scholarly journals DIABETES MELLITUS DENGAN HIPERTENSI MENINGKATKAN RISIKO CHRONIC KIDNEY DISEASE: STUDI KASUS KONTROL DI RS PANTI NIRMALA MALANG

2021 ◽  
Vol 6 (2) ◽  
pp. 121
Author(s):  
Rea Ariyanti ◽  
Cecilia Wdijati Imam
Keyword(s):  
Diabetes Mellitus ◽  
Chronic Kidney Disease ◽  
Renal Failure ◽  
Kidney Disease ◽  
Public Health Problem ◽  
Global Public Health ◽  
Gender And Age ◽  
History Of ◽  
Relationship Of ◽  
The Relationship

Chronic Kidney Disease (CKD) is a global public health problem with the prevalence and incidence of increased renal failure. Approximately 1 in 10 global populations suffers from chronic renal failure at a particular stage. There are several risk factors that are suspected to increase the incidence of Chronic Kidney Disease, one of which is Diabetes Mellitus. This study aims to determine the relationship between diabetes mellitus and chronic kidney disease in the Panti Nirmala Hospital. Research design is case-control. The sample amounted to 286 respondents, consisting of 143 case groups and 143 control groups. Data analysis using logistic regression analysis. The results of multivariable analyses showed that there are two confounding variables in the relationship of diabetes mellitus with CKD i.e. gender and age. In addition, diabetes mellitus also interacts with hypertension. Diabetes mellitus interacts with hypertension to increase the risk of CKD (OR=15.9; 95% CI 4.4 to 57.4; p=<0.001). After controlled by gender and age, Hypertension or a history of Hypertension, respondents with Diabetes Mellitus were 15.9 times more likely to have Chronic Kidney Disease than non-Diabetes Mellitus respondents. 

THE RELATIONSHIP OF FAMILY SUPPORT WITH QUALITY OF LIFE AMONG PATIENTS WITH CHRONIC KIDNEY DISEASE IN RUNNING HEMODIALIZATION THERAPY AT PMI HOSPITAL BOGOR

2018 ◽  
Vol 10 (1) ◽  
pp. 15-19
Author(s):  
Fajar Adhie Sulistyo
Keyword(s):  
Quality Of Life ◽  
Chronic Kidney Disease ◽  
Renal Failure ◽  
Chronic Renal Failure ◽  
Kidney Disease ◽  
Family Support ◽  
Kidney Failure ◽  
Relationship Of ◽  
The Relationship

Background : Chronic kidney disease is a pathophysiological process with diverse etiology, resulting in a progressive decline in renal function, and the patients generally end up with kidney failure. Family support is a support given by families who have blood relations in favor of the health of patients with kidney failure. Quality of life is an individual perception of patients with kidney failure toward his position in life. The aim of this study was to determine the relationship of family support with the quality of life of patients with chronic renal failure undergoing hemodialysis therapy in PMI hospital Bogor. The method of this research uses uses descriptively analytic type with cross sectional approach. The sample of this researchconsists of 129 respondents. The sampling was taken by accidental sampling technique. The instrument in this study were questionnaires family support and quality of life. The data were analyzed by using univariate and bivariate (using the chi-square test with α = 0.05). Result : Based on the research results through 88 respondents that (68.2%) whose family support is good, then 86 respondents (93%) have a good quality of life, and 2 respondents (5%) have less quality of life. From 8 respondents (6.2%) whose family support is less, 1 respondent (2%) have a good quality of life, and 7 respondents (19%) have a less quality of life. Based on statistical test p = 0.000, it can be concluded that there is significant correlation between both variables. Clonclusion : It is concluded that there is a relationship between family support and the quality of life among patients with chronic renal failure undergoing hemodialysis therapy in PMI hospital Bogor. Through this research, it is expected to be used as a source reference of information for nurses in hemodialysis room.

scholarly journals The Relationship between Type 2 Diabetes Mellitus with Chronic Kidney Disease In Indonesian Population In 2014-2015 (Data Analysis of IFLS 5)

2021 ◽  
Vol 4 (2) ◽  
Author(s):  
Tri Damayanti Simanjuntak ◽  
Tri Yunis Miko Wahyono
Keyword(s):  
Diabetes Mellitus ◽  
Type 2 Diabetes ◽  
Chronic Kidney Disease ◽  
Type 2 Diabetes Mellitus ◽  
Kidney Disease ◽  
Smoking Status ◽  
Chi Square ◽  
History Of ◽  
The Relationship

