Features of the thyroid status in patients receiving programmed hemodialysis

2020 ◽  
Vol 24 (4) ◽  
pp. 61-66
Author(s):  
V. A. Kovalevskiy ◽  
A. N. Shishkin
Keyword(s):  
Endocrine System ◽  
Hemodialysis Patients ◽  
Thyroid Status ◽  
Average Value ◽  
Urgent Task ◽  
Ckd Stage ◽  
Group 3 ◽  
Group 2 ◽  
And Gender ◽  
People Group

INTRODUCTION. In patients with CKD stage 5 receiving hemodialysis as the main method of renal replacement therapy (RRT), the endocrine system organs, including the thyroid gland, are affected over time. The study of changes in the thyroid status is an urgent task. AIM OF STUDY. Study of functional and gender characteristics of the thyroid status, depending on the duration of patients stay on hemodialysis. PATIENTS AND METHODS. The thyroid status was measured in 108 patients (44 women and 64 men, average age 51.7±15.4 years) undergoing hemodialysis. Patients were divided into quartiles according to the duration of stay on the RRT: group 1 4 – 25 months (28 people), group 2 41 – 59 months (26 people), group 3 68 – 97 months (26 people) and the fourth more than 100 months (28 people). We performed correlation analysis and comparison between groups on the level of free T 4, TSH, the ratio of fT4 to TSH. RESULTS. The average value of fT4 was 11.95±2.07 pmol / ml and TSH 1.5± 0.94 mcME/ml. Significant differences in thyroid status were obtained between the first and second groups in terms of TSH level and ratio fT 4 to TSH (P<0.01) – the level of TSH in the second group is higher (0.74 to 2.1 mсME/ml) and the ratio of fT4 to TSH is lower (13.09 to 4.91). In total, thyroid dysfunction was detected in 20.3% of the examined patients. CONCLUSION. Thus, deviations in the thyroid status occur after 2 years of being on RRT by hemodialysis. In patients who have been on RRT for more than 5 years, the thyroid status stabilizes. The reasons for this phenomenon are completely incomprehensible.

The Relationship between Serum Ferritin Levels and 5-Year All-Cause Mortality in Hemodialysis Patients

2021 ◽  
pp. 1-7
Author(s):  
Emre Erdem ◽  
Ahmet Karatas ◽  
Tevfik Ecder
Keyword(s):  
Serum Ferritin ◽  
Hemodialysis Patients ◽  
Rank Test ◽  
Significant Difference ◽  
All Cause Mortality ◽  
Group 3 ◽  
Group 2 ◽  
The Relationship ◽  
Group 1

<b><i>Introduction:</i></b> The effect of high serum ferritin levels on long-term mortality in hemodialysis patients is unknown. The relationship between serum ferritin levels and 5-year all-cause mortality in hemodialysis patients was investigated in this study. <b><i>Methods:</i></b> A total of 173 prevalent hemodialysis patients were included in this study. The patients were followed for up to 5 years and divided into 3 groups according to time-averaged serum ferritin levels (group 1: serum ferritin &#x3c;800 ng/mL, group 2: serum ferritin 800–1,500 ng/mL, and group 3: serum ferritin &#x3e;1,500 ng/mL). Along with the serum ferritin levels, other clinical and laboratory variables that may affect mortality were also included in the Cox proportional-hazards regression analysis. <b><i>Results:</i></b> Eighty-one (47%) patients died during the 5-year follow-up period. The median follow-up time was 38 (17.5–60) months. The 5-year survival rates of groups 1, 2, and 3 were 44, 64, and 27%, respectively. In group 3, the survival was lower than in groups 1 and 2 (log-rank test, <i>p</i> = 0.002). In group 1, the mortality was significantly lower than in group 3 (HR [95% CI]: 0.16 [0.05–0.49]; <i>p</i> = 0.001). In group 2, the mortality was also lower than in group 3 (HR [95% CI]: 0.32 [0.12–0.88]; <i>p</i> = 0.026). No significant difference in mortality between groups 1 and 2 was found (HR [95% CI]: 0.49 [0.23–1.04]; <i>p</i> = 0.063). <b><i>Conclusion:</i></b> Time-averaged serum ferritin levels &#x3e;1,500 ng/mL in hemodialysis patients are associated with an increased 5-year all-cause mortality risk.

