scholarly journals Stability assessment of Lanette Lotion of a magistral pharmacy in the region of Curitiba

2020 ◽  
Vol 13 (5) ◽  
pp. 69
Author(s):  
A. C. Santos ◽  
B. K. Souza ◽  
A. F. T. Souza ◽  
N. C. Lubi ◽  
T. F. B. X. Silva
Keyword(s):  
Room Temperature ◽  
Heterogeneous Systems ◽  
Slight Modification ◽  
Stability Study ◽  
Chemical Parameters ◽  
Product Quality Control ◽  
Organoleptic Characteristics ◽  
Accelerated Stability ◽  
The Stability ◽  
Physical And Chemical

Emulsions are heterogeneous systems, thermodynamically unstable, formed by the combination of hydrophilic and lipophilic substances through agents of surface tension. The product quality control is handled as the most important to study the stability of the final product which determines the length of time that can be considered stable, that means, able to keep up with the same characteristics which have been developed. The study aimed to evaluate the physical and chemical parameters, by determining the pH, viscosity and organoleptic characteristics (color, odor and appearance) of the lotion Lanette used in a magistral pharmacy in Curitiba. The formulation commonly used in the pharmacy was stored at temperatures of 4 ° C ambient and 45 ° C over a period of 90 days which was divided into 6 times to carry out aspects of analysis. In the preliminary stability study there was no change, but in the accelerated there was a slight modification in appearance, this change was more intense in the formulation conditioned at room temperature and 4 ° C. The pH has had a significant change at all temperatures. Concluding that against accelerated stability tests Lanette lotion, even with the changes, showed good stability.

scholarly journals Formulation and Evaluation of a Moisturizing Cream using Almond Butter

2017 ◽  
Vol 9 (3) ◽  
Author(s):  
M. N. Karemore ◽  
Hemendra Shah ◽  
P. Dharmadhikari ◽  
S. M. Bhise
Keyword(s):  
Thermal Stability ◽  
Specific Gravity ◽  
Subjective Evaluation ◽  
Stability Study ◽  
Chemical Parameters ◽  
Fatty Matter ◽  
Accelerated Stability ◽  
Globule Size ◽  
Total Fatty Matter ◽  
Physical And Chemical

Almond butter is one of the moisturizing agents, which has good emollient and moisturizing properties and hence can be well utilized to design a moisturizing cream, which can provide a good moisturizing property and help to maintain the healthy skin. The aim of the present study is to formulate moisturizing cream using Almond Butter and to evaluate its moisturizing property. In the present study, proper cream base was formulated by taking different trials and evaluated. The cream base showing the best results with respect to pH, thermal stability, total fatty matter and specific gravity was used for the incorporation of the active ingredient in different concentration and was evaluated for physical and chemical parameters. The subjective evaluation of the final product was carried out on volunteers of age 20 - 25 years with dry skin and moisturizing capacity was studied using corneometer. The values for pH, thermal stability, total fatty matter and specific gravity of the selected cream base were found to be within the standard limits. From the results of accelerated stability study of cream, it was found that the cream containing 3% Almond Butter was stable and effective with respect to color, odor, pH, viscosity, globule size and centrifugation. This cream was used for subjective evaluation and it was found that all the candidates experienced desired effect without any irritation. Hence it can be concluded that Almond Butter is having excellent moisturizing effect and can be used as moisturizing agent in different cosmetic products.

scholarly journals GRAPES BREEDED BY ALL-RUSSIAN RESEARCH INSTITUTE FOR VITICULTURE AND WINEMAKING FOR CREATION OF RED DESSERT WINES

Russian vine ◽  
2020 ◽  
Vol 14 ◽  
pp. 74-79
Author(s):  
N.V. Matveeva ◽  
◽  
M.V. Bahmetova ◽  
Keyword(s):  
Sugar Accumulation ◽  
Chemical Parameters ◽  
Wine Production ◽  
Organoleptic Characteristics ◽  
Russian Research Institute ◽  
Technological Evaluation ◽  
Grape Varieties ◽  
Physical And Chemical ◽  
Russian Research ◽  
Research Institute

The paper presents the results of technological evaluation of red wine varieties breeded by All-Russian Research Institute for Viticulture and Winemaking: Vesta, Cherny, Zhemchug, Au-gusta, Teremnoy, Mugofir. These varieties are characterized by high sugar accumulation. Li-queur wines were prepared using classical tech-nology. The research was conducted in the la-boratory of wine technology in micro-wine production. The weight of one batch of grapes was 10–25 kg. The main physical and chemical parameters of wort and wine were determined. Wine distillate was used as an alcoholic agent. For maintaining and enhancing the varietal aroma of grapes we used technology of frac-tional alcoholization. With the help of degusta-tions, organoleptic characteristics of the ob-tained samples of liqueur wines were carried out, as a result of which preliminary conclusions were made about the feasibility of using the studied varieties for the preparation of red li-queur wines. All the studied grape varieties can be recommended for the production of liqueur wines, pink and red.

