scholarly journals Perbandingan prevalensi pterygium pada nelayan di Tuminting dengan petani di Rurukan

e-CliniC ◽  
2016 ◽  
Vol 4 (1) ◽  
Author(s):  
Yusuf S. Tangdilintin ◽  
Laya M. Rares ◽  
Yamin Tongku
Keyword(s):  
High Altitude ◽  
Sea Level ◽  
Sun Exposure ◽  
Cross Sectional ◽  
North Sulawesi ◽  
High Prevalence ◽  
High Altitude Area ◽  
Eye Examination ◽  
Low Altitude ◽  
The Difference

Abstract: Based on Riset Kesehatan Dasar 2013, North Sulawesi is one of 10 provinces in Indonesia that have the highest pterygium prevalence. Previous findings at different areas showed that pterygium is more common at areas with high altitude than at areas with low altitude. Topography of North Sulawesi with mountains and hills might be related to the high prevalence of pterygium at this province. This study was aimed to obtain the difference in pterygium prevalence at area with high altitude compared to area with low altitude at North Sulawesi. This study used a cross sectional quantitative design and was conducted at Tuminting (mean altitude about 0 km above sea level) and at Rurukan (mean altitude about 1km above sea level). There were 51 respondents at each location. Eye examination was performed and data about sun exposure were collected among fishermen at Tuminting and farmers at Rurukan. The results showed that the pterygium prevalence at Rurukan was 56.9% and at Tuminting was 41.2%. Conclusion: There was a difference in pterygium prevalence between people at high altitude area from people at low altitude area at North Sulawesi.Keywords: pterygium, altitude Abstrak: Berdasarkan hasil Riset Kesehatan Dasar 2013 Provinsi Sulawesi Utara termasuk dalam 10 provinsi dengan prevalensi pterygium tertinggi di Indonesia. Temuan sebelumnya di daerah yang lain menemukan prevalensi pterygium lebih tinggi di daerah dengan ketinggian dari permukaan laut yang tinggi dibandingkan daerah dengan ketinggian dari permukaan laut yang rendah. Topografi provinsi Sulawesi Utara yang sebagian besar terdiri dari pegunungan dan bukit-bukit mungkin berhubungan dengan tingginya prevalensi pterygium di Sulawesi Utara. Penelitian ini bertujuan untuk mendapatkan perbedaan prevalensi pterygium pada daerah dengan ketinggian yang tinggi dengan daerah dengan ketinggian yang rendah di Sulawesi Utara. Desain penelitian ialah potong lintang kuantitatif yang dilakukan di Tuminting (ketinggian rata-rata sekitar 0 km di atas permukaan laut) dan di Rurukan (ketinggian rata-rata sekitar 1 km di atas permukaan laut). Terdapat 51 responden pada tiap-tiap lokasi penelitian dan dilakukan pemeriksaan mata serta pengumpulan data mengenai paparan terhadap matahari dari responden nelayan di Tuminting dan responden petani di Rurukan. Hasil penelitian mendapatkan prevalensi pterygium di Rurukan 56,9% dan di Tuminting 41,2%. Simpulan: Terdapat perbedaan prevalensi pterygium di daerah dengan ketinggian dari permukaan laut yang tinggi (Rurukan) dibandingkan daerah dengan ketinggian dari permukaan laut yang rendah (Tuminting) di Sulawesi Utara. Kata kunci: pterygium, ketinggian daerah

Serum levels of adrenal androgens up to adrenarche in Peruvian children living at sea level and at high altitude

1993 ◽  
Vol 136 (3) ◽  
pp. 517-523 ◽  
Author(s):  
C. Goñez ◽  
A. Villena ◽  
G. F. Gonzales
Keyword(s):  
Public Schools ◽  
High Altitude ◽  
Sea Level ◽  
Serum Levels ◽  
Dehydroepiandrosterone Sulphate ◽  
Adrenal Androgen ◽  
Adrenal Androgens ◽  
Cross Sectional ◽  
Low Altitude ◽  
Cross Sectional Design

