scholarly journals Комплексное лечение больных ревматоидным миокардитом коров

2019 ◽  
pp. 44-46
Author(s):  
A.V. Timakov ◽  
T.K. Timakova
Keyword(s):  
Biochemical Parameters ◽  
Inflammatory Process ◽  
Clinical Symptoms ◽  
Rapid Development ◽  
Underlying Disease ◽  
The Body ◽  
Symptomatic Therapy ◽  
Portal Circulation ◽  
Hematological And Biochemical Parameters ◽  
Sick Animal

Ревматоидный миокардит у коров протекает остро и характеризуется быстрым развитием клинических симптомов, поражает соединительную ткань сердечнососудистой системы (эндокард, миокард, реже перикард) и крупные суставы. Проявляется как осложнение при инфекционных и гемоспоридиозных болезнях, интоксикациях химическими и медикаментозными ядами, а также при аутоинтоксикациях вследствие поражения кишечника, почек. Воспалительный процесс развивается под воздействием токсинов основного заболевания. Всё это ведёт к нарушению портального кровообращения, развитию застоя крови в печени, кишечнике, легких. Как следствие возникает одышка, цианоз, отёки (начинаются на нижних частях тела), резкие нарушения ритма. Общее состояние больного животного резко ухудшается, и на фоне токсикоаллергических состояний могут возникать артриты. У коров могут быть послеродовые осложнения. В крови отмечают несоответствие гематологических и биохимических показателей. Своевременная диагностика и комплексное лечение коров с использованием средств патогенетической и симптоматической терапии позволяют восстановить нарушенные функции организма и продуктивность животных.Rheumatoid myocarditis in cows follows acute and is characterized by the rapid development of clinical symptoms, affects the connective tissue of the cardiovascular system (endocardium, myocardium, less often the pericardium) and major joints. It is come out as a complication of infectious and hemosporidial diseases, intoxication with chemical and drug poisons as well as during autointoxication due to bowel and kidney damage. The inflammatory process develops under the influence of toxins of the underlying disease. All this leads to a violation of the portal circulation, the development of blood stagnation in the liver, bowel, lungs. As a result, apnoea, cyanosis, edema (start on the lower parts of the body), sharp rhythm disturbances occur. The general condition of the sick animal is deteriorating dramatically and arthritides can occur in the course of toxicoallergic conditions. Cows can have postpartum complications. There is a discrepancy between hematological and biochemical parameters in the blood. Timely diagnosis and complex treatment of cows with the use of pathogenetic and symptomatic therapy can restore impaired body functions and animal productivity.

scholarly journals Chronic cerebral venous dysfunction: diagnostic and treatment-and-prophylactic aspects

2021 ◽  
Vol 17 (2) ◽  
pp. 77-81
Author(s):  
O.Ye. Kovalenko ◽  
N.G. Prityko
Keyword(s):  
Clinical Symptoms ◽  
Underlying Disease ◽  
The Body ◽  
Independent Unit ◽  
Verification Methods ◽  
Icd 10 ◽  
Analytical Review ◽  
Synthetic Agents ◽  
Key Issues ◽  
Intermittent Noise

As a continuation of the topic of the article in the previous issue of the International Neurological Journal, which presents an analytical review of domestic and foreign studies on the syndrome of chronic cerebral venous dysfunction (SСCVD), this section discusses the classification of pathology, key issues of diagnosis and treatment. It is noted that in Ukraine and in most countries of the post-Soviet space, clinical classifications of M.Ya. Berdychevsky and A.V. Shemagonov are still used, where clinical forms, etiological factors, stages and types of the pathology were identified. In the ICD-10, venous cerebral insufficiency may correspond to the following chapters: G46, I87.8, I98, I99. Diagnosis of SCСVD, first of all, is based on a clinical assessment. Having quite characteristic general clinical symptoms, the pathology nevertheless differs in certain features of the course. Most often patients with SCСVD complain of chronic stabbing, monotonous headache, a feeling of heaviness in the head and so on. In addition, most patients have constant or intermittent noise in the head, ears, dizziness and vertigo. Additional verification methods are ultrasound examination of the vessels of the head and neck, plethysmography, magnetic resonance angiography. Since SCСVD is not an independent unit, the treatment of this pathology primarily requires the elimination of the underlying disease that provoked cerebral venous discirculation. As important preventive and curative measures, non-drug methods that reduce congestion in the body should be considered: regular physical activity, dosed exercises for the spine, various types of massage and physiotherapy, reflexology. It is important to adhere to a certain diet and quality of food. Among venotonic drugs, there are those of plant origin (flavonoids and saponins), synthetic agents, combined drugs.

