scholarly journals Meta-prebiotics: a new way to control the intestinal microbiota

2021 ◽  
Vol 6 (1) ◽  
pp. 29-32
Author(s):  
Irina А. Кrylova ◽  
Vitalii I. Kupaev ◽  
Аrtem V. Lyamin ◽  
Danir D. Ismatullin
Keyword(s):  
Health Status ◽  
Gut Microbiota ◽  
Intestinal Microbiota ◽  
Intestinal Microflora ◽  
Healthy People ◽  
Gram Negative ◽  
The Past ◽  
Suboptimal Health Status ◽  
Number Of Bacteria ◽  
Suboptimal Health

Objectives to analyze the quality and quantity of the intestinal microflora of relatively healthy people and/or of those who did not visit a doctor in the last 3 months, before and 1 month after taking a meta-prebiotic complex containing dietary fiber (inulin) and oligosaccharides (oligofructose). Material and methods. We examined the individuals who considered themselves healthy and/or did not consult a doctor during the past 3 months. To detect the presence of dyspeptic complaints, the clinical data were collected. 114 people with different suboptimal status and non-specific dyspeptic complaints were chosen for the study and underwent the clinical examination for the degree of gut microbiota imbalance before taking the meta-prebiotic complex. 78 people followed the course of the meta-prebiotic and were examined after 1 month after the start. Results. We have obtained new data on intestinal biocenosis at various suboptimal status in relatively healthy people: the total number of bacteria is insufficient. When using a meta-prebiotic complex containing inulin and oligofructose, the composition of the intestinal microflora was improved due to the decreased cases of detection of opportunistic enterobacteria and other gram-negative microorganisms. Conclusion. The significance of studying the intestinal microbiotic complex in patients with the increased suboptimal health status is proved, and the earlier active screening of this category of patients is recommended.

scholarly journals Microbiological Characteristics of Intestinal Biocenosis of Ambulator Patients Having Behavioral Risk Factors for Chronic Non-Communicable Diseases

2021 ◽  
Vol 11 (3) ◽  
pp. 217-224
Author(s):  
I. A. Krylova ◽  
V. I. Kupaev ◽  
A. V. Ljamin
Keyword(s):  
Risk Factors ◽  
Body Mass Index ◽  
Health Status ◽  
Intestinal Microflora ◽  
Communicable Diseases ◽  
Behavioral Risk Factors ◽  
Behavioral Risk ◽  
Non Communicable Diseases ◽  
Suboptimal Health Status ◽  
Suboptimal Health

The earliest correction of behavioral risk factors for chronic non-communicable diseases will reduce the rates of premature mortality of the population. Currently, the relationship between the altered spectrum of intestinal microflora in various indicators of suboptimal health status and body mass index is not sufficiently studied. When they are in a state of suboptimal health status, patients consider themselves healthy and do not go to the doctor for a long time, which makes it difficult to implement early preventive measures in this group of patients. Goal. To determine the qualitative and quantitative composition of the intestinal microflora before and 1 month after taking a metaprebiotic complex containing dietary fiber (inulin) and oligosaccharides (oligofructose) in outpatient patients who consider themselves healthy, have behavioral risk factors for chronic non-communicable diseases or chronic non-communicable diseases in remission, and/or do not consult a doctor within the last 3 months. Materials and methods. Outpatient patients were examined (114 people: 36 men, 78 women aged 18 to 72 years). A survey was conducted, including a detailed active collection of complaints (including using the international SHSQ-25 questionnaire) and anamnesis, as well as a thorough physical examination with an anthropometric study. Using the MALDI-ToF mass spectrometry method, the degree of microbiotic disorders, the structure of the intestinal microflora were determined with the identification of microorganisms isolated from feces before and after taking the course of the metaprebiotic complex with various indicators of suboptimal status and body mass index. Results. New data were obtained on the intestinal biocenosis of patients who consider themselves healthy at different levels of suboptimal status. When using a metaprebiotic complex containing inulin and oligofructose, an improvement in the composition of the intestinal microflora was found due to a decrease in the frequency of release of conditionally pathogenic enterobacteria and other gram-negative microorganisms (median degree of contamination: from 0.45 (0.3-0.98) to 0.3(0.21-0.7) at low suboptimal status and from 0.5(0.7-1.7) to 0.31 (0.2-1.3) at high) and increase the frequency of enterococcal excretion (median degree of contamination: from 5,58 (4,16-7,0) tо 6,3 (4,8-7,8) at low suboptimal status and from от 4,5 (2,8-6,3) tо 5,1 (3,8-6,4) at high). Conclusion. The importance of studying the microbiotic complex of the intestine in increasing the indicators of suboptimal health status and body mass index in patients who consider themselves healthy is proved, which will allow for the earliest detection and rational individual prevention of chronic non-communicable diseases.

scholarly journals Association of suboptimal health status with intestinal microbiota in Chinese youths

2019 ◽  
Vol 24 (2) ◽  
pp. 1837-1847 ◽  
Author(s):  
Qi Sun ◽  
Xizhu Xu ◽  
Jie Zhang ◽  
Ming Sun ◽  
Qiuyue Tian ◽  
...  
Keyword(s):  
Health Status ◽  
Intestinal Microbiota ◽  
Suboptimal Health Status ◽  
Suboptimal Health