ABSTRACT Serum levels of adrenal androgens were measured in children of both sexes living at sea level and at high altitude using a cross-sectional design. The levels were compared in relation to age at each altitude (150 m and 3400 m above sea level), and the first significant increase in mean levels compared with values at preceding ages was assessed and defined as adrenarche. A total of 118 boys and 95 girls aged 6–12 years living at low altitude and 95 boys and 104 girls aged 7–15 years living at high altitude, all of them attending public schools, were studied. Serum dehydroepiandrosterone, dehydroepiandrosterone sulphate and androstenedione were measured by radioimmunoassay and height and weight by standard anthropometric techniques. There were two significant increases in serum levels of adrenal androgens, the first observed in children between 6 and 8 years at sea level, and between 7 and 9 years at high altitude, and the second in children between 10 and 12 years at sea level and between 12 and 15 years at high altitude. Serum adrenal androgen levels increased earlier in children at sea level than at high altitude. It is concluded that adrenarche occurs later at high altitude than at sea level. Journal of Endocrinology (1993) 136, 517–523

scholarly journals Blood Pressure in Inhabitants of High Altitude of Western Nepal

2012 ◽  
Vol 52 (188) ◽  
Author(s):  
S Shrestha ◽  
A Shrestha ◽  
S Shrestha ◽  
D Bhattarai
Keyword(s):  
Blood Pressure ◽  
High Altitude ◽  
Cross Sectional Study ◽  
Cross Sectional ◽  
Blood Pressures ◽  
Study Population ◽  
Low Altitude ◽  
The Difference ◽  
The Given ◽  
Permanent Residents

Introduction: Studies conducted amongst the inhabitants of high altitude suggested that systolic and diastolic blood pressures are lower in the high than in low altitude population. So a study was designed to look at the blood pressure values among permanent residents of high altitudes of rural Western Nepal. Methods: This is a descriptive cross sectional study conducted at two different altitudes (2670 and 2950 meters) of Humla District, Nepal, looking at the blood pressure values among the permanent inhabitants at these altitudes.  Results: Total number of 137 subjects with 73 (53.3%) from 2950 meters and 64 (46.7%) from 2670 meters altitude were enrolled. Mean age of the study population was 35.29 years. Male were 57 (41.6%) and female 80 (58.4%). The difference in systolic blood pressures (118.59 and 114.66 mmHg, P=0.01) and mean arterial pressures (92.0 and 89.5 mmHg, P=0.02) at the altitudes of 2670 and 2950 meters were statistically significant whereas the difference in diastolic BP at these altitudes were not statistically significant. There was no significant correlation of BMI with blood pressure values and no difference was noted in the blood pressure values among the two different ethnic groups at the given altitudes.  Conclusions: Lower rate of hypertension was observed among the inhabitants of high altitude of rural western Nepal. Blood pressure was found to decreases with increase in altitude among permanent inhabitants of high altitude.  Keywords: altitude; blood pressure; high altitude inhabitants; hypertension; physiological change.  

scholarly journals Effect of high altitude on human placental amino acid transport

2020 ◽  
Vol 128 (1) ◽  
pp. 127-133 ◽  
Author(s):  
Owen. R. Vaughan ◽  
Fredrick Thompson ◽  
Ramón. A. Lorca ◽  
Colleen G. Julian ◽  
Theresa L. Powell ◽  
...  
Keyword(s):  
Birth Weight ◽  
Amino Acid ◽  
High Altitude ◽  
Sea Level ◽  
Amino Acid Transport ◽  
Acid Uptake ◽  
Acid Transport ◽  
Transport Capacity ◽  
System A ◽  
Low Altitude

Women residing at high altitudes deliver infants of lower birth weight than at sea level. Birth weight correlates with placental system A-mediated amino acid transport capacity, and severe environmental hypoxia reduces system A activity in isolated trophoblast and the mouse placenta. However, the effect of high altitude on human placental amino acid transport remains unknown. We hypothesized that microvillous membrane (MVM) system A and system L amino acid transporter activity is lower in placentas of women living at high altitude compared with low-altitude controls. Placentas were collected at term from healthy pregnant women residing at high altitude (HA; >2,500 m; n = 14) or low altitude (LA; <1,700 m; n = 14) following planned, unlabored cesarean section. Birth weight, but not placenta weight, was 13% lower in HA pregnancies (2.88 ± 0.11 kg) compared with LA (3.30 ± 0.07 kg, P < 0.01). MVM erythropoietin receptor abundance, determined by immunoblot, was greater in HA than in LA placentas, consistent with lower placental oxygen levels at HA. However, there was no effect of altitude on MVM system A or L activity, determined by Na+-dependent [14C]methylaminoisobutyric acid uptake and [3H]leucine uptake, respectively. MVM abundance of glucose transporters (GLUTs) 1 and 4 and basal membrane GLUT4 were also similar in LA and HA placentas. Low birth weights in the neonates of women residing at high altitude are not a consequence of reduced placental amino acid transport capacity. These observations are in general agreement with studies of IUGR babies at low altitude, in which MVM system A activity is downregulated only in growth-restricted babies with significant compromise. NEW & NOTEWORTHY Babies born at high altitude are smaller than at sea level. Birth weight is dependent on growth in utero and, in turn, placental nutrient transport. We determined amino acid transport capacity in placentas collected from women resident at low and high altitude. Altitude did not affect system A amino acid transport across the syncytiotrophoblast microvillous membrane, suggesting that impaired placental amino acid transport does not contribute to reduced birth weight in this high-altitude population.

