scholarly journals ALLERGENS AND «HIDDEN» ALLERGENS. WHAT IS THE DIFFERENCE?

2009 ◽  
Vol 6 (6) ◽  
pp. 26-33
Author(s):  
Lyudmila Vasil'evna Luss ◽  
T Yu Repina ◽  
E B Tuzlukova ◽  
L V Luss ◽  
T Ju Repina ◽  
...  
Keyword(s):  
Allergic Reaction ◽  
Adverse Reactions ◽  
Allergic Reactions ◽  
Hidden Allergens ◽  
The Difference ◽  
Hidden Allergen

There is an increasing of allergic reactions on the so called «hidden» allergens during the last years. Nowadays a lot of allergens and various compositions could be regarded as the so called «hidden» allergens. At the same time their role in adverse reactions as well as in allergic reactions is not clear. This review is devoted to definition, classification and clinical contribution of «hidden» allergens. The allergic reaction to «hidden» allergen in genferon preparation is described as a clinical example.

scholarly journals Consequences of Use

Antibiotics ◽  
2019 ◽  
Author(s):  
Mary Elizabeth Wilson
Keyword(s):  
Adverse Reaction ◽  
Allergic Reaction ◽  
Adverse Drug Reactions ◽  
Signs And Symptoms ◽  
Allergic Reactions ◽  
Drug Reactions ◽  
The Difference

What is the difference between an allergic reaction and an adverse reaction? What are the signs and symptoms of an allergic reaction? All allergic reactions to a drug are adverse drug reactions, but adverse drug reactions also include many other kinds of reactions. Every antibiotic...

scholarly journals Analysis of Adverse Reactions of Blood Transfusion and Discus-sion of Influencing Factors in Linyi Area from 2013 To 2020

2021 ◽  
Author(s):  
Xiuping Zhang ◽  
Yanli Zhang ◽  
Yanli Zhang ◽  
Cao Qi ◽  
Chunling Ma
Keyword(s):  
Blood Transfusion ◽  
Influencing Factors ◽  
Theoretical Basis ◽  
Adverse Reactions ◽  
Allergic Reactions ◽  
City Center ◽  
History Of ◽  
The Difference ◽  
Safe Blood ◽  
Transfusion Reactions

Background: We aimed to explore the influencing factors of clinical adverse blood transfusion reactions, to provide theoretical basis and support for clinical safe blood transfusion, and to minimize the occurrence of adverse blood transfusion reactions. Methods: The method was to retrospectively analyze the report of adverse blood transfusion reports from 6 hospitals in Linyi area, Shandong, China to the blood station in Linyi City center from 2013 to 2020. We aimed to classify factors, analyze the occurrence of adverse transfusion reactions, and discuss the correlation between the occurrence of adverse transfusion reactions and the above factors. Results: Overall, 248 patients (77.98%) had a history of blood transfusion. The difference between this group and the group with no history was statistically significant (P<0.05). The incidence of adverse transfusion reactions in middle-aged and elderly patients was relatively high, especially for those over 50 yr old, with an adverse reaction of 135, for example, the proportion reached 42.45%. In addition, a retrospective analysis found that the occurrence of adverse transfusion reactions was mostly concentrated from Mar to Sep, a total of 228 cases, accounting for 71.69% of all adverse reactions, which was the highest incidence of adverse transfusion reactions. Conclusion: The main adverse reactions of transfusion were allergic reactions, followed by non-hemolytic febrile reactions, mainly caused by transfusion of suspended red blood cells.

scholarly journals Allergic Reaction of the Body to Drugs Used in Dental Practice

2021 ◽  
pp. 182-187
Author(s):  
Anastasiia Vladimirovna Shefova ◽  
Andrey Olegovich Galustyan ◽  
Angelina Olegovna Shershneva ◽  
Olga Vladimirovna Tyukavina ◽  
Marina Mikhailovna Krekova ◽  
...  
Keyword(s):  
Allergic Reaction ◽  
Human Body ◽  
Local Anesthetics ◽  
Adverse Reactions ◽  
Negative Impact ◽  
The Body ◽  
Allergic Reactions ◽  
Dental Practice ◽  
Pharmacological Agents ◽  
Dental Office

