scholarly journals ROLE OF VARIOUS IHC MARKERS IN CLASSIFICATION OF LUNG CARCINOMA ON ENDOBRONCHIAL BIOPSIES.

2020 ◽  
pp. 1-3
Author(s):  
Raj Kumar Gupta ◽  
Namita Bhutani ◽  
Sachet Dawar
Keyword(s):  
Diagnostic Algorithm ◽  
Diagnostic Techniques ◽  
Major Type ◽  
Biopsy Specimens ◽  
Napsin A ◽  
Highly Sensitive ◽  
Poorly Differentiated ◽  
Higher Sensitivity

BACKGROUND: Lung cancer is the most frequently diagnosed cancer and leading cause among cancer mortality worldwide. An accurate classification is difficult in small biopsy specimens due to a variety of reasons. Therefore, there is an increasing need for additional diagnostic techniques such as immunohistochemistry. METHODS: This study was conducted on Endobronchial biopsies of One hundred and sixty patients were subjected to routine H & E and IHC staining. RESULTS: The patients were in age group of 25-75 years with a mean of 55.67 years with M: F ratio of 6.61:1. NSCLC constituted the major type, contributing to 83.1% of cases. Amongst, TTF-1 and napsin-A, the later had higher sensitivity (96.15%) as compared to TTF-1 (92.30%) for diagnosing adenocarcinoma. CONCLUSION: CK and p63 served as highly sensitive markers for diagnosis of squamous cell carcinoma and TTF-1 and napsin A for adenocarcinoma, forming an important diagnostic algorithm for subtyping of poorly differentiated NSCLC on small biopsies.

Role of laparoscopic in diagnosis and treatment of undescended testis in children at Viet Duc Hospital

2018 ◽  
Vol 8 (4) ◽  
Author(s):  
Viet Hoa Nguyen
Keyword(s):  
Laparoscopic Surgery ◽  
Undescended Testis ◽  
Correct Diagnosis ◽  
Diagnosis And Treatment ◽  
Highly Sensitive ◽  
The Mean ◽  
The Right ◽  
Time Of Operation

Abstract Introduction: Evaluating the role of laparoscopic for diagnosis and treatment of undescended testis in children. Material and Methods: Restrospective study, between 6/ 2014 and 6/2017. All the patients are aged from 1 to 16 years with undescended testis underwent laparoscopic surgery for diagnosis and treatment in Deparment of pediatric surgery – Viet Duc hospital enrolled. Results: Of 95 patiens in total had 106 undescended testis diagnosed and treated by laparoscopy. The mean age of patients was 7,5 ± 3,8 years. 44,2% undescended were on the left side, 44,2% were on the right and 11,6% were undescended bilateral. The correct diagnosis by ultrasound accounted in 79,4%. The locations of testis diagnosed by laparoscopic are : intra abdomen in 45,3%, deep inguinal orifice in 16,9%, extra inguinal orifice in 26,4%, no testicle found in 11,4%. The mean time of operation were 67,33± 28,01 pht. Scrotal positions were achieved 74,5%, remove atrophic testis accounted in 7,6%. Stephen- Flowler technique including step I were in 4,7%, step II in 1,9%. The outcome evaluated by testicular positions following 3 months after operation are : good in 79,2%, moderate 13,2%, poor in 7,6%; By classification of Aubert are : good in 81,1%, moderate in 11,3% and poor in 7,6 %. Conclusion: Laparoscopic surgery is not only a highly sensitive diagnostic method to find accurately the location and size of the testes, but also the most effective method to treat impalpable undescended testes.

scholarly journals Review on Molecular Diagnosis of Cestode and Metacestode in Cattle

2021 ◽  
Vol 6 (1) ◽  
pp. 6-12
Author(s):  
Ziyad M. Bilal ◽  
◽  
Kedir S. Musa ◽  
Keyword(s):  
Sensitivity And Specificity ◽  
Diagnostic Techniques ◽  
Laboratory Research ◽  
Molecular Diagnostic ◽  
Enzyme Linked Immunosorbent Assay ◽  
Host Interaction ◽  
Highly Sensitive ◽  
Elisa Technique ◽  
Polymerase Chain ◽  
Higher Sensitivity

