scholarly journals Serological Screening of Celiac Disease in Patients with Juvenile Idiopathic Arthritis

2021 ◽  
Vol 24 (10) ◽  
pp. 783-785
Author(s):  
Payman Sadeghi ◽  
Kobra Salari ◽  
Vahid Ziaee ◽  
Nima Rezaei ◽  
Kambiz Eftekhari
Keyword(s):  
Juvenile Idiopathic Arthritis ◽  
Celiac Disease ◽  
Screening Tests ◽  
P Value ◽  
Growth Disorders ◽  
Gluten Free ◽  
Medical Sciences ◽  
Sex Distribution ◽  
Serological Screening ◽  
Rule Out

There is a possible association between celiac disease (CD) and juvenile idiopathic arthritis (JIA). Our aim was to evaluate the serological incidence of CD in patients with JIA. Children under 16 years of age with JIA who did not respond adequately to routine treatment, who referred to the pediatric centers of Tehran University of Medical Sciences (2017–2019), were enrolled in this study. Manifestations of CD were also evaluated. CD-related serological screening tests were measured. Seventy-eight patients were enrolled in the study. Their mean age was 7.9±3.9 (1.6–16) years. Three patients with oligoarticular JIA had Anti-TTG-Ab levels above normal (prevalence=3.8%). None of them had symptoms of CD. There were no significant statistical differences in terms of growth disorders, sex distribution, and different subtypes of JIA (P value ˃ 0.05) between the groups (sero-positive vs. sero-negative). In one case, CD was confirmed by pathology and the gluten-free diet was recommended. The absence of CD symptoms in patients with JIA does not rule out concomitant CD.

scholarly journals Clinical Features and Symptom Recovery on a Gluten-Free Diet in Canadian Adults with Celiac Disease

2013 ◽  
Vol 27 (8) ◽  
pp. 449-453 ◽  
Author(s):  
Olga Pulido ◽  
Marion Zarkadas ◽  
Sheila Dubois ◽  
Krista MacIsaac ◽  
Isabelle Cantin ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Clinical Features ◽  
Gluten Free Diet ◽  
Screening Tests ◽  
Gluten Free ◽  
Serological Screening ◽  
Support Organizations ◽  
Perceived Quality Of Life ◽  
Symptom Recovery ◽  
Delays In Diagnosis

BACKGROUND: Celiac disease can present with mild or nongastrointestinal symptoms, and may escape timely recognition. The treatment of celiac disease involves a gluten-free diet, which is complex and challenging.OBJECTIVE: To evaluate clinical features and symptom recovery on a gluten-free diet in a Canadian adult celiac population.METHODS: All adult members (n=10,693) of the two national celiac support organizations, the Canadian Celiac Association andFondation québécoise de la maladie coeliaque,were surveyed using a questionnaire.RESULTS: A total of 5912 individuals (≥18 years of age) with biopsy-confirmed celiac disease and/or dermatitis herpetiformis completed the survey. The female to male ratio was 3:1, and mean (± SD) age at diagnosis was 45.2±16.4 years. Mean time to diagnosis after onset of symptoms was 12.0±14.4 years. Abdominal pain and bloating (84.9%), extreme weakness/tiredness (74.2%), diarrhea (71.7%) and anemia (67.8%) were the most commonly reported symptoms at the time of diagnosis. Many respondents continued to experience symptoms after being on a gluten-free diet for >5 years. Sex differences were reported in clinical features before diagnosis, recovery after being on gluten-free diet and perceived quality of life, with women experiencing more difficulties than men.CONCLUSIONS: Delays in diagnosis of celiac disease in Canada remain unacceptably long despite wider availability of serological screening tests. Many patients report continuing symptoms despite adhering to a gluten-free diet for >5 years, with women experiencing more symptoms and a lower recovery rate than men. Awareness of celiac disease needs improvement, and follow-up with a physician and a dietitian is essential for all patients with celiac disease.