scholarly journals Antifungal Activity and Acute and Repeated-Dose Toxicity Study of Geranyl Cinnamate Ester in Mice

2021 ◽  
Vol 2021 ◽  
pp. 1-14
Author(s):  
Micheli Zanetti ◽  
Mikaela Scatolin ◽  
Amanda Rebonatto Oltramari ◽  
Maria Luiza Lima da Costa Lopes ◽  
Rubieli Carla Frezza Zeferino ◽  
...  
Keyword(s):  
Antifungal Activity ◽  
Acute Toxicity ◽  
Biochemical Parameters ◽  
Body Weight Gain ◽  
The Body ◽  
Repeated Dose ◽  
Male Mice ◽  
Minimum Concentration ◽  
Repeated Dose Toxicity ◽  
Hematological And Biochemical Parameters

In the present study, the antifungal activity and toxicity of the geranyl cinnamate ester (GCE) were investigated. The GCE showed antifungal activity at a minimum concentration of 0.16 μL/mL against Candida albicans and at concentrations greater than 2.5 μL/mL against Aspergillus niger. In acute toxicity studies, the administration of GCE (2.000 mg/kg) affected the body weight gain and food intake but did not induce the mortality of the animals studied. After the investigation of repeated-dose toxicity of GCE at 2 and 4 mg/kg, the hematological and biochemical parameters were changed. In addition, the adrenal weight of male mice treated with GCE at 4 mg/kg was affected. In conclusion, according to the Organization for Economic Cooperation and Development (OECD) acute toxicity parameters, the geranyl cinnamate ester can be classified into safety category number 5. The results of this study suggested that the geranyl cinnamate ester may be a source of natural antifungals.

scholarly journals The effect of the insect-acaricidal drug Delcid 7.5® on the body of rabbits

2021 ◽  
Author(s):  
M.I. Burmistrova ◽  
F.I. Vasilevich ◽  
A.A. Deltsov
Keyword(s):  
Peripheral Blood ◽  
Biochemical Parameters ◽  
Hematological Parameters ◽  
Spinal Column ◽  
The Body ◽  
Control Group ◽  
Toxicological Effect ◽  
Hematological And Biochemical Parameters ◽  
External Stimuli ◽  
Average Hemoglobin

The effect of the drug Delcid 7.5 ® on the clinical, hematological and biochemical parameters of rabbits of the New Zealand breed, 6 months of age, when used in doses of 2 ml or 4 ml. Three times with a cutaneous application along the vertebral column from the head to the tail. The conducted studies allow us to conclude that after applying the drug in these doses for 3 days, there were no external signs of intoxication in rabbits. All the animals of the experimental groups were active. The reaction to external stimuli is preserved. Hematological parameters of peripheral blood (number of erythrocytes, leukocytes, hemoglobin, color index, the average hemoglobin content of PG in erythrocytes, mean corpuscular volume, the exponent of anisocytosis of red blood cells, etc.) of the experimental group after treatment in 5, 15, 25 days had no significant differences from those in the control group, this suggests that the applied drug to the skin along the spine from the withers to the rump at a dose of 2 and 4 ml has no Toxicological effect on peripheral blood. The leukogram of the peripheral blood of rabbits when using the drug did not differ from the control parameters. The analysis of biochemical parameters (activity of aminotransferase, alkaline phosphatase, lactate dehydrogenase, creatinine, urea, glucose, total protein, bilirubin, etc.) of the blood of the experimental groups when applying the drug Delcid 7.5 ® along the spinal column at the maximum therapeutic dose did not reveal statistically significant differences from the control, which indicates that the drug does not have a genotoxic effect, does not interfere with the kidneys and metabolism in the body of rabbits. The results of the conducted studies show that the insecticide-acaricide drug Delcid 7.5® for veterinary use, developed by NVC Agrovetzashchita LLC, is safe for rabbits, and therefore it can be recommended for studying the effectiveness of acarosis in rabbits and other animal species.