Cestode infestations in animals are the most important parasite of livestock and humans because most of these parasites are zoonotic causing cysticercosis and hydatidosis in man and it causes economic and production losses in livestock. Diagnosis of Taenia Spp by microscopic observation lack sensitivity and specificity and detection by enzyme-linked immunosorbent assay (ELISA) technique form cross-reaction. The molecular diagnostic can be best to detect in adult and larval stage in definitive and intermediate host based on the amplification of deoxyribonucleic acid (DNA) of target gene with the primer using a different technique of polymerase chain reaction (PCR) such as multiplex PCR. Conventional PCR, real-time PCR, nested PCR, and PCR-restriction fragment length polymorphism (RFLP) are highly sensitive for the diagnosis of cestode and metacestode. Those diagnoses are used for differentiation of Taenia species and differentiation of Taenia and Echinococcus species. As compared to other diagnostic techniques most molecular methods have higher sensitivity and specificity but due to the relatively higher cost, few are commercially available. Most of the molecular diagnostic tests developed to date are generally applicable for laboratory research purposes. The developments in the genomic and proteomic analysis should be used for further understanding of parasite-animal host interaction to find additional targets for diagnosis.

The Significant Impact of Immunohistochemistry in the Classification of Lung Carcinoma on Small Biopsies

2021 ◽  
Vol 8 (3) ◽  
pp. 60-65
Author(s):  
Debjani Mallick ◽  
Sayan Kundu ◽  
Sudipta Chakrabarti ◽  
Prosun Gayen
Keyword(s):  
Cell Carcinoma ◽  
Squamous Cell ◽  
Lung Carcinoma ◽  
Clinical Findings ◽  
Small Cell ◽  
Napsin A ◽  
Morphological Diagnosis ◽  
Poorly Differentiated ◽  
Undifferentiated Tumors

Background : There are limitations of histomorphology in the appropriate categorization of lung carcinoma where immunohistochemistry can confirm the morphological diagnosis and may add value in the poorly differentiated and undifferentiated tumors. The aim of the study was to assess the role of immunohistochemistry in classifying lung carcinoma on small biopsy samples. Methods and Material: A retrospective hospital based, observational study was conducted on cases of lung carcinoma diagnosed by core needle or bronchoscopic biopsies over a 3- year period. After evaluation of clinical findings and H&E sections, all biopsies were evaluated by immunohistochemical staining. The immunohistochemistry panel included cytokeratin cocktail, CK7, CK 20, TTF1, Napsin A, CK5/6, p40, synaptophysin, chromogranin, CD 56. Result: Out of 78 cases, the mean age was 58 +/- 11 years. Most prevalent malignancy type was adenocarcinoma (30, 38.1%). Adenocarcinoma cases were positive for CK7 (25/26, 96%), Napsin A (24/26, 92%), TTF1 (15/30, 50%) and negative for CK 20. Squamous cell carcinoma cases showed positivity for p40(18/22, 82%) and CK 5/6 (17/22.71%).Small cell carcinoma showed positivity for neuroendocrine markers synaptophysin (5/7,71%) and chromogranin(4/7, 57%) and CD 56 (6/7cases (85%).88% of small cell carcinomas,75% of adenocarcinomas and 72 % of squamous cell carcinomas were accurately diagnosed by morphology. Morphologic prediction was poor in the NSCC NOS group (0%) and poorly differentiated carcinomas (64%), which were finally, diagnosed by immunohistochemistry.In the morphologically diagnosed cases, immunohistochemistry confirmed the diagnosis. Conclusion: Thus, morphology added with immunohisto chemistry provides a crisp diagnosis thereby improving therapeutic efficacy

The molecular and genetic basis of carcinogenesis

2019 ◽  
Author(s):  
Аскольд Майборода ◽  
Aleksei Kaliagin
Keyword(s):  
Genetic Basis ◽  
Diagnostic Techniques ◽  
Federal State ◽  
Clinical Aspects ◽  
Tumor Type ◽  
Cellular Events ◽  
Oncological Diseases ◽  
State Educational

