scholarly journals UJI EFEK DAUN ILER (Coleus atropurpureus [L.] Benth.) TERHADAP PENYEMBUHAN LUKA INSISI PADA KULIT KELINCI (Oryctolagus cuniculus)

2013 ◽  
Vol 1 (1) ◽  
Author(s):  
Rudianto Tari ◽  
Jimmy Posangi ◽  
P. M. Wowor
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Evaluation Criteria ◽  
Wound Healing Process ◽  
Chemical Substances ◽  
Speed Up ◽  
Healing Wounds ◽  
Left And Right ◽  
The Right ◽  
Active Substances

Abstract: Indonesia has a lot of herbs. One of the well-known and frequently used by people is miana. Empirical experience showed that miana is used to healing wounds. The chemical substances of miana leaves such as essential oil, flavonoid, tanin, and other active substances are expected to involved in the process of wound healing. The purpose of this reseach is to find out the healing effect of miana leaves to the insicion wound on rabbits’ skin. This research used an experimental method by using 5 rabbits as the experimental animals. Skin insicions were generated over  rabbits’  left and right back by 5 cm each. The wound on the left back is given miana leaves, and the wound on the right back without miana leaves. The wound healing was observed on third, seventh and fourteenth day, with the length, the superficial and the edges of the wounds as the evaluation criteria. The incision wounds on the rabbits’ back that given miana leaves are dry and heal faster than the rabbits without miana leaves. Using miana leaves for the rabbits’ insicion wounds can speed up the wound healing process. Keywords: miana leaves, wound healing, insicion wound.     Abstrak: Indonesia memiliki banyak tanaman yang berkhasiat obat. Salah satu tanaman yang berkhasiat, dikenal, dan digunakan masyarakat yaitu tumbuhan iler. Pengalaman empiris menunjukkan tumbuhan iler digunakan sebagai obat luka. Kandungan kimia daun iler seperti minyak atsiri, flavonoid, tanin, dan zat-zat aktif lainnya diduga terlibat dalam penyembuhan luka. penelitian ini bertujuan untuk mengetahui efek penyembuhan daun iler terhadap penyembuhan luka insisi pada kulit kelinci. Penelitian ini menggunakan metode eksperimental, dengan menggunakan lima ekor kelinci sebagai hewan uji. Kelinci diinsisi pada punggung kiri dan kanan sepanjang 5 cm. Luka pada punggung kiri diberi daun iler, sedangkan luka pada punggung kanan tidak diberi daun iler. Penyembuhan luka diamati pada hari ke-3, 7, dan 14, dengan kriteria penilaian panjang, permukaan dan tepi luka. Luka insisi pada kulit kelinci yang diberi daun iler terlihat lebih cepat kering dan menutup dibandingkan dengan luka yang tidak diberi daun iler. Pemberian daun iler pada luka insisi kulit kelinci dapat mempercepat proses penyembuhan luka. Kata Kunci: daun iler, penyembuhan luka, luka insisi.

scholarly journals Uji efek ekstrak daun dewa (Gyanurasegetum [Lour]. Merr) terhadap masa penyembuhan luka insisi kulit kelinci (Oryctolaguscuniculus)

2016 ◽  
Vol 4 (1) ◽  
Author(s):  
. Aaron ◽  
Henoch Awaloei ◽  
Jane Wuisan
Keyword(s):  
Experimental Study ◽  
Wound Healing ◽  
Healing Process ◽  
Wound Healing Process ◽  
Rabbit Skin ◽  
The Public ◽  
Accelerate Wound Healing ◽  
Left And Right ◽  
The Right ◽  
Incision Wound

