scholarly journals Wild Honey Poisoning: A Case Report from Remote Mountains

2021 ◽  
pp. 33-35
Author(s):  
Santosh Adhikari ◽  
Abhishek Bhandari
Keyword(s):  
Nervous System ◽  
Case Report ◽  
District Hospital ◽  
Altered Mental Status ◽  
Sodium Ion ◽  
Pain Reliever ◽  
The World ◽  
Cardiac Muscles ◽  
Sodium Ion Channels ◽  
Different Parts

Wild honey is consumed as a tonic in different parts of the world with a belief of increasing libido and treating various musculoskeletal, gastrointestinal and cardiovascular symptoms. However, honey produced from the nectar of several species of the Ericaceae (Rhododendron) family may contain grayanotoxins which act on sodium ion channels and place them in partially open state which causes symptoms like sweating, dizziness and altered sensorium owing to their effect on cardiac muscles and nervous system. We report a case of 60 years male who consumed wild honey as a pain reliever and later presented to the emergency room of Manang District Hospital with bradycardia, hypotension and altered mental status.

Case report of neurotoxicity with blinatumomab and concurrent intrathecal chemotherapy in second relapse of acute lymphoblastic leukemia with central nervous system disease

2018 ◽  
Vol 25 (8) ◽  
pp. 2027-2030 ◽  
Author(s):  
Jason Chen ◽  
Dat Ngo ◽  
Joseph Rosenthal
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Case Report ◽  
Acute Lymphoblastic Leukemia ◽  
Lymphoblastic Leukemia ◽  
Central Nervous System Involvement ◽  
Altered Mental Status ◽  
Intrathecal Chemotherapy ◽  
Speech Impairment ◽  
Central Nervous System Toxicity

A 26-year-old male with a history of pre-B cell acute lymphoblastic leukemia and seizures presented with second relapse of acute lymphoblastic leukemia and central nervous system involvement, 19 years after the initial diagnosis. Over the next two months, the patient received six doses of triple intrathecal chemotherapy (cytarabine, methotrexate, and hydrocortisone), three concurrently with continuous blinatumomab in the second month. Approximately 12 days after blinatumomab initiation, he developed central nervous system toxicity manifesting as speech impairment, altered mental status, incontinence, and diffuse weakness. Blinatumomab was discontinued, and he was started on dexamethasone. Within the next couple of months, his neurologic status recovered, and he was able to perform all of his baseline activities without limitation. Unfortunately, the patient eventually expired after further relapse approximately one year later. To our knowledge, this is the first published case report of severe neurotoxicity in a patient who was given blinatumomab concurrently with intrathecal chemotherapy.

scholarly journals Research on the Neurobiology of COVID-19

2021 ◽  
Vol 245 ◽  
pp. 03045
Author(s):  
Yilun Tong
Keyword(s):  
Nervous System ◽  
Molecular Mechanism ◽  
The Novel ◽  
Neurologic Manifestations ◽  
Neurological Manifestations ◽  
Corona Virus ◽  
The World ◽  
Human Nervous System ◽  
Different Parts

More studies have shown the neurological manifestations of the novel corona virus (COVID-19) and have inferred the molecular mechanism by which it invades the nervous system. The neurological aspect of the COVID-19 pandemic has been differently interpreted and dealt with in different parts of the world. To review the neurological manifestations and the neurovirulent mechanism by which CoV attacks the human nervous system and to examine different perspectives on this very same topic, the research on PubMed and ScienceDirect is conducted. The mechanisms that CoV enter and attack the nervous system and the subsequent neurologic manifestations have been proposed and now seems quite clear. However, more studies have to be done directly on the effect of COVID-19 on the CNS as well as the PNS.

Acute Pancreatitis Following Organophosphate Compound Poisoning: A Case Report

2021 ◽  
Vol 1 (4) ◽  
pp. 250-252
Author(s):  
Suman K. Jha ◽  
Sabin Chaulagain ◽  
Shiva Kumar Ojha ◽  
Angela Basnet Neela Sunuwar ◽  
Akanchha Khadka
Keyword(s):  
Central Nervous System ◽  
Acute Pancreatitis ◽  
Nervous System ◽  
Case Report ◽  
Rural Communities ◽  
South Asian ◽  
Asian Countries ◽  
Organophosphate Compounds ◽  
The World ◽  
Agrarian Communities