scholarly journals APPLICATION OF NATURAL PETROLEUM ACIDS AS HEXAMETYLENDIAMIN COMPLEX COMBINES AS BACTERIA

2021 ◽  
Vol 10 (06) ◽  
pp. 58-63
Author(s):  
Teyyub İsmayılov, Sevinj Suleymanova Teyyub İsmayılov, Sevinj Suleymanova
Keyword(s):  
Room Temperature ◽  
Bactericidal Effect ◽  
Complex Compounds ◽  
Chemical Parameters ◽  
Sulfate Reducing ◽  
Bactericidal Properties ◽  
Physical And Chemical ◽  
Reducing Bacteria ◽  
Growth Of Bacteria ◽  
Petroleum Acid

Complex compounds were synthesized by mixing natural petroleum acids with hexamethylene diamine at a ratio of 1:1 and 2:1 at room temperature, IR spectra of the complexes were studied and confirmed, physical and chemical parameters were determined, solutions were prepared and bactericidal properties were studied. The bactericidal effect of a complex compound of natural petroleum acids synthesized with hexamethylenediamine in a ratio of 1: 1 mol at a concentration of 250 mg / l is 95%, a complex combination obtained at a concentration of 500 mg / l and 1000 mg / l is 100%, bactericidal at a concentration of 2: 1 mol at a concentration of 250 mg / l The effect was 98%, 100% at 500 and 1000 mg / l concentrations. According to the results, complex compounds of natural petroleum acids synthesized with hexamethylenediamine can be used to prevent the growth of bacteria. Keywords: natural petroleum acid, hexamethylenediamine, sulfate-reducing bacteria, complex compounds, bactericidal properties.

scholarly journals Physicochemical Stability of 5 mg/mL Pediatric Prednisone Oral Suspension in Syrspend® SF PH4

2018 ◽  
Vol 0 (0) ◽  
Author(s):  
Anne-Claire Bonnaure ◽  
Romain Bellay ◽  
Pauline Rault ◽  
Marie-Antoinette Lester ◽  
Pierre-Nicolas Boivin
Keyword(s):  
Degradation Product ◽  
Sodium Benzoate ◽  
High Performance ◽  
Room Temperature ◽  
Inflammatory Diseases ◽  
Oral Suspension ◽  
Stability Indicating Method ◽  
Physicochemical Stability ◽  
The Stability ◽  
Physical And Chemical

Abstract Background Prednisone is a corticosteroid used in several inflammatory diseases and cancers. In France, no available prednisone drinkable formulation exists. Instead, an oral syrup of prednisone with ethanol, sodium benzoate and simple syrup is produced. However, sodium benzoate can induce neonatal icterus and alcohol is not authorized for children below 3 years of age. The aim of this study was to determine the stability of 5 mg/mL prednisone oral suspension in a commercial compounding excipient: Syrspend® SF PH4. Methods Three batches of oral suspensions were prepared, using micronized prednisone and Syrspend® SF PH4. They were packaged in amber glass vials and stored at room temperature. On day 0, 1, 4, 10, 30, 60 and 90, we observed physical and chemical stability (pH measurement, osmolality measurement, residual concentrations of prednisone and degradation product identification). A stability indicating method was developed using high performance liquid chromatography with Ultraviolet detection at 254 nm. Results Prednisone concentrations remained stable within ± 5 % of nominal values for 60 days. No degradation product and change of physicochemical properties were detected. Conclusion This study showed that 5 mg/mL prednisone oral suspension in Syrspend® SF PH4 is stable for 60 days, at room temperature and protected from light.

Stability of Colloidal Dispersions: A Thermodynamic Approach

1993 ◽  
Vol 27 (10) ◽  
pp. 117-129 ◽  
Author(s):  
Raj Rajagopalan
Keyword(s):  
Virial Coefficient ◽  
Second Virial Coefficient ◽  
Colloidal Dispersions ◽  
Chemical Parameters ◽  
Interaction Forces ◽  
Colloidal Forces ◽  
Stability Diagrams ◽  
The Stability ◽  
Physical And Chemical ◽  
Interparticle Collisions

The classical theory of coagulation relies on relating the rate of interparticle collisions to the interaction forces, and thus to the physical and chemical parameters of the dispersion, through kinetic arguments, and is restricted to dilute systems. Here, we present a modern, thermodynamic theory capable of predicting stability diagrams for dense as well as dilute dispersions. Although based on statistical thermodynamics, the method is simple to use and requires only the second virial coefficient of osmotic pressure of the dispersion. All the information necessary for applying the model to arbitrary dispersions is given. The method is illustrated for a model colloidal potential, and it is shown how static light scattering measurements can be used for predicting the stability diagrams when information about the colloidal forces are not known in advance.

