scholarly journals Should Women Consult Health Agencies in Matters of Birth Control and Contraception?

2020 ◽  
Vol 1 (2) ◽  
pp. 28-37
Author(s):  
Kraetschmer K
Keyword(s):  
Birth Control ◽  
Economic Perspective ◽  
Safety And Efficacy ◽  
Contraceptive Devices ◽  
Scholarly Publications ◽  
Health Agencies ◽  
The Us ◽  
Other Information ◽  
Recent Developments ◽  
Harmful Effects

Background and Aim: On the background of recent developments revealing the harmful effects of contraceptive devices which are recommended by health agencies the paper aims at analyzing publications and other information material emanating from these agencies. This analysis – guided by the bioethical principle of informed consent — focuses on flawed science, ambiguous language, and misleading data. Method and Material: The method consists of collecting and analyzing information provided by health agencies for consumers inquiring about the safety and efficacy of contraceptive products. The material comprises documents, charts, leaflets and other publications emanating from the most authoritative and most frequently consulted health agencies, in particular those active in the US and European countries. Results and Implications: As a result of the investigation women must be advised to consult only a selected number of health agencies, especially those which take into account findings of pharmacovigilance, pharmaceutical vigilance, and scholarly publications focusing on the safety of contraception. The implications from an economic perspective are the discontinuation of funding through taxpayer money for those health agencies which continue to disseminate flawed science and demonstrate incompetence in questions about the safety of contraception.

The influence of media on upbringing and behavior of children

GIS Business ◽  
2019 ◽  
Vol 14 (6) ◽  
pp. 656-666
Author(s):  
Dr. Entisar Al-Obaidi
Keyword(s):  
New Technologies ◽  
The Internet ◽  
Negative Effects ◽  
Online Newspapers ◽  
Media Messages ◽  
Other Information ◽  
Family Home ◽  
Effects Of Media ◽  
And Behavior ◽  
Harmful Effects

Media refers to the channels of communication through which we distribute news, education, movies, music, advertising messages and other information. It includes physical and online newspapers and magazines, television, radio, telephone, the Internet, fax and billboards, are a dominant force in lives of children. Although television is remaining the predominant medium for children and adolescents, the new technologies are become more popular. We have to concern about the potential harmful effects of media "messages and images"; however, the positive and negative effects of media should be recognized. Parents have to establish the plan for all media in family home. Media that are influences on children should be recognized by "schools, policymakers, product advertisers, and entertainment producers".

Novel agents for myelodysplastic syndromes

2021 ◽  
pp. 107815522110379
Author(s):  
Katie Xu ◽  
Elizabeth Hansen
Keyword(s):  
Drug Administration ◽  
Myelodysplastic Syndromes ◽  
Primary Outcome ◽  
Food And Drug Administration ◽  
Review Article ◽  
Phase Iii ◽  
Phase Iii Trial ◽  
Safety And Efficacy ◽  
Transfusion Independence ◽  
The Us

Review objective There have been several advances in the field of myelodysplastic syndromes over the past year, yielding two new US Food and Drug Administration drug approvals. The pharmacology, pharmacokinetics, clinical trials, therapeutic use, adverse effects, clinical use controversies, product description, and upcoming trials for myelodysplastic syndromes novel agents luspatercept-aamt and decitabine/cedazuridine are reviewed. Data sources This review article utilized primary information obtained from both the published studies involved in the approval of luspatercept-aamt and decitabine/cedazuridine and package inserts for the respective medications. This review article utilized secondary information obtained from National Comprehensive Cancer Network guidelines using filters and keywords to sustain information relevancy as well as key studies using the keywords, “luspatercept-aamt, myelodysplastic syndromes, decitabine, cedazuridine, hypomethylating agent, ASTX727” from scholarly journal database PubMed. Data summary Myelodysplastic syndromes consist of myeloid clonal hemopathies with a diverse range of presentation. Until recently, there have been relatively few new therapies in the myelodysplastic syndromes treatment landscape. On April 3, 2020 the US Food and Drug Administration approved Reblozyl®(luspatercept-aamt), then on July 7, 2020, the US Food and Drug Administration approved INQOVI® (decitabine and cedazuridine). Luspatercept-aamt acts as a erythroid maturation agent through differentiation of late-stage erythroid precursors. The safety and efficacy of luspatercept-aamt was demonstrated in the MEDALIST trial, a phase III trial in patients with very low-intermediate risk refractory myelodysplastic syndromes and ring sideroblasts. Luspatercept-aamt met both primary and secondary endpoints of transfusion independence of 8 weeks or longer and transfusion independence of 12 weeks or longer, respectively. Decitabine/cedazuridine has a unique mechanism of action in which decitabine acts as a nucleoside metabolic inhibitor promoting DNA hypomethylation and cedazuridine then prevents degradation of decitabine. The safety and efficacy of decitabine/cedazuridine was shown in the ASCERTAIN study, a phase III trial in patients with intermediate or high risk myelodysplastic syndromes or chronic myelomonocytic leukemia. The primary outcome evaluated was 5-day cumulative area under the curve between decitabine/cedazuridine and IV decitabine as well as additional outcomes including safety. Decitabine/cedazuridine met primary outcome and had a similar safety profile to IV decitabine. Conclusion The novel myelodysplastic syndromes agents luspatercept-aamt and decitabine/cedazuridine provide a clinical benefit in the studied populations.

