scholarly journals Violation of Local Immunity of the Oral Cavity in Agro-Industrial Workers with Generalized Periodontitis under the Influence of Pesticides

2021 ◽  
Vol 6 (1) ◽  
pp. 222-227
Author(s):  
V. T. Dyryk ◽  
◽  
R. V. Shkrebniyuk ◽  
O. M. Vynogradova

Among dental diseases, periodontal diseases occupy a prominent place. The polyetiology and polypathogenicity of periodontal diseases are different in nature: pathological processes at the level of the whole organism, its cells and environments, periodontal tissues, biochemically reactive substrates. The significant impact of adverse environmental factors on the state of human organs and systems is confirmed by the tendency to increase the incidence of periodontal disease in industrialized countries, which in different age groups ranges from 80% to 100%. Pesticides are one of the most important factors determining the well-being and balance of the human-environment system today. This is due to their characteristics as chemical pollutants, which deliberately and purposefully contributes to the environment pollution. The main among these features are constant and excessive scattering over large areas; high biological activity on pets, as well as on humans and other living organisms; the ability to persist in the environment and circulate in its objects; metabolized in biological objects and transformed into the environment with the formation of more toxic and dangerous, compared to the original, compounds; the ability to cause the development of long-term effects. The group of risk of periodontal tissue diseases naturally includes employees of agricultural enterprises, who in the process of work are exposed to occupational pathogens of different nature, intensity and duration of action. Continuous intake of agro-industrial xenobiotics creates a chemical load, causes the occurrence of toxic hypoxia, anemia, imbalance in the immune system, promotes the activation of endogenous intoxication, which in turn is projected on the periodontal tissues, and disease of tooth-retaining tissues. The purpose of our research was to study the state of local immunity of the oral cavity in agro-industrial workers with generalized periodontitis under the influence of pesticides. Material and methods. To determine the changes in local immunity in the oral and gingival fluid we determined the concentrations of lysozyme, sIgA, IgA and IgG in 39 patients with generalized periodontitis who were not adversely affected by greenhouse factors (comparative group) and 81 agricultural workers (41 people in open (I main group) and 40 people in closed soils) II main group), exposed to pesticides). The obtained values were compared with data in 31 dentistically healthy people not in contact with pesticides (control group). Results and discussion. The obtained results showed that generalized periodontitis marked changes in the local immune mechanisms of the oral cavity. However, the most pronounced violations were observed in patients with generalized periodontitis working in closed and open soils under the influence of pesticides, and in subjects who were exposed to toxic effects of chemicals in closed soil, this trend was more intense. Conclusion. The study results proved that agro-industrial workers in contact with pesticides in open and closed soils have significant disturbances in the local immune system, which was characterized by a decrease in the levels of immunoglobulins A, G, sIgA and lysozyme in oral and gingival fluids

Author(s):  
A. V. Chornij ◽  
V. V. Shmanko

In recent decades, both in the world and in our country, thyroid gland diseases are not only widespread, but also have a tendency to constant growth. Currently, more attention is paid to diseases of the thyroid gland that are associated with endemic foci of iodine defi ciency in soil and water.The aim of the study – to investigate the state of periodontal tissues in individuals with primary hypothyroidism.Materials and Methods. We conducted a survey of 86 people with primary hypothyroidism, 16 of them with manifestation and 70 with subclinical forms. A comparison group was 45 people without thyroid gland diseases. Index assessment of periodontal tissues included the defi nition of a simplifi ed oral hygiene index of the oral cavity of the Green-Vermillion (Oral Hygiene Index-Simlifi ed, Green-Vermillion, 1964), the degree of gingival infl ammation was determined by Parma (C. Parma, 1960, Papillary-Marginal Alveolar Index)), the state of periodontal tissues in the complex periodontal index (KPI) (1987), destructive changes in the bone tissue of the alveolar appendix were determined by the Fux index.Results and Discussion. The article presents the results of the index estimation of periodontal tissues in individuals with primary hypothyroidism. An analysis of the conducted index evaluation found that they had a poor level of hygienic state of the oral cavity. This was manifested by the development of infl ammatory and, to a lesser extent, infl ammatory and dystrophic lesions of periodontal tissues, as evidenced by papillarymarginalalveolar (PMA) and complex periodontal indices (KPI).Conclusions. Even more signifi cant changes in these indicators were found in individuals with a manifestation of hypothyroidism. So, we can conclude that in persons with primary hypothyroidism metabolic processes ofthe organism are violated, which leads through a number of pathophysiological changes to the activity of parodontopathogenic microfl ora and the development of infl ammatory and infl ammatory and dystrophic periodontal diseases.