The textbook deals with the classification of tumor growth, signs of malignancy, genetic basis of cancer, chronology of cellular events of oncogenesis. The differences between oncogenes and suppressor genes by the principle of action, the role of apoptosis in the processes of programmed cell death and their utilization are discussed. Attention is paid to the role of apoptosis defects in the development of oncogenic States. The modern ideas about the diagnosis of oncological diseases, which include screening examinations and individual verification of the tumor type, are generalized. The modern successes of diagnostic techniques, which were the result of the combined capabilities of molecular genetics and cytogenetics, are noted. The features of the course of virus-induced and non-viral forms of cancer are analyzed. Fundamental and clinical aspects of Oncology are combined. Meets the requirements of the Federal state educational standards of higher education of the last generation. For students on programs of specialization "Medical business", "Pediatrics", "Medical biochemistry". It will also be useful for residents and doctors.

scholarly journals The Use of Singlish Discourse Particle ‘Lah’ in Sgag’s Videos

HUMANIS ◽  
2018 ◽  
pp. 1104
Author(s):  
Ryan Febryanto ◽  
I Made Suastra ◽  
I Nyoman Tri Ediwan
Keyword(s):  
Qualitative Method ◽  
Major Type ◽  
Particle Theory ◽  
Syntactic Function ◽  
And Function ◽  
Discourse Particle ◽  
Context Of Situation ◽  
Descriptive Qualitative

This study entitled The Use of Singlish Discourse Particle ‘lah’ in SGAG’s Videos is aimed to analyze the types and function of discourse particle in SGAG’s videos. The data were taken from the conversation in SGAG’s video collection. Descriptive qualitative method was applied to analyze the types and functions of discourse particle ‘lah’. The theories used to analyze it are the classification of the type of discourse particle theory by Wong, role of particles theory by Ling and Deterding and Context of Situation by Halliday. The result of analysis shows that there were 62 discourse particle lah in the SGAG’s video collection from May 28th 2017 until October 10th 2017. The major type of discourse particle lah was Propositional lah (33 occurrences) and the function is more often as a pragmatic role (56 occurrences) rather than a syntactic function (6 occurrences).

scholarly journals Care Gaps and Recommendations in Vestibular Migraine: An Expert Panel Summit

2022 ◽  
Vol 12 ◽  
Author(s):  
Monica P. Mallampalli ◽  
Habib G. Rizk ◽  
Amir Kheradmand ◽  
Shin C. Beh ◽  
Mehdi Abouzari ◽  
...  
Keyword(s):  
Diagnostic Algorithm ◽  
Vestibular Migraine ◽  
Community Needs ◽  
Vestibular Tests ◽  
Care Gaps ◽  
Specific Outcome ◽  
Collaborative Efforts ◽  
Pathophysiologic Mechanisms

Vestibular migraine (VM) is an increasingly recognized pathology yet remains as an underdiagnosed cause of vestibular disorders. While current diagnostic criteria are codified in the 2012 Barany Society document and included in the third edition of the international classification of headache disorders, the pathophysiology of this disorder is still elusive. The Association for Migraine Disorders hosted a multidisciplinary, international expert workshop in October 2020 and identified seven current care gaps that the scientific community needs to resolve, including a better understanding of the range of symptoms and phenotypes of VM, the lack of a diagnostic marker, a better understanding of pathophysiologic mechanisms, as well as the lack of clear recommendations for interventions (nonpharmacologic and pharmacologic) and finally, the need for specific outcome measures that will guide clinicians as well as research into the efficacy of interventions. The expert group issued several recommendations to address those areas including establishing a global VM registry, creating an improved diagnostic algorithm using available vestibular tests as well as others that are in development, conducting appropriate trials of high quality to validate current clinically available treatment and fostering collaborative efforts to elucidate the pathophysiologic mechanisms underlying VM, specifically the role of the trigemino-vascular pathways.