scholarly journals Seasonal and Altitudinal Prevalence of Fascioliasis in Buffalo in Eastern Nepal

2018 ◽  
Vol 4 ◽  
pp. 48-53
Author(s):  
Ramesh Prasad Sah ◽  
Hari Kumar Prasai ◽  
Jiban Shrestha ◽  
Md Hasanuzzaman Talukder ◽  
AKM Anisur Rahman ◽  
...  
Keyword(s):  
High Risk ◽  
High Altitude ◽  
Sea Level ◽  
Rainy Season ◽  
Meat Production ◽  
Parasitic Diseases ◽  
Sedimentation Technique ◽  
Risk Period ◽  
Pasture Contamination ◽  
Low Altitude

Buffalo is the most important livestock commodities for milk, meat production and several other multipurpose uses distributed densely from southern tarai to northern mid-hills in Nepal. Among several internal parasitic diseases fascioliasis is highly economic one caused by Fasciola in buffaloes. However, there are only few studies carried on prevalence of fascioliasis emphasizing buffaloes in relation to seasonal (summer and rainy, and winter) and altitudinal variations. Therefore, we examined prevalence of fascioliasis seasonally and vertically. For the purpose, we selected two districts of eastern Nepal and sampled from low altitude area known as Madhesha ranging from 175-200, Dhankuta from 800-1200 m, and Murtidhunga from 1800-2200 m elevation from the sea level, representing tarai, mid hills and high hills, respectively. Altogether from February 2013 to January 2014 at every two months interval we collected 798 fecal samples from buffaloes; 282 from Murtidhunga, 239 from Dhankuta and 277 from Madhesha. The samples were examined microscopically for the presence of Fasciola eggs using sedimentation technique. Results showed that overall prevalence of fascioliasis in buffaloes was 39.9% (319/798), ranging highest 42.6%in Madhesha followed by 39.7% in Murtidhunga and 37.2% in Dhankuta, respectively. The prevalence of fascioliasis was found to be significantly (p <0.05) high in winter (44.9%) comparing to rainy season (34.4%). The prevalence of fascioliasis in buffaloes was relatively higher in low altitude than high altitude, although it was not statistically significant (p <0.05). In our findings the female buffaloes showed higher prevalence for fascioliasis than in male. Since the fascioliasis in buffaloes is highly endemic, thus strategic deworming in high risk period is recommended along with measure to prevent pasture contamination with buffalo feces.

Comparative analysis of vitamin D content in population of different climatic zones of Carpathian region

2014 ◽  
Vol 18 (4 (72)) ◽  
Author(s):  
V. V. Povorozniuk ◽  
I. V. Pankiv
Keyword(s):  
Vitamin D ◽  
Comparative Analysis ◽  
High Altitude ◽  
Vitamin D Deficiency ◽  
Sea Level ◽  
Severe Form ◽  
Climatic Zones ◽  
Vitamin D Intake ◽  
Carpathian Region ◽  
Low Altitude

The adequate vitamin D intake is found only in 19,5 % of inspected habitants of Carpathian region. The vitamin D deficiency is marked in 135 (80,5 %) and among them severe form is detected in 48 (28,4 %) of the inspected people. Frequency of vitamin D deficiency depends on a residence and increases with the height above a sea level. 25 (ОН) D level is higher among the ihabitants of low altitude region (27,14±1,26 nmol/l) comparatively with data of middle altitude region (21,37±1,34 nmol/l) and high altitude region (15,56±1,04 nmol/l).

