scholarly journals Association between rankl [RS9594759] and IL10 [RS1800896] Genes polymorphism and deciduous tooth eruption terms in Ukrainians born macrosomic

2020 ◽  
Vol 73 (2) ◽  
pp. 342-351
Author(s):  
Olga V. Garmash ◽  
Zoia I. Rossokha ◽  
Nataliya G. Gorovenko
Keyword(s):  
Tooth Eruption ◽  
Deciduous Tooth ◽  
Molecular Profile ◽  
Dominant Model ◽  
Female Ratio ◽  
Multi Stage ◽  
Increased Risk ◽  
Male Female Ratio ◽  
Modifying Effect ◽  
Female Male Female

The aim: The article deals with analyzing the influence of polymorphic variants of CYP19A1 [rs2414096, rs936306], ESR1 [rs2234693, rs9340799], IL1 [rs1143627], IL6 [rs1800796], IL10 [rs1800896] and RANKL [rs959389] genes on deciduous tooth eruption terms in individuals born macrosomic. Materials and methods: 171 individuals participated in the multi-stage study (144 macosomic-at-birth individuals and 27 normosomic-at-birth persons). This study included only persons who have preserved information about the timing of deciduous tooth eruption – 159 persons (aged from 4 to 55 years), male and female (male / female ratio was 1.5 / 1). Results and conclusions: The presence of the G allele in CYP19A1 [rs2414096] gene and the -351 A allele in ESR1 [rs9340799] gene were found to be risk factors for fetal macrosomia formation. The research revealed an association of RANKL [rs9594759] gene variants which is a multiplicative model of inheritance and IL-10 [rs1800896], an over-dominant model of inheritance, with an increased risk of tooth delay. Besides the variants of RANKL [rs9594759] and IL-10 [rs1800896] genes a multidirectional modifying effect on the timing of tooth eruption in macrosomic-at-birth individuals made the variant of CYP19A1 [rs2414096] gene – a significant dominant and over-dominant model of inheritance. Further analysis of intergenic interactions will facilitate the application of the obtained results in clinical practice by creating a molecular profile of individuals with deviations in the tooth eruption timing.

CLINICAL, ENDOSCOPIC AND PATHOGICAL CHARACTERISTICS OF COLORECTAL CANCER AT DA NANG HOSPITAL FROM 2016 TO 2017

2018 ◽  
pp. 9-14
Author(s):  
Thanh Trung Nguyen ◽  
Duc Nhan Le ◽  
Van Xung Nguyen ◽  
Hieu Trung Doan
Keyword(s):  
Colorectal Cancer ◽  
Descriptive Study ◽  
Bloody Stool ◽  
Key Words Colorectal Cancer ◽  
Right Colon ◽  
Female Ratio ◽  
Histopathological Classification ◽  
Male Female Ratio ◽  
Female Male Female ◽  
Colorectal Cancer Patients

Objective: To study the clinical, endoscopy and pathogical characteristics of colorectal cancer at Da Nang Hospital. Methods: A retrospectively descriptive study, performed from 01/01/2016 to 31/12/2017 at Da Nang Hospital. Results: During two years, there were 205 cases of colorectal cancer patients hospitalized to Da Nang Hospital. Male: 59.51%, female: 40.49%, mean age: 65.8 ± 16.07. Male is higher than female, male/ female ratio is 1.4/1. The period from the first symptoms to admission < 3months predominated (83.8%). The predominant symptoms: Abdominal pain (85.85%), bloody stool (63.41%), defecation (62.44%), anemia (34.63%), weight loss (25.85%), fatigue (17.56%), abdominal distention (12.19%), nausea and vomiting (5.36%). Location of Lesions: Rectum (43.42%), sigmoid colon (20%), right colon (10.73%),cecum (10.73%), transverse colon (7.80%), left-colon (7.32%). Type of lesion on endoscopy: Exophytic (63.41%), ulceration-Exophytic (21.95%), ulceration (7.32%), polyp chemotherapy (7.32). Tumor size: ≥ 3/4 perimeter (39%), occupying the whole circumference (37.0%), occupying ≥ 1/2 perimeter (15.6%), accounting for 1/4 Perimeter (8.4%). The colon completely narrowed rate: 70.73%., incompletely was 29.27%. Histopathological classification: adenocarcinoma (85.85%), Mucinous adenocarcinoma: (9.27%) and non-differentiated epithelial carcinoma was 4.88%. Conclusion: Colorectal cancer was quite popular and was usually detected at advanced stages.Therefore, screening for subjects with risk factors for early detection and treatment is recommended. Key words: Colorectal cancer, endoscopy, pathogical characteristics...

