective To assess audiologic performance and quality of life in geriatric cochlear implantation patients and to determine whether comorbid medical conditions, etiology, and duration of hearing loss impact audiologic and quality of life outcomes. Methods Geriatric patients who underwent cochlear implantation between 1990 and 2006 were evaluated. Inclusion criteria were 55 years of age or older at time of implantation and post-lingual hearing loss. Patients with primary language other than English were excluded. 49 cochlear implant recipients were identified. A group of younger implanted patients was used as a control. All patients completed standardized audiologic tests including the Hearing In Noise Test. Validated surveys, including the Glasgow Benefit Inventory and the Hearing Handicap Inventory for the Elderly, were used to assess quality of life. Results The mean age at implantation was 69.5 (range 58–85) and the average time interval from the implantation to the completion of the surveys was 73.2 months (6 to 229). Identified comorbid conditions included hypertension, diabetes, and malignancies, among others. Audiologic performance and quality of life scores between the two groups were similar. In the geriatric group there was no difference in patient satisfaction between subgroups with 0–1, 2–3 or > 3 comorbid conditions. Conclusions Our results suggest that the audiologic performance and quality of life scores between the older and younger age groups are similar. In the geriatric group associated comorbidities did not interfere with patient satisfaction as assessed by survey instruments.

Ageing, Meaning and the Allocation of Resources

1995 ◽  
Vol 15 (2) ◽  
pp. 163-184 ◽  
Author(s):  
Harry R. Moody
Keyword(s):  
Quality Of Life ◽  
Old Age ◽  
Age Groups ◽  
Health Resources ◽  
Basic Research ◽  
The Elderly ◽  
Ageing Society ◽  
Scarce Resources ◽  
Productive Ageing

ABSTRACTDifferent scenarios for an ageing society presume different approaches to the meaning of old age. One scenario anticipates a Prolongation of Morbidity, where quality of life concerns might permit active euthanasia or suicide as a means of saving money. Those who believe in a Compression of Morbidity opt for health promotion to delay morbidity in favour of productive ageing. Optimists look to a scenario of Lifespan Extension, where scarce health resources are not expended for incremental gains in life expectancy but rather for basic research to postpone or eliminate ageing. Finally, those who emphasize Voluntary Acceptance of Limits identify the meaning of old age with voluntary acceptance of finitude, where claims of future generations might limit longevity for any one generation. Thus, contrasting meanings such as quality of life, productive ageing, indefinite survival and voluntary limits entail very different consequences for the allocation of scarce resources across age-groups and among sub-groups of the elderly population.

Functional Outcomes and Quality of Life in Elderly Patients after Restorative Proctocolectomy for Ulcerative Colitis

Digestion ◽  
2019 ◽  
Vol 101 (6) ◽  
pp. 737-742 ◽  
Author(s):  
Tomohiro Minagawa ◽  
Hiroki Ikeuchi ◽  
Ryuichi Kuwahara ◽  
Yuki Horio ◽  
Hirofumi Sasaki ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Ulcerative Colitis ◽  
Elderly Patients ◽  
Functional Outcomes ◽  
The Elderly ◽  
First Year ◽  
Significant Difference ◽  
Fecal Soiling

<b><i>Background/Aim:</i></b> Ileal pouch anal anastomosis (IPAA) has become the surgical procedure of choice for patients with ulcerative colitis (UC). However, to date few studies have examined functional outcomes or quality of life (QOL) in elderly patients after pouch construction. <b><i>Methods:</i></b> In December 2017, we sent questionnaires to 224 patients aged 65 years and older at the time who underwent an IPAA at our hospital between June 1987 and May 2015 regarding issues related to QOL and functional outcomes. Responders aged 65–69 years old were defined as the elderly group (EG), while those 70 years old and over comprised the super-EG (SEG). <b><i>Results:</i></b> The response rate was 60.7% (136/224); 70 patients were classified as EG, and 66 were classified as SEG. The SEG were older at the time of the IPAA and during the follow-up period (<i>p</i> &#x3c; 0.01). The stool frequency per day was 8 times in both groups (<i>p</i> = 0.21). There was no significant difference between the EG and SEG with regard to daytime (53 vs. 56%, <i>p</i> = 0.73) or nighttime (65.7 vs. 53%, <i>p</i> = 0.16) soiling. There was also no difference in the exacerbation of daytime or nighttime soiling compared to the first year after the operation (daytime 5.7 vs. 12.1%, <i>p</i> = 0.23; nighttime 7.1 vs. 9.1%, <i>p</i> = 0.76). QOL was evaluated using the modified fecal incontinence QOL (mFIQL) scale, with no significant difference between the EG and SEG (27 vs. 31 points). Since both groups had mFIQL scores &#x3c;50, QOL was considered to be maintained. <b><i>Conclusion:</i></b> In our analysis of elderly patients in the long-term period following surgery for UC, some noted fecal soiling, though QOL was largely maintained, and there were no serious effects on daily life.