scholarly journals Carbidopa Capsules for Insulinoma Diagnostic: Compounding and Stability Study

2020 ◽  
Vol 4 (3-4) ◽  
pp. 99-104
Author(s):  
Christophe Curti ◽  
Fanny Mathias ◽  
Morane Savelli ◽  
Philippe Garrigue ◽  
Edouard Lamy ◽  
...  
Keyword(s):  
Single Dose ◽  
Hospital Pharmacy ◽  
Room Temperature ◽  
Active Pharmaceutical Ingredient ◽  
Oral Formulation ◽  
Stability Study ◽  
Dose Administration ◽  
Disease Associations ◽  
One Year ◽  
The Stability

AbstractBackgroundCarbidopa is a drug mainly used to treat Parkinson’s disease. Associations with levodopa or with levodopa/entacapone are commercialized, but there is no oral formulation of carbidopa alone available in Europe. As carbidopa can also be used as premedication of adult patients for insulinoma diagnosis, it must be compounded as single dose mg capsules. The single dose administration of a magistral preparation implies the compounding of only one capsule, or the loss of consequent quantities of active pharmaceutical ingredient. As an alternative solution, carbidopa capsules could be compounded as batches of hospital preparation.MethodWith this objective, a stability-indicating dosing method for 200 mg carbidopa capsules was developed. Then, the compounding process was assessed according to the European Pharmacopeia requirements. Finally, the stability of carbidopa capsules stored protected from light at room temperature was studied for one year.Results200 mg carbidopa capsules compounding process was validated on three independent batches. The beyond use date was fixed at one year.ConclusionOur work confirms that carbidopa 200 mg capsules can be realized in hospital pharmacy and its stability allows the compounding of large batches.

scholarly journals Characterization and stability studies of emulsion systems containing pumice

2014 ◽  
Vol 50 (2) ◽  
pp. 361-369 ◽  
Author(s):  
Marilene Estanqueiro ◽  
Jaime Conceição ◽  
Maria Helena Amaral ◽  
Delfim Santos ◽  
João Baptista Silva ◽  
...  
Keyword(s):  
Stress Test ◽  
Textural Properties ◽  
Stability Study ◽  
Skin Care ◽  
Lauryl Sulfate ◽  
Accelerated Stability ◽  
Emulsifying Agent ◽  
Emulsion Systems ◽  
The Stability ◽  
Skin Care Products

Emulsions are the most common form of skin care products. However, these systems may exhibit some instability. Therefore, when developing emulsions for topical application it is interesting to verify whether they have suitable physical and mechanical characteristics and further assess their stability. The aim of this work was to study the stability of emulsion systems, which varied in the proportion of the emulsifying agent cetearyl alcohol (and) sodium lauryl sulfate (and) sodium cetearyl sulfate (LSX), the nature of the oily phase (decyl oleate, cyclomethicone or dimethicone) and the presence or absence of pumice (5% w/w). While maintaining the samples at room temperature, rheology studies, texture analysis and microscopic observation of formulations with and without pumice were performed. Samples were also submitted to an accelerated stability study by centrifugation and to a thermal stress test. Through the testing, it was found that the amount of emulsifying agent affects the consistency and textural properties such as firmness and adhesiveness. So, formulations containing LSX (5% w/w) and decyl oleate or dimethicone as oily phase had a better consistency and remained stable with time, so exhibited the best features to be used for skin care products.

scholarly journals Short-term physical and chemical stability of mixtures of anti-tuberculosis drugs for intravenous administration

2018 ◽  
pp. 13-18
Author(s):  
M.M. Kuzhko ◽  
T.M. Tlustova ◽  
O.S. Denysov ◽  
T.A. Sprynsian ◽  
Yu.V. Shukha
Keyword(s):  
Intravenous Administration ◽  
Chemical Stability ◽  
Chemical Interaction ◽  
Stability Study ◽  
Chromatographic Study ◽  
Pharmaceutical Ingredients ◽  
Resistant Tuberculosis ◽  
Study Results ◽  
The Stability ◽  
Physical And Chemical