scholarly journals Role of Multidetector Computerised Tomography in Evaluation of Proptosis

2019 ◽  
Vol 9 (2) ◽  
pp. 24-31
Author(s):  
Elina Shrestha ◽  
Narayan Bikram Thapa ◽  
Shankar Bahadur Singh Rajbhandari
Keyword(s):  
Predictive Value ◽  
Clinical Information ◽  
Cross Sectional Study ◽  
Computerised Tomography ◽  
Cross Sectional ◽  
Female Ratio ◽  
Male Female Ratio ◽  
One Year ◽  
Female Male Female

Introduction: Proptosis is defined as bulging of eye anteriorly out of the orbit. Our main objective was to analyze the pattern of computerised tomographic findings in evaluation of proptosis. Computerised tomography (CT) is noninvasive, easily accessible, affordable and reliable imaging which helps in early diagnosis and prompt treatment. Methods: A descriptive cross sectional study of total 58 patients presenting with proptosis referred to our department of radiology for computerised tomography evaluation during one year period were undertaken into study. The clinical information provided by ophthalmologist also helped our study to derive into conclusion. SPSS version 20 software was used for statistical data analysis. Results: Out of 58 patients, the most common cause of proptosis was neoplasm constituting of 25 cases (43.1%). Retinoblastoma was the commonest orbital tumor. Out of remaining cases, 15 (25.8%) were infective, 14 (24.1%) were inflammatory, two (3.44%) were traumatic and remaining two cases (3.44%) had no definitive cause for proptosis. Bilateral proptosis was commonly associated with thyroid ophthalmopathy. Among the subjects 32 were male, 26 were female. Male: Female ratio was 1:1.23. Age group was ranging from 1 month to 73 years.Mean age was 26.4 ± 22 years. Conclusions: Computerised tomography has an important role in distinguishing the different types of lesions based on their characteristics, location and extension prior to undertaking definitive surgical and medical treatment. Overall accuracy of CT in our study was 81%, sensitivity of 82.6%, specificity of 80.6%, positive predictive value of 76% and negative predictive value of 86.2%.

Migrainous Disorder and its Relation to Migraine Without Aura and Migraine with Aura. A Genetic Epidemiological Study

Cephalalgia ◽  
1996 ◽  
Vol 16 (6) ◽  
pp. 431-435 ◽  
Author(s):  
MB Russell ◽  
J Olesen
Keyword(s):  
Migraine With Aura ◽  
Migraine Without Aura ◽  
International Headache Society ◽  
Large Population ◽  
Population Based ◽  
Population Based Study ◽  
Female Ratio ◽  
First Degree Relatives ◽  
Increased Risk ◽  
Male Female Ratio

Migrainous disorder was analysed in a large population-based study of 4000 forty-year-old males and females. All interviews were conducted by one physician and the diagnostic criteria of the International Headache Society were used. Of the 48 people with migrainous disorder, 40 had migrainous disorder without aura and 9 had migrainous disorder with aura One person had co-occurrence of migrainous disorder with and without aura. The lifetime prevalence of migrainous disorder was 2.5% with a male: female ratio of 1:1.2. The first-degree relatives of probands with migrainous disorder were blindly interviewed. Compared with the general population, first-degree relatives of probands with migrainous disorder without aura had a slightly but less increased risk of migraine without aura than first-degree relatives of probands with migraine without aura. First-degree relatives of probands with migrainous disorder with aura had no increased risk of migraine with aura. We conclude that migrainous disorder without aura in some people is a type of migraine without aura and in other people not. Migrainous disorder with aura may be unrelated to migraine with aura. œ

scholarly journals Papillary Thyroid Cancer, Macrofollicular Variant: The Follow-Up and Analysis of Prognosis of 5 Patients

2014 ◽  
Vol 2014 ◽  
pp. 1-4 ◽  
Author(s):  
Varlık Erol ◽  
Özer Makay ◽  
Yeşim Ertan ◽  
Gökhan İçöz ◽  
Mahir Akyıldız ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Demographic Data ◽  
Pathology Report ◽  
Papillary Cancer ◽  
Female Ratio ◽  
Increased Risk ◽  
Large Populations ◽  
Male Female Ratio ◽  
Prognostic Data