scholarly journals CELIAC DISEASE;

2018 ◽  
Vol 21 (02) ◽  
pp. 275-279
Author(s):  
Sikandar Ali Bhand ◽  
Farzana Shaikh ◽  
Hussain Bux Korejo ◽  
Syed Jamal Raza
Keyword(s):  
Bone Mineral Density ◽  
Celiac Disease ◽  
Bone Mineral ◽  
Gluten Free Diet ◽  
P Value ◽  
Gluten Free ◽  
Mineral Density ◽  
Dexa Scan ◽  
Group I ◽  
Group Ii

Objective: To evaluate effectiveness of treating previously untreated patients withceliac disease with both a gluten free diet and bisphosphonate in order to significantly increasetheir BMD’s to a greater extent than a gluten free diet alone. Patients and methods: The studywas conducted in National Institute of Child Health (NICH) Karachi to evaluate the effectiveness oftreating previously untreated patients with celiac disease with a gluten free diet andbisphosphonate in terms of increase in bone mineral density in comparison to a gluten free dietalone over a period of three months (January 2013 – March 2013). The study includes 30 childrenpatients below fifteen years of age either sex. All study subjects were untreated celiac patientsdiagnosed by clinical presentation, small bowel histology and serologic testing. On day dexascan was done. Fifteen patients kept on Gluten Free Diet (GFD) and remaining 15 patients keptGFD plus tablet of bisphosphonate. After three months dexa scan was repeated. The patientswith other disease of bone or mineral metabolism, as well as subjects taking systemicglucocorticoids or high doses of thyroid hormones, were excluded. Results: A total of 30 patientswith celiac disease were included in this study. Out of 30 patients 18 (60%) were female and 12(40%) male (M: F = 1:1.5). Thirty patients were divided in two equal groups (15 patients in eachgroup). In group-I we gave gluten free diet and in group-II we gave gluten free diet and one tabletof bisphosphonate. Mean± SD of Bone Mineral Density (BMD) in group-I was 0.402± 0.081gm/cm2 (range=0.234 – 0.503 gm/cm2), and in group-II was 0.543± 0.098 gm/cm2 (range=0.402 – 0.743 gm/cm2), mean difference of bone mineral density was significant between twogroups (P-value=0.0002). Conclusions: At three months DEXA scan showed a significant rise inBMD in group-II as compared to group-I

scholarly journals CELIAC DISEASE

2016 ◽  
Vol 23 (07) ◽  
pp. 807-811
Author(s):  
Nagina Shahzadi ◽  
Muhammad Almas Hashmi ◽  
Sadida Bahawal
Keyword(s):  
Celiac Disease ◽  
Health Benefit ◽  
Gluten Free Diet ◽  
Control Group ◽  
P Value ◽  
Gluten Free ◽  
Newly Diagnosed ◽  
And Gender ◽  
Disease Study ◽  
Trial Setting

Objectives: Probiotics are alive organisms which confer health benefit whentaken at an appropriate dosage. This study was done to determine the efficacy of probiotics indecreasing the frequency of diarrhea in children with celiac disease. Study Design: Randomizedcontrolled trial. Setting: Department of Pediatrics/DHQ Allied Hospital, Faisalabad. Period:November 2011 to October 2012. Methods: Newly diagnosed patients with CD having diarrheawere included by consecutive non-probability sampling. Patients were randomized in twogroups using computer generated numbers. One group was given probiotic along with glutenfree diet while other was only prescribed gluten free diet. Reduction in frequency of diarrhea intwo groups was compared after a period of 28 days. Results: A total of 116 cases (58 in eachgroup) were enrolled. Mean age was 9.11 years. The groups were similar in age and gender ofpatients. Comparison of efficacy of probiotics in children with CD was done with control groupwhich revealed reduction in stools frequency to less than half in 86.21% (n=50) in probioticgroup but only 62.07% (n=36) in control group. P-value was 0.00015 which shows a highlysignificant difference in both groups. Conclusion: Probiotics in addition to gluten free diet arehighly effective in reducing the frequency of diarrhea in newly diagnosed patients with CD, incomparison with gluten free diet alone.