The article examines allergic reactions of the body to drugs used in dental practice. The authors note that adverse or allergic reactions of medicines to the human body are possible with any medications that are prescribed or administered in a dental office. Although most of the pharmacological agents used today have a favorable profile and they are relatively safe, a modern specialist should be aware of potential adverse reactions that may occur and one should be ready to cope with any complications. Adverse or allergic reactions are possible when working with drugs such as local anesthetics, sedatives, analgesics and antibiotics, for this reason, it is necessary to study the possible reactions of the patient's body to them when administering such drugs to reduce the negative impact on the body. In general, the pharmacological arsenal of a practicing dentist is relatively safe today. However, a prudent clinician should be aware of potential adverse reactions that may occur as a result of taking medications, and be confident in the treatment of such complications.

Characteristics of Asian Mosquito Saliva Allergens for Specific Diagnoses and Effective Therapies

2020 ◽  
Vol 21 (2) ◽  
pp. 153-158 ◽  
Author(s):  
Soung-Hoo Jeon
Keyword(s):  
Allergic Reaction ◽  
East Asia ◽  
East Asian ◽  
Diagnosis And Treatment ◽  
Recombinant Allergens ◽  
Systemic Reactions ◽  
The Future ◽  
Mosquito Saliva ◽  
The Difference ◽  
Future Direction

An allergic reaction to mosquitoes can result in severe or abnormal local or systemic reactions such as anaphylaxis, angioedema, and general urticarial or wheezing. The aim of this review is to provide information on mosquito saliva allergens that can support the production of highly specific recombinant saliva allergens. In particular, candidate allergens of mosquitoes that are well suited to the ecology of mosquitoes that occur mainly in East Asia will be identified and introduced. By doing so, the diagnosis and treatment of patients with severe sensitivity to mosquito allergy will be improved by predicting the characteristics of East Asian mosquito allergy, presenting the future direction of production of recombinant allergens, and understanding the difference between East and West.

scholarly journals Lidocaine: A Local Anesthetic, Its Adverse Effects and Management

Medicina ◽  
2021 ◽  
Vol 57 (8) ◽  
pp. 782
Author(s):  
Entaz Bahar ◽  
Hyonok Yoon
Keyword(s):  
Adverse Effects ◽  
Local Anesthetic ◽  
Local Anesthetics ◽  
Adverse Reactions ◽  
Rapid Diagnosis ◽  
Diagnosis And Treatment ◽  
Allergic Reactions ◽  
Life Threatening

The most widely used medications in dentistry are local anesthetics (LA), especially lidocaine, and the number of recorded adverse allergic responses, particularly of hazardous responses, is quite low. However, allergic reactions can range from moderate to life-threatening, requiring rapid diagnosis and treatment. This article serves as a review to provide information on LA, their adverse reactions, causes, and management.

scholarly journals Iodine allergy: Common misperceptions

2021 ◽  
Author(s):  
Nicole R Wulf ◽  
John Schmitz ◽  
Amy Choi
Keyword(s):  
Literature Review ◽  
Adverse Reactions ◽  
Povidone Iodine ◽  
Cross Reactivity ◽  
Current Evidence ◽  
Allergic Reactions ◽  
Iodinated Contrast Media ◽  
Inclusion Criteria ◽  
Iodinated Contrast ◽  
Final Article

Abstract Disclaimer In an effort to expedite the publication of articles related to the COVID-19 pandemic, AJHP is posting these manuscripts online as soon as possible after acceptance. Accepted manuscripts have been peer-reviewed and copyedited, but are posted online before technical formatting and author proofing. These manuscripts are not the final version of record and will be replaced with the final article (formatted per AJHP style and proofed by the authors) at a later time. Purpose The current evidence regarding iodine-containing compounds and iodine allergy cross-reactivity is reviewed. Summary Iodine is an essential human nutrient found in the thyroid gland. It is used in the synthesis of the thyroid hormones thyroxine and triiodothyroxine. Patients who report having adverse reactions to iodine-containing substances are often labelled as having an “iodine allergy,” which can result in delays in care or patients being denied essential ICM or other iodine-containing drugs. A literature review was conducted to evaluate the evidence regarding iodine allergy and iodine-containing drugs. Of 435 articles considered potentially appropriate for full review (plus 12 additional articles included on the basis of references from the eligible articles), 113 could not be obtained. After exclusion of 353 articles that did not meet all inclusion criteria, the remaining 81 articles were included in the review. The results of the literature review indicated that iodine has not been shown to be the allergen responsible for allergic reactions to iodinated contrast media, amiodarone, povidone-iodine, and other iodine-containing compounds. Conclusion There is a lack of evidence to support cross-reactivity between iodine-containing compounds in so called iodine-allergic individuals.