scholarly journals The Utility of the Callosal/Supratentorial-Supracallosal Area Ratio to Evaluate Corpus Callosum Morphometry in Children

2020 ◽  
Author(s):  
Mehmet Öztürk ◽  
Emine Uysal ◽  
Halil İbrahim Duran ◽  
Zuhal İnce Bayramoğlu ◽  
Abidin Kılınçer
Keyword(s):  
Corpus Callosum ◽  
Sagittal Plane ◽  
Pediatric Population ◽  
Age Group ◽  
Age And Gender ◽  
Mean Values ◽  
Group 3 ◽  
Group 2 ◽  
And Gender ◽  
Group 1

Objective: To perform morphometric analysis of corpus callosum (CC) by using callosal area (CA), supratentorial-supracallosal area (SSA) and CA/SSA parameters in a healthy pediatric population and to investigate changes according to age and gender. Method: Method: This retrospective study included a total of 313 children (154 boys, 159 girls) aged between 3-17 years. The cases were divided into three groups according to age: 3-6 years (Group 1) (pre-school), 7-12 years (Group 2) (preadolescent) and 13-17 years (Group 3) (adolescent). CA and SSA were measured on the mid-sagittal plane on T1-weighted images. CA/ SSA index was calculated. Differences in age, CA, SSA, and ratio parameters among the gender groups were compared using the Mann-Whitney U or the t-test. Results: Median values of CA (p= 0.002), mean values of SSA (p=0.001) and CA/SSA ratios (p= 0.04) were significantly higher in boys compared to girls. The median CA and mean CA/SSA ratios in Group 3 were significantly higher than Groups 1 and 2 (p= 0.001). Mean CA/SSA ratio values of boys and girls in Age Group 3 were significantly higher than Group 1 (p= 0.001) and significantly higher than Age Group 2 in girls. There were highly significant positive correlations of age with CA (p=0.001, r=0.47), SSA (p=0.028, r=0.12) and CA/SSA ratio (p=0.001, r=042). There was a highly significant and positive correlation between CA and SSA (p=0.001, r=0.25) and CA/SSA ratio (p=0.001, r=0.87). Conclusion: CA, SSA, and CA/ SSA ratio values in children are affected by age and gender. These parameters can be used as reference values for the diagnosis of congenital and acquired pathologies affecting the corpus callosum.

scholarly journals Changes of MicroRNA-377 in Diabetic Nephropathy

QJM ◽  
2020 ◽  
Vol 113 (Supplement_1) ◽  
Author(s):  
H A Elshinnawy ◽  
C R Kamel ◽  
M H A Elkeleng
Keyword(s):  
Diabetic Nephropathy ◽  
Diabetic Patients ◽  
Ckd Stage ◽  
Significant Difference ◽  
Group 3 ◽  
Group 2 ◽  
Stage Renal Disease ◽  
End Stage ◽  
Stage 1

Abstract Background as one of the most important long term complications of diabetes, Diabetic nephropathy is the major cause of end stage renal disease and high mortality. Purpose to identify the pattern of microRNA-377 changes specific for diabetic nephropathy in diabetic patients and in patients with chronic kidney disease of different etiology. Patients and Methods the study was conducted from 2016 to 2018, included 50 patients for analysis of MicroRNA-377 and its control gene U18 at El Demrdash Hospital Ain shams university and Quessena Hospital El Monfia. The miRNA-U18 was analyzed for normalization of correction ratio. Results the results of our research found that the highest median IQR of miR-377 was significantly present in DN stage 1&2 and the lowest median IQR was significantly present in CKD stage 1&2, and there was significant difference between group 1 (DN stage 1&2) versus group 2 (DN stage 3&4), group 3 (Diabetics without nephropathy) and all stages of CKD. Conclusion in diabetic nephropathy stage 1&2, serum miR-377 was highly significant increased more than diabetics without nephropathy, diabetic nephropathy stage 3&4 and all satges of CKD.

scholarly journals Circulating salusin-beta levels in the patients with age-related macular degeneration