PURPOSE. To evaluate the stability of mixtures of anti-tuberculosis drugs for intravenous administration used for treatment of sensitive and resistant tuberculosis in time and in conditions close to the conditions of the use. MATERIALS AND METHODS. Studied combinations: ethambutol + isoniazid in various concentrations, ethambutol + levofloxacin, ethambutol + moxifloxacin. In the stability study, samples were taken for analysis of the appearance, pH and concentration of drugs at specified times (immediately after mixing, after 16, and 24 hours). RESULTS. The results of the chromatographic study indicate the absence of chemical interaction between the active pharmaceutical ingredients, high physical and chemical stability of the mixtures for up to 24 hours of storage under conditions close to the conditions of use, except the mixture of isoniazid with ethambutol, in which it is recommended to reduce the storage term to 16 hours due to the complexity of interpretation and the nature of potential impurities. CONCLUSIONS. Study results indicate the possibility of simultaneous administration of a mixture of isoniazid and ethambutol when the preparation of the mixture was not more than 16 hours prior to administration and mixtures of ethambutol + levofloxacin and ethambutol + moxifloxacin with the preparation of the mixture no more than 24 hours before administration.

scholarly journals FORMULATION, CHARACTERIZATION, AND DETERMINATION OF THE DIFFUSION RATE STUDY OF ANTIOXIDANT SERUM CONTAINING ASTAXANTHIN NANOEMULSION

2021 ◽  
pp. 200-204
Author(s):  
LUSI NURDIANTI ◽  
RISNA CLARA ◽  
HENDY SUHENDY ◽  
FAJAR SETIAWAN ◽  
KENI IDACAHYATI
Keyword(s):  
Diffusion Rate ◽  
Topical Administration ◽  
Storage Conditions ◽  
Stability Study ◽  
Gelling Agent ◽  
Rate Study ◽  
Antioxidant Characteristics ◽  
The Stability ◽  
Physical And Chemical ◽  
And Diffusion

Objective: Astaxanthin is one of the natural carotenoids with strong antioxidant characteristics which is widely used in skin care. The aim of this study was developed to formulate and characterize the antioxidant serum containing astaxanthin nanoemulsion and the diffusion rate studies using diffusion Franz method. Methods: Astaxanthin nanoemulsion (As-NE) was prepared by using the self-nanoemulsifying method, followed by incorporation into serum preparation with the using carbomer as a gelling agent. Evaluation of serum As-NE was performed by physical, chemical characterizations and diffusion assay. Stability study was carried out in both accelerated (temperature of 40±2 °C/75±5%RH) and non-accelerated (at ambient temperature) conditions. Results: These results suggest that antioxidant serum As-NE had good physical and chemical characteristics that are suitable for topical administration. Conclusion: For the study of diffusion and stability under different storage conditions, it was proven that antioxidant serum As-NE form was packed in a carbomer as a gelling agent that could enhance the stability and diffusion rate of the astaxanthin.

scholarly journals Stability-indicating LC-MS Method for Determination of Stability of Extemporaneously Compounded Buprenorphine Oral Syringes for Neonatal Abstinence Syndrome

2021 ◽  
Vol 26 (4) ◽  
pp. 395-404
Author(s):  
Ankit Rochani ◽  
Vinh Nguyen ◽  
Robin Becker ◽  
Walter Kraft ◽  
Gagan Kaushal
Keyword(s):  
High Performance ◽  
Room Temperature ◽  
Color Change ◽  
Storage Condition ◽  
Stability Study ◽  
Neonatal Abstinence Syndrome ◽  
Limited Information ◽  
Abstinence Syndrome ◽  
Stability Indicating ◽  
The Stability

OBJECTIVE In the hospital settings, buprenorphine is used for the treatment of patients with neonatal abstinence syndrome. It is extemporaneously compounded and stored in oral plastic syringes. However, limited information exists about the stability of buprenorphine and its compounded formulations when stored under specific conditions. Hence, we developed a stability-indicating high-performance liquid chromatography–mass spectrometry (LC-MS) method to analyze the stability of buprenorphine over time. METHODS A stability-indicating LC-MS method was developed to map the potential degradation peaks of buprenorphine when exposed to acidic, basic, and oxidative conditions. This method was used to study the stability of compounded buprenorphine oral syringes stored under refrigeration (2°C–8°C) and room temperature (25°C ± 2°C with 60% relative humidity). Syringes from each storage condition were assessed for stability using pH meter and stability-indicating LC-MS assay for 30 days. RESULTS Buprenorphine gets completely degraded in the presence of acid at the end of 1 hour of exposure. Various degradation peaks were identified using LC-MS assay for buprenorphine under acidic, basic, and peroxide conditions. Stability study of oral buprenorphine syringes showed no precipitation, cloudiness, or color change during this study at all storage conditions. The LC-MS assay revealed that buprenorphine oral syringes retained greater than 90% of the initial concentrations for 30 days. CONCLUSIONS Highly sensitive stability-indicating LC-MS method was developed for studying the stability of extemporaneously compounded buprenorphine oral syringes. This study demonstrates that buprenorphine extemporaneous formulation prepared according to the manufacturers' recommendations is stable under refrigerated or room temperature conditions for 30 days in oral plastic syringes.

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