Objective.The main aim of this study was to comparatively analyze the recurrence and prognosis of this rare variant with the literature by analyzing the follow-up data of 5 patients diagnosed with papillary cancer macrofollicular variant.Methods.The demographic data, radiological and pathological data, and prognostic data of 5 patients who underwent surgery for thyroid cancer and were diagnosed with papillary cancer macrofollicular variant pathologically were retrospectively analyzed.Results.The mean age of patients whose mean follow-up period was determined as 7.2 years was 41, and the male/female ratio was 4/1. All patients underwent total thyroidectomy. The pathology report of 2 patients (40%) revealed macrofollicular variant of papillary microcancer, and 3 patients papillary cancer macrofollicular variant. Central dissection was performed in one patient (20%) due to macroscopic pathologic lymph node and 4 metastatic lymph nodes were reported. Also, locoregional recurrence was present in 3 out of 5 patients (60%).Conclusions.Although an impression of earlier and increased risk of recurrence in papillary carcinoma with macrofollicular variant has been documented, more studies with extensive follow-up times and large populations are required.

Correlation between FNAC and Histopathology in the Diagnosis of Thyroid Lesions

2021 ◽  
Vol 27 (1) ◽  
pp. 81-85
Author(s):  
Md Nazmul Haque ◽  
Mahmudul Amin Sakik ◽  
Mohammad Ashequr Rahman Bhuiyan ◽  
Moshammat Fatima Akhter ◽  
Saif Rahman Khan ◽  
...  
Keyword(s):  
Thyroid Gland ◽  
Accurate Method ◽  
Needle Aspiration ◽  
Female Ratio ◽  
Male Female Ratio ◽  
Review Study ◽  
Needle Aspiration Cytology ◽  
Female Male Female ◽  
Record Review ◽  
Thyroid Lesions

Objective: To observe the correlation between fine needle aspiration cytology (FNAC) and Histopathology in the diagnosis of thyroid lesions. Methods:It was a Retrospective record review study .One hundred four (104) Patients with enlarged thyroid gland of both sexes were selected from admitted patients of National institute of ENT, Tejgaon, Dhaka, Duration was from January 2017 to December 2018. Every patients had preoperative FNAC & postoperative histopathology report of thyroid lesions. Results: FNACdiagnosis of thyroid lesions were correlated with histopathology diagnosis. Out of 104 patients 26 were male 78 were female. Male-Female ratio were 1:3.out of 104 patients most Patients were 31 to 40 years of ageGroup.out of 104 cases of FNAC 9 cases were false Cyto-diagnosis. Overall accuracy rate was 91.35%. Conclusion: FNAC is a reliable, safe and relatively accurate method as apreoperative evaluationin thyroid gland swelling before surgery. FNAC has more accuracy in detecting thyroid gland malignancy and therefore it is a reliable diagnostic test for evaluation of thyroid swelling. Bangladesh J Otorhinolaryngol; April 2021; 27(1): 81-85

Assessment of Anti-Asparaginase (ASNase) Antibodies (Ab) and ASNase Activity after Suspected Clinical Allergy.

Blood ◽  
2006 ◽  
Vol 108 (11) ◽  
pp. 1878-1878 ◽  
Author(s):  
Prakash N. Tiwari ◽  
Monica Zielinski ◽  
John J. Quinn ◽  
Stuart E. Siegel ◽  
Paul S. Gaynon ◽  
...  
Keyword(s):  
Lymphoblastic Leukemia ◽  
Negative Control ◽  
Serum Samples ◽  
Anamnestic Response ◽  
Cutaneous Manifestations ◽  
Female Ratio ◽  
Clinical Reaction ◽  
Clinical Allergy ◽  
Increased Risk ◽  
Male Female Ratio