Low P50 in deer mice native to high altitude

1985 ◽  
Vol 58 (1) ◽  
pp. 193-199 ◽  
Author(s):  
L. R. Snyder
Keyword(s):  
High Altitude ◽  
Significant Negative Correlation ◽  
Deer Mice ◽  
Hypoxic Stress ◽  
Hemoglobin Saturation ◽  
Partial Pressures ◽  
Theoretical Predictions ◽  
Low Altitude ◽  
The Difference

Whereas it is widely believed that animals native to high altitude show lower O2 partial pressures at 50% hemoglobin saturation (P50) than do related animals native to low altitude, that “fact” has not been well documented. Consequently, P50 at pH 7.4, PCO2(7.4), the CO2 Bohr effect, and the buffer slope (delta log PCO2/delta pH) were determined via the mixing technique in Peromyscus maniculatus native to a range of altitudes but acclimated to 340 or 3,800 m. PCO2(7.4) and buffer slope were substantially lower at high altitude. The change in P50(7.4) between acclimation altitudes was minimal (0.8% increase at 3,800 m), because of counterbalancing changes in PCO2, 2,3-diphospho-D-glycerate concentration, and perhaps other factors. At both acclimation altitudes there was a highly significant negative correlation between P50(7.4) and native altitude. Since pH in vivo probably increases slightly at high altitude, the data on P50 corrected to pH 7.4 are probably underestimates of the difference in in vivo P50 at low vs. high altitude. Hence these results corroborate theoretical predictions that low P50 is advantageous under severe hypoxic stress.

Comparison of Sleep Disturbances Between Older Nursing Home Residents in High- and Low-Altitude Areas

2019 ◽  
Vol 33 (6) ◽  
pp. 370-376
Author(s):  
Shou Liu ◽  
Ines H. I. Chow ◽  
Li Lu ◽  
Yan-Ming Ren ◽  
Hui-Lian Yang ◽  
...  
Keyword(s):  
Nursing Home ◽  
Sleep Disturbance ◽  
High Altitude ◽  
Sleep Disturbances ◽  
Nursing Home Residents ◽  
Male Gender ◽  
Multiple Logistic Regression ◽  
Regression Analyses ◽  
High Altitude Area ◽  
Low Altitude

Background and Objective: This study compared sleep disturbances between older adults living in nursing home located in high- and low-altitude areas and explored the association between sleep disturbances and quality of life (QoL). Method: In total, 207 participants living in a high-altitude area and 437 participants in a low-altitude area were included. Sleep disturbances (ie, difficulty in initiating sleep, difficulty in maintaining sleep, and early morning awakening) were measured using standardized questions. The independent demographic and clinical correlates of sleep disturbances in high-altitude area were examined using multiple logistic regression analyses. Each type of sleep disturbance was entered as the dependent variable separately, while those with significant group differences in the univariate analyses (ie, male gender, married status, age and depressive symptoms) were entered as independent variables. Results: The prevalence of any type of sleep disturbances in the whole sample was 26.09%, with 41.54% in the high-altitude area and 18.76% in the low-altitude area. Physical, psychological, social, and environmental QoL domains were negatively associated with sleep disturbances in high-altitude area. Multiple logistic regression analyses revealed that male gender and married status were less likely to have sleep disturbances, while those with more severe depressive symptoms were more likely to have sleep disturbances in high-altitude area. Conclusion: Sleep disturbance is common among older nursing home residents in high-altitude areas. Considering the negative impact of sleep disturbance on QoL, regular screening and treatment strategies need to be developed directly for this population.

Cerebrospinal fluid in man native to high altitude

1964 ◽  
Vol 19 (2) ◽  
pp. 319-321 ◽  
Author(s):  
J. W. Severinghaus ◽  
A. Carceleń B.
Keyword(s):  
Cerebrospinal Fluid ◽  
High Altitude ◽  
Sea Level ◽  
Regulation Of Respiration ◽  
Acid Base ◽  
Peripheral Chemoreceptor ◽  
Arterial Blood ◽  
Blood Ph ◽  
The Difference

CSF pH was shown in a prior report to remain essentially constant during 8 days of acclimatization to 3,800 m. In order to further evaluate the possible role of CSF acid-base equilibria in the regulation of respiration, 20 Peruvian Andean natives were studied at altitudes of 3,720–4,820 m. In ten subjects at 3,720 m, means were: CSF pH 7.327, Pco2 43, HCO3- 21.5, Na+ 136, K+ 2.6, Cl- 124, lactate 30 mg/100 ml. Arterial blood: pH 7.43, Pco2 32.5, HCO3- 21.3, Na+ 136, K+ 4.2, Cl- 107, hematocrit 49, SaOO2 89.6. In six subjects at 4,545 m and four at 4,820 m CSF values were not significantly different; mean arterial Pco2 was 32.6 and 32.3, respectively. The only significant variations with altitude were the expected lowering of PaOO2 to 47 and 43.5 mm Hg, and of SaOO2 to 84.2 and 80.7, and increase of hematocrit to 67% and 75%, respectively. The natives differed from recently acclimatized sea-level residents in showing less ventilation (higher Pco2) in response to the existing hypoxia, and less alkaline arterial blood. The difference appears to relate to peripheral chemoreceptor response to hypoxia rather than central medullary chemoreceptor. respiratory regulation at high altitude; chronic acclimatization to altitude; peripheral chemoreceptor response to hypoxia; CSF and medullary respiratory chemoreceptors Submitted on June 12, 1963

scholarly journals Progeny of Xenopus laevis from altitudinal extremes display adaptive physiological performance