Carbon monoxide: modern concepts to the treatment of acute poisonings (literature review)

2021 ◽  
Vol 29 (5) ◽  
pp. 17-24
Author(s):  
Aleksandr Nikolaevich Grebenyuk ◽  
Vladimir Nikolaevich Bykov
Keyword(s):  
Carbon Monoxide ◽  
Medical Care ◽  
Rapid Development ◽  
First Aid ◽  
The Body ◽  
Toxic Encephalopathy ◽  
Bibliographic Databases ◽  
Symptomatic Therapy ◽  
Co Poisoning ◽  
Oxygen Inhalation

Introduction. Carbon monoxide (CO) is one of the most common causes of chemical injuries and the main toxic factor in the people death in fires. The mechanism of the toxic effect of CO, associated with the formation of carboxyhemoglobin and the development of hypoxia, determines the rapid development of the clinical picture of acute intoxication and the need for emergency first aid and medical care to the poisoned. Material and methods. Literature sources, summarized in the bibliographic databases eLIBRARY.RU, PubMed and Scopus, were the material for analysis. Results. First aid is based on quickly removing the victim from the fire zone or other area with a high concentration of CO and providing him with oxygen as soon as possible. During medical evacuation, it is necessary to carry out continuous inhalation of 80-100% oxygen, to ensure rest and warmth of the victim. In the emergency department of the hospital, oxygen inhalation and maintenance therapy should be continued, clinical and laboratory diagnostic measures aimed at assessing the severity of intoxication, identifying complications and concomitant pathology should be performed. In the case of severe CO poisoning, medical care continues to be provided to the victims in the intensive care unit or in the oxygen-barotherapy unit. The main antidote for CO poisoning is oxygen, which can be used in two versions - normobaric or hyperbaric oxygenation. As a pharmacological antidote to CO, zinc bisvinylimidazole diacetate (acizol) which can accelerate the breakdown of carboxyhemoglobin, improve the oxygen-binding and gas-transport properties of blood, as well as the dissociation of oxyhemoglobin in tissues is used. Along with antidotes, an important role in the treatment of CO poisoning is played by pathogenetic and symptomatic therapy aimed at the prevention and treatment of toxic encephalopathy, brain edema, cognitive dysfunction, toxic myocardiodystrophy and arrhythmia, prevention of pneumonia, correction of the acid-base state, compensation of the energy needs of the body, etc. Conclusion. Further improvement of existing means and methods for the treatment of intoxication, the development and introduction of new antidots into medical practice will increase the effectiveness of therapeutic measures, reduce the number of deaths and disabilities after acute poisoning with carbon monoxide.

Subacute oral toxicity evaluation of the ethanolic extract of Hydnophytum formicarum Jack. tubers in Phu Quoc, Vietnam

MedPharmRes ◽  
2020 ◽  
Vol 4 (1) ◽  
pp. 1-6
Author(s):  
Mai Nguyen Ngoc Trac ◽  
Pham Thu Ha ◽  
Do Thi Hong Tuoi
Keyword(s):  
Biochemical Parameters ◽  
Ethanolic Extract ◽  
Hepatoprotective Activity ◽  
The Body ◽  
Oral Toxicity ◽  
Analgesic Effects ◽  
Significant Difference ◽  
Body Weights ◽  
Health Products ◽  
Hematological And Biochemical Parameters

The tubers of Hydnophytum formicarum Jack. have been used for the treatment of rheumatism, liver and intestinal diseases in the traditional medicine of Vietnam. The 50% ethanolic extract of H. formicarum (EEHF) has been proved anti-inflammatory and analgesic effects as well as hepatoprotective activity at the oral doses of 100 and 200 mg/kg in Swiss albino mice. The aim of this work was to study on the subacute oral toxicity of the EEHF at the doses of 100 and 200 mg/kg for 30 and 60 consecutive days in both sexes of mice. The observations were undertaken on the mortality, the body weights, the toxic signs, hematological and biochemical parameters. At the end of the experiment, the histopathology of liver and kidneys was studied. The results showed that the 100 mg/kg of EEHF did not cause any toxic signs in mice. There was no significant difference of hematological and biochemical parameters between the treated animals and the controls. Histopathological examinations of livers and kidneys showed no significant difference suggesting no morphological disturbances in treated mice. In conclusion, the results indicated that the EEHF did not cause any subacute toxicity in mice at the dose of 100 mg/kg, providing the evidence of the safety of health products from this medicinal plant.

