ALTERATIONS IN SOME BIOCHEMICAL PARAMETERS IN CATTLE AFFECTED WITH FOOT AND MOUTH DISEASE IN DAKAHLIA GOVERNORATE, EGYPT

2018 ◽  
pp. 49-56
Author(s):  
Eman Kamal ◽  
MOhamed Salama ◽  
Ahmed Elgamal ◽  
Nabil Heakal
Keyword(s):  
Biochemical Parameters ◽  
Serum Insulin ◽  
Clinical Signs ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Control Group ◽  
Infected Cattle ◽  
Blood Samples ◽  
Foot And Mouth ◽  
Healthy Control

This study was carried out to evaluate the changes in serum biochemical parameters during foot and mouth disease (FMD) viral infection, so blood samples were collected from different farms in Dakahlia Governorate during the outbreak of the disease in 2016. Blood samples were collected after complete clinical and physical examination of twenty five cattle; their ages were ranging from 1-2 years and divided into two groups as follows: 15 cattle were showing the clinical signs of the disease and 10 cattle were clinically healthy (control group). The obtained results showed a significant increase in glucose level (P<0.01), non-esterified fatty acids (NEFA) (P<0.001), beta hydroxyl butyric acid (BHBA) (P<0.001) and lipase enzyme (P<0.01) in infected cattle compared to control group. On the other hand, serum insulin concentration and amylase were significantly lower in blood of infected cattle than control group (P<0.001) and (p<0.01) respectively. from the obtained results it could be concluded that FMD infection in cattle is associated with hyperglycemia, hypoinsulinemia and ketosis

scholarly journals Heat-Intolerance Syndrome subsequent Foot-and-Mouth Disease in Cattle; ThiQar –Iraq

2012 ◽  
Vol 36 (0E) ◽  
pp. 286-292
Author(s):  
Adil M. Abbas
Keyword(s):  
Cortisol Level ◽  
Clinical Signs ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Infected Cattle ◽  
Low Level ◽  
Foot And Mouth ◽  
Radio Immunoassay ◽  
Low Levels ◽  
High Level

The investigation on Heat-Intolerance Syndrome following foot and mouth disease (FMD) infection in cattle in ThiQar–Iraq, used 3ABC FMD ELISA kit, and Radio- immunoassay (RIA) to detect the cortisol level. From 105 there were 65(62%) infected cattle with FMD, which was high at 5- less 8 years old, while the cortrisol level showed three levels; normal (13-21 nmol⁄L), high and low levels were; 6(5.6%), 44(42%) and 55(52%) subsequently. More over the combined result of ELISA and RIA had divided cattle into six groups. First group of 40(38%) cattle infected with FMD and had low level of cortisol, this group containing 21(20%) with clinical signs of heat intolerance. Second group contain 22(21%) FMD infected cattle with high level of cortisol. Third group of 3(2.8%) FMD Infected cattle but normal cortisol level. Fourth group included 3(2.8%) not infected by FMD with normal cortisol level. Fifth group contain 22(21%) not infected with FMD but had high level of cortisol may related to stress. Sixth group consisted 15 (14%) cattle not infected with FMD and had low level of cortisol due to un known cause.Clinical signs of heat intolerance that showed in 21 head of cattle in the first group were: panting, overgrowth of hair coat, emaciation and seeking for shad. The diseased cow known locally as ”Mahrorah” meaning heat-intolerance.

scholarly journals Effect of Foot-and-Mouth Disease Vaccination on Acute Phase Immune Response and Anovulation in Hanwoo (Bos taurus coreanae)

Vaccines ◽  
2021 ◽  
Vol 9 (5) ◽  
pp. 419
Author(s):  
Daehyun Kim ◽  
Joonho Moon ◽  
Jaejung Ha ◽  
Doyoon Kim ◽  
Junkoo Yi
Keyword(s):  
Immune Response ◽  
Artificial Insemination ◽  
Bos Taurus ◽  
Foot And Mouth Disease ◽  
Test Group ◽  
Mouth Disease ◽  
Control Group ◽  
Amyloid A ◽  
Mouth Disease Virus ◽  
Foot And Mouth

