scholarly journals DENTAL STATUS FEATURES OF PATIENTS WITH CHRONIC MYELOID LEUKEMIA

2021 ◽  
Vol 16 (4) ◽  
pp. 71-76
Author(s):  
Kamilla Yanbuhtina ◽  
Milyausha Kabirova ◽  
Bulat Kabirov

Subject. At the present stage of society development cancer incidence remains among the most pressing medical and social problems. In the structure of oncopathology a special place is occupied by malignant neoplasms of lymphoid and hematopoietic tissues which include chronic myeloid leukemia (CML). In some patients, the disease can appear with dental symptoms associated with a decrease in local immunity of the oral cavity — the appearance of aphthae, plaque on the oral mucosa, angular cheilosis, bleeding gums, dry mouth. It is diagnostically significant that such oral symptoms may precede general clinical symptoms, that is, they can be considered as early symptoms of CML. In addition, their severity often prompts a patient with CML to see a dentist. Thus, the importance of the professional knowledge of the dentist in general clinical and dental symptomatology of CML, the correct routing of the patient for further clinical and laboratory examination, treatment and observation by a hematologist is undeniably high. The goal is to study and identify the features of the dental status of patients with chronic myeloid leukemia. Methodology. The work carried out a comprehensive assessment of the state of the oral cavity and the need for dental treatment of patients with chronic myeloid leukemia in which patients with preserved systemic status and patients with chronic myeloid leukemia took part. Results. According to the results of a complex dental examination and the calculation of the main dental indices, patients with CML were found to have serious disorders in the state of their oral health. Conclusions. Patients with CML showed a high need for various types of dental care, primarily in conservative oral cavity sanitation, periodontal treatment and rationalization of oral hygiene protocols (professional and individual).

2021 ◽  
Vol 17 (3) ◽  
pp. 29-34
Author(s):  
Alisa Nasibullina ◽  
Milyausha Kabirova ◽  
Il'dar Kabirov ◽  
Damir Valishin

At the end of 2019, an outbreak of a new coronavirus infection occurred in the People's Republic of China with an epicenter in the city of Wuhan [26]. The causative agent was given the temporary name 2019-nCoV. The World Health Organization officially named the infection-COVID-19 on February 11, 2020. The official name of the causative agent of infection SARS-CoV-2, was assigned by the international committee on the taxonomy of viruses [22]. A number of authors have established that the main role is played by receptors of angiotensin converting enzyme 2 (ACE2) in the penetration of the virus into target cells [19]. It is known that the transmission of SARS-CoV-2 occurs more often by airborne droplets during close contact with infected patients [15], as well as through direct contact with infected people and infected objects [17, 18, 20]. For healthcare professionals, SARS-CoV-2 has set tasks related to the rapid diagnosis and provision of medical care to patients. Currently, information on the clinical features, epidemiology, prevention and treatment of this disease is limited [13, 14]. To date, there is a limited amount of literature describing the dental status in patients diagnosed with SARS-CoV-2. Thus, the purpose of this study was to study the state of oral mucosa and substantiate its changes in patients with a laboratory-confirmed diagnosis of SARS-CoV-2 of mild to moderate severity, with or without concomitant oral coinfection. On the other hand, knowledge of the peculiarities of the dental status of Sars-CoV-2 patients and timely rational treatment of diseases of the oral cavity should constitute an important stage in the algorithm for their specialized therapy [2]. The work carried out a comprehensive assessment of the state of the oral cavity and the need for dental treatment in patients with Sars-CoV-2. The conclusions are based on the results of a simple observational clinical study, in which a comparative assessment of dental status indicators was carried out in 40 patients with Sars-CoV-2 and 20 somatically healthy individuals of the same sex and age.