scholarly journals Celiac Disease in Bangladesh – Two Case Reports

2013 ◽  
Vol 37 (1) ◽  
pp. 45-48 ◽  
Author(s):  
Md Rukunuzzaman ◽  
ASM Bazlul Karim ◽  
SM Baqui Billah ◽  
Md Atiar Rahman ◽  
Md Mahbubul Islam ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Screening Test ◽  
Villous Atrophy ◽  
Case Reports ◽  
Growth Failure ◽  
Gluten Free Diet ◽  
Chronic Diarrhoea ◽  
Gluten Free ◽  
Immunological Disorder ◽  
Rule Out

Celiae disease is an immunological disorder precipitated by gluten in genetically susceptible persons. Its prevalence is not known in Bangladesh because of unavailability of its screening test. There is diversity in the presentation of celiac disease. Two children of 5 and 8 years of age who were diagnosed as celiac disease are reported here. One presented typically with chronic diarrhoea & growth failure. Another child presented with features of chronic liver disease. In both the cases IgA tTGA were positive and duodenal biopsy showed villous atrophy. After diagnosis, both the patients were kept on gluten free diet (GFD). After six months of GFD, IgA tTGA came down to normal in both the cases. They were then given gluten containing diet again & after few months IgA tTGA again raised in both the cases. Thereafter the cases were finally diagnosed as celiac disease and were advised life long gluten free diet. Celiac disease is not uncommon in Bangladesh and screening test should be done to diagnose or rule out celiac disease when there is a suspicion. DOI: http://dx.doi.org/10.3329/bjch.v37i1.15351 BANGLADESH J CHILD HEALTH 2013; VOL 37 (1) : 45-48

scholarly journals REVIEW OF CELIAC DISEASE PRESENTATION IN A PEDIATRIC TERTIARY CENTRE

2018 ◽  
Vol 55 (1) ◽  
pp. 86-93 ◽  
Author(s):  
Gracinda Nogueira OLIVEIRA ◽  
Rajiv MOHAN ◽  
Andrew FAGBEMI
Keyword(s):  
Celiac Disease ◽  
Clinical Laboratory ◽  
Positive Family History ◽  
Human Leukocyte ◽  
Gluten Free Diet ◽  
P Value ◽  
Gluten Free ◽  
Human Leukocyte Antigen Typing ◽  
Hydroxyvitamin D ◽  
Tertiary Centre

ABSTRACT BACKGROUND: Celiac disease is an immune-mediated disorder with a multiform presentation and therefore a challenging diagnosis. OBJECTIVE: Our purpose is to identify the epidemiological, clinical, laboratory and histologic characteristics of children with celiac disease at diagnosis and on follow-up. METHODS: Children with previously established or newly diagnosed celiac disease, admitted in a tertiary centre in a two-year period (2014-2016) were recruited. Data was collected retrospectively from electronic medical records and clinical notes, and subsequently analysed with SPSS version 20.0. RESULTS: A total of 159 patients, out of 312, were included. Age ranged from 1 to 17 years (mean ± SD: 8.5±4.5 years, 69% girls). Disease presentation was classical in 60%, non-classical in 25%, subclinical in 10% and 5% classified as potential celiac disease. Non-classical and subclinical profiles had a higher mean age at presentation but not statistically significant (P-value 0.24). The most frequent gastrointestinal features at presentation were abdominal pain (58%), diarrhea (43%) and bloating (27%). A positive family history for celiac disease was present in 24% (n=35). We found anaemia in 23%, low ferritin in 63% and a moderate to severe deficiency of 25-hydroxyvitamin D in 62%. celiac disease -specific serologic testing and esophagogastroduodenoscopy were performed in 99%. Histology revealed modified Marsh 2 or 3 enteropathy in 94%, the remaining had normal histology but positive human leukocyte antigen typing. Clinical improvement at 12 months of gluten-free diet was complete in 51% and partial in 49%. IgA tTG normalized after 12-30 months of gluten-free diet in 45%. On growth assessment at diagnosis and after 12-28 months of gluten-free diet, 100% had height increase (mean ±SD: 7.11±4.43 cm) and 96% weight gain (mean ±SD: 5.60±4.91 kg). CONCLUSION: Our findings outline the diverse clinical presentations of pediatric celiac disease that should be considered irrespective of age. Increased clinician’s awareness will enable an early diagnosis and treatment, with subsequent symptom and nutritional status improvement.