Abstract: Marsh fleabane (Gynurasegetum [Lour].Merr.) is one of the medicinal plants used by the public as an anti-septic to accelerate wound healing. The contents of Marsh fleabane that could accelerate wound healing are flavonoids, saponins, and atsiri oil. This study aimed to determine the effect of Marsh fleabane extract on wound healing incision of rabbit skin. This was an experimental study. This study was conducted in the Laboratory of Pharmacology and Therapeutics Faculty of Medicine, University of Sam Ratulangi. Samples were 3 rabbits. Incised wounds of 4 cm length and 2 mm depth were made on the rabbits’ left and right backs. The wounds on the left backs were given Marsh fleabane extract, meanwhile the wounds on the right backs were not treated. The results showed that the wound healing process of the incised wounds treated with Marsh fleabane extract was faster compared to the incised wounds without treatment. Conclusion: Marsh fleabane extract could accelerate the wound healing process of rabbit incised wound. Keywords: marsh fleabane, incision wound healing Abstrak: Daun dewa (Gyanurasegetum [Lour].Merr.) merupakan salah satu tanaman berkhasiat yang biasa digunakan oleh masyarakat sebagai obat anti septik dan mempercepat penyembuhan luka. Kandungan yang terkandung dalam daun dewa yang dipercaya dapat mempercepat penyembuhan luka yaitu flavonoid, saponin, dan minyak atsiri. Penelitian ini bertujuan untuk mengetahui uji efek ekstrak daun dewa terhadap penyembuhan luka insisi pada kulit kelinci. Metode penelitian yang digunakan ialah rancangan eksperimental. Penelitian ini dilaksanakan di Laboratorium Farmakologi dan Terapi Fakultas Kedokteran Universitas Sam Ratulangi. Sampel yang digunakan berjumlah 3 ekor kelinci yang masing-masing punggung kiri dan kanannya diberi luka insisi sepanjang 4 cm dan kedalaman 2 mm. Luka pada punggung sebelah kiri diberikan ekstrak daun dewa sedangkan luka pada punggung bagian kanan tidak diberikan ekstrak daun dewa. Hasil penelitian memperlihatkan bahwa masa penyembuhan luka insisi kulit kelinci yang diberikan ekstrak daun dewa lebih singkat dibandingkan dengan luka insisi kulit kelinci yang tidak diberikan ekstrak daun dewa. Simpulan: Ekstrak daun dewa berefek terhadap penyembuhan luka insisi kulit kelinci.Kata kunci: daun dewa, penyembuhan luka insisi

scholarly journals Novel formulation approaches for wound healing

2020 ◽  
Vol 11 (SPL4) ◽  
pp. 937-948
Author(s):  
Tanaji D Nandgude ◽  
Syed Nateque Naser
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Cell Types ◽  
Wound Management ◽  
Wound Healing Process ◽  
Anatomic Structure ◽  
Tissue Integrity ◽  
Molecular Events ◽  
Acute Injuries ◽  
Healing Wounds

A wound is damage to the typical anatomic structure. Wound healing is an immediate therapeutic response to injury. It is a creation of the combined response of some cell types towards injury. Wound healing takes place by a sequence of molecular events which cooperate to fix tissue integrity and cell work. In typical healthy individual under ordinary conditions, these physiological events take place smoothly. Though sometimes, these molecular events are arrested, this brings about in struggle to heal. There is an assortment of approaches for the way toward managing and controlling both acute injuries (acute wounds) and ceaseless non-mending wounds (chronic non-healing wounds). The principal objective of these two cases is to achieve better-wound healing. Ideal formulations of wound healing should not only enhance the healing process but also reduce pain, infection and loss of electrolytes, proteins and liquids from the injury. A broad scope of items typically introduced with target various parts of the wound healing process depends on numerous types of wounds and novel polymers utilised for the conveyance of medications to both acute and ceaseless injuries. These include alginate, hydrocolloids, hydrofibers, polyurethane, and hydrogels. This article gives particular importance to different novel approaches in the management of wound healing. This review draws out the data and hopes to provide understanding into traditional, current and imminent techniques and methods for wound management.

scholarly journals Myocardial infarction remodeling that progresses to heart failure: a signaling misunderstanding

2018 ◽  
Vol 315 (1) ◽  
pp. H71-H79 ◽  
Author(s):  
Alan J. Mouton ◽  
Osvaldo J. Rivera ◽  
Merry L. Lindsey
Keyword(s):  
Myocardial Infarction ◽  
Heart Failure ◽  
Wound Healing ◽  
Current Knowledge ◽  
Healing Process ◽  
Cell Types ◽  
Left Ventricular ◽  
Wound Healing Process ◽  
The Status ◽  
The Right

