Changes in Liver, Kidney and Atherogenic Indices of Women in Ebocha, Niger-Delta, Nigeria due to Gas Flaring

2021 ◽  
Vol 7 (5) ◽  
pp. 59-64
Author(s):  
L. A. Nwaogu ◽  
◽  
G. O. C. Onyeze ◽  
R. N. Nwabueze ◽  
I. E. Adieze ◽  
...  
Keyword(s):  
Niger Delta ◽  
Ldl Cholesterol ◽  
Serum Triglyceride ◽  
Hdl Cholesterol ◽  
Negative Effects ◽  
Native Women ◽  
Gas Flaring ◽  
Human Organs ◽  
Atherogenic Indices ◽  
Aspartate Transferase

Gas flaring causes pollution to the environment and also affects the human organs such as the liver and kidneys. The present study seeks to investigate changes in liver, kidney function and atherogenic predictor indices of native women of Ebocha, Niger Delta, Nigeria who have over the years been chronically exposed to the persistent gas flaring in the area. Two hundred (200) healthy and freely consented women aged between 30 to 50 years were recruited; one hundred (100) from Ebocha and one hundred (100) from Uturu the control station. Results revealed that the values of serum activities of alanine aminotransferase (ALT), aspartate transferase (AST) alkaline phosphatase (ALP), and the concentrations of albumin and total protein were significantly (p<0.05) higher in Ebocha women when compared to values of women from Uturu. The pollution caused as a result of gas flaring did not affect the concentrations of bilirubin in women from both sites. However, serum creatinine, urea, K+, Na+, Cl- and HCO3-concentrations were significantly (p<0.05) higher in Ebocha women when compared to values for women from the control station. Ebocha women had significantly (p<0.05) reduced concentrations of serum triglyceride, total cholesterol and HDL cholesterol but significantly (p<0.05) increased LDL-cholesterol and atherogenic predictor indices in comparison with those from Uturu indicating that chronic gas flaring has negative effects on the liver, renal function, lipid profile and atherogenic predictor indices of women resident in Ebocha. Liver, kidney, atherogenic indices, gas flaring, women, Niger Delta.

scholarly journals Evaluation of some biochemical changes in the serum of phensedyl addicts of Gaibandha District, Bangladesh

2014 ◽  
Vol 20 ◽  
pp. 57-65
Author(s):  
Md Rashidul Hasan ◽  
Parvez Hassan ◽  
Md Abdul Jalil Miah
Keyword(s):  
Serum Cholesterol ◽  
Biochemical Parameters ◽  
Ldl Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Serum Triglyceride ◽  
Hdl Cholesterol ◽  
Total Serum ◽  
Total Serum Cholesterol ◽  
P Value

Context: Abuse of the drug, Phensedyl like any other drug might exert adverse effects on vital organs of th e h u m an body like liver, kidney and heart. Objectives: To determine the effects of Phensedyl intake on the serum biochemical parameters of the addicts in order to access for damages of vital human organs like liver, kidney and heart. Materials and Methods: Study population consisted of 127 male Phensedyl addicts within the ages of 18–55 years of defined criteria from Gaibandha district, a Northern part of Bangladesh, during July 2009 to December 2011. Fifty (50) non-drug dependent healthy men of matched age, height, and socioeconomic status were included as controls from the same community. Biochemical parameters analyzed were – Serum creatinine, SGOT, SGPT and Lipid profiles (total serum cholesterol (TC), Serum triglyceride (TG), serum high-density lipoprotein (HDL) and low-density lipoprotein (LDL) cholesterol determined by semiautomatic biochemistry analyzer using commercially available kits Results: Abuse of Phensedyl appears not to hamper the normal renal and liver function in most of the addicts even after 8 years of Phensedyl intake irrespective of age except in case of 4 abusers. Serum total cholesterol (TC) remained almost unchanged among the addicts abusing Phensedyl for less than 8 years. But very strikingly, addicts taking Phensedyl for more than 8 years had higher trends in serum cholesterol i.e. more than 200 ml/dl. Of the addict’s, 44.36% abusing Phensedyl for less than 8 years had normal triglyceride (TG) values whereas, in 45.66% addicts abusing the drug for more than 8 years had clinically very significantly elevated triglyceride levels, which was also found to be statistically very significant (p value =0.0001), indicating the risk of developing cardiac diseases. Of the total addicts 53.53% had low levels of HDL cholesterol, which is clinically and statistically found to be very significant (p value =0.002). Of the addict’s 43% taking the drug for less than 8 years had normal LDL levels but significantly elevated values were recorded in 34% of the abusers who had been taking the drug for more than 8 years. Conclusion: Long time (> 8 years) Phensedyl abusers are at the high risk of developing Brain stroke, Coronary Heart Disease (CHD), Ischemic stroke or transient ischemic attack (TIA) as there is the triad of: Elevated LDL cholesterol, Low HDL cholesterol and elevated Triglyceride. DOI: http://dx.doi.org/10.3329/jbs.v20i0.17656 J. bio-sci. 20: 57-65, 2012