2021 ◽  
Vol 77 (3) ◽  
pp. 14-23
Author(s):  
Robert Badalov ◽  
Irina Chernyavskaya

Purpose: to study the effect of type 2 diabetes mellitus on the state of the mucous membrane and tissues of the oral cavity to optimize the prevention and increase the effectiveness of dentition defects complex treatment in this contingent of patients. Materials and methods. We examined 112 patients with type 2 diabetes mellitus aged 35 to 64 years, who were further divided into three groups. The state of the oral mucosa, morphological changes, local immunity, lysozyme were determined. The work used morphological, microscopic methods, enzyme immunoassay and spectrophotometry. To test the statistical significance of intergroup differences, the nonparametric Mann- Whitney test was used. Results. Oral use in patients with diabetes mellitus type 2, applications of 1% Clotrimazole cream and Echinacea Compositum S had a positive preventive and therapeutic effect, which was accompanied by an increase in capillary resistance, a decrease in the degree of migration of leukocytes, an increase in the functional activity of immune system cells and an increase in the level of regenerative processes. In patients with defects in the dentition against the background of type 2 diabetes mellitus, violations of the oral cavity local immunity were revealed, characterized by a significant increase in the S-IgA content and a decrease in lysozyme.Orthopedic treatment with partial removable denturesled to a significant decrease in the concentration of S-IgA and an increase in the bactericidal activity of saliva due to increased lysozyme synthesis. It was concluded that type 2 diabetes mellitus affects the state of the oral mucosa, which must be taken into account when providing orthopedic and dental treatment.


Author(s):  
E.Yu. Leontyeva ◽  
A.V. Dmitrieva ◽  
P.S. Kravchenko ◽  
G.S. Leontyev

The review conducted research of the Russian and foreign literature of recent years on the methods of using photo and video recording in dentistry in the databases of the Russian Science Citation Index, SCOPUS, Web of Science, Pubmed and others. The data of the possibilities of using the method of registration of the dental status and the state of the tissues of the oral cavity using photo and video fixation in the diagnosis, treatment and observation of patients are presented.


10.12737/4801 ◽  
2014 ◽  
Vol 8 (1) ◽  
pp. 1-5
Author(s):  
Габибуллаева ◽  
S. Gabibullaeva ◽  
Абдурахманов ◽  
A. Abdurakhmanov

The considerable prevalence of dental diseases in the patients with hemophilia is due to the absence of prevention and the proper care of the oral cavity, as well as regular medical examination. This category of patients reluctantly turns to the dentists for fear of bleeding, and the doctors for the same reason, avoid interventions in the mouth. Dental aspects of hemophilia are relevant problem of modern medicine due to the high intensity of organs and tissues of the oral cavity, a real risk of complications during dental procedures of therapeutic, surgical and orthopedic profiles. Epidemiological studies on lesions of the oral cavity in the patients with hereditary coagulative pathologies show a high prevalence of various dental disease, poor hygienic condition of the mouth, which entails a considerable need for dental treatment and prevention activities. To ensure timely quality dental care, control over the hygienic condition of oral cavity it is necessary to conduct regular examination of the state of the oral cavity in the patients with hemophilia. Dentists refuse to the patients in need of assistance because of fear of bleeding and the risk of infection with hepatitis and HIV infection. The high level of dental diseases at hemophilia may be due to the poor hygienic condition of the mouth, change of physicochemical properties of saliva and local immunity. Most patients with hemophilia brush their teeth not regularly and unsatisfactory. A vast number of microorganisms contained in this RAID, low local immunity can cause various diseases of the oral cavity. In this group of patients it is more important to prevent the development of dental disease than to treat them, for fear of complications.