A Method to Extract Essential Information from Meteorological Facsimile Charts

2018 ◽  
Vol 33 (01) ◽  
pp. 1954001
Author(s):  
Kefeng Mao ◽  
Xi Chen ◽  
Kelan Zhu ◽  
Dong Hu ◽  
Yan Li
Keyword(s):  
Template Matching ◽  
Weather Forecasting ◽  
Contour Detection ◽  
Connected Region ◽  
Good Effect ◽  
Weather System ◽  
Essential Information ◽  
The Us ◽  
Different Types ◽  
Other Information

Using image processing technology to extract important information, such as isoline and weather system of the meteorological facsimile chart, is conducive to integration with other information, and has important practical value in navigation operations, marine weather forecasting, target recognition, and image retrieval. In meteorological facsimile charts, there are many types of medium-value lines, dense lines in some areas, superimposition and presence of multiple information, such as isolines and isoline characters, intersection of specific weather system symbols, etc. For different types of contours, numeric characters, weather system symbols and other object characteristics, the corresponding object extraction and recognition methods are proposed: Remove the latitude and longitude lines and coastline in the meteorological facsimile map by basemap matching; According to the position and shape features of the figure box, extract the meteorological fax figure box, separate and remove the different character tagging information; On the basis of identifying triangles and semicircles in weather symbols of the frontal system, the frontal symbols are extracted based on the circumscribed triangles and template matching. First the contour character on the fax image is expanded into a block connected region. Determine the position of the character information by judging the number of pixels in the connected region, and then use rotation and template matching to identify the numeric character. Using the meteorological facsimile maps of the US Meteorological Center and the Japan Meteorological Center for the main information extraction, experiments show that the method of this paper has a good effect on the complete and accurate symbol extraction of frontal weather systems, and reduces the computational complexity of contour detection, isoline extraction and numerical recognition. The methods can detect some information from weather charts properly and the error rate is very low.

The Use of Bitumen Linear Viscoelastic Properties to Assess Rutting Sensitivity

2014 ◽  
Vol 567 ◽  
pp. 755-762
Author(s):  
Salah E. Zoorob ◽  
Ibrahim B. Kamaruddin ◽  
Napiah Madzlan
Keyword(s):  
Energy Equation ◽  
Empirical Relationship ◽  
Stored Energy ◽  
Theoretical Derivation ◽  
The Us ◽  
Modified Binders ◽  
Recent Developments ◽  
Linear Viscoelastic ◽  
Modified Binder ◽  
Performance Grading

The use of viscosity temperature relationships to predict creep performance of road bitumens have been shown to be inadequate in particular with respect to the analysis of polymer modified binders. In this paper we explore the origins of the US Strategic Highway Research Programmebinder performance grading system and detail two examples of more recent developments towards improved creep characterisation.Starting from first principles, an equation to analyse the ratio of dissipated to stored energy during sinusoidal loading of viscoelastic bitumen was derived. The energy equation was contrasted with an empirical relationship proposed by Anderson D.A., and with a second more theoretical derivation proposed by Shenoy A.Using frequency sweep data from a conventional 40/50 pen grade bitumen and a proprietary SBS modified binder, the applicability of the energy equation was subsequently compared to the two aforementioned post-SHRP creep relations. Recommendations are made regarding the suitability of the proposed relations in ranking bitumen creep performance.

scholarly journals Recent Developments in Clinical Applications of Mesenchymal Stem Cells in the Treatment of Rheumatoid Arthritis and Osteoarthritis

2021 ◽  
Vol 12 ◽  
Author(s):  
Joel Jihwan Hwang ◽  
Yeri Alice Rim ◽  
Yoojun Nam ◽  
Ji Hyeon Ju
Keyword(s):  
Rheumatoid Arthritis ◽  
Clinical Trials ◽  
Clinical Applications ◽  
Clinical Settings ◽  
Positive Outcomes ◽  
Joint Function ◽  
Safety And Efficacy ◽  
High Expectations ◽  
Recent Developments

Mesenchymal stem cell (MSC) therapies have been used as cell-based treatments for decades, owing to their anti-inflammatory, immunomodulatory, and regenerative properties. With high expectations, many ongoing clinical trials are investigating the safety and efficacy of MSC therapies to treat arthritic diseases. Studies on osteoarthritis (OA) have shown positive clinical outcomes, with improved joint function, pain level, and quality of life. In addition, few clinical MSC trials conducted on rheumatoid arthritis (RA) patients have also displayed some optimistic outlook. The largely positive outcomes in clinical trials without severe side effects establish MSCs as promising tools for arthritis treatment. However, further research is required to investigate its applicability in clinical settings. This review discusses the most recent advances in clinical studies on MSC therapies for OA and RA.