2020 ◽  
Vol 75 (3) ◽  
pp. 83-86
Author(s):  
Ye.I. Alexandrov ◽  

90 pregnant women with inflammatory periodontal diseases, aged 27 to 35 years were examined. The main group consisted of 60 pregnant women with gestational diabetes mellitus and the control one consisted of 30 patients with physiological pregnancy. All patients were examined before providing treatment and preventive measures at 14–15 weeks of pregnancy and after them at 37–38 weeks. Studies have shown deterioration in periodontal health, oral hygiene and increase in contamination of the oral cavity in patients of the main group as compared with patients of the control group. The use of the anti-inflammatory succinic acid based preparation is effective for inflammatory periodontal diseases in pregnant women with gestational diabetes. The improvement of periodontal tissues health was confirmed by the posttreatment indices of hygiene, immunoglobulins, microbiocenosis and periodontal indices that promote normalization of the oral cavity.


Author(s):  
Наталия Владимировна Чиркова ◽  
Алена Алексеевна Плутахина ◽  
Алик Эдикович Петросян ◽  
Елена Анатольевна Андреева ◽  
Марина Николаевна Бобешко

Лечение заболеваний пародонта представляет собой одну из наиболее сложных и важных проблем современной стоматологии, актуальность которой обусловлена высокой частотой воспалительных заболеваний пародонта среди населения во всех возрастных группах - до 90% в популяции. Несмотря на прогрессивное развитие медицинской науки и практики, заболеваемость данной патологией сохраняется на высоком уровне не только в группах населения среднего и пожилого возраста, но при этом выявляется тенденция к ее распространению в молодом возрасте. Исследования, проведенные ВОЗ более, чем в 30 странах, выявили высокую распространенность заболеваний пародонта (свыше 60%) среди пациентов возрасте от 18 до 30 лет. Наиболее частой формой поражения околозубных тканей в молодом возрасте является хронический гингивит по классификации СКБ-10 К 05.1. Нерегулярность профилактики и эпизодические обращения к врачу-пародонтологу для лечения заболеваний пародонтита утяжеляют течение заболевания, которое при отсутствии лечения прогрессирует. В связи с этим, от пациента требуется неоднократное прохождение курсов лечения у врача-пародонтолога и выполнение в домашних условиях профилактических мероприятий по рекомендации врача. Однако установлено, что степень комплаентности пациентов молодого возраста к стоматологическому лечению недостаточно высокая, а кратность обращения к врачу-пародонтологу в 62% ограничивается выраженной стоматофобией. Известно, что развитие пародонтита является результатом дисбаланса между микрофлорой полости рта и иммунной защитой организма. Иммунологические изменения при хроническом катаральном гингивите связаны с нарушением взаимодействия факторов неспецифической резистентности организма, изменением клеточного и гуморального иммунитета и подавлением системы местного иммунитета. Поэтому с целью ликвидации воспаления применяют различные иммунокорректоры и антибактериальные средства (антисептики, антибиотики, фитопрепараты). Однако в последнее время появились формы пародонтита, обусловленные нетипичными инфекционными агентами (вирусами, грибами), либо резистентные к антибактериальной терапии. В результате нерационального применения антимикробных препаратов, которые негативно воздействуют на представителей облигатной микрофлоры полости рта, они еще больше снижают местные факторы антибактериальной защиты. Альтернативой антибактериальной терапии при заболеваниях пародонта являются различные методы биотерапевтического воздействия, предполагающие местное и системное применение пробиотиков, фаговых препаратов и других средств. Вместе с тем, такие исследования в отечественной стоматологии единичные, как и исследования по повышению степени соответствия между поведением пациента и рекомендациями, полученными от врача Treatment of periodontal diseases is one of the most difficult and important problems of modern dentistry, the relevance of which is due to the high frequency of inflammatory periodontal diseases among the population in all age groups - up to 90% in the population. Despite the progressive development of medical science and practice, the incidence of this pathology remains at a high level not only in middle-aged and elderly population groups, but at the same time a tendency towards its spread at a young age is revealed. Studies conducted by WHO in more than 30 countries have revealed a high prevalence of periodontal disease (over 60%) among patients aged 18 to 30 years. The most common form of damage to the periodontal tissues at a young age is chronic gingivitis according to the SKB-10 K 05.1 classification. Irregular prophylaxis and occasional visits to a periodontist for the treatment of periodontitis complicate the course of the disease, which progresses in the absence of treatment. In this regard, the patient is required to undergo repeated courses of treatment with a periodontist and to perform preventive measures at home on the recommendation of a doctor. However, it was found that the degree of compliance of young patients to dental treatment is not high enough, and the frequency of visits to a periodontist in 62% is limited by pronounced stomatophobia. It is known that the development of periodontitis is the result of an imbalance between the microflora of the oral cavity and the body's immune defenses. Immunological changes in chronic catarrhal gingivitis are associated with a violation of the interaction of factors of nonspecific resistance of the organism, changes in cellular and humoral immunity and suppression of the local immunity system. Therefore, in order to eliminate inflammation, various immunocorrectors and antibacterial agents (antiseptics, antibiotics, herbal medicines) are used. However, recently there have been forms of periodontitis caused by atypical infectious agents (viruses, fungi), or resistant to antibiotic therapy. As a result of the irrational use of antimicrobial drugs, which negatively affect the representatives of the obligate microflora of the oral cavity, they further reduce the local factors of antibacterial protection. An alternative to antibiotic therapy for periodontal diseases are various methods of biotherapeutic action, involving the local and systemic use of probiotics, phage preparations and other agents. At the same time, such studies in domestic dentistry are rare, as well as studies to improve the degree of correspondence between the patient's behavior and the recommendations received from the doctor