Raiders Activity on the Market for Corporate Control as a Product of Coercive Entrepreneurship Evolution

2007 ◽  
pp. 80-92
Author(s):  
A. Kireev
Keyword(s):  
Corporate Control ◽  
Role Of Government ◽  
Market For Corporate Control ◽  
Basic Characteristics

The paper studies the problem of raiders activity on the market for corporate control. This activity is considered as a product of coercive entrepreneurship evolution. Their similarities and sharp distinctions are shown. The article presents the classification of raiders activity, discribes its basic characteristics and tendencies, defines the role of government in the process of its transformation.

ASPECTS IN BUILDING A COMPANY WEB-SITE AND ITS ROLE FOR THE DEVELOPMENT OF BUSINESS

2018 ◽  
pp. 117-124
Author(s):  
Petar Halachev ◽  
Victoria Radeva ◽  
Albena Nikiforova ◽  
Miglena Veneva
Keyword(s):  
Life Cycle ◽  
Web Site ◽  
The Internet ◽  
A Company ◽  
The Web ◽  
Design Construction ◽  
Made In ◽  
Site Types

This report is dedicated to the role of the web site as an important tool for presenting business on the Internet. Classification of site types has been made in terms of their application in the business and the types of structures in their construction. The Models of the Life Cycle for designing business websites are analyzed and are outlined their strengths and weaknesses. The stages in the design, construction, commissioning, and maintenance of a business website are distinguished and the activities and requirements of each stage are specified.

Highly sensitive adolescent benefits in positive school transitions: Evidence for vantage sensitivity in Japanese high-schoolers

2020 ◽  
Author(s):  
Shuhei Iimura
Keyword(s):  
High School ◽  
Statistical Power ◽  
Environmental Influences ◽  
Differential Susceptibility ◽  
School Transition ◽  
Well Being ◽  
Crossover Point ◽  
Japanese Adolescents ◽  
Highly Sensitive

Some researchers indicate that the transition to high school deflects adolescent developmental trajectories. Others assert it provides a new possibility for the promotion of adolescents’ socioemotional well-being. One critical view missing in such claims is that individual variabilities interact with environmental influences. We employed the framework of Differential Susceptibility Theory, which postulates that individual susceptibilities moderate external influences for better and for worse. In order to clarify the mechanism of adolescents’ differential adjustments, this paper investigated the role of sensory-processing sensitivity using the Japanese version of Highly Sensitive Child Scale for Adolescence (J-HSCS), and tested whether the diathesis-stress model or the differential susceptibility model best describes students’ socioemotional adjustment across their high school transition. The current paper used the two-wave data collected from Japanese adolescents aged from 14 to 15 years (n = 412, 50% girls). In Study 1, we investigated the replicability of psychometric properties of J-HSCS. The results supported previous findings, indicating its validity for the bifactor model. In Study 2, we utilized confirmatory competitive model testing, which maximizes statistical power by parameterizing the crossover point to allow a direct comparison of alternative models. The results indicated that neither the diathesis-stress nor the differential susceptibility models fitted the data. Rather, a strong vantage sensitivity model was revealed, suggesting that highly susceptible adolescents disproportionately benefitted from a positive school transition over their counterparts. This finding signified the role of adolescents’ sensitivity to environmental influences and the importance of considering its moderation under person x environment interactions.

Processing the Future

2018 ◽  
Author(s):  
Martin Giraudeau
Keyword(s):  
Venture Capital ◽  
Diagnostic Techniques ◽  
Business Administration ◽  
Knowledge Practices ◽  
Project Appraisal ◽  
Development Corporation ◽  
Close Relationship ◽  
Administrative Procedures ◽  
American Research

This chapter is an analysis of the project appraisal procedures in place at American Research and Development Corporation (ARD) between 1946 and 1973, under the management of Georges F. Doriot. It shows the importance of knowledge technologies and administrative procedures in the way the venture capital company dealt with uncertain futures. The origins of these knowledge practices are traced back to Georges F. Doriot’s own views on business and more generally to the pragmatist movement in business administration of which he was a member. The conduct of project appraisal at ARD is then observed directly, and this reveals its reliance on a rich set of knowledge and diagnostic techniques as well as administrative procedures. These observations allow for a specification of the nature and role of imagination in the entrepreneurship and venture capital practices examined here—in particular, its close relationship with organized knowledge.

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