scholarly journals Short-term Effect of Garlic Extract on Patients with Dyslipidemia

2019 ◽  
Vol 21 (4) ◽  
pp. 301-305
Author(s):  
A Limbu ◽  
GP Rauniar ◽  
SK Sharma ◽  
DR Panday ◽  
BK Shah ◽  
...  
Keyword(s):  
Serum Cholesterol ◽  
Ldl Cholesterol ◽  
Serum Triglyceride ◽  
Hdl Cholesterol ◽  
Lipid Lowering ◽  
Total Serum ◽  
Total Serum Cholesterol ◽  
P Value ◽  
Vldl Cholesterol ◽  
Significant Difference

Dyslipidemia is a metabolic abnormality leading to a persistent increase in the plasma concentration of cholesterol and triglycerides. Dyslipidemia is known to promote atherosclerosis. It is a complex disease and is a major risk factor for adverse cardiovascular events. Allium sativum commonly known as garlic has been found to have several medicinal value including, lipid-lowering property, blood pressure decreasing, anti-diabetic, anti-cancer and anti-oxidant activity. It was a double-blind, two-parallel-group, prospective interventional clinical trial. Total no of 112 patients were enrolled in the study and divided into two equal groups (56 in each group) viz; Group 1 (Lasuna TM) and Group 2 (placebo). Lipid profile was measured at day 0 and 90. Independent–sample‘t’ test was applied to find out the significant difference between the two groups, P-value being 0.05. The mean difference Total Serum Cholesterol, Serum Triglyceride, Serum LDL Cholesterol and Serum VLDL cholesterol on day 0 was nonsignificant with p being 0.539, 0.811, 0.230, 0.770 and 0.811 and on 90th day was significantly lower in group taking garlic with p being 0.001, 0.014, 0.003 and 0.008 respectively whereas Serum HDL cholesterol on 90th day was significantly higher in group taking garlic with p being 0.001. Garlic, when given as supplement decreases Total Serum Cholesterol, Serum Triglycerides, Serum LDL Cholesterol and Serum VLDL Cholesterol and on the other hand it increases Serum HDL Cholesterol.

Association of osteoprotegerin and rankl levels with insulin resistance in pubertal obese children

Open Medicine ◽  
2010 ◽  
Vol 5 (2) ◽  
pp. 261-267
Author(s):  
Ediz Yeşilkaya ◽  
Aysun Bideci ◽  
Orhun Çamurdan ◽  
Mehmet Boyraz ◽  
Sebahattin Vurucu ◽  
...  
Keyword(s):  
Insulin Resistance ◽  
Nuclear Factor Kappa B ◽  
Ldl Cholesterol ◽  
Hdl Cholesterol ◽  
Atherogenic Index ◽  
Nuclear Factor ◽  
Obese Children ◽  
Cholesterol Levels ◽  
Atherogenic Indices ◽  
Receptor Activator