Quality of life of prostate cancer (PCa) patients aged 60 years and older: Changes in QLQ-ELD14 dimensions after a six-month gonadotropin-releasing hormone agonist (GnRHa) therapy, according to age groups–Primary analysis of PRISME study.

2021 ◽  
Vol 39 (6_suppl) ◽  
pp. 55-55
Author(s):  
Francois Rozet ◽  
Christophe Hennequin ◽  
Pierre Mongiat-Artus ◽  
Nathalie Pello Leprince Ringuet ◽  
Anne-Sophie Grandoulier ◽  
...  
Keyword(s):  
Quality Of Life ◽  
Burden Of Illness ◽  
Age Groups ◽  
Joint Stiffness ◽  
Final Analysis ◽  
The Elderly ◽  
Least Square ◽  
Primary Analysis ◽  
Eortc Qlq

55 Background: PCa mostly affects elderly men and impacts their health-related quality of life (HRQOL). Our purpose was to compare the evolution, between age groups, of HRQOL measured through EORTC QLQ-ELD14 instrument, specific to the elderly cancer patients, after a 6-month GnRHa therapy. Methods: Between March 2018 and February 2020, a prospective, multicenter, non-interventional study was conducted in France (PRISME, NCT03516110). Urologists, radiation oncologists and medical oncologists recruited patients aged 60 years and older, with PCa, initiating a GnRHa therapy. 1000 patients were planned to be included 1:2:1 in prespecified age groups ([60-70[, [70-75[, ≥ 75 years). They reported HRQOL using ELD14 (7 dimensions, each scored 0-100): “Maintaining purpose”, “Family support” (higher scores represent better functioning), “Mobility”, “Worries about others”, “Future worries”, “Burden of illness” and “Joint stiffness” (higher scores represent worse functioning). Analyses of covariance (ANCOVA) were performed to compare evolution of each of the 7 dimensions of ELD14 between subgroups of ages, adjusted on baseline scores. Level of significance was set to 0.002 because of the multiplicity testing on the 7 dimensions (Bonferroni). Results: After enrollment of 814 patients by 138 investigators, enrollment was stopped because of a slow recruitment in the [70-75[ group. The final analysis included 652 patients (full analysis set population). Mean (±SD) age was 72.5±6.2 years. There were 193, 269 and 190 patients, in the [60-70[, [70-75[ and ≥75y age groups, respectively. 71.6% had at least one comorbidity at baseline and 65.0% were receiving at least one concomitant systemic treatment. Main reasons for GnRHa initiation were high risk PCa in 65.3%, metastatic stage in 18.4%, biochemical recurrence in 13.3%. For each dimension, ANCOVA analyses showed that changes from baseline, adjusted on baseline values, were not significantly different between age groups. For example, least square (LS) means (SE) changes in “Mobility” scores from baseline were 3.01 (1.13), 3.14 (0.95) and 6.13 (1.15) in the [60-70[, [70-75[ and ≥75y age groups, indicating a worsening in all groups, but without significant differences between groups (Table). Conclusions: In this large observational cohort of PCa men with prespecified age groups, HRQOL changes after a 6-month GnRHa therapy didn’t depend on age group. Clinical trial information: NCT03516110. [Table: see text]

scholarly journals Satisfaction in Old Age: Activity or Disengagement?

2020 ◽  
Vol 12 (1) ◽  
pp. 7
Author(s):  
Sumi Rani Saha ◽  
Ashik Zaman
Keyword(s):  
Quality Of Life ◽  
Elderly People ◽  
Aging Process ◽  
Life Experiences ◽  
Age Groups ◽  
The Elderly ◽  
Activity Level ◽  
Face To Face ◽  
Descriptive Research