Abstract Background: ASNase is a critical treatment component in childhood acute lymphoblastic leukemia (ALL). As ASNase is a bacterial protein, production of anti-ASNase Ab, often associated with clinical allergy, poses a frequent problem during ASNase therapy. Sixty percent of higher risk ALL patients, who received native ASNase in induction, were Ab(+) by 5 months into therapy (Panosyan et al., 2004). Moreover, 22%–29% of these patients had no clinical allergy (silent hypersensitivity) and were at increased risk for relapse. Patients and Methods: Physicians from 13 institutions submitted samples for 48 children in first remission, aged 14 to 252 months, on various SR or HR ALL protocols with suspected ASNase allergy. The male/female ratio was 1.4. The serum samples were assessed for ASNase activity and anti-ASNase Ab as reported earlier (Avramis, et al., Blood 2002). Ab titer is expressed as the numeric ratio relative to an Ab negative control. Results: Allergic symptoms ranged from localized skin rash and swelling to respiratory difficulties and/or anaphylaxis. Neutralizing anti-PEG-ASNase Ab’s were seen in 41 patients (85%). The results were examined with respect to age, gender, ASNase formulation received, time of post-ASNase administration, and the physician’s clinical observations. Higher Ab ratios > 1.1 correlated with low or no ASNase activity post-PEG-ASNase (46/48 patients) or post-Native ASNase dosing (2 patients). Fourteen patients had cutaneous manifestations (rash, hives, urticaria). All had neutralizing Ab and no enzymatic activity. Nine had higher Ab ratios and 5 had lower Ab ratios. Eight additional patients had localized or generalized swelling; all had higher Ab ratios. Similarly, over the entire CCG-1961 study, 526/1100 patients had a clinical reaction; 476/526 had higher Ab ratios (90%). Conclusions: We found neutralizing Ab in 85% of patients with apparent clinical ASNase allergy. Neutralizing Ab was correlated with lower or absent ASNase activity. Lower Ab ratios may be associated with earlier time points in the anamnestic response. In the remaining 15% of patients with an apparent clinical reaction, we found no Ab and substantial ASNase activity. Monitoring ASNase activity and Ab may be useful for guiding ASNase therapy. Patients with no Ab and substantial activity, might be rechallenged with the same product despite an apparent allergic reaction.

scholarly journals Clinico - epidemiological study of corrosive poisoning by different agents in Dhaka Medical College Hospital

2014 ◽  
Vol 42 (3) ◽  
pp. 78-81
Author(s):  
MSJH Chowdhury ◽  
M Baque ◽  
MTI Islam ◽  
H Ahmed ◽  
MA Faiz ◽  
...  
Keyword(s):  
Acute Poisoning ◽  
Medical College Hospital ◽  
Dominant Group ◽  
College Hospital ◽  
Female Ratio ◽  
Mortality And Morbidity ◽  
Medical College ◽  
Male Female Ratio ◽  
Female Male Female ◽  
Commit Suicide

Acute poisoning is a serious threat to society and one of the commonest causes of mortality and morbidity. The purpose of this study was to have an idea about the pattern of corrosive poisoning and their socio-demographic background. This study was conducted in Dhaka Medical College Hospital over a period of six months from January to June, 2008. The total respondents were 126 in number. All patients, aged 13 years and above with acute corrosive poisoning were included. The results revealed that 23% were male and 77% female. Male, female ratio was 1: 3.34. Age between (13-30) years (88.09%) was the most vulnerable. Most of the patients (45.25%) had a background of secondary education. Students (43.7%) were the dominant group followed by housewives (30.2%). Most of the patients (80.2%) came from urban area. 88.9% attempted to commit suicide. Familial disharmony (75.4%) was the leading motive of poisoning. Twenty five types of corrosive agents were identified; out of which 83.34% cases took either Savlon (51.59%) or Harpic (31.75%). Female is the most vulnerable target who attempted to commit suicide. DOI: http://dx.doi.org/10.3329/bmj.v42i3.19000 Bangladesh Med J. 2013 Sept; 42 (3): 78-81

scholarly journals Diffuse aspiration bronchiolitis: analysis of 20 consecutive patients

2015 ◽  
Vol 41 (2) ◽  
pp. 161-166 ◽  
Author(s):  
Xiaowen Hu ◽  
Eunhee Suh Yi ◽  
Jay Hoon Ryu
Keyword(s):  
Chest Ct ◽  
Predisposing Factors ◽  
Recurrent Pneumonia ◽  
Female Ratio ◽  
Sputum Production ◽  
Increased Risk ◽  
Male Female Ratio ◽  
History Of ◽  
Swallow Study ◽  
Aged Subjects