AbstractOsteoprotegerin (OPG)/“receptor activator of nuclear factor kappa B-ligand” (RANKL) system has an important role in the remodeling of bone through regulation of osteoclastogenesis. We aimed to detect OPG and RANKL levels, particularly in obese children in the pubertal period and to investigate whether these parameters correlate with insulin resistance in childhood. Our study included 66 obese children ranging in age from 9.1 to 16 years, and 22 non-obese children ranging in age from 10.5 to 16 years. Blood glucose, insulin, total cholesterol, HDL cholesterol, and LDL cholesterol levels were measured for all cases; HOMA-IR, Quicki index and atherogenic index were calculated. Serum OPG and RANKL levels were also measured. OPG and RANKL levels did not show any difference between obese and non-obese children (P>.05). No difference in these 2 parameters were observed among the children with and without insulin resistance (P>.05). No correlation could be established between the OPG, the HOMA-IR, Quick and atherogenic indices. Obesity and insulin resistance are believed to show their effect in the later period of life to become able to change some of the parameters.

scholarly journals A Comparative Study of Drospirenone and Desogestrel: An Overview of Benefi ts and Side Effects

1970 ◽  
Vol 6 (1) ◽  
pp. 17-21
Author(s):  
Pamamita Bhattacharya ◽  
Nandini Kapoor ◽  
Amit Kyal ◽  
Partha Mukhopadhyay
Keyword(s):  
Blood Pressure ◽  
Body Weight ◽  
Cholesterol Level ◽  
Serum Sodium ◽  
Ldl Cholesterol ◽  
Ethinyl Estradiol ◽  
Oral Contraceptive Pill ◽  
Serum Triglyceride ◽  
Hdl Cholesterol ◽  
The Other

Aims: To study the antiandrogenic and antimineralocorticoid activity of drospirenone, a novel progestogen used as a component of combined oral contraceptive pill (COC) and compare it’s clinical and biochemical effects with that of desogestrel, the most commonly used progestogenic component of COC. Methods Study design: prospective analytical study. Population and setting: study was conducted in our department from July 2008 to June 2010. Two hundred women were randomly allocated into two groups. First group received combination of 3mg drospirenone and 30 mcg ethinyl estradiol (DRSP/EE) and the other group was given COC containing 150mcg desogestrel and 30 mcg ethinyl estradiol (other OCP group). Results: The DRSP/EE group showed no significant decrease in body weight, Ferriman gallwey Score (FG), systolic and diastolic blood pressure. No evidence of sodium retention seen in any patients. 86% women had decrease in serum sodium from baseline. There was significant increase in HDL-Cholesterol level by 7.52% and no significant decrease in LDL-Cholesterol level. In the other OCP group, 52 subjects had increase in body weight, 30% showed increase in FG score and none had any decrease in blood pressure. 62% women had net gain in serum sodium level. Serum Triglyceride, HDL-Cholesterol, LDL-Cholesterol all were increased. Conclusion: DRSP/EE combination is well tolerated, demonstrating good cycle control and a beneficial effect on skin condition. It exerts significant antiandrogenic activity and is effective in improving hirsutism. It also has positive effect on serum electrolyte composition and lipid profile. Keywords: Combined oral contraceptives, drospirenone, desogestrel DOI: http://dx.doi.org/10.3126/njog.v6i1.5247 NJOG 2011; 6(1): 17-21

Platelet Aggregation and Plasma Lipoproteins in Alcoholics During Alcohol Withdrawal

1986 ◽  
Vol 55 (02) ◽  
pp. 173-177 ◽  
Author(s):  
K Desai ◽  
J S Owen ◽  
D T Wilson ◽  
R A Hutton
Keyword(s):  
Platelet Aggregation ◽  
Alcohol Withdrawal ◽  
Ldl Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Plasma Lipoprotein ◽  
Cholesterol Concentration ◽  
Arachidonic Acid Content ◽  
Low Density

SummaryPlatelet aggregation, platelet lipid composition and plasma lipoprotein concentrations were measured each week in a group of seventeen alcoholics, without overt liver disease, for one month, following acute, total alcohol withdrawal. The platelets were initially hypoaggregable but, within 1-2 weeks of cessation of drinking, they became hyperaggregable and then gradually returned towards normal values. Hyperaggregability could not be explained by increases in either the cholesterol or the arachidonic acid content of the platelets. Plasma very-low-density lipoprotein cholesterol levels remained high throughout the study, but the initially raised levels of high-density lipoprotein (HDL) cholesterol fell by 26%. Low-density lipoprotein (LDL) cholesterol concentration rose by 10% after two weeks of withdrawal but then returned to about the starting level. The resulting changes in the plasma LDL-cholesterol: HDL-cholesterol ratio, which had increased by more than 50% after two weeks of abstinence, essentially paralleled the time course of enhanced platelet reactivity in all but four of the alcoholics. These findings suggest that alterations in plasma lipoprotein concentrations during acute alcohol withdrawal may be a contributory factor to the haemostatic disorders present in such patients.