Vaccination against foot-and-mouth disease is the most common method for preventing the spread of the disease; the negative effects include miscarriage, early embryo death, lower milk production, and decreased growth of fattening cattle. Therefore, in this study, we analyze the side effects of vaccination by determining the acute immune response and ovulation rate after vaccinating cows for foot-and-mouth disease. The test axis was synchronized with ovulation using 100 Hanwoo (Bos taurus coreanae) cows from the Gyeongsangbuk-do Livestock Research Institute; only individuals with estrus confirmed by ovarian ultrasound were used for the test. All test axes were artificially inseminated 21 days after the previous estrus date. The control group was administered 0.9% normal saline, the negative control was injected intramuscularly with lipopolysaccharide (LPS; 0.5 µg/kg), and the test group was administered a foot-and-mouth disease virus vaccine (FMDV vaccine; bioaftogen, O and A serotypes, inactivated vaccine) 2, 9, and 16 days before artificial insemination. White blood cells and neutrophils increased significantly 1 day after vaccination, and body temperature in the rumen increased for 16 h after vaccination. Ovulation was detected 1 day after artificial fertilization by ovarian ultrasound. The ovulation rates were as follows: control 89%, LPS 60%, FMDV vaccine (−2 d) 50%, FMDV vaccine (−9 d) 75%, and FMDV vaccine (−16 d) 75%. In particular, the FMDV vaccine (−2 d) test group confirmed that ovulation was delayed for 4 days after artificial insemination. In addition, it was confirmed that it took 9 days after inoculation for the plasma contents of haptoglobin and serum amyloid A to recover to the normal range as the main acute immune response factors. The conception rate of the FMDV vaccine (−2 d) group was 20%, which was significantly lower than that of the other test groups.

scholarly journals Hemato-Biochemical studies on Egyptian Buffaloes and Calves naturally infected with Foot and Mouth Disease Virus serotype SAT 2

2016 ◽  
Vol 73 (2) ◽  
pp. 230
Author(s):  
Essam A Mahmoud ◽  
Ahmed N.F Neamat-allah
Keyword(s):  
Clinical Signs ◽  
Foot And Mouth Disease ◽  
Viral Disease ◽  
Mouth Disease ◽  
Cardiac Markers ◽  
Mouth Disease Virus ◽  
Virus Serotype ◽  
Foot And Mouth ◽  
Infected Adult ◽  
Apparently Healthy

Foot and mouth disease (FMD) is a highly contagious viral disease of all cloven footed domestic and wild animals. This work was planned to study the different markers for diagnosis of FMDV serotype Sat2 in adult buffaloes and calves including clinical, hematological and biochemical examinations. A total number of sixty animals were divided into four groups. The first group was apparently healthy adult buffaloes, while the second was naturally infected adult buffaloes, a third group was apparently healthy suckling calves and finally the fourth group was naturally infected suckling calves. The recorded clinical signs were fever, salivation, loss of appetite, depression, lameness, blisters or vesicles, erosions and ulcers in the mucosa of the mouth, tongue, lips, gums, pharynx, palate and between the claws. Anemia, leucopenia, lymphopenia and monocytopenia were recorded in infected adult buffaloes and calves. Myocardial injury proved by presence of degenerated myocardial fibers and lymphocyte cell infiltration with a significant increase in cardiac markers like cardiac torponin I, CPK and LDH in addition to a significant hyperkalemia, hypocalcaemia and hypomagnesemia in buffaloe calves. Moreover, electrophoresis showed hyoproteinemia, hypoalbuminemia and hypoglobulinemia in infected animals. It could be concluded that the elevation of cardiac markers emphasized that FMD is more severe in young calves than adult animals. Therefore, it is recommended to evaluate the prognosis of FMD infection in calves by these markers.

scholarly journals Early Detection of Foot-And-Mouth Disease Virus from Infected Cattle Using A Dry Filter Air Sampling System

2015 ◽  
Vol 64 (2) ◽  
pp. 564-573 ◽  
Author(s):  
J. M. Pacheco ◽  
B. Brito ◽  
E. Hartwig ◽  
G. R. Smoliga ◽  
A. Perez ◽  
...  
Keyword(s):  
Early Detection ◽  
Disease Virus ◽  
Foot And Mouth Disease ◽  
Air Sampling ◽  
Mouth Disease ◽  
Infected Cattle ◽  
Sampling System ◽  
Mouth Disease Virus ◽  
Foot And Mouth

scholarly journals 16 Standardized phytomolecules improve foot and mouth disease vaccine response in grower pigs

2019 ◽  
Vol 97 (Supplement_3) ◽  
pp. 16-17
Author(s):  
Alexandra Blanchard ◽  
Josselin le Cour Grandmaison ◽  
In Ho Kim ◽  
Yong Min Kim
Keyword(s):  
Foot And Mouth Disease ◽  
Viral Disease ◽  
Mouth Disease ◽  
Vaccine Response ◽  
Blood Samples ◽  
Vaccination Response ◽  
Foot And Mouth ◽  
Negative Effect ◽  
Antibody Titers ◽  
Antibody Levels