The aging process of human being is intertwined with two vital aspects of life experiences; work and retirement when elderly people face greater uncertainties than other age groups as they have to replace themselves in the newer environs with shifting roles. Thus, in this process, researchers have queries whether elderly disengage or withdraw, whether their disengagement or activity brings satisfactions and how is their attitude towards the functionality of disengagement. To measure these, disengagement and activity theories have been used with descriptive research design when respondents were selected purposively and interviewed Face-to-Face. Most of the elderly in Bangladesh believe themselves to be forced to retire. A significant portion of retired elderly answered that they wanted to be engaged instead retire but, in reality, most of them enjoy disengagement escaping from earlier activities that ensures their quality of life and satisfaction. After all, it is found that disengagement is functional as the sense that the elderly people give up their positions to the young as they are not able to defeat them in the activity level.

scholarly journals Quality of life of an elderly person in the conditions of urban space

2020 ◽  
Vol 80 ◽  
pp. 01004
Author(s):  
Olga A. Antipanova ◽  
Galina A. Barysheva
Keyword(s):  
Quality Of Life ◽  
Urban Environment ◽  
Urban Space ◽  
Age Groups ◽  
Elderly Person ◽  
The Elderly ◽  
Active Ageing ◽  
Social Partnership ◽  
Relevant Today

The article considers the problem of the quality of life of the elderly in the city. A high-quality innovative urban environment is understood as a safe, comfortable space for living and recreation using smart city (home) technologies, adapted for all social groups of the population, including age groups. In modern Russia, the demographic situation requires paying attention to the compliance with city standards and criteria for the quality of life of seniors in a digital economy. This work is relevant today due to the increase in the retirement age. Principles of the active ageing effective strategy shall be based on the social partnership of state and elderly people. In the context of the foregoing, the quality of life of an elderly person is becoming increasingly important for the formation of a humanistic social urban environment in connection with the need to adapt a person to living conditions that change late in life.

scholarly journals Autonomic Dysfunctions in Parkinson’s Disease: Prevalence, Clinical Characteristics, Potential Diagnostic Markers, and Treatment

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Zhe Zhang ◽  
Sheng-Di Chen
Keyword(s):  
Quality Of Life ◽  
Parkinson’S Disease ◽  
Parkinson's Disease ◽  
Clinical Characteristics ◽  
Treatment Options ◽  
Clinical Manifestations ◽  
The Elderly ◽  
Disease Prevalence ◽  
Autonomic Dysfunctions

Parkinson’s disease (PD) is a common neurodegenerative disease in the middle-aged and the elderly. Symptoms of autonomic dysfunctions are frequently seen in PD patients, severely affecting the quality of life. This review summarizes the epidemiology, clinical manifestations, and treatment options of autonomic dysfunctions. The clinical significance of autonomic dysfunctions in PD early diagnosis and differential diagnosis is also discussed.

scholarly journals Differences in quality of life and cognition between the elderly and the very elderly hemodialysis patients

2019 ◽  
Vol 41 (3) ◽  
pp. 375-383
Author(s):  
Fernanda Siqueira Viana ◽  
Yolanda Eliza M. Boechat ◽  
Jocemir Ronaldo Lugon ◽  
Jorge Paulo Strogoff de Matos
Keyword(s):  
Quality Of Life ◽  
Elderly Patients ◽  
Functional Capacity ◽  
Short Form ◽  
Age Groups ◽  
The Elderly ◽  
Chronic Hemodialysis ◽  
Life Assessment ◽  
Very Elderly

Abstract Introduction: In the last decades, there was an expressive increase in the number of elderly patients with chronic kidney disease starting hemodialysis. Thus, our goal was to evaluate the profile of the elderly in chronic hemodialysis and to compare the cognition and quality of life of the younger elderly with those of the very elderly. Methods: Patients on hemodialysis for at least 3 months, who were 65 years of age or older when they started dialysis were invited to participate, and stratified according to age (under or over 80 years). The participants answered a clinical-epidemiological questionnaire and underwent cognitive tests (Mini Mental State Exam [MMSE], clock drawing test [CDT] and verbal fluency test [VFT]) and a quality of life assessment 36- Item Short Form Health Survey). Results: Of the 125 eligible patients, 124 agreed to participate. The mean age was 76 ± 6 years (28% ≥ 80 years), 56% were men and 55% had ≥ 8 years of schooling. Depression was suggested in 38%. The prevalence of cognitive deficit was 38%, 70% and 30%, by MEEM, CDT and VFT, respectively. The prevalence of any deficit was higher among the very elderly (94% vs. 72%, p = 0.007). Quality of life scores were similar between the two age groups, except for the functional capacity domain, worse in the group with ≥ 80 years (p = 0.033). Conclusion: Elderly patients on chronic hemodialysis have a high prevalence of cognitive deficits, especially the very elderly, but this group does not have a worse quality of life, except for functional capacity.

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