2018 ◽  
pp. 24-27
Author(s):  
V.M. Zubachyk ◽  
M.P. Ilchyshyn

Tobacco smoking remains one of the most important problems of the present time due to significant prevalence and harmful effects on human health. The area of primary contact with components of tobacco smoke is organs and tissues of the oral cavity, oral fluid. In this regard, there is a theoretical and practical interest in the problem of studying the nature and mechanisms of the damaging effects of tobacco smoke during smoking, in particular, on periodontal tissues. Depending on the duration and intensity of smoking misuse, one of the modern methods of treatment is oxygen-ozonized therapy (ozonotherapy), which reduces the risk of polypragrammia and is well combined with both medicines and phytopreparations. The aim of our study was to evaluate the effectiveness of ozonized sea buckthorn oil on periodontal tissues in tobacco-dependent patients. During the diagnosis, common clinical and paraclinical methods of examination were used, taking into account the results of examination and palpation, determining the depth of periodontal pockets, the degree of gum recession and abnormal movement of the teeth. For the correction of pathogenetic disorders, smokers suffering from GP were prescribed: in the comparative group, a common methodology based on hygiene education and upbringing, removal of local stimuli, orthopedic and surgical indications, as well as physiotherapy and general rehabilitation. In the main group − in addition to the generally accepted technique, applications in the gingival area were applied with ozonized sea buckthorn oil and rinsing the oral cavity with a 0.1% solution of myramystine. In order to enhance the therapeutic effect, the patients were recommended oral baths with sea buckthorn oil enriched with oxygen and toothpaste “Parodontax”. As a result of the application of the proposed therapeutic agent, in patients with GP of I degree a stabilization of the results for direct data was observed after 6 and 12 months after treatment. However, in patients with GP of II degree and III degree, both the main group and the comparison group were diagnosed with an increase in the pathological process with respect to data after treatment and after 6 months (p<0,05). With an increase in the disease, no pattern was found regarding the causes of its recurrence. The best steady result was in a group of ex-smokers with chronic generalized periodontitis in different terms of the study. Improvement of the results of the proposed therapeutic agent application confirms the parodontoprotective properties and the bacteriological action of ozone. It also emphasizes the social significance of the problem of smoking cessation in people with inflammatory-destructive changes in periodontal tissues.