2020 ◽  
Vol 101 (3) ◽  
pp. 365-370
Author(s):  
J G Hajiyev

Aim. To reveal the rate and severity of clinical manifestations of common dental diseases and dentofacial anomalies in professional athletes Methods. The effect of intense physical exertion and overtraining syndrome on the state of the organs and tissues of the dental system were examined in 200 professional athletes aged 1825 years between 2014 and 2016. Five groups where each has the same number of athletes (n=40) included: team sport athletes (volleyball, handball), martial arts athletes (wrestling, boxing), gymnasts, swimmers, athletes. The control group consisted of 40 individuals who were not professionally involved in sports. The state of the oral cavity, in particular periodontal tissues, was judged by changes in the following indicators: prevalence of dentofacial anomalies, the incidence of dental caries, state of the oral cavity hygienic using by simplified oral hygiene index (OHI-S) ( Green J.С., Vermillion J.R., 1963), degree of gums bleeding by using the MuhlemannCowell bleeding index, degrees of severity of periodontopathy by using the papillary-marginal alveolar index (RMA) [Massler, Schour (1949) in Parma modification (1960)]. Results. According to the values of the simplified oral hygiene index the worst state of the oral cavity hygienic was in wrestlers (2.120.022 points) and boxers (2.030.029) compared to the control group (1.620.026, p=0.049 and p=0.001, respectively). Catarrhal gingivitis and generalized chronic periodontitis are most often diagnosed in the groups of wrestling (82.56.01%), gymnastics (77.56.60%), boxing (70.07.25%) and swimming (70.07.25%). Dentoalveolar anomalies were more often detected in boxers (77.5% of cases, p=0.001) and in gymnasts (34.0%, p=0.365) compared to the control group. In these groups, diastema was also more often diagnosed. Conclusion. Periodontal inflammation indicators were higher in wrestlers and gymnasts groups compared to the dental status of all other groups of athletes; caries and maximum level of dental anomalies are more common for boxers.


2020 ◽  
Vol 18 (3) ◽  
pp. 26-31
Author(s):  
K. P. Kamilov ◽  
G. I. Lukina ◽  
F. A. Shokirova ◽  
G. I. Sharipova

Aim. The study of the effectiveness of the use of the biologically active additive Reptin-plant in the complex treatment of patients with herpetic stomatitis.Materials and methods. We examined 189 patients with a diagnosis of herpetic stomatitis, which were divided into 2 groups depending on the receipt of complex antiviral therapy with the inclusion of ERYX biomass lipid concentrate in the treatment regimen and without it. The following were assessed: clinical status, index assessment of the state of the oral cavity, state of local immunity, frequency of relapses and duration of the latency period.Results. 57 (30.2%) patients were identified with a mild form of herpetic stomatitis (HS), the average severity of HS was determined in 93 (49.2%) and a severe course of the disease was diagnosed in 39 (20.6%) patients. Analysis of the index assessment of the state of the oral cavity (OHIS, PMA), molecular genetic parameters, immunological studies (lysozyme titer, phagocytosis, concentration of sIg A in saliva) showed a statistically significant difference when included in the complex treatment of Reptin-plant, demonstrating the benefits of using it.Conclusions. The use of ERYX biomass lipid concentrate in the complex treatment of herpetic stomatitis effectively affects the dynamics of the course of the disease, improves the quality of life of patients.


Medicine ◽  
2020 ◽  
Vol 99 (44) ◽  
pp. e22904
Author(s):  
Chunshui Liu ◽  
Cong Wang ◽  
Zhonghua Du ◽  
Hongwei Xue ◽  
Zhihe Liu

Blood ◽  
2011 ◽  
Vol 117 (1) ◽  
pp. 316-322 ◽  
Author(s):  
Navneet S. Majhail ◽  
Ruta Brazauskas ◽  
J. Douglas Rizzo ◽  
Ronald M. Sobecks ◽  
Zhiwei Wang ◽  
...  