2021 ◽  
pp. jeb.233031
Author(s):  
Carla Wagener ◽  
Natasha Kruger ◽  
John Measey
Keyword(s):  
Xenopus Laevis ◽  
High Altitude ◽  
Sea Level ◽  
Phenotypic Variation ◽  
Swimming Performance ◽  
Common Garden ◽  
Parental Origin ◽  
Thermal Limits ◽  
Critical Thermal Limits ◽  
Low Altitude

Environmental temperature variation generates adaptive phenotypic differentiation in widespread populations. We used a common garden experiment to determine whether offspring with varying parental origins display adaptive phenotypic variation related to different thermal conditions experienced in parental environments. We compared burst swimming performance and critical thermal limits of African clawed frog (Xenopus laevis) tadpoles bred from adults captured at high (∼ 2000 m above sea level) and low (∼ 5 m above sea level) altitudes. Maternal origin significantly affected swimming performance. Optimal swimming performance temperature had a >9°C difference between tadpoles with low altitude maternal origins (Topt: pure- and cross-bred 35.0°C) and high altitude maternal origins (Topt: pure-bred 25.5°C, cross-bred 25.9°C). Parental origin significantly affected critical thermal limits. Pure-bred tadpoles with low altitude parental origins had higher CTmax (37.8±0.8°C) than pure-bred tadpoles with high altitude parental origins and all cross-bred tadpoles (37.0±0.8 and 37.1±0.8°C). Pure-bred tadpoles with low altitude parental origins and all cross-bred tadpoles had higher CTmin (4.2±0.7 and 4.2±0.7°C) than pure-bred tadpoles with high altitude parental origins (2.5±0.6°C). Our study shows Xenopus laevis tadpoles’ varying thermal physiological traits is the result of adaptive responses to their parental thermal environments. This study is one of few demonstrating potential intraspecific evolution of critical thermal limits in a vertebrate species. Multi-generation common garden experiments and genetic analyses would be required to further tease apart the relative contribution of plastic and genetic effects to the adaptive phenotypic variation observed in these tadpoles.

scholarly journals Hematological parameters of high and low altitude Tibetan populations

2020 ◽  
Author(s):  
Nipa Basak ◽  
Tsering Norboo ◽  
Mohammed S. Mustak ◽  
Kumarasamy Thangaraj
Keyword(s):  
High Altitude ◽  
Hematological Parameters ◽  
Hemoglobin Concentration ◽  
P Value ◽  
Mean Corpuscular Hemoglobin ◽  
Tibetan Population ◽  
Significant Difference ◽  
High Altitude Acclimatization ◽  
Low Altitude ◽  
The Difference

AbstractHigh altitude hypoxia is believed to be experienced at elevations more than 2500 meters. A few studies have shed light on the biochemical aspects of high altitude acclimatization that profoundly included the subjects sojourning to the high altitude from low altitude and observation of the transient changes. However, information regarding the difference between the adapted people in high altitude and their counterpart, who reside in the low altitude are lacking. To address that issue, we have measured various hematological parameters and level of serum erythropoietin (EPO) in Tibetan population, who are residing in both high and low altitudes. We observed significant difference (p value < 0.0001) between high and low altitude Tibetan, in various hematological parameters, including red blood cells (RBC) count, hematocrit (HCT) or packed cell volume (PCV), and hemoglobin concentration (Hb). In case of mean corpuscular volume (MCV), significant difference was observed only in females (p value < 0.0001). Mean corpuscular hemoglobin concentration (MCHC) was significantly different between both males and females, but age was a potential confounder. There was no significant difference in serum EPO level between these two groups, either in males or females, which might be due to blunted erythropoietin response in the Tibetan population. We have also analyzed correlation between serum EPO with Hb and serum EPO with HCT and found no significant correlation. In multiple regression analysis, low altitude and male-gender showed significant impact on both Hb and HCT. In conclusion, our study suggests significant perturbation of hematological parameters, when native high altitude populations migrated to low altitude and inhabited for a long period.

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