2021 ◽  
Vol 5 (1) ◽  
pp. 001-004
Author(s):  
Turgut Burak ◽  
Mercan Kadir ◽  
Demir Nesrin ◽  
Ilhan Nevin ◽  
Çatak Onur
Keyword(s):  
Macular Degeneration ◽  
Study Groups ◽  
Age Related Macular Degeneration ◽  
Enzyme Linked Immunosorbent Assay ◽  
Age Related ◽  
Significant Difference ◽  
Group 3 ◽  
Group 2 ◽  
And Gender ◽  
Group 1

Purpose: To evaluate the levels of salusin-beta (β-SAL) in the serum in patients with age-related macular degeneration (ARMD). Methods: Our study was designed as a controlled comparative clinical study. The β-SAL levels in serums of age and sex-matched 20 healthy volunteers as controls (Group 1), 20 patients with dry-age related macular degeneration (d-ARMD) (Group 2) and 20 patients with wet-age related macular degeneration (w-ARMD) (Group 3) were measured with the enzyme-linked immunosorbent assay (ELISA) method. Results: In our study, it was found that age and gender didn’t show a statistically significant difference among the study groups (p > 0. 05). The mean serum β-SAL levels in Group 1, Group 2 and Group 3 were 1372,17 ± 1126.69 pg/mL; 1423,71 ± 1196.84 pg/mL and 940,57 ± 1092.05 pg/mL, respectively. Although the meanβ-SAL levels in w-ARMD seem numerically lower than both the control and d-ARMD groups, this difference among the study groups was not statistically significant (p > 0.05). Conclusion: Our study suggests that β-SAL levels in the patients with ARMD and healthy controls were not different than each other. Further studies with large numbers may reveal possible relationships between β-SAL and ARMD.

scholarly journals Pengaruh Kepemimpinan Terhadap Kinerja Dosen dan Karyawan STIKES NU Tuban

2019 ◽  
Vol 4 (3) ◽  
pp. 174
Author(s):  
Sugiyono Sugiyono
Keyword(s):  
Research Method ◽  
Job Design ◽  
Positive Direction ◽  
Descriptive Research ◽  
Group 3 ◽  
Group 2 ◽  
High Level ◽  
People Group ◽  
Group 1

To achieve a high level of performance, of course depends on various factors that influence it. There are at least six external factors that determine the level of performance of an employee, namely: (a) environment, (b) management behavior, (c) job design, (d) education level, (e) training, (f) motivation and (g) administration payment. The purpose of this study was to analyze the effect of leadership on the performance of Stikes NU lecturers and staff in Tuban. The research method is descriptive research, the population of all lecturers and staff of STIKES NU Tuban is 120 people, the sample is divided into 3 groups (group 1 (17 people), group 2 (27 people), and group 3 (76 people)). Techniques for collecting data through observation and interviews. Data analysis uses Pearson Product moment (PPM). Based on the results of the study indicate that leadership has a significant effect on the performance of lecturers and employees in a positive direction. In addition to supporting the second hypothesis which states that leadership has a significant effect on the performance of lecturers and employees. Leadership applied by STIKES NU Tuban has been felt in accordance with the expectations and desires of lecturers and employees in the long term and caused lecturers and employees to be loyal to STIKES NU Tuban

scholarly journals Bilirubin Links HO-1 and UGT1A1*28 Gene Polymorphisms to Predict Cardiovascular Outcome in Patients Receiving Maintenance Hemodialysis

Antioxidants ◽  
2021 ◽  
Vol 10 (9) ◽  
pp. 1403
Author(s):  
Yang Ho ◽  
Tzen-Wen Chen ◽  
Tung-Po Huang ◽  
Ying-Hwa Chen ◽  
Der-Cherng Tarng
Keyword(s):  
Gene Polymorphisms ◽  
Serum Bilirubin ◽  
Hemodialysis Patients ◽  
Chronic Hemodialysis ◽  
Maintenance Hemodialysis ◽  
Heme Oxygenase 1 ◽  
Uridine Diphosphate ◽  
Group 3 ◽  
Group 2 ◽  
Group 1