Evaluation of Acute, Subacute and LD50 values of Methanolic extract of Sphaeranthus indicus leaves in Albino mice

2021 ◽  
pp. 2487-2492
Author(s):  
Gajendra Pratap Choudhary ◽  
Ashutosh Pal Jain
Keyword(s):  
Body Weight ◽  
Acute Toxicity ◽  
Biochemical Parameters ◽  
Methanolic Extract ◽  
The Body ◽  
Therapeutic Window ◽  
System Response ◽  
Acute Administration ◽  
Sphaeranthus Indicus ◽  
Hematological And Biochemical Parameters

Sphaeranthus indicus is one of the extremely precious herbs in the Indigenous System of Medicine. The present study was carried out to acute, subacute and LD50 values of methanolic extract of S. indicus leaves in Swiss mice of both sexes. The acute toxicity studies were conducted oral administration of 1.75, 5.5, 17.5, 55, 175, 550, 2000mg/kg body weight SIME used. Observations were recorded systemically up to 24 h after dose administration for behavior related to nervous system response or autonomic functions. Food and water intake, body weight variations, hematological and biochemical parameters were assessed. In sub acute toxicity treatment there were no significant variation in the body weights and haematological parameters except dose-dependent increase in lymphocyte count was noted in both sexes supported immunostimulant activity. Pathologically, significant protective effect on hepatic, renal functions and decreased cholesterol, triglyceride levels. The results did not show any treatment related abnormalities in terms of hematological and biochemical parameters in sub-acute toxicity. After acute administration, no mortality was recorded in mice treated with the SIME orally at a dose of 1000mg/kg. The LD50 values were determined using graphical method; we found a broad therapeutic window and a high therapeutic index value showed that the LD50 of the extract is 2480mg/kg. The results suggest that the plant seems to be high margin of drug safety in mice.

Influence of feed additives on the hematological and biochemical parameters of the blood of lactating cows

2022 ◽  
pp. 27-33
Author(s):  
R. A. Maksimova ◽  
◽  
E. M. Ermolova ◽  
V. I. Kosilov ◽  
Yu. A. Karmatskikh ◽  
...  
Keyword(s):  
Biochemical Parameters ◽  
Live Weight ◽  
Blood Parameters ◽  
Feed Additives ◽  
The Body ◽  
Farm Animals ◽  
Feed Additive ◽  
Main Task ◽  
Lactating Cows ◽  
Hematological And Biochemical Parameters

Increasing the milk productivity of cows is the main task facing the livestock industry of our country. The study of some hematological and biochemical blood parameters in dairy cows when different feed additives are included in their rations is an urgent research task. The purpose of the investigations was to study the hematological and biochemical parameters of the blood of lactating cows when using different feed additives in the ration. During the investigations, the influence of feed additives such as Zaslon 2+ (at a dose of 20 g/head/day to the main ration), Diatomite (100 g/head/day to the main ration) and Monosporin (70 g/head/day to the main ration) on the hematological and biochemical blood parameters of lactating cows has been observed. The studied feed additives are used for the adsorption of mycotoxins in feed, normalization of digestive processes, and improvement of the livability and productivity of farm animals. In order to study the influence of the tested feed additives on the hematological parameters of the blood of lactating cows under the conditions of the Troitsky area in the Chelyabinsk region, on four groups of cows selected according to the principle of analogues (age, live weight, productivity, breed, physiological condition) the scientific and economic experiment has been carried out. As the result of the investigations, data have been obtained indicating that the feed additive Zaslon 2+ at the dose of 20 g/head/day has the greatest effect on the metabolism in the body of lactating cows.

scholarly journals Hematological and Biochemical Parameters in Symptomatic and Asymptomatic Leishmania-Seropositive Dogs

2015 ◽  
Vol 38 (2) ◽  
pp. 175-182 ◽  
Author(s):  
Igor Ulchar ◽  
Irena Celeska ◽  
Jovana Stefanovska ◽  
Anastasija Jakimovska
Keyword(s):  
Renal Failure ◽  
Biochemical Parameters ◽  
Serum Proteins ◽  
Clinical Symptoms ◽  
Wide Spectrum ◽  
Hematological Parameters ◽  
Individual Variability ◽  
Canine Leishmaniosis ◽  
Hematological And Biochemical Parameters ◽  
G Ratio

Abstract Leishmaniosis caused by Leishmania infantum is vector-born severe enzootic disease in dogs. It includes a wide spectrum of clinical symptoms, but the most characteristic are alterations in the hematopoetic system and renal failure. Also, infected animals could be asymptomatic, so the manifestation of L. infantum infection depends on many factors, including host’s immunological status. The aim of this survey was to find parameters related with hematopoetic and renal failure (hematology, biochemical parameters - urea, creatinine, serum proteins) in symptomatic and asymptomatic dogs seropositive for canine leishmaniosis. Within the hematological parameters, we found significant differences between symptomatic and asymptomatic dogs in the erythrogram and platelet count, but not in the leukogram. Significant differences between the two groups were found also for urea, creatinine, serum albumin and globulin, but not in serum total protein and A/G ratio. These findings indicate individual variability of the host’s response to infection with L. infantum.