OBJECTIVE: Aspiration can cause a variety of pulmonary syndromes, some of which are not well recognized. The objective of this study was to assess the demographic, clinical, radiological, and histopathological correlates of diffuse aspiration bronchiolitis (DAB), a bronchiolocentric disorder caused by recurrent aspiration. METHODS: This was a retrospective study of 20 consecutive patients with DAB seen at the Mayo Clinic in Rochester, Minnesota, between January 1, 1998 and June 30, 2014. RESULTS: The median age of the patients was 56.5 years (range, 22-76 years), and the male/female ratio was 2.3:1.0. In 18 patients, the diagnosis of DAB was based on the results of a lung biopsy; in the 2 remaining patients, it was based on clinical and radiological features, together with documented aspiration observed in a videofluoroscopic swallow study. In 19 patients (95%), we identified predisposing factors for aspiration, including gastroesophageal reflux disease (GERD), drug abuse, and dysphagia. Common presenting features included cough, sputum production, dyspnea, and fever. Twelve patients (60%) had a history of recurrent pneumonia. In all of the patients, chest CT revealed bilateral pulmonary infiltrates consisting of micronodules and tree-in-bud opacities. In the majority of patients, interventions aimed at preventing recurrent aspiration (e.g., anti-GERD therapies) led to improvement in the symptoms of DAB. CONCLUSIONS: Young to middle-aged subjects with recognizable predisposing factors for aspiration and who report a history of recurrent pneumonia are at increased risk for DAB. Although DAB is not well recognized, certain chest CT features are characteristic of the disorder.

scholarly journals Increased prevalence of acromegaly in a highly polluted area

2010 ◽  
Vol 163 (4) ◽  
pp. 509-513 ◽  
Author(s):  
S Cannavò ◽  
F Ferraù ◽  
M Ragonese ◽  
L Curtò ◽  
M L Torre ◽  
...  
Keyword(s):  
Environmental Factors ◽  
Industrial Pollution ◽  
Population Based ◽  
Environmental Context ◽  
Environmental Toxins ◽  
Female Ratio ◽  
Pathogenetic Role ◽  
Increased Risk ◽  
Male Female Ratio

ObjectiveDespite the contribution of national registries and population-based reports, data concerning the epidemiology of acromegaly is scanty. In addition, the role of the environmental context has not been investigated.DesignEpidemiology of acromegaly was studied in the province of Messina (Sicily, Italy), focusing on the influence of environmental factors.MethodsFour zones, characterized by different degrees of exposition to environmental toxins due to industrial pollution, were identified in the province: area A (76 338 inhabitants), area B (287 328 inhabitants), area C (243 381 inhabitants), and area D (47 554 inhabitants) at low, middle-low, middle, and high industrial density respectively. We identified all acromegalics who were born and resided in the province of Messina, among patients either referred to our endocrine unit or referred elsewhere but recorded in the archives of the provincial healthcare agency.ResultsIn the province of Messina, we found 64 patients (2 in area A, 24 in area B, 28 in area C, and 10 in area D). Macroadenomas were 60%, the male/female ratio was 1, and mean age at diagnosis (±s.e.m.) was 45.4±1.6 years. Overall, prevalence was 97 c.p.m. in the province (26 c.p.m. in area A, 84 c.p.m. in area B, 115 c.p.m. in area C, and 210 c.p.m. in area D). Risk ratio (RR), calculated in every area assuming area A as a reference, showed an increased risk of developing acromegaly in people residing in area D (RR=8.03; P<0.0014).ConclusionThis study confirms the prevalence of acromegaly reported recently. The increased risk of developing this disease in area D suggests that the pathogenetic role of environmental context needs to be better evaluated.

Suicide in Nógrád County, Hungary, 1970-1994

Crisis ◽  
1999 ◽  
Vol 20 (2) ◽  
pp. 64-70 ◽  
Author(s):  
Tamás Zonda
Keyword(s):  
High Risk ◽  
Psychiatric Disorders ◽  
Suicide Rate ◽  
Risk Groups ◽  
The Elderly ◽  
Female Ratio ◽  
Suicide Notes ◽  
Suicidal Intention ◽  
Male Female Ratio

The author examined completed suicides occurring over a period of 25 years in a county of Hungary with a traditionally low (relatively speaking) suicide rate of 25.8. The rates are clearly higher in villages than in the towns. The male/female ratio was close to 4:1, among elderly though only 1.5:1. The high risk groups are the elderly, divorced, and widowed. Violent methods are chosen in 66.4% of the cases. The rates are particularly high in the period April-July. Prior communication of suicidal intention was revealed in 16.3% of all cases. Previous attempts had been undertaken by 17%, which in turn means that 83% of suicides were first attempts. In our material 10% the victims left suicide notes. Psychiatric disorders were present in 60.1% of the cases, and severe, multiple somatic illnesses (including malignomas) were present in 8.8%. The majority of the data resemble those found in the literature.

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