Abstract Foot and Mouth Disease (FMD) is a severe viral disease with significant economic impact. In endemic countries, livestock may be vaccinated. Standardized capsicum and turmeric oleoresins have demonstrated a boosting effect of vaccination in broiler, but little is known on their efficacy in swine. The objective of this trial was to evaluate the efficiency of these phytomolecules to improve FMD vaccine response in pigs. Cross-breed pigs (n = 120) with body weight of 24.6 kg were allotted into 3 groups of 40 pigs and assigned into 10 replicates from days 70 to 112 of age. Following treatments were applied: NS: no vaccination; FMD-NS: FMD vaccination; FMD-XT: FMD vaccination + supplementation of XT-N (4% capsicum + 4% turmeric oleoresins, Pancosma, Switzerland) at 125 g/ton in feed. The FMD vaccine (Omanisa + O3039 + A22 Iraq-strain, Merial) was injected at day 78. Blood samples were collected at days 88, 93, 98 and 103 to evaluate antibody levels. Growth performance was evaluated at day 112. Data were analyzed using the GLM procedure of SAS®. During the trial, non-vaccinated pigs (NS) did not display antibody titers against FMD, but vaccinated pigs (FMD-NS and FMD-XT) exhibited significant levels of FMD antibodies (P &lt; 0.05). Pigs of FMD-XT group showed significant higher antibody levels at day 93 (P &lt; 0.05), day 98 (P = 0.06) and day 103 (P &lt; 0.05) in comparison to FMD-NS pigs. It indicated significant improvement of FMD vaccine response in comparison to the vaccinated control. At 112 days, FMD-NS pigs were numerically lighter (53.46 kg) in comparison to non-vaccinated pigs (53.89 kg). However, FMD-XT pigs were heavier (54.51 kg) in comparison to NS pigs (+0.62 kg, P &gt;0.05) and FMD-NS pigs (+1.05 kg, P &lt; 0.05). These findings showed that standardized phytomolecules (XT-N) incorporated into pig diet significantly supported FMD vaccination response and alleviated its negative effect on growth.

scholarly journals Genetic and antigenic variation of foot-and-mouth disease virus during persistent infection in naturally infected cattle and Asian buffalo in India

PLoS ONE ◽  
2019 ◽  
Vol 14 (6) ◽  
pp. e0214832 ◽  
Author(s):  
Jitendra K. Biswal ◽  
Rajeev Ranjan ◽  
Saravanan Subramaniam ◽  
Jajati K. Mohapatra ◽  
Sanjay Patidar ◽  
...  
Keyword(s):  
Disease Virus ◽  
Persistent Infection ◽  
Antigenic Variation ◽  
Foot And Mouth Disease ◽  
Mouth Disease ◽  
Infected Cattle ◽  
Mouth Disease Virus ◽  
Foot And Mouth

scholarly journals Identification of Foot-and-Mouth Disease Virus-Specific Linear B-Cell Epitopes To Differentiate between Infected and Vaccinated Cattle

2003 ◽  
Vol 77 (16) ◽  
pp. 8633-8639 ◽  
Author(s):  
Bettina-Judith Höhlich ◽  
Karl-Heinz Wiesmüller ◽  
Tobias Schlapp ◽  
Bernd Haas ◽  
Eberhard Pfaff ◽  
...  
Keyword(s):  
B Cell ◽  
Foot And Mouth Disease ◽  
The United States ◽  
Mouth Disease ◽  
Enzyme Linked Immunosorbent Assay ◽  
Infected Cattle ◽  
B Cell Epitopes ◽  
Foot And Mouth ◽  
Fmdv Strain ◽  
Linear B

ABSTRACT Foot-and-mouth disease (FMD) is a highly contagious viral disease of cloven-hoofed animals. For several years, vaccination of animals, which had proven to be successful for the eradication of the disease, has been forbidden in the United States and the European Community because of the difficulty of differentiating between vaccinated and infected animals. In this study, detailed investigations of the bovine humoral immune response against FMD virus (FMDV) were performed with the aim of identifying viral epitopes recognized specifically by sera derived from FMDV-infected animals. The use of overlapping 15-mer synthetic peptides, covering the whole open reading frame of FMDV strain O1K in a peptide enzyme-linked immunosorbent assay, allowed the identification of 12 FMDV strain O1K-specific linear B-cell epitopes. Six of these linear B-cell epitopes, located in the nonstructural proteins, were used in further assays to compare the reactivities of sera from vaccinated and infected cattle. Antibodies recognizing these peptides could be detected only in sera derived from infected cattle. In further experiments, the reactivity of the six peptides with sera from animals infected with different strains of FMDV was tested, and strain-independent infection-specific epitopes were identified. Thus, these results clearly demonstrate the ability of a simple peptide-based assay to discriminate between infected and conventionally FMD-vaccinated animals.

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