Organophosphate compounds are chemicals containing central phosphate molecules with alkyl or aromatic substituent’s. They occur in diverse forms and are used as pesticides, herbicides, nerve agents, etc. Organophosphate compounds are frequently used as pesticides in agrarian communities all across the world. South Asian countries such as Nepal use vast quantities of Organophosphate compounds for pest control in agriculture. Therefore, accidental and suicidal ingestion of Organophosphate compound poisoning has been common especially among the agricultural rural communities. Apart from muscarinic, nicotinic and central nervous system effects in rare instances, Organophosphate compounds are known to cause pancreatitis.

scholarly journals Covid - 19 Associated Pulmonary Aspergillosis (CAPA) in Critically Ill Patients : A Case Report

2021 ◽  
Vol 10 (9) ◽  
pp. 402-406
Author(s):  
Himadri Dutta Vandana Sinha ◽  
Anup Jyoti Dutta Pinku Sarma
Keyword(s):  
Intensive Care ◽  
Case Report ◽  
Early Diagnosis ◽  
Critically Ill Patients ◽  
Private Hospital ◽  
Standard Treatment ◽  
Pulmonary Aspergillosis ◽  
The World ◽  
Different Parts

In the present study report three cases of covid-19 associated Pulmonary Aspergillosis from covid ICU of a private hospital. There is increased incidence of different co infections including fungal from severe cases of covid-19 requiring ICU care from different parts of the world. None of the patients in our report had any predisposing lung conditions and none of them were on long term steroids treatment. Out of the three cases, two cases clinically improved dramatically after initiation of antifungals. Second case deteriorated even before culture diagnosis was established and the patient died before antifungals could be started. So, possibility of a fungal infection should be always ruled out in all COVID-19 pneumonia cases without any clinical improvement after standard treatment and intensive care. Early diagnosis and treatment will help improve clinical outcomes in such cases.

scholarly journals “Long COVID”: A case report of persistent symptoms in a patient with prolonged SARS-CoV-2 shedding for over 110 days

2021 ◽  
Vol 9 ◽  
pp. 2050313X2110154
Author(s):  
Ayanfe Omololu ◽  
Barakah Ojelade ◽  
Oluwatomiwa Ajayi ◽  
Tolu Adesomi ◽  
Oreoluwa Alade ◽  
...  
Keyword(s):  
Health Care ◽  
Central Nervous System ◽  
Nervous System ◽  
Case Report ◽  
Musculoskeletal Symptoms ◽  
Viral Shedding ◽  
Persistent Symptoms ◽  
The World ◽  
Care Worker

Coronavirus disease 2019 is a novel disease currently ravaging the world as a pandemic. More emphasis has been focused on the acute disease, with less attention on the detection and management of long-term sequelae which develop in some patients, variously termed “Long COVID,” Post-coronavirus disease 2019 syndrome, or ongoing coronavirus disease. There are also various reports in the literature on the duration of viral shedding, with the longest known recorded being about 70 days, and whether this duration has an effect on prognosis or patients remaining infectious is still unknown. We report the case of a 22-year-old health care worker with prolonged multi-systemic features of coronavirus disease 2019 including cardiovascular, respiratory, central nervous system, and musculoskeletal symptoms lasting about 18 weeks from symptom onset, though never hospitalized, and persistent detection of severe acute respiratory syndrome coronavirus 2 attributed to viral shedding for over 110 days, which is the longest duration recorded to our knowledge.

scholarly journals  Equine grass sickness in the Czech Republic a case report

2014 ◽  
Vol 59 (No. 3) ◽  
pp. 137-140 ◽  
Author(s):  
P. Melkova ◽  
P. Cizek ◽  
E. Ludvikova ◽  
B. Bezdekova
Keyword(s):  
Czech Republic ◽  
Case Report ◽  
Sympathetic Neurons ◽  
Clinical Signs ◽  
Neural System ◽  
The Czech Republic ◽  
Grass Sickness ◽  
First Case ◽  
The World ◽  
Different Parts

Equine grass sickness (EGS) is a degenerative polyneuropathy affecting postganglionic parasympathetic and sympathetic neurons. The major clinical signs relate to dysfunction of the gastrointestinal tract and the condition is frequently fatal. EGS has been reported in different parts of the world including Europe. This paper describes the first case of equine dysautonomia in the Czech Republic. The ante mortem diagnosis was based on typical clinical signs and a positive phenylephrine eye-drop test and was confirmed at necropsy following observation of pathognomic histopathological lesions in the enteric neural system of the ileum.  