In 2010, the Global Burden of Disease research revealed that cases of chronic kidney disease had increased and became a serious health problem. Indonesia Basic Health Research data in 2013 revealed that the proportion of patients with chronic kidney failure aged ≥ 15 years old based on doctor's diagnosis was 0,2% and 0,6% kidney stones. Therefore the aim of the study is to analyze the relationship between type 2 diabetes mellitus and chronic kidney disease in the population of Indonesia in 2014-2015. This type of research is observational with a cross-sectional design. The study used secondary data from the Indonesia Family Life Survey (IFLS) 5 in 2014-2015. The sampling technique used total sampling, which found 34,012 people who met the inclusion and exclusion criteria. The independent variables of this study are type 2 diabetes mellitus and chronic kidney disease as the dependent variable. Covariate variables are age, sex, smoking status, history of hypertension, and history of high cholesterol. Analysis bivariate of the relationship between type 2 diabetes mellitus and chronic kidney disease in this study using chi square and multivariate analysis using logistic regression test. The magnitude of the effect expressed in the prevalence odds ratio (POR) with confident interval (CI: 95%.) This study shows the prevalence of chronic kidney disease in Indonesia population in 2014 – 2015 is 1%. The result of chi-square test of the relationship between type 2 diabetes mellitus and chronic kidney disease in the Indonesian population showed POR=2.48 (p-value =0.0002; 95%CI 1.422-4.071). Multivariate analysis with logistic regression tests shows that smoking status, history of high cholesterol, and history of hypertension influence the relationship of type 2 diabetes mellitus and chronic kidney disease.

scholarly journals A Systematic Review and Meta-Analysis of Pharmacogenetic Studies in Patients with Chronic Kidney Disease

2021 ◽  
Vol 22 (9) ◽  
pp. 4480
Author(s):  
Maria Tziastoudi ◽  
Georgios Pissas ◽  
Georgios Raptis ◽  
Christos Cholevas ◽  
Theodoros Eleftheriadis ◽  
...  
Keyword(s):  
Systematic Review ◽  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Meta Analysis ◽  
Public Health Problem ◽  
Response To Treatment ◽  
Genotype Distribution ◽  
Global Public Health ◽  
High Prevalence ◽  
Additive Inheritance

Chronic kidney disease (CKD) is an important global public health problem due to its high prevalence and morbidity. Although the treatment of nephrology patients has changed considerably, ineffectiveness and side effects of medications represent a major issue. In an effort to elucidate the contribution of genetic variants located in several genes in the response to treatment of patients with CKD, we performed a systematic review and meta-analysis of all available pharmacogenetics studies. The association between genotype distribution and response to medication was examined using the dominant, recessive, and additive inheritance models. Subgroup analysis based on ethnicity was also performed. In total, 29 studies were included in the meta-analysis, which examined the association of 11 genes (16 polymorphisms) with the response to treatment regarding CKD. Among the 29 studies, 18 studies included patients with renal transplantation, 8 involved patients with nephrotic syndrome, and 3 studies included patients with lupus nephritis. The present meta-analysis provides strong evidence for the contribution of variants harbored in the ABCB1, IL-10, ITPA, MIF, and TNF genes that creates some genetic predisposition that reduces effectiveness or is associated with adverse events of medications used in CKD.

Flt3 inhibition alleviates chronic kidney disease by suppressing CD103+ dendritic cell-mediated T cell activation

2018 ◽  
Vol 34 (11) ◽  
pp. 1853-1863 ◽  
Author(s):  
Ruifeng Wang ◽  
Titi Chen ◽  
Chengshi Wang ◽  
Zhiqiang Zhang ◽  
Xin Maggie Wang ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
T Cells ◽  
T Cell ◽  
Kidney Disease ◽  
T Cell Activation ◽  
Cell Activation ◽  
Kidney Injury ◽  
Public Health Problem ◽  
Global Public Health ◽  
Flt3 Inhibitor

Abstract Background Chronic kidney disease (CKD) is a global public health problem, which lacks effective treatment. Previously, we have shown that CD103+ dendritic cells (DCs) are pathogenic in adriamycin nephropathy (AN), a model of human focal segmental glomerulosclerosis (FSGS). Fms-like tyrosine kinase 3 (Flt3) is a receptor that is expressed with high specificity on tissue resident CD103+ DCs. Methods To test the effect on CD103+ DCs and kidney injury of inhibition of Flt3, we used a selective Flt3 inhibitor (AC220) to treat mice with AN. Results Human CD141+ DCs, homologous to murine CD103+ DCs, were significantly increased in patients with FSGS. The number of kidney CD103+ DCs, but not CD103− DCs or plasmacytoid DCs, was significantly decreased in AN mice after AC220 administration. Treatment with AC220 significantly improved kidney function and reduced kidney injury and fibrosis in AN mice. AC220-treated AN mice had decreased levels of inflammatory cytokines and chemokines, tumor necrosis factor-α, interleukin (IL)-1β, IL-6, CCL2 and CCL5 and reduced kidney infiltration of CD4 T cells and CD8 T cells. The protective effect of AC220 was associated with its suppression of CD103+ DCs-mediated CD8 T cell proliferation and activation in AN mice. Conclusion Flt3 inhibitor AC220 effectively reduced kidney injury in AN mice, suggesting that this inhibitor might be a useful pharmaceutical agent to treat CKD.