Serum bilirubin levels, which are determined by a complex interplay of various enzymes, including heme oxygenase-1 (HO-1) and uridine diphosphate–glucuronosyl transferase (UGT1A1), may be protective against progression of cardiovascular disease (CVD) in hemodialysis patients. However, the combined effect of HO-1 and UGT1A1*28 gene polymorphisms on CVD outcomes among hemodialysis patients is still unknown. This retrospective study enrolled 1080 prevalent hemodialysis patients and the combined genetic polymorphisms of HO-1 and UGT1A1 on serum bilirubin were analyzed. Endpoints were CVD events and all-cause mortality. Mean serum bilirubin was highest in patients with S/S + S/L of the HO-1 promoter and UGT1A1 7/7 genotypes (Group 1), intermediate in those with S/S + S/L of the HO-1 promoter and UGT1A1 7/6 + 6/6 genotypes (Group 2), and lowest in the carriers with the L/L HO-1 promoter and UGT1A1 7/6 + 6/6 genotypes (Group 3) (p < 0.001). During a median follow-up of 50 months, 433 patients developed CVD. Compared with patients in Group 3, individuals among Groups 1 and 2 had significantly lower risks for CVD events (adjusted hazard ratios (aHRs) of 0.35 for Group 1 and 0.63 for Group 2), respectively. Compared with the lower bilirubin tertile, the aHRs were 0.72 for the middle tertile and 0.40 for the upper tertile for CVD events. We summarized that serum bilirubin as well as HO-1 and UGT1A1 gene polymorphisms were associated with CVD among patients receiving chronic hemodialysis.

Parent-Reported BIS/BAS Scales for Children: Factor Structure and Measurement Invariance Across Age and Gender

Assessment ◽  
2017 ◽  
Vol 26 (7) ◽  
pp. 1282-1295 ◽  
Author(s):  
Leentje Vervoort ◽  
Elien De Caluwé ◽  
Laura Vandeweghe ◽  
Annelies De Decker ◽  
Laura Wante ◽  
...  
Keyword(s):  
Measurement Invariance ◽  
Factor Structure ◽  
Parent Report ◽  
Behavioral Approach ◽  
Behavioral Inhibition System ◽  
Group 4 ◽  
Group 3 ◽  
Group 2 ◽  
And Gender ◽  
Group 1

The present study examined the factor structure and measurement invariance of the Behavioral Inhibition System/Behavioral Approach System (BIS/BAS) scales parent-report in children and adolescents ( N = 1,444, 58% girls) across age (Group 1, 2-5 years; Group 2, 6-9 years; Group 3, 10-13 years; Group 4, 14-18 years old) and gender. The results consistently underscored a four-factor structure, resembling the original factor structure, with one BIS-factor and three BAS-factors. Multigroup confirmatory factor analysis showed full measurement invariance across gender as well as across Group 1 and 2, and Group 2 and 3. Strong measurement invariance was found across Group 3 and 4, Group 1 and 3, and Group 2 and 4. Configural and metric invariance was found across Group 1 and 4. Hence, mean-level BIS/BAS scores can be compared across gender and age although comparison between preschool children (Group 1) and late secondary school children (Group 4) should be done with caution.

scholarly journals Prevalence of Chewing Side Preference in the Deciduous, Mixed and Permanent Dentitions

2011 ◽  
Vol 12 (5) ◽  
pp. 339-342 ◽  
Author(s):  
Daphne Câmara Barcellos ◽  
Alessandra Buhler Borges ◽  
Cesar Rogério Pucci ◽  
Carlos Rocha Gomes Torres ◽  
Sergio Eduardo de Paiva Gonçalves ◽  
...  
Keyword(s):  
Direct Method ◽  
Visual Observation ◽  
Permanent Dentition ◽  
Mixed Dentition ◽  
Chi Square ◽  
Side Preference ◽  
Group 3 ◽  
Group 2 ◽  
And Gender ◽  
Group 1

ABSTRACT Aim This study evaluated the prevalence of the chewing side preference (CSP) in the deciduous, mixed and permanent dentitions. Materials and methods Three-hundred subjects were divided in three groups (n = 100): Group 1 – children with deciduous dentition; group 2—children with mixed dentition; group 3 – subjects with permanent dentition. The CSP was determined using a direct method (visual observation) developed by McDonnell et al. (2004). Descriptive statistic was used to observe the prevalence of CSP. The Pearson's Chi-square was used to investigate signicant associations between gender, presence of CSP and preferred side (right/left). Results and conclusion Eighty-seven percent of group 1 had a CSP. Eighty-two percent of group 2 had a CSP. Seventy-six percent of group 3 had a CSP. There was no statistically significant association between presence of CSP and gender in all groups. There was no statistically significant association between preferred side (right/left) and gender in all groups. Clinical significance There is a higher prevalence of subjects in deciduous, mixed and permanent dentition that presented chewing side preference. The early diagnosis of the presence of chewing side preference can prevent the unilateral chewing pattern with prophylactic therapy applied to the first teeth (deciduous). How to cite this article Barcellos DC, de Paiva Gonçalves SE, da Silva MA, Batista GR, Pleffken PR, Pucci CR, Borges AB, Torres CRG. Prevalence of Chewing Side Preference in the Deciduous, Mixed and Permanent Dentitions. J Contemp Dent Pract 2011; 12(5):339-342.