2016 ◽  
Vol 97 (3) ◽  
pp. 363-367
Author(s):  
I R Shafeev ◽  
A I Bulgakova ◽  
I V Valeev ◽  
G Sh Zubairova

Aim. To study the state of local immunity of the oral cavity in patients with fixed aesthetic dental prostheses and inflammatory periodontal diseases.Methods. 90 patients with fixed aesthetic dental prostheses and inflammatory periodontal diseases (main group) and 21 patients without dental prostheses and inflammatory periodontal disease (control group) were examined. Immunoglobulin A, sA, G, M, E classes, interleukin-4, -6 and -1β, interferon α contents in oral liquid were determined using enzyme immunoassay.Results.. As a result of our study of immunoglobulins level in saliva in patients of the main and control groups an increase in the immunoglobulin A level, compared with the normal value, statistically significant increase in secretory immunoglobulin A were revealed; difference in the immunoglobulin G level was not determined. The increase in immunoglobulin E level in patients of the main group was determined. When studying the interleukins content in the oral fluid a statistically significant decrease in the concentration of IL-4 and increase in interleukin-6 and -1β content in patients of the main group were determined. The tendency to decrease in the interferon α content in the main group compared to the control group was registered.Conclusion. In patients with fixed aesthetic dental prostheses and inflammatory periodontal diseases humoral immunity imbalance was identified, manifesting in changes of the immunoglobulin classes A, sA and E, interleukin-4, -6 and -1β contents in oral fluid.


2020 ◽  
Vol 25 (4) ◽  
pp. 323-330
Author(s):  
E. S. Ovcharenko ◽  
V. V. Erichev ◽  
S. I. Risovannij ◽  
T. V. Aksenova ◽  
S. V. Melekhov ◽  
...  

Relevance. A long-term inflammation in the oral cavity, unreasonable treatment of periodontal patients with antibiotics cause imbalance between certain types of fungal-bacterial associations accompanied by oral dysbiosis and change of local immune status. So, development and application of new comprehensive diagnosis and treatment techniques in periodontal patients, use of products for correction of microbiota and local immunity are a current and a long-term task. Purpose is to optimize the comprehensive treatment protocol of inflammatory periodontal diseases by introducing probiotics and evaluation of oral microbiome and cytokine profile.Materials and methods. 140 patients were examined. Of these 60 patients had chronic generalized plaque-induced gingivitis and 60 patients suffered from moderate chronic generalized periodontitis. Bacterial and fungal microbiome was assessed and the host immune response was evaluated in all patients before and after the treatment. Half of the patients were treated conventionally and the other half were treated according to a modified scheme: probiotic “Bifidumbacterin Forte” was added.Results. A large number of yeast-like fungi Candida and commensal bacteria were detected in periodontal pockets of patients with chronic generalized plaque-induced gingivitis and moderate chronic generalized periodontitis. That correlates with a significant increase of pro-inflammatory cytokines (TNF-α, IL—8), decrease of concentration of INF-γ and increase of antiinflammatory cytokine IL-4.Conclusion. Changes in clinical, microbiological and immunological values during a modified combination therapy with a probiotic and during a conventional treatment demonstrated that effectiveness of treatment of chronic gingivitis and chronic periodontitis increased by 40% and 37% respectively.


Author(s):  
Sultanshina A.R. ◽  
Kabirova M.F. ◽  
Bashirova T.V.