scholarly journals Atherosclerotic vascular disease is more prevalent among black ESKD patients on long-term CAPD in South Africa

2019 ◽  
Vol 20 (1) ◽  
Author(s):  
S. O. Oguntola ◽  
M. O. Hassan ◽  
R. Duarte ◽  
A. Vachiat ◽  
P. Manga ◽  
...  
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Vascular Disease ◽  
Left Ventricular ◽  
Atherosclerotic Vascular Disease ◽  
Ckd Stage ◽  
Significant Difference ◽  
Echocardiographic Parameters ◽  
Relationship Of ◽  
The Relationship

Abstract Background Occurrence of cardiovascular disease (CVD) in the setting of chronic kidney disease (CKD) can be described as a “cruel alliance”, with CVD responsible for about half of all deaths among CKD patients. Chronic kidney disease patients are more likely to die from CVD than progress to end stage kidney disease (ESKD). Dyslipidaemia, a known traditional risk factor for CVD, is highly prevalent among CKD patients and with an even higher frequency among ESKD patients on dialytic therapies. Prolonged exposure of continuous ambulatory peritoneal dialysis (CAPD) patients to high glucose concentrations in CAPD fluid have been associated with increased risk of cardiovascular events. In this study, we investigated the relationship of atherosclerotic vascular disease (AsVD) to clinical and echocardiographic parameters among black South Africans with CKD (stage 3) and ESKD on CAPD and haemodialysis (HD). Methods This was a cross-sectional study of 40 adult (18–65 years) non-diabetic CKD patients (kidney disease outcome quality initiative [KDOQI] stage 3), 40 ESKD patients on CAPD, 40 ESKD patients on HD and 41 age and sex-matched healthy controls. An interviewer-administered questionnaire was used to obtain information on participants’ sociodemographic and cardiovascular risk factors. Anthropometric parameters were measured. Serum blood samples were analysed for creatinine, albumin and lipid profile; lipoprotein ratios, Framingham’s risk score and the 10-year risk of developing coronary heart disease (CHD) were calculated. Echocardiography was performed on all patients and carotid intima media thickness (CIMT) was measured in both right and left carotid arteries at 1 cm proximal to the carotid bulb. Spearman’s rank correlation and binary logistic regression were conducted to determine the relationship of AsVD to clinical and echocardiographic parameters. Results Atherosclerotic vascular disease was most prevalent among ESKD patients on CAPD (70%, n = 28/40). Chronic kidney disease and HD patients exhibited a similar prevalence (47.5%, n = 19/40), while the prevalence in controls was 17.1% (n = 7/41). Presence of AsVD was associated with significantly older age, higher waist hip ratio (WHR), left ventricular mass index (LVMI) and Framingham’s 10-year risk of developing CHD. Significant differences in clinical and echocardiographic parameters were observed when the study groups were compared. Age and LVH independently predicted AsVD. Conclusion Atherosclerotic vascular disease was more prevalent among CAPD patients compared to pre-dialysis CKD and HD patients. Among all lipoprotein ratios assessed, non-HDL-C showed the most consistent significant difference between the groups. Age (> 40 years) and presence of LVH were independent predictors of AsVD.

The chronic kidney disease “epidemy”

2013 ◽  
Vol 154 (2) ◽  
pp. 43-51 ◽  
Author(s):  
Judit Nagy
Keyword(s):  
Chronic Kidney Disease ◽  
Kidney Disease ◽  
Adult Population ◽  
Public Health Problem ◽  
General Term ◽  
Structure And Function ◽  
Global Public Health ◽  
New Classification ◽  
And Function ◽  
Global Public Health Problem

Chronic kidney disease is a general term for heterogenous disorders with >3 months duration affecting kidney structure and function. Nowadays, involving 10–16% of the adult population worldwide, chronic kidney disease is recognised as a major global public health problem. The number of cases is continuously increasing. In this review, epidemiology, definition, new classification and a conceptual model for development, progression and complications of chronic kidney disease as well as strategies to improve outcome are summarized. Orv. Hetil., 2013, 154, 43–51.

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