scholarly journals Delirium Associated with Salicylate and Acetaminophen Overdose in a Patient with COVID-19: A Case Report

2020 ◽  
Vol 4 (4) ◽  
pp. 517-520
Author(s):  
Tyler Wen ◽  
Jason Chu ◽  
Danielle Allenspach ◽  
David Van
Keyword(s):  
Emergency Department ◽  
Central Nervous System ◽  
Nervous System ◽  
Case Report ◽  
Mental Status ◽  
Clinical Manifestations ◽  
Altered Mental Status ◽  
Psychosocial Stressors ◽  
Acetaminophen Overdose ◽  
Wide Range

Introduction: The coronavirus disease 2019 (COVID-19) pandemic has created numerous clinical challenges for physicians, in part due to its wide range of clinical manifestations and associated complications. Case Report: Here we present the case of a 69-year-old man who was admitted to the emergency department with fever, dyspnea, and altered mental status. We believe the patient’s condition was precipitated by a COVID-19 infection-induced delirium, a setting in which he ingested aspirin and acetaminophen in overdose that required lifesaving interventions. Conclusion: This case illustrates the potential for neuropsychiatric effects in COVID-19 patients due to both direct viral central nervous system pathology and pandemic-related psychosocial stressors.

scholarly journals Primary Central Nervous System Infection by Histoplasma in an Immunocompetent Adult: A Case Report

2021 ◽  
pp. 1-2
Author(s):  
Henry Koiti Sato ◽  
◽  
Joel Fernando Sanabria Duarte ◽  
Keyword(s):  
Central Nervous System ◽  
Nervous System ◽  
Latin America ◽  
Case Report ◽  
Histoplasma Capsulatum ◽  
Clinical Presentation ◽  
Central Nervous System Infection ◽  
Immunocompetent Adult ◽  
Disseminated Histoplasmosis ◽  
The World

Histoplasma capsulatum infection is endemic in many regions around the world, including Latin America [1]. However, cerebral presentation occurs in less than 25% of patients with disseminated histoplasmosis and even rarer as a stand-alone presentation. Three forms are described: meningeal, miliary granulomatous and parenchymal with formation of “histoplasmoma” [2]. Due to the rarity of the case and unusual clinical presentation and topography we describe the case below.

scholarly journals The internet is not limitless

2015 ◽  
pp. 81-86
Author(s):  
Niamh Kavanagh
Keyword(s):  
Nervous System ◽  
Optical Communications ◽  
High Capacity ◽  
The Internet ◽  
Optical Fibres ◽  
Digital Information ◽  
Communications Systems ◽  
The World ◽  
Electrical Pulses ◽  
Different Parts

Consider this: you’re moving to a new country and you have to fit everything into a single suitcase. Your airline is being very stringent in this situation and you don’t want to give them the satisfaction of paying more fees! So, what can you do? You could spend weeks trying to fit it all in, trying different ways to organise everything, but sometimes there’s just too much stuff. Well, why not try a completely new, lighter, bigger suitcase? In my research, I try to think the same way about optical fibres. The basis of my PhD is the development of high-capacity optical communications systems based on new types of optical fibres. In optical communications, digital information is transmitted via optical fibres. Similar to our nervous system, which sends information to different parts of our body via electrical pulses, optical fibres transmit information throughout the world using pulses of light. These ...

scholarly journals Wild Honey Poisoning: A Case Report

2019 ◽  
Vol 2 (1) ◽  
pp. 86-88
Author(s):  
Olita Shilpakar ◽  
Bibek Rajbhandari ◽  
Bipin Karki
Keyword(s):  
Case Report ◽  
Emergency Room ◽  
Sodium Channel ◽  
Mental Status ◽  
Altered Mental Status ◽  
Alternative Source ◽  
Altered Sensorium ◽  
The World

Wild honey is consumed in many parts of the world as an alternative source of medicine with the belief of reducing cardiovascular, gastrointestinal and many other ailments. However, intoxication secondary to consumption of wild honey produced from the nectar of a few species rhododendrons has been encountered due to a toxin known as grayanotoxin. It is a sodium channel toxin causing symptoms like bradycardia, arrhythmias, hypotension, sweating, dizziness and altered sensorium. We report a case of a 58 year old man who presented to the emergency room following ingestion of wild honey with bradycardia, hypotension and altered mental status. Keywords: bradycardia; grayanotoxin; hypotension; wild honey poisoning.

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