A Comparative Review of Erythropoiesis Stimulating Agents

2008 ◽  
Vol 21 (6) ◽  
pp. 424-430
Author(s):  
Nicole L. Metzger ◽  
Kerry E. Francis ◽  
Stacy A. Voils
Keyword(s):  
Chronic Kidney Disease ◽  
Clinical Trials ◽  
Kidney Disease ◽  
Tumor Progression ◽  
Safety And Efficacy ◽  
Regulatory Issues ◽  
Erythropoiesis Stimulating Agents ◽  
Disease States ◽  
Comparative Review ◽  
The Us

Erythropoiesis stimulating agents have been used for more than a decade in patients with chronic kidney disease, malignancy, and other disease states where anemia is common. Recently, several clinical trials have questioned the safety and efficacy of these agents. Thrombosis and increase in tumor progression as well as a potential increase in mortality have been noted in some trials and have generated growing concern regarding whether these agents should remain on the US market. Subsequently, reimbursement from some payers for erythropoiesis stimulating agent administration has become somewhat restrictive. We address the pharmacology, pharmacokinetics, pharmacodynamics, safety, efficacy, and pharmacoeconomics of erythropoiesis stimulating agents as well as emerging regulatory issues pertaining to the administration of erythropoiesis stimulating agents.

Biosimilar epoetin for cancer and chemotherapy-induced anaemia in the US

2021 ◽  
Vol 10 (3) ◽  
pp. 122-122
Author(s):  
Charles L Bennett
Keyword(s):  
Advisory Committee ◽  
Drug Administration ◽  
Food And Drug Administration ◽  
Pharmacokinetics And Pharmacodynamics ◽  
Safety And Efficacy ◽  
Biological Drug ◽  
Drug Products ◽  
Fda Approval ◽  
The Us ◽  
Approval Letter

Biosimilars are biological drug products that are highly similar to reference products in analytic features, pharmacokinetics and pharmacodynamics, immunogenicity, safety and efficacy. Biosimilar epoetin received US Food and Drug Administration (FDA) approval in 2018 [1]. The manufacturer received an FDA non-approval letter in 2017, despite receiving a favourable review by the FDA’s Oncologic Drugs Advisory Committee (ODAC) and an FDA non-approval letter in 2015 for an earlier formulation.

The opioid crisis: evaluating the safety and efficacy of opioid analgesia in the management of acute post-operative dental pain

Dental Update ◽  
2021 ◽  
Vol 48 (10) ◽  
pp. 859-864
Author(s):  
Daniel Merrick ◽  
Michael O'Sullivan ◽  
Mary Clarke
Keyword(s):  
Management Strategies ◽  
Opioid Analgesics ◽  
Dental Pain ◽  
Opioid Analgesia ◽  
Dental Practice ◽  
Opioid Use ◽  
Safety And Efficacy ◽  
Post Operative Pain ◽  
The Us ◽  
The Uk

The use and misuse of opioid analgesics have been highlighted in recent years. This review assesses dental opioid use, the effectiveness of opioid-containing analgesics versus non-opioid alternatives and the implications for post-operative pain management strategies in the dental practice. Guidelines for the management of acute post-operative dental pain differ from country to country. The UK has a low dental opioid use rate when compared to the US. The combination of paracetamol and ibuprofen has similar, if not better, analgesic properties compared to opioid-containing alternatives, with fewer adverse effects. CPD/Clinical Relevance: Non-opioid analgesics are both a safe and effective alternative to opioid analgesics in the management of post-operative dental pain.

Haemophilus influenzae Type b Vaccines: Lessons for the Future

PEDIATRICS ◽  
1988 ◽  
Vol 81 (6) ◽  
pp. 886-893
Author(s):  
JOEL I. WARD ◽  
CLAIRE V. BROOME ◽  
LEE H. HARRISON ◽  
HENRY SHINEFIELD ◽  
STEVEN BLACK
Keyword(s):  
Infectious Disease ◽  
Haemophilus Influenzae ◽  
Conjugate Vaccine ◽  
Alternative Interpretation ◽  
Polysaccharide Vaccine ◽  
Haemophilus Influenzae Type ◽  
Haemophilus Influenzae Type B ◽  
Type B ◽  
Safety And Efficacy ◽  
The Us

In recent months much controversy has focused on interpretations of new data concerning the safety and efficacy of Haemophilus influenzae type b vaccines.1-3 These controversies led the Infectious Disease Committee (Redbook Committee) of the Academy of Pediatrics (AAP) on Nov 13, 1987, to issue by telegram a change in recommendations for the H influenzae type b polysac-charide vaccine. Then, on Dec 22, 1987, the US Food and Drug Administration (FDA) licensed a new, more immunogenic, H influenzae type b conjugate vaccine (Prohibit-Connaught). The aim of this commentary is (1) to provide some background to these events, (2) to elucidate some of the difficulties involved in evaluating vaccines after licensure, (3) to present an alternative interpretation of available data regarding the polysaccharide vaccine, and (4) to comment on the new H influenza type b conjugate vaccine.

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