Abstract Risks of secondary solid cancers among allogeneic hematopoietic cell transplant (HCT) recipients who receive conditioning without total body irradiation are not well known. We evaluated the incidence and risk factors for solid cancers after HCT using high-dose busulfan-cyclophosphamide conditioning in 4318 recipients of first allogeneic HCT for acute myeloid leukemia in first complete remission (N = 1742) and chronic myeloid leukemia in first chronic phase (N = 2576). Our cohort represented 22 041 person-years at risk. Sixty-six solid cancers were reported at a median of 6 years after HCT. The cumulative-incidence of solid cancers at 5 and 10 years after HCT was 0.6% and 1.2% among acute myeloid leukemia and 0.9% and 2.4% among chronic myeloid leukemia patients. In comparison to general population incidence rates, HCT recipients had 1.4× higher than expected rate of invasive solid cancers (95% confidence interval, 1.08-1.79, P = .01). Significantly elevated risks were observed for tumors of the oral cavity, esophagus, lung, soft tissue, and brain. Chronic graft-versus-host disease was an independent risk factor for all solid cancers, and especially cancers of the oral cavity. Recipients of allogeneic HCT using busulfan-cyclophosphamide conditioning are at risk for developing solid cancers. Their incidence continues to increase with time, and lifelong cancer surveillance is warranted in this population.


2021 ◽  
Vol 6 (5) ◽  
pp. 316-321
Author(s):  
O. V. Khmil ◽  
◽  
D. O. Khmil ◽  
L. F. Kaskova ◽  
O. V. Silkova ◽  
...  

The purpose of the study was to study the relationship between the state of the oral cavity microbiocenosis and the level of local immunity in children and adolescents with chronic liver diseases. Materials and methods. 45 children aged 10 to 16 years, who were treated in the public utility "City Children's Clinical Dental Hospital of the Poltava City Council" were examined. All children were divided into 2 groups: the main group – children and adolescents with chronic hepatitis (n = 26) with diseases of concomitant oral mucosa and periodontal disease; control group – children of the same age without concomitant somatic pathology (n = 20). In all observation groups, the state of oral hygiene was recorded using the simplified oral hygiene index (Green-Vermillion, 1964) and the intensity of the inflammatory process in the periodontal tissues, which was assessed by the papillary-marginal-alveolar index modified by Parma (1960). The degree of dysbiosis in the oral cavity was determined using the enzymatic method of A. P. Levitsky by the ratio of the relative activity of urease and lysozyme. The state of local immunity was investigated by the level of immunoglobulins IgA, IgM, IgG and secretory immunoglobulin sIgA. Results and discussion. It was found that the majority of patients with chronic hepatitis had an unsatisfactory and even poor state of oral hygiene, according to the Green-Vermillion simplified oral hygiene index, in combination with moderate and severe gingivitis (according to the papillary-marginal-alveolar index). The most negative results were registered in children 9-13 years old. The effect of the low level of oral hygiene in children and adolescents with chronic liver diseases, which is accompanied by increased dysbiosis, was studied, which indicates a drop in the level of antimicrobial protection, suppression of local mucosal immunity, a decrease in lysozyme activity and a decrease in the content of secretory sIgA in the oral fluid. The mediated mechanism of sIgA action through the phagocyte activation system with subsequent lysis of pathogenic microorganisms is considered. Conclusion. Chronic liver diseases reliably lead to changes in the body's immunobiological reactivity, and also cause suppression of the protective mechanisms of the oral cavity and its local immunity, characterized by a decrease in the activity of lysozyme and secretory IgA in the oral fluid of sick children and adolescents


Author(s):  
Наталия Владимировна Чиркова ◽  
Алена Алексеевна Плутахина ◽  
Алик Эдикович Петросян ◽  
Елена Анатольевна Андреева ◽  
Марина Николаевна Бобешко