scholarly journals Data Analysis from Two-choice Decision Tasks in Visual Information Processing

2021 ◽  
Vol 5 (2) ◽  
Author(s):  
Radoslava Kraleva ◽  
Velin Kralev ◽  
Petia Koprinkova-Hristova
Keyword(s):  
Data Analysis ◽  
Response Time ◽  
Visual Information ◽  
Data Sets ◽  
Average Value ◽  
Choice Decision ◽  
Group 3 ◽  
Group 2 ◽  
Group 1 ◽  
Decision Tasks

Data analysis are important tasks in research. The present study focuses on the analysis of data sets from human eye movement experiments. The results of the experiments were analyzed according to two criteria – gender and age of the participants. The participants were divided into 3 groups, respectively group 1: between 20 and 35 years, group 2: between 36 and 55 years and group 3: between 56 and 85 years. The results showed that 75% of the two-choice decision tasks were solved correctly. This trend was maintained among the participants from group 1 – respectively 75.4%. The participants from group 2 gave more correct answers – respectively 82.2%, but the participants from group 3 gave fewer correct answers – respectively 70.2%. The average value of the response time indicator (of all participants) was 1455 ms. The response time of the participants from groups 1 and 2 was shorter than the average (respectively with 483 ms and 235 ms). The response time of the participants from group 3 was longer than the average (respectively with 626 ms).

scholarly journals Some aspects of comorbidity in hospitalized patients of a therapeutic hospital

2020 ◽  
pp. 16-26
Author(s):  
Natalia V. Pyrikova ◽  
Oksana N. Antropova ◽  
Irina V. Osipova ◽  
Irina A. Frolova
Keyword(s):  
Cross Sectional Study ◽  
Hospitalized Patients ◽  
Noncommunicable Diseases ◽  
Cross Sectional ◽  
Type D ◽  
Urgent Task ◽  
Comorbidity Index ◽  
Condition Characteristic ◽  
Group 3 ◽  
Group 2

Objective - to analyze the risk factors (RF) of noncommunicable diseases depending on the comorbidity index (CI) in hospitalized patients. Materials and methods. A cross-sectional study was performed at the Altai Regional Hospital for War Veterans. 128 people were invited to take part in the study during the month in the therapeutic department, 100 people agreed (78.1% response). The average age is 77.9±8.3 years, 48% of women, 52% of men. A general clinical examination, RF analysis of noncommunicable diseases, psychosocial factors, Montreal Cognitive Function Scale (MoCA test), and an examination by a neurologist to detect encephalopathy were performed. Based on the Charlson CI data, patients were divided into 3 groups: group 1 - CI 1-2 points - 46%, group 2 - CI 3-4 points - 38%, group 3 - CI 5 and more points - 16%. Results. Regardless of gender, CI 5 or more was more common than CI 1-2 by 16.8%; among men, CI 5 and more occurred more often than CI 3-4 by 17.8%; middle-aged persons were only in the group with CI 1-2. In patients with CI 5 or more, compared with patients with CI 1-2, there was a higher frequency of such RFs as obesity (by 29.9%, all persons with CI 5 or more had abdominal obesity), social isolation (by 29.7%), type D personality (by 36.5%), as well as cognitive impairment (by 28.5%) and encephalopathy (by 32.9%). Depression was found 26.1% more often in patients with CI 3-4 than in patients with CI 1-2. Conclusion. Comorbidity is not a mandatory condition characteristic of an aging population, it is primarily the result of individual behavior. Therefore, the identification and correction of RF of noncommunicable diseases, especially in conditions of comorbidity, seems to be an urgent task, which determines the success of treatment in this category of patients.

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