scholarly journals Response to gluten free diet in sero-positive celiac disease children suffering from severe acute malnutrition in age group 1-5 years

2019 ◽  
Vol 6 (3) ◽  
pp. 1090
Author(s):  
Mahendra Meena ◽  
Pradeep Meena ◽  
R. L. Suman ◽  
Suresh Goyal
Keyword(s):  
Celiac Disease ◽  
Weight Gain ◽  
Severe Acute Malnutrition ◽  
Gluten Free Diet ◽  
Acute Malnutrition ◽  
P Value ◽  
Age Group ◽  
Gluten Free ◽  
Group 1

Background: Diagnosis of celiac disease in children suffering from severe acute malnutrition without duodenal biopsy or HLA typing is a dilemma. The objective of this study was to study the response to gluten free diet in sero-positive Celiac Disease children suffering from severe acute malnutrition in age group 1-5 years.Methods: This prospective, observational, hospital-based study was conducted at MTC of tertiary care medical college hospital of southern Rajasthan from Dec. 2017 to Nov. 2018. Total 110 children with SAM were enrolled and screened for celiac disease on the basis of tissue tTg-IgA/IgG serology. Seropositive cases were kept on gluten free diet for short period of time and observed for the resolution of symptoms and improvement in growth, monitored by anthropometry on discharge and follow up visit.Results: Mean weight gain (gm/kg/day) on follow up was 3.87±3.49 in seropositive and 1.88±3.79 in seronegative cases (P-value<0.05). Mean weight gain was 6.43±3.28gm/kg/day in only tTg-IgA positive and 3.04±2.95 gm/kg/day in only tTg-IgG positive cases (P-value-<0.05). The mean weight gain in strictly gluten free adherent sero-positive cases was 4.89±2.97 gm/kg/day while in gluten free non-adherent patients it was -0.49±1.70 (P-value <0.001). Mean weight gain in probable (tTg-Ig-A <10 times ULN) and presumptive (tTg-IgA >10 times ULN) Celiac disease were 3.44±3.73 and 5.44±3.78, respectively without statically significant difference (P-value >0.05).Conclusions: In situations where facility of duodenal biopsy and or HLA DQ2/DQ8 typing is not available, resolution of symptoms and improvement in growth on gluten free diet confirms the diagnosis of celiac disease.

scholarly journals Misuse of serological screening tests for celiac disease in children: A prospective study in Italy

2019 ◽  
Vol 51 (11) ◽  
pp. 1547-1550 ◽  
Author(s):  
Elisa Franceschini ◽  
Maria Elena Lionetti ◽  
Grazia D’Adamo ◽  
Elisa D’Angelo ◽  
Simona Gatti ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Prospective Study ◽  
Screening Tests ◽  
Serological Screening ◽  
A Prospective Study

scholarly journals The Role of Gluten-Free Diet in Rebalancing Micronutrient Deficiencies in Children With Celiac Disease

2020 ◽  
Vol 5 (1) ◽  
pp. 22-27
Author(s):  
Seyed Mohsen Dehghani ◽  
Anis Amirhakimi ◽  
Iraj Shahramian ◽  
Najmeh Rahanjam ◽  
Fatemeh Fazeli ◽  
...  
Keyword(s):  
Vitamin D ◽  
Celiac Disease ◽  
Gluten Free Diet ◽  
Gluten Free ◽  
Micronutrient Deficiencies ◽  
Medical Sciences ◽  
Normal Range ◽  
Before And After ◽  
The Status ◽  
The Mean