Лечение заболеваний пародонта представляет собой одну из наиболее сложных и важных проблем современной стоматологии, актуальность которой обусловлена высокой частотой воспалительных заболеваний пародонта среди населения во всех возрастных группах - до 90% в популяции. Несмотря на прогрессивное развитие медицинской науки и практики, заболеваемость данной патологией сохраняется на высоком уровне не только в группах населения среднего и пожилого возраста, но при этом выявляется тенденция к ее распространению в молодом возрасте. Исследования, проведенные ВОЗ более, чем в 30 странах, выявили высокую распространенность заболеваний пародонта (свыше 60%) среди пациентов возрасте от 18 до 30 лет. Наиболее частой формой поражения околозубных тканей в молодом возрасте является хронический гингивит по классификации СКБ-10 К 05.1. Нерегулярность профилактики и эпизодические обращения к врачу-пародонтологу для лечения заболеваний пародонтита утяжеляют течение заболевания, которое при отсутствии лечения прогрессирует. В связи с этим, от пациента требуется неоднократное прохождение курсов лечения у врача-пародонтолога и выполнение в домашних условиях профилактических мероприятий по рекомендации врача. Однако установлено, что степень комплаентности пациентов молодого возраста к стоматологическому лечению недостаточно высокая, а кратность обращения к врачу-пародонтологу в 62% ограничивается выраженной стоматофобией. Известно, что развитие пародонтита является результатом дисбаланса между микрофлорой полости рта и иммунной защитой организма. Иммунологические изменения при хроническом катаральном гингивите связаны с нарушением взаимодействия факторов неспецифической резистентности организма, изменением клеточного и гуморального иммунитета и подавлением системы местного иммунитета. Поэтому с целью ликвидации воспаления применяют различные иммунокорректоры и антибактериальные средства (антисептики, антибиотики, фитопрепараты). Однако в последнее время появились формы пародонтита, обусловленные нетипичными инфекционными агентами (вирусами, грибами), либо резистентные к антибактериальной терапии. В результате нерационального применения антимикробных препаратов, которые негативно воздействуют на представителей облигатной микрофлоры полости рта, они еще больше снижают местные факторы антибактериальной защиты. Альтернативой антибактериальной терапии при заболеваниях пародонта являются различные методы биотерапевтического воздействия, предполагающие местное и системное применение пробиотиков, фаговых препаратов и других средств. Вместе с тем, такие исследования в отечественной стоматологии единичные, как и исследования по повышению степени соответствия между поведением пациента и рекомендациями, полученными от врача Treatment of periodontal diseases is one of the most difficult and important problems of modern dentistry, the relevance of which is due to the high frequency of inflammatory periodontal diseases among the population in all age groups - up to 90% in the population. Despite the progressive development of medical science and practice, the incidence of this pathology remains at a high level not only in middle-aged and elderly population groups, but at the same time a tendency towards its spread at a young age is revealed. Studies conducted by WHO in more than 30 countries have revealed a high prevalence of periodontal disease (over 60%) among patients aged 18 to 30 years. The most common form of damage to the periodontal tissues at a young age is chronic gingivitis according to the SKB-10 K 05.1 classification. Irregular prophylaxis and occasional visits to a periodontist for the treatment of periodontitis complicate the course of the disease, which progresses in the absence of treatment. In this regard, the patient is required to undergo repeated courses of treatment with a periodontist and to perform preventive measures at home on the recommendation of a doctor. However, it was found that the degree of compliance of young patients to dental treatment is not high enough, and the frequency of visits to a periodontist in 62% is limited by pronounced stomatophobia. It is known that the development of periodontitis is the result of an imbalance between the microflora of the oral cavity and the body's immune defenses. Immunological changes in chronic catarrhal gingivitis are associated with a violation of the interaction of factors of nonspecific resistance of the organism, changes in cellular and humoral immunity and suppression of the local immunity system. Therefore, in order to eliminate inflammation, various immunocorrectors and antibacterial agents (antiseptics, antibiotics, herbal medicines) are used. However, recently there have been forms of periodontitis caused by atypical infectious agents (viruses, fungi), or resistant to antibiotic therapy. As a result of the irrational use of antimicrobial drugs, which negatively affect the representatives of the obligate microflora of the oral cavity, they further reduce the local factors of antibacterial protection. An alternative to antibiotic therapy for periodontal diseases are various methods of biotherapeutic action, involving the local and systemic use of probiotics, phage preparations and other agents. At the same time, such studies in domestic dentistry are rare, as well as studies to improve the degree of correspondence between the patient's behavior and the recommendations received from the doctor


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