Utilization of N-glycosylation profiles as risk stratification biomarkers for suboptimal health status and metabolic syndrome in a Ghanaian population

2019 ◽  
Vol 13 (15) ◽  
pp. 1273-1287 ◽  
Author(s):  
Eric Adua ◽  
Elham Memarian ◽  
Alyce Russell ◽  
Irena Trbojević-Akmačić ◽  
Ivan Gudelj ◽  
...  
Keyword(s):  
Metabolic Syndrome ◽  
Health Status ◽  
Logistic Regression Model ◽  
Area Under The Curve ◽  
Information Criterion ◽  
Ultra Performance Liquid Chromatography ◽  
Clinical Assessments ◽  
Suboptimal Health Status ◽  
Case Status ◽  
Suboptimal Health

Aim: The study sought to apply N-glycosylation profiles to understand the interplay between suboptimal health status (SHS) and metabolic syndrome (MetS). Materials & methods: In this study, 262 Ghanaians were recruited from May to July 2016. After completing a health survey, plasma samples were collected for clinical assessments while ultra performance liquid chromatography was used to measure plasma N-glycans. Results: Four glycan peaks were found to predict case status (MetS and SHS) using a step-wise Akaike’s information criterion logistic regression model selection. This model yielded an area under the curve of MetS: 83.1% (95% CI: 78.0–88.1%) and SHS: 67.1% (60.6–73.7%). Conclusion: Our results show that SHS is a significant, albeit modest, risk factor for MetS and N-glycan complexity was associated with MetS.

scholarly journals Correlation between vascular endothelial function parameters with indicators of suboptimal health status and the factors of cardiovascular risk

2016 ◽  
Vol 7 (3-4) ◽  
pp. 86-90
Author(s):  
E. Yu Marutina ◽  
V. I Kupaev ◽  
P. A Lebedev ◽  
O. Yu Borisov
Keyword(s):  
Risk Factors ◽  
Cardiovascular Risk ◽  
Health Status ◽  
Endothelial Function ◽  
Screening Methods ◽  
Vascular Endothelial ◽  
Vascular Endothelial Function ◽  
Work Activity ◽  
Suboptimal Health Status ◽  
Suboptimal Health

The problem of prevention of chronic non-communicable diseases continues to be relevant. It is a promising non-invasive integration of new screening methods to assess the patient's health system. The goal was to establish the relationship of vascular endothelial function parameters with indicators of suboptimal health status and the factors of cardiovascular risk. Materials and methods. A total of 327 residents of Samara, who had no history of disease and did not receive treatment in the last 3 months. We used a questionnaire diagnostic screening suboptimal health status SHSQ-25, the risk factors of cardiovascular diseases, endothelin-1, human blood index of endothelial function was determined by computer photopletismography. Results and discussion. Suboptimal health status is associated with the prevalence and severity of cardiovascular risk factors, smoking, overweight, total cholesterol, glucose, blood endothelin, vascular endothelium reactivity, indicating that their dominant influence on the quality of life in a population of healthy individuals. Vascular reactivity non-invasively evaluated in terms of endothelial function in the sample with ischaemia of the upper limb by computer photopletismography reflects systemic vascular endothelial function as a negative associated with endothelin blood and the main factors of cardiovascular risk: age, male gender, body mass index, the nature of work activity, blood pressure value.

scholarly journals Suboptimal Health Status of High School Students in Guangzhou, Shanxi, and Tibet, China: A Cross-Sectional Study

2020 ◽  
Author(s):  
Gehendra Mahara ◽  
Jiazhi Liang ◽  
Zhirong Zhang ◽  
Qi Ge ◽  
Jinxin Zhang
Keyword(s):  
Risk Factors ◽  
High School ◽  
High School Students ◽  
Health Status ◽  
Protective Factors ◽  
Associated Factors ◽  
Control Measures ◽  
School Students ◽  
Suboptimal Health Status ◽  
Suboptimal Health

Suboptimal health status (SHS) is a state between health and disease, has several associated factors, although, its underlying mechanism is still unclear. This study aimed to investigate the status of SHS and its associated factors of high school students in three areas of China (Shanxi, Guangzhou, and Tibet). A multidimensional sub-health questionnaire of adolescent (MSQA) is used to evaluate SHS. Among 1461 respondents, females proportion 56.47% was higher than males 43.53% where SHS was higher in Shanxi followed by Tibet and then Guangzhou. The rural area, grade, lack of sleep, home visit in a week, lack of exercise, a heavy burden of study, smoking, drinking, and fewer friends were the risk factors of SHS, while, families living status, seeking help and extroversion were the protective factors. SHS is significantly associated with different influencing factors. For comprehensive prevention and control measures, reduce the risk factors and enhance the protective factors.

scholarly journals sensitivity estimates suboptimal HealtH status using a QuestionnaiRe sHsQ-25

2014 ◽  
Vol 7 (2) ◽  
pp. 18-21
Author(s):  
Vitalii i. KupaeV ◽  
◽  
eKaterin Yu. Marutina ◽  
Oleg Yu. BOrisOV ◽  
◽  
...  
Keyword(s):  
Health Status ◽  
Suboptimal Health Status ◽  
Suboptimal Health
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