scholarly journals Weil’s syndrome (Leptospiral infection): A case report

2007 ◽  
Vol 60 (9-10) ◽  
pp. 493-496
Author(s):  
Zeljko Mijailovic ◽  
Predrag Canovic ◽  
Olgica Gajovic
Keyword(s):  
Renal Failure ◽  
Case Report ◽  
Clinical Symptoms ◽  
Clinical Manifestations ◽  
Severe Form ◽  
The Body ◽  
Symptomatic Therapy ◽  
Clinical Syndromes ◽  
Febrile Condition ◽  
Therapeutic Measures

Introduction. Leptospirosis is an acute zoonotic infection, caused by spirochetes of the genus Leptospira. It is characterized by extensive vasculitis. It is usually transmitted indirectly, per contaminated water, rarely directly, through contact with infected animals. Leptospira bacteria commonly enter the body through damaged skin or mucous membranes. The clinical syndromes may vary from a subclinical infection and mild febrile condition to severe clinical symptoms with jaundice and renal failure. Case report. This is a case report of a patient with leptospirosis (Weil's disease) whose clinical manifestations included: icterus, renal failure, hemorrhagic syndrome and disturbances of consciousness. After the use of antibiotics, symptomatic and substitution therapy, all symptoms resolved completely. However, in our patient, hemodialysis was necessary due to renal failure, as a palliative measure. Discussion. Weil?s syndrome is a severe form of leptospirosis, which can be fatal. Early clinical diagnosis of the disease, as well as serologic verification of infection, are very important prerequisites, followed by antibiotic and other symptomatic therapy, as soon as possible. Conclusion. This is a case report of a patient with rare clinical manifestations of leptosirosis. Although presenting with severe symptoms, thanks to palliative therapeutic measures, complete and fast recovery was achieved. We especially point out the role of hemodialysis in the treatment of this patient. .

scholarly journals Dynamics of morphological and biochemical indicators of blood of sucking piglets at different levels of iodine citrate in sows rations

2018 ◽  
Vol 20 (84) ◽  
Author(s):  
R. V. Hunchak ◽  
H. M. Sedilo
Keyword(s):  
Biochemical Parameters ◽  
Experimental Studies ◽  
The Body ◽  
Control Group ◽  
Metabolic Reactions ◽  
Hematological And Biochemical Parameters ◽  
Physiological Values ◽  
High Bioavailability ◽  
Positive Effect

The article presents the results of experimental studies on the determination of the influence of iodine citrate on hematological and biochemical parameters of blood of sucking piglets. It was established that hemopoiesis and metabolic reactions in pigs depend on the level of Iodine in the sows, and in the later period (the 10th day) and from the receipt of the biometal as part of the prestarter. Iodine, in nanocitate form, at the expense of high bioavailability and chemical activity, provided the need for thyroid gland in it in much less quantities than the amounts recommended for pregnant and lactating sows in the form of potassium iodide. It has been established that at the admission to the body of a sow 0.095–0.19 mg/kg of feeding of iodine in a nanocyte form (1/4–1/2 of the recommended amount of iodine in the form of CI), its positive effect on hemopoiesis and metabolic processes in newborn piglets is peculiar (increased number of red blood cells, hemoglobin content, high percentage of lymphocytes, increases in the concentration of total protein and in particular albumin, against the backdrop of growth in blood plasma levels of CSF, the concentration of hormones T3 and T4 is quite stable. A higher dose in the premix of iodine citrate (1 : 1) is irrational and most likely undesirable, since against the background of inhibition of this group of erythropoiesis, eosinophilia and lymphopenia, the protein synthesis function decreases and the activity of AlAT, AsAT increases. Hematological and biochemical parameters of blood of piglets obtained from sows, which received a minimum amount of iodine in the form of citrate (0.1 : 1) with premix, did not undergo significant changes, were within the limits of physiological values, although in comparison with the animals of the control group, and particularly, the piglets of the group D2 and D3 tended to decrease (growth). Consequently, iodine citrate as a source of iodine for pregnant and subsistence sows can be recommended in the amounts: 0.095–0.19 mg/kg and 0.125–0.25 mg/kg feed.

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