After myocardial infarction, remodeling of the left ventricle involves a wound-healing orchestra involving a variety of cell types. In order for wound healing to be optimal, appropriate communication must occur; these cells all need to come in at the right time, be activated at the right time in the right amount, and know when to exit at the right time. When this occurs, a new homeostasis is obtained within the infarct, such that infarct scar size and quality are sufficient to maintain left ventricular size and shape. The ideal scenario does not always occur in reality. Often, miscommunication can occur between infarct and remote spaces, across the temporal wound-healing spectrum, and across organs. When miscommunication occurs, adverse remodeling can progress to heart failure. This review discusses current knowledge gaps and recent development of the roles of inflammation and the extracellular matrix in myocardial infarction remodeling. In particular, the macrophage is one cell type that provides direct and indirect regulation of both the inflammatory and scar-forming responses. We summarize current research efforts focused on identifying biomarker indicators that reflect the status of each component of the wound-healing process to better predict outcomes.

scholarly journals Hydrogel plus growth factors treatment after 2940nm erbium:YAG lattice laser improves periorbital wrinkles and wound healing: a case report

2021 ◽  
Vol 49 (9) ◽  
pp. 030006052110425
Author(s):  
Jiaqi Zeng ◽  
Zhen Li ◽  
Feiyan Lin ◽  
Shaohong Fu ◽  
Jingyi Li ◽  
...  
Keyword(s):  
Wound Healing ◽  
Case Report ◽  
Laser Therapy ◽  
Wound Care ◽  
Healing Process ◽  
Alternative Therapy ◽  
Skin Aging ◽  
Wound Healing Process ◽  
Gel Treatment ◽  
The Right

Skin aging is an inevitable physiological process and periorbital wrinkling is an active sign of the process. Laser therapy is an effective method for improving periorbital wrinkles and wound care after laser therapy can accelerate the wound healing process. This case report describes a typical case of a 47-year-old male that presented with a 10-year history of gradually-worsening bilateral periorbital wrinkles. These were treated using a 2940 nm erbium (Er):YAG lattice laser combined with recombinant bovine basic fibroblast growth factor (bFGF) gel and hydrogel (HG) treatment on the left side of his face compared with laser therapy and bFGF gel on the right side of his face. HG combined with bFGF gel treatment after 2940 nm Er:YAG lattice laser therapy improved postoperative swelling and pigmentation compared with bFGF gel alone; and it promoted periorbital wrinkle improvement and wound healing. In conclusion, HG combined with GFs after laser therapy could be an alternative therapy for periorbital wrinkles.

scholarly journals Bicellular Tight Junctions and Wound Healing

2018 ◽  
Vol 19 (12) ◽  
pp. 3862 ◽  
Author(s):  
Junhe Shi ◽  
May Barakat ◽  
Dandan Chen ◽  
Lin Chen
Keyword(s):  
Wound Healing ◽  
Endothelial Cells ◽  
Epithelial Cells ◽  
Tight Junctions ◽  
Wound Repair ◽  
Chronic Wounds ◽  
Healing Process ◽  
Intercellular Junctions ◽  
Wound Healing Process ◽  
Healing Wounds

Bicellular tight junctions (TJs) are intercellular junctions comprised of a variety of transmembrane proteins including occludin, claudins, and junctional adhesion molecules (JAMs) as well as intracellular scaffold proteins such as zonula occludens (ZOs). TJs are functional, intercellular structures that form a barrier between adjacent cells, which constantly seals and unseals to control the paracellular passage of molecules. They are primarily present in the epithelial and endothelial cells of all tissues and organs. In addition to their well-recognized roles in maintaining cell polarity and barrier functions, TJs are important regulators of signal transduction, which modulates cell proliferation, migration, and differentiation, as well as some components of the immune response and homeostasis. A vast breadth of research data is available on TJs, but little has been done to decipher their specific roles in wound healing, despite their primary distribution in epithelial and endothelial cells, which are essential contributors to the wound healing process. Some data exists to indicate that a better understanding of the functions and significance of TJs in healing wounds may prove crucial for future improvements in wound healing research and therapy. Specifically, recent studies demonstrate that occludin and claudin-1, which are two TJ component proteins, are present in migrating epithelial cells at the wound edge but are absent in chronic wounds. This indicates that functional TJs may be critical for effective wound healing. A tremendous amount of work is needed to investigate their roles in barrier function, re-epithelialization, angiogenesis, scar formation, and in the interactions between epithelial cells, endothelial cells, and immune cells both in the acute wound healing process and in non-healing wounds. A more thorough understanding of TJs in wound healing may shed new light on potential research targets and reveal novel strategies to enhance tissue regeneration and improve wound repair.