Risk factors for cardiovascular diseases and development of prehypertension

2018 ◽  
pp. 37-43
Author(s):  
В.В. Шерстнев ◽  
М.А. Грудень ◽  
В.П. Карлина ◽  
В.М. Рыжов ◽  
А.В. Кузнецова ◽  
...  
Keyword(s):  
Risk Factors ◽  
Blood Pressure ◽  
Cardiovascular Disease ◽  
Ldl Cholesterol ◽  
Low Density Lipoprotein ◽  
Density Lipoprotein ◽  
Hdl Cholesterol ◽  
Serum Levels ◽  
Left Ventricular ◽  
Optimal Blood Pressure

Цель - исследование взаимосвязи факторов риска сердечно-сосудистых заболеваний и развития предгипертонии. Методика. Проведен сравнительный и корреляционный анализы показателей модифицируемых и немодифицируемых факторов риска сердечно-сосудистых заболеваний у обследованных лиц в возрасте 30-60 лет с «оптимальным» артериальным давлением, (n = 63, АД <120/80 мм рт.ст.) и лиц с предгипертонией (n = 52, АД = 120-139/80-89 мм рт.ст.). Результаты. Показано, что лица с предгипертонией по сравнению с группой лиц, имеющих «оптимальное» артериальное давление характеризуются статистически значимо повышенным содержанием холестерина и холестерина липопротеидов низкой плотности, интеллектуальным характером трудовой деятельности, а также значимыми сочетаниями факторов риска: повышенный уровень холестерина липопротеидов низкой плотности с интеллектуальным характером трудовой деятельности; повышенное содержание креатинина с уровнем триглициридов; наследственная отягощенность по заболеваниям почек и интеллектуальным характером трудовой деятельности; наследственная отягощенность по сахарному диабету и гипертрофия левого желудочка сердца. У лиц с предгипертонией документированы перестройки структуры взаимосвязи (количество, направленность и сила корреляций) между показателями факторов риска в сравнении с лицами, имеющими «оптимальное» артериальное давление. Заключение. Выявленные особенности взаимосвязей факторов риска сердечно-сосудистых заболеваний при предгипертонии рассматриваются как проявление начальной стадии дизрегуляционной патологии и нарушения регуляции физиологических систем поддержания оптимального уровня артериального давления. The aim of the study was to investigate the relationship between risk factors for cardiovascular disease and development of prehypertension. Methods. Comparative and correlation analyses of modifiable and non-modifiable risk factors for cardiovascular disease were performed in subjects aged 30-60 with «optimal» blood pressure (n = 63, BP <120/80 mm Hg) and prehypertension (n = 52, BP = 120-139 / 80-89 mm Hg). Results. The group with prehypertension compared with the «optimal» blood pressure group had significantly increased serum levels of low-density lipoprotein (LDL) cholesterol and high-density lipoprotein (HDL) cholesterol, sedentary/intellectual type of occupation, and significant combinations of risk factors. The risk factor combinations included an increased level of LDL cholesterol and a sedentary/intellectual occupation; increased serum levels of creatinine and triglycerides; hereditary burden of kidney disease and a sedentary/intellectual occupation; hereditary burden of diabetes mellitus and cardiac left ventricular hypotrophy. In subjects with prehypertension compared to subjects with «optimal» blood pressure, changes in correlations (correlation number, direction, and strength) between parameters of risk factors were documented. Conclusion. The features of interrelationships between risk factors for cardiovascular disease observed in prehypertension are considered a manifestation of early dysregulation pathology and disordered regulation of physiological systems, which maintain optimal blood pressure.

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