Evaluation of Allergic Reactions Following Intravenous Infusion of Polyvalent Antivenom in Snakebite Patients

2021 ◽  
Vol 20 ◽  
Author(s):  
Ghafar-Ali Mahmoudi ◽  
Maryam Ahadi ◽  
Ali Fouladvand ◽  
Bareza Rezaei ◽  
Zahra Bodagh ◽  
...  
Keyword(s):  
Rural Areas ◽  
Adverse Reactions ◽  
Standard Treatment ◽  
Clinical Presentation ◽  
Demographic Data ◽  
Maculopapular Rash ◽  
Clinical Feature ◽  
Allergic Reactions ◽  
Related Data ◽  
The Mean

Background: Antivenom is a gold-standard treatment for snakebite envenoming. However, adverse reactions to snake antivenom are common in many parts. Objective: The aim of this study was to evaluate the allergic reactions following intravenous administration of antivenom sera. Methods: This was retrospective study, conducted snakebites patients referred to the Rahimi Hospital in Khorramabad. The files of these patients were accessed for demographic data, snakebite-related data, treatment provided, clinical presentation and allergic reaction status as a result of antivenom treatment. Results: 141 cases were investigated including 73.8% male and 26.2% female patients. The mean age of the patients was 38.1±17.1years. Age group 30-39 years accounted for highest number of snakebite cases (24.1%). A majority of victims (89.4%) were from the rural areas. Most of the patients (51.8%) were bitten in the spring and highest number of snakebite were reported in May (39.1%). The most common site of snakebite was lower extremities (50.4%) and upper extremities (44.7%). Among clinical feature of snakebite, pain was the most prevalent in 135 cases (95.7%) followed by swelling (83.7%). The mean antivenom vials used were 6.5±3.7 vials. Allergic reactions occurred in 6 patients (4.26%); reactions were mild in 5 patients and sever in 1patient. The commonest presentation was maculopapular rash (1.4%) and the least common were headache (0.71%), nausea (0.71%), fever (0.71) and hypotension (0.71%). Conclusion: Snakebite is one of the significantlife-threatening environmental events.Immediate antivenom treatment can reduce mortality however, patients should be carefully monitored for adverse allergic reactions.

scholarly journals Allergy to cephalosporin antibiotics in children

2003 ◽  
Vol 131 (3-4) ◽  
pp. 127-130 ◽  
Author(s):  
Marina Atanaskovic-Markovic ◽  
Branimir Nestorovic
Keyword(s):  
Allergic Reaction ◽  
Cross Reactivity ◽  
Skin Tests ◽  
Allergic Reactions ◽  
First Line ◽  
Positive Skin ◽  
Cephalosporin Antibiotics ◽  
The Cross ◽  
Single Blind ◽  
Common Infections

A particular problem is the safety of administering cephalosporins to penicillin-allergic children, because cephalosporin allergenic determinants have not been properly identified. Cephalosporin antibiotics are widely used to treat common infections and are often the first-line prophylaxis before many types of surgery. So the arm of this study is to determine the frequency of allergic reactions of anaphylactic type to cephalosporins and their cross-reactivity with penicillins. At University Children?s Hospital in Belgrade a group of 1,170 children with suspected anaphylactic allergic reaction to penicillins and/or cephalosporins were tested for the last eight years. Skin tests were performed with standard concentration of penicillins and cephalosporins. In children where skin tests were negative single-blind placebo-controlled challenges were performed. In case of positive skin tests further examinations were interrupted and the children were considered allergic to that drug. The frequency of anaphylactic allergic reactions to cephalosporins is 0.2 % to 17 %, and depends on cephalosporins generation. The cross-reactivity between cephalosporins and penicillins is 0.1 % to 14.5 %, and among cephalosporins is 0 % to 11.7 %.