scholarly journals The Role of Chemokines in Wound Healing

2018 ◽  
Vol 19 (10) ◽  
pp. 3217 ◽  
Author(s):  
Anisyah Ridiandries ◽  
Joanne Tan ◽  
Christina Bursill
Keyword(s):  
Wound Healing ◽  
Therapeutic Potential ◽  
Healing Process ◽  
Inflammatory Cells ◽  
Wound Healing Process ◽  
Preclinical Research ◽  
Cxcr4 Antagonist ◽  
Impaired Wound Healing ◽  
Novel Approach ◽  
Healing Wounds

Wound healing is a multistep process with four overlapping but distinct stages: hemostasis, inflammation, proliferation, and remodeling. An alteration at any stage may lead to the development of chronic non-healing wounds or excessive scar formation. Impaired wound healing presents a significant health and economic burden to millions of individuals worldwide, with diabetes mellitus and aging being major risk factors. Ongoing understanding of the mechanisms that underly wound healing is required for the development of new and improved therapies that increase repair. Chemokines are key regulators of the wound healing process. They are involved in the promotion and inhibition of angiogenesis and the recruitment of inflammatory cells, which release growth factors and cytokines to facilitate the wound healing process. Preclinical research studies in mice show that the administration of CCL2, CCL21, CXCL12, and a CXCR4 antagonist as well as broad-spectrum inhibition of the CC-chemokine class improve the wound healing process. The focus of this review is to highlight the contributions of chemokines during each stage of wound healing and to discuss the related molecular pathologies in complex and chronic non-healing wounds. We explore the therapeutic potential of targeting chemokines as a novel approach to overcome the debilitating effects of impaired wound healing.

scholarly journals Propolis Modulates Fibronectin Expression in the Matrix of Thermal Injury

2014 ◽  
Vol 2014 ◽  
pp. 1-10 ◽  
Author(s):  
Pawel Olczyk ◽  
Katarzyna Komosinska-Vassev ◽  
Grzegorz Wisowski ◽  
Lukasz Mencner ◽  
Jerzy Stojko ◽  
...  
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Silver Sulfadiazine ◽  
Wound Healing Process ◽  
Burn Wound ◽  
Burn Treatment ◽  
Burn Wound Healing ◽  
Fibronectin Expression ◽  
The Matrix ◽  
Healing Wounds

The aim of the study was to assess the propolis effect on fibronectin metabolism in the course of burn wounds healing process. A model of burn wound healing of pig skin was applied. The amount of the released glycoprotein was assessed by a surface plasmon resonance. The profile of extracted fibronectin components was also assessed by an electrophoresis in polyacrylamide gel, with a subsequent immunodetection by Western Blotting. Propolis burn treatment decreased the release of fibronectin components from healing wounds in relation to damages treated with silver sulfadiazine. The main reason of decreased extraction of fibronectin components from wounds treated with propolis was a substantial decrease of degradation product release of the mentioned glycoprotein, which was observed particularly from the 3rd to 5th day of the repair. Wounds treatment with propolis demonstrated, especially in relation to damages treated with silver sulfadiazine, the decreased release of synthesized fibronectin molecules. The obtained results suggest that propolis modifies fibronectin metabolism in the course of wound healing process. The influence of propolis is reflected in prevention of fibronectin biosynthesis as well as its degradation in the wound area. The above-mentioned metabolic changes may decrease the risk of complications in the repair wounds process.

Efficient in vivo wound healing using noble metal nanoclusters

Nanoscale ◽  
2021 ◽  
Author(s):  
Kuo Li ◽  
Dan Li ◽  
Cheng-Hsuan Li ◽  
pengfei Zhuang ◽  
Chunmei Dai ◽  
...  
Keyword(s):  
Wound Healing ◽  
Noble Metal ◽  
Healing Process ◽  
Tissue Remodeling ◽  
Wound Healing Process ◽  
Metal Nanoclusters ◽  
Healing Wounds ◽  
Noble Metal Nanoclusters

The wound healing process involves multiple steps including hemostasis, inflammation, proliferation, and tissue remodeling. Nanomaterials have been employed externally for healing wounds. However, their use as systemic therapeutics has not...

scholarly journals Diabetic Wound Care: A Concise Review of Diabetic Wound and Skincare Ingredients