With diabetes, there is a violation of the microvasculature, a violation of the immune status, an increase in destructive processes in the bone tissue, which leads to the development and / or intensification of pathological processes. In the oral cavity, the most frequently diagnosed inflammatory periodontal diseases, chronic injuries of the oral mucosa (COP), recurrent aphthous stomatitis, COP candidiasis. The aim of our study was to study the dental status of patients with type 2 diabetes mellitus. Materials and Methods: A descriptive evaluative epidemiologically controlled, non-randomized study was conducted to determine the effect of type 2 diabetes on dental status. The main group (“case”) consisted of 68 patients with type 2 diabetes in the compensation phase (IA) and 56 patients in the subcompensation phase (IB). The comparison group included 60 patients without somatic pathology. All patients underwent a comprehensive dental examination, bacteriological and microscopic examination to identify fungi of the genus Candida. Results: in patients with subcompensated form of type 2 diabetes, there was an increase in the frequency of complaints of plaque on the tongue, burning sensation in the COP, dryness and changes in taste. Periodontal indices indicate that the patients of the main group have a high prevalence of inflammatory and destructive processes in the periodontal tissues (indices of PMA, KPI, Mullemann indices) with poor oral hygiene (OHI-S = 3.5 ± 0.4), which confirms the Friedman criterion (χ2 = 116.27; p = 0.0000) based on the calculation of Kendall's concordance coefficient (0.743). The diagnosis of oral mucosa candidiasis was confirmed in 74.6% of patients in the main group by bacteriological examination.


1998 ◽  
Vol 62 (1) ◽  
pp. 71-109 ◽  
Author(s):  
Harold Marcotte ◽  
Marc C. Lavoie

SUMMARY In the oral cavity, indigenous bacteria are often associated with two major oral diseases, caries and periodontal diseases. These diseases seem to appear following an inbalance in the oral resident microbiota, leading to the emergence of potentially pathogenic bacteria. To define the process involved in caries and periodontal diseases, it is necessary to understand the ecology of the oral cavity and to identify the factors responsible for the transition of the oral microbiota from a commensal to a pathogenic relationship with the host. The regulatory forces influencing the oral ecosystem can be divided into three major categories: host related, microbe related, and external factors. Among host factors, secretory immunoglobulin A (SIgA) constitutes the main specific immune defense mechanism in saliva and may play an important role in the homeostasis of the oral microbiota. Naturally occurring SIgA antibodies that are reactive against a variety of indigenous bacteria are detectable in saliva. These antibodies may control the oral microbiota by reducing the adherence of bacteria to the oral mucosa and teeth. It is thought that protection against bacterial etiologic agents of caries and periodontal diseases could be conferred by the induction of SIgA antibodies via the stimulation of the mucosal immune system. However, elucidation of the role of the SIgA immune system in controlling the oral indigenous microbiota is a prerequisite for the development of effective vaccines against these diseases. The role of SIgA antibodies in the acquisition and the regulation of the indigenous microbiota is still controversial. Our review discusses the importance of SIgA among the multiple factors that control the oral microbiota. It describes the oral ecosystems, the principal factors that may control the oral microbiota, a basic knowledge of the secretory immune system, the biological functions of SIgA, and, finally, experiments related to the role of SIgA in oral microbial ecology.


2019 ◽  
Vol 23 (1-2) ◽  
pp. 17-21
Author(s):  
M. Skrypnyk ◽  
T. Petrushanko ◽  
T. Kryvoruchko ◽  
K. Neporada

Obesity prevalence has significantly increased especially in young adults, which is caused by a particular lifestyle, food quality and dietary behavior. Obesity leads to development of huge array of comorbid conditions such as arterial hypertonia, heart stroke, arthritis and other diseases. We conducted standard clinical examination of oral cavity of 154 young patients (18-21 years old) – all of them were students of Ukrainian Medical Stomatological Academy. It has been determined that the majority of patients with BMI >30 kg/cm2 have aggravated family heredity, in 66,2% cases one parent of obese students had obesity and 32,43% patients have both parents with obesity that is significantly higher compared with persons with normal BMI and overweight. There was a high prevalence of periodontal diseases about 74% and carious lesions of teeth - 97.4% among young people despite the age and contingent of examined patients - medical students. In patients with BMI >30 kg/cm2 prevalence of generalized forms of gingivitis and periodontitis was by three times higher compared with individuals with normal BMI. The values of oral hygienic indexes were poor in all examined groups, but their values were slightly lower in patients with normal BMI than in those with overweight and obesity. The prevalence of inflammatory changes in gums was higher in persons with obesity: all of them had a mild degree of lesions in periodontal tissues. Inflammatory processes in the gums were the most intense in patients with the second degree of obesity. According to the results of the study, the presence of the first and the second degree of obesity should be considered as a risk factor triggering periodontal tissues diseases. For persons with BMI >30 kg/cm2 with periodontal disease measures for the secondary prevention of inflammatory and inflammatory dystrophic periodontal diseases should be carried out and in persons without periodontal disease on the background of obesity measures primary prevention should be done.