Introduction: Celiac disease (CD) is one of the most common reasons for malnutrition. This study aimed to determine the status of the micronutrients, including vitamins and minerals in children with CD. Methods: The participants of this study included children <18 years old newly diagnosed with CD from January 2016 to December 2017 in the Clinic of Gastrointestinal and Digestive Diseases affiliated with Shiraz University of Medical Sciences. The diagnosis of CD was based on serological and pathologic findings. Finally, the data was analyzed using SPSS 22. Results: In the present study, 78 children with CD were evaluated, including 30 (38.5%) males and 48 (61.5%) females. The levels of hemoglobin and iron significantly improved after 6 months of treatment (P=0.001). In the present study, the level of calcium was below the normal range in 5 (6.4%) patients at diagnosis. However, its level was within a normal range in all patients 6 months after the treatment. Based on the results, the level of phosphorus was low in 24 (30.7%) and 5 (6.4%) patients before and after the treatment, respectively (P=0.001). Further, the vitamin D level was below a normal range in 66 (84.6%) and 15 (19.2%) patients at diagnosis and 6 months after the treatment, respectively (P=0.001). On the other hand, the mean level of folic acid increased from 16.5 at diagnosis to 22.39 after 6 months of treatment (P=0.001). Finally, the mean level of zinc also increased from 73.3 at diagnosis to 81.6 after 6 months of treatment (P=0.001). Conclusion: In general, the levels of iron, folate, vitamin D, and zinc reduced in patients with CD. In most patients, these deficiencies improved by receiving a gluten-free diet (GFD). Monitoring patients with CD is recommended for the diagnosis of micronutrient deficiencies.

A Clinical and Histochemical Study of Celiac Disease Before and During a Gluten-Free Diet

1965 ◽  
Vol 48 (2) ◽  
pp. 155-172 ◽  
Author(s):  
I. Michael Samloff ◽  
John S. Davis ◽  
Eric A. Schenk
Keyword(s):  
Celiac Disease ◽  
Histochemical Study ◽  
Gluten Free Diet ◽  
Gluten Free

D-Dimer Determination to Exclude Pulmonary Embolism: a Two-Step Approach Using Latex Assay as a Screening Tool

1994 ◽  
Vol 72 (01) ◽  
pp. 089-091 ◽  
Author(s):  
P de Moerloose ◽  
Ph Minazio ◽  
G Reber ◽  
A Perrier ◽  
H Bounameaux
Keyword(s):  
Pulmonary Embolism ◽  
Screening Tool ◽  
Screening Tests ◽  
Enzyme Linked Immunosorbent Assay ◽  
Elisa Assay ◽  
Elisa Technique ◽  
Diagnostic Step ◽  
D Dimer ◽  
Rule Out ◽  
Latex Test

SummaryD-dimer (DD), when measured by a quantitative enzyme-linked immunosorbent assay (ELISA), is a valuable test to exclude venous thromboembolism (VTE). However, DD ELISA technique is not appropriate for emergency use and the available agglutination latex assays are not sensitive enough to be used as an alternative to rule out the diagnosis of VTE. Latex assays could still be used as screening tests. We tested this hypothesis by comparing DD levels measured by ELISA and latex assays in 334 patients suspected of pulmonary embolism. All but one patient with a positive (DD ≥500 ng/ml) latex assay had DD levels higher than 500 ng/ml with the ELISA assay. Accordingly, ELISA technique could be restricted to patients with a negative result in latex assay. This two-step approach would have spared about 50% of ELISA in our cohort. In conclusion, our data indicate that a latex test can be used as a first diagnostic step to rule out pulmonary embolism provided a negative result is confirmed by ELISA and the performance of the latex assay used has been assessed properly.

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