2020 ◽  
Vol 8 (2) ◽  
Author(s):  
Mohammad Afsahi ◽  
Hamid Reza Ahmadi Ashtiani ◽  
Amir Hosein Askari Pour ◽  
Ebrahim Hazrati
Keyword(s):  
Wound Healing ◽  
Wound Care ◽  
Healing Process ◽  
Topical Administration ◽  
The Body ◽  
Wound Healing Process ◽  
Diabetic Wound ◽  
Normal Wound Healing ◽  
Healing Wounds ◽  
Diabetic Wounds

: Chronic wound healing remains a complicated issue in the world's scientific health society. Alterations in the human body conditions such as biochemical, immunological, and physiological states may lead to non-healing wounds, making the treatment an insurmountably long and expensive procedure. Diabetes mellitus disposes the body to many complicated conditions while preventing diabetic wounds away from the normal wound-healing process. As topical administration is a favorable route of treating wounds, here, in this article, different topical materials and their roles are briefly reviewed.

scholarly journals EFEK SERBUK KOPI ROBUSTA (Coffea canephora) TERHADAP PENYEMBUHAN LUKA INSISI PADA KELINCI (Oryctolagus cuniculus)

2015 ◽  
Vol 3 (3) ◽  
Author(s):  
Lilian N. Artho ◽  
Jane Wuisan ◽  
J. A. Najoan
Keyword(s):  
Wound Healing ◽  
Healing Process ◽  
Treated Group ◽  
Coffea Canephora ◽  
Control Group ◽  
Wound Healing Process ◽  
Robusta Coffee ◽  
Coffee Powder ◽  
The Right ◽  
Sterile Gauze

Abstract: Coffee is known as food and drink as well as alternative medicine for various types of wounds. One of the most coffee plants in Indonesia is Robusta coffee (Coffea canephora). This study aimed to determine whether Robusta coffee powder could accelerate the wound healing process. This was an experimental study using four rabbits as subjects. Incisions were made on the rabbit backs, right and left, with a length of 5 cm. Wounds on the left backs, the untreated/control group, were only covered with sterile gauze. Wounds on the right backs, the treated group, were applied with robusta coffee powder and covered with sterile gauze. Robusta coffee powder and gauze were replaced two times a day. Wounds were macroscopically observed for 2 weeks. The results showed that at day 7, the wounds were still equally opened, dry, looked not too deep, and there was a crust on each wound surface. The lengths of the treated wounds were shorter than of the control wounds. At day 14, the edges of the treated wounds looked closer, the crusts were still attached to the wound surfaces and were smaller than of the control wounds. Conclusion: Robusta coffee powder (Coffea canephora) could accelerate the healing process of incised wounds on rabbit skin.Keywords: wound healing, wound incision, robusta coffee powder, coffea canephoraAbstrak: Kopi bukan hanya dikenal sebagai makanan dan minuman saja tetapi bisa juga sebagai obat alternatif dalam menangani berbagai jenis luka. Salah satu jenis tanaman kopi yang paling banyak di Indonesia ialah kopi Robusta (Coffea canephora). Penelitian ini bertujuan untuk menentukan apakah sebuk kopi robusta mempunyai efek untuk mempercepat proses penyembuhan luka. Penelitian ini menggunakan metode eksperimental dengan 4 ekor kelinci sebagai hewan coba. Luka insisi dibuat pada punggung kanan dan kiri kelinci dengan panjang 5 cm. Luka pada punggung kiri merupakan luka kontrol yang tidak diberi perlakuan, hanya ditutupi dengan kasa steril. Luka pada punggung kanan merupakan luka perlakuan dengan diberi serbuk kopi robusta lalu ditutup kasa steril. Serbuk kopi robusta dan kasa diganti dua kali sehari. Pengamatan dilakukan selama 2 minggu dengan membandingkan gambaran makroskopik kedua luka. Hasil penelitian memperlihatkan pada hari ke 7 kedua luka masih sama-sama terbuka, kering, tampak sudah tidak terlalu dalam, dan terdapat kerak yang menempel pada permukaan luka. Ukuran luka perlakuan lebih pendek dari luka kontrol. Hari ke 14 kedua luka sudah mulai menutup, kerak masih menempel pada permukaan luka dan ukuran kerak luka perlakuan lebih kecil dari luka kontrol. Simpulan: Serbuk kopi robusta (Coffea canephora) memiliki efek untuk mempercepat penyembuhan luka insisi pada kulit kelinci.Kata kunci: penyembuhan luka, luka insisi, kopi robusta, coffea canephora

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