2018 ◽  
pp. 28-31
Author(s):  
A.V. Mandych

The abnormalities of maxillodental system take one of the leading places among diseases of the maxillofacial area. Thus, they are diagnosed more than in 50% cases among the younger population and in 30% cases among the adult population.   Most often, there are prerequisites for the incorrect position of individual teeth: anomalies are formed at the genetic level because of heredity of pathologies of size, amount, shape of teeth and size of the jaw bones of the facial skeleton. If the position of the teeth is incorrect, the periodontium retains the occlusal load of the functional injury. Therefore, the aim of our research was to study the prevalence of periodontal tissue diseases in young individuals on the background of crowded teeth. The material and research methods. The study was conducted on the base of Dental Center of Danylo Galytsky Lviv National Medical University during 2015−2017 years. 1146 people at the age from 18 to 44 years were examined. Every participant of research underwent general dental examination, as well as a special examination aimed at clarification of orthodontic treatment. The diagnosis of periodontal tissue diseases was made according to the classification of N. F. Danilevskyi and was determined using paraclinical indicators. The obtained results were worked out statistically using functions of MS Excel and Statistica 6. Results of the research and their discussion. The total number of the examined with orthodontic pathology was found on average in 77.24% of patients (885 people). At the same time, abnormalities of dental jaw system were not detected in about 261 (22.76%) of the examined. As a result of the conducted studies we found that among the examined without dental jaw abnormalities 38.89±.,32% of patients had intact periodontium, that was 1.6 times more for data in individuals with crowding − 23.73±2.00, p<0.01. At the same time, in patients of the main group the prevalence of periodontal tissue diseases was 1.2 times higher than in the examined of the comparative group (76.27±2.00% against 61.11±3.32%, respectively, p<0.01). It should be noted, that with the increase of the age of patients the prevalence of periodontal tissue diseases increased in both study groups, but in patients with crowded teeth this tendency was more pronounced. So, in the younger age group in patients with crowding the prevalence of periodontal diseases was 1.5 times higher in relation to the data of their peers from the comparison group (71.37±3.00% vs. 46.99±5.48%, p<0.01). In 27−35-year-old patients the prevalence of periodontal tissue diseases amounted to 72.38±4.03% of the examined of the main group and 65.62±5.94% of the examined of the comparison group, but the obtained data were not statistically significant, p>0.05. At the same time, in the patients of the main group aged 36−44 years the prevalence of periodontal tissue diseases was maximal and exceeded the value of their peers in the comparison group by 1.2 times (92.08±2.69% vs. 73.91±5.29%, respectively, p<0.01). The analysis of the obtained data allowed to assert that on average crowding of teeth on the upper jaw was found in 237 patients (52.55%) and on the lower jaw in 214 patients (47.45%). Thus, the maximum frequency of crowded teeth on the upper jaw was observed in the examined in the age range of 27−35 years, 60.16±4.41% of patients, with the minimum prevalence of this pathology in the youngest group (18−26 years), 49.34±4, 72%. The analysis of diagnostic structure of periodontal tissue diseases showed that inflammatory diseases of periodontal tissues (gingivitis, localized periodontitis) were found in patients with crowded teeth, on average 1.2 times more often than in patients without orthodontic pathology (42.42±1.88% vs. 36.33±3.54%, respectively, p<0.05). Conclusions. Thus, as a result of the conducted studies, higher prevalence of periodontal tissue diseases was proved in patients with crowding of teeth, which made progress in increasing the age of the examined than in patients without orthodontic pathology.


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