scholarly journals Clinical Observation of Zhuang Medicine Crystal Sugar Ye’An Decoction in Treating Senile Skin Pruritus and Its Effects on Serum IgE

2020 ◽  
Vol 4 (6) ◽  
Author(s):  
Yun Zhang ◽  
Yuying Lan
Keyword(s):  
Adverse Reactions ◽  
Clinical Observation ◽  
Skin Lesions ◽  
Effective Rate ◽  
Inflammatory Factors ◽  
Control Group ◽  
Observation Group ◽  
Serum Ige ◽  
The Difference ◽  
Lesion Severity

Objective: To discuss the specific application of Zhuang Medicine Crystal Sugar Ye’An Decoction in senile skin pruritus and its effects on serum IgE detection level. Methods: 90 patients with senile skin pruritus admitted to our hospital from February 2019 to April 2020 were randomly grouped. The general treatment effect, itching, secondary skin lesion severity, serum IL-6, IgE level and adverse reactions between 45 patients treated with Chlorcyclizine Hydrochloride Tablets (The control group) and 45 patients treated with Crystal Sugar Ye’An Decoction were compared. Results: The total effective rate of the treatment in the observation group was 93.33%, much higher than that in the control group, 75.56%. The difference was verified and statistically significant (P<0.05). Before the treatment, the itching area, frequency, duration and severity of secondary skin lesions were at the same level (P>0.05). After the treatment, the above data were all reduced, and the reduction of the observation group was more significant than that of the control group, indicating the difference was statistically significant (P<0.05). Before the treatment, there was no difference in serum IL-6 and IgE test data between the two groups (P>0.05). After the treatment, the tendency all declined, and that of the observation group was more obvious, indicating the difference was statistically significant (P<0.05). During the experiment, no obvious adverse reactions were observed in both groups. Conclusion: In the treatment of patients with senile pruritus, the application of Zhuang Medicine Crystal Sugar Ye’An Decoction is not only safe and reliable, but can promote the improvement of patients’ symptoms, adjust the level of inflammatory factors, and enhance clinical efficacy.

Prevention of Recurrent Urinary Tract Infections in Girls

PEDIATRICS ◽  
1977 ◽  
Vol 59 (4) ◽  
pp. 562-565
Author(s):  
Jacob A. Lohr ◽  
Donna H. Nunley ◽  
Stuart S. Howards ◽  
Raymond F. Ford
Keyword(s):  
Urinary Tract ◽  
Adverse Reactions ◽  
Low Dose ◽  
Double Blind ◽  
Urinary Tract Abnormality ◽  
History Of ◽  
The Difference ◽  
Tract Infections ◽  
Blind Crossover Study ◽  
Double Blind Crossover Study

Eighteen girls between the ages of 3 and 13 years—with a history of at least three culture-documented episodes of bacteriuria in the previous year, but without radiologic evidence of major urinary tract abnormality—were placed on a double-blind, crossover study comparing the effectiveness of nitrofurantoin macrocrystals against a placebo in preventing the recurrence of bacteriuria. Each child was placed on a daily low dose of nitrofurantoin (1.2 to 2.4 mg/kg/day) or an identical-appearing placebo for six months. Each child was then placed on the opposite capsule for a similar period. There were 35 episodes of bacteriuria (4.2 episodes/patient/yr) in the patients taking the placebo, which compared with a rate of 3.8 episodes/patient/yr during the year prior to the study. Only two episodes (0.2 episodes/patient/yr) occurred in the patients taking the drug. The difference in the rate of recurrent bacteriuria between the girls on placebo and on medication is significant at the 0.01 level using the Wilcoxin matched-pairs test. There were no adverse reactions to the drug. Nitrofurantoin macrocrystals in a single daily low dose appear to be a safe, effective method of preventing recurrent bacteriuria in girls at high risk.

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