scholarly journals Moderate Intensity Physical Exercise Decreases Gastrocnemius Caspase-3 Expression on Mus musculus with Statin Treatment

1970 ◽  
Vol 10 (1) ◽  
pp. 30-36
Author(s):  
Junita Jeanne Paliman ◽  
Ratna Darjanti Haryadi ◽  
Rwahita Satyawati Darmanta ◽  
Willy Sandhika ◽  
Martha Kurnia Kusumawardani
Keyword(s):  
Physical Exercise ◽  
Mus Musculus ◽  
Caspase 3 ◽  
Lipid Fraction ◽  
Intervention Group ◽  
Statin Treatment ◽  
Moderate Intensity ◽  
Hmg Coa Reductase Inhibitor ◽  
Coa Reductase ◽  
And Control

ABSTRACTIntroduction: Dyslipidemia is a lipid metabolism abnormality marked by increase or decrease of lipid fraction in the plasma. Statin or 3-Hydroxy-3-Methylglutaryl coenzyme A (HMG-CoA) reductase inhibitor is an important dyslipidemia medication that may induce apoptosis of the skeletal muscle.Decrease of Bcl-2 and Bax ratio causing caspase-9 activation followed by caspase-3 activation occur in apoptosis. Moderate intensity physical exercise (MIPE) decreases DNA fragmentation, increases Bcl-2 protein level and decreases Bax transcript level.Methods: Thirty healthy BALB/C strain Mus musculus divided into 3 groups: first intervention group with statin only treatment (S), second intervention group with statin treatment plus MIPE using motorized treadmill (ST), and control (C) group with no statin and nor exercise. The duration of treatmentwas 28 days. Statin treatment dose was 2.06mg/kg bodyweight. Measurement caspase-3 was done by immunohistochemistry evaluation and the expression of capase-3 was calculated by cells count which expressing caspase-3.Results: There were more muscle cells expressing caspase-3 in the S group (47.00±12.92cells) than the C group (2.70±1.94 cells); p=0.000, the ST group (21.44±10.13 cells) than the C group (p=0.001), as well as S group and the ST group (p=0.000).Conclusion: Moderate intensity physical exercise can decrease caspase-3 expression in statin treated subject.Keywords: apoptosis, caspase-3, dyslipidemia, moderate intensity physical exercise, statin.

Effect of Aquatic Exercise on Sleep Efficiency of Adults With Chronic Musculoskeletal Pain

2021 ◽  
pp. 1-9
Author(s):  
Billy C.L. So ◽  
Sze C. Kwok ◽  
Paul H. Lee
Keyword(s):  
Intervention Group ◽  
Exercise Program ◽  
Sleep Time ◽  
Sleep Efficiency ◽  
Activity Level ◽  
Aquatic Exercise ◽  
Moderate Intensity ◽  
Control Group ◽  
Before And After ◽  
And Control

Background: Aerobic exercise improves sleep for people who have difficulty in sleeping soundly, but most research to date has focused on land-based exercise. There has been only very limited research into the effect of aquatic exercise on people with chronic musculoskeletal (MSK) pain. The purpose of this study is to examine the effect of a 6-week aquatic exercise program on sleep efficiency among adults with chronic MSK pain. Methods: A total of 30 adults with chronic MSK pain were recruited by convenience sampling and assigned into intervention and control groups by a trained research assistant. Their sleep efficiency, sleep quality, activity level, stress level, and pain level were measured with ActiGraph GT3X accelerometer before and after the intervention group completed a 6-week, biweekly program of aquatic exercise. Results: Following intervention, the intervention group had significantly longer total true sleep time (by 27.6 min, P = .006); greater sleep efficiency (+3.01%, P = .005); and less pain (−1.33/10, P = .026). The control group had significantly shorter total true sleep time by 5.8 minutes (P = .036) while changes in the other outcomes were not significant. Conclusions: Six weeks of moderate-intensity aquatic exercise may improve sleep efficiency and reduce pain for persons suffering chronic MSK pain.

scholarly journals Physical Exercise To Recovery of Consciousness in Post Operative Patients With General Anesthesia

2020 ◽  
Vol 9 (2) ◽  
pp. 1223-1229
Author(s):  
Hapipah Hapipah ◽  
Erida Apsarina ◽  
Istianah Istianah
Keyword(s):  
Data Analysis ◽  
Physical Exercise ◽  
General Anesthesia ◽  
Intervention Group ◽  
Control Group ◽  
Group 4 ◽  
Post Surgery ◽  
And Control ◽  
Recovery Of Consciousness

General anesthesia is one of the techniques that is often chosen in performing surgery as a painkiller when going through surgery, followed by loss of consciousness. Early post-surgery there may be aspiration and decreased ventilation. This study aims to find out the effect of physical exercise to recovery of consciousness of post operative patients with general anesthesia. This study is Pre experimental with one shot case study design with 20 respondents. The technique used to collect samples is purposive sampling. Instruments in this study used Aldrete score. The data analysis showed an average difference in the aldrete score scoring of the control and the intervention group (4), (4), (6.1), (7.8), (8.3), (9.3) and (4), (6), (9.3), (9.9), (9.9), (10). The results of the data analysis showed a signification value of 0.000 ( < 0.05), which means there was a difference in consciousness recovery between the intervention group and control group

scholarly journals The Effect of Pilates on Pain in Pregnant Women

2021 ◽  
Author(s):  
bahareh motaghi ◽  
fereshte Aein ◽  
ziba Reisi
Keyword(s):  
Low Back Pain ◽  
Back Pain ◽  
Pregnant Women ◽  
Pelvic Pain ◽  
Intervention Group ◽  
Moderate Intensity ◽  
Low Back ◽  
Double Blind ◽  
And Control ◽  
In Pregnancy

Abstract Background and ObjectivesAlthough pregnancy is a joyful period for most women, the physiological, anatomical, and biochemical changes can cause stress among mothers. low back pain (LBP), and pelvic pain (PP) are common in pregnancy. Also, considering that Pilates also has an effect on reducing LBP during non-pregnancy, in order to promote women's health during pregnancy and reduce economic costs, we decided to measure the effect of Pilates on reducing pain in pregnant women.Materials and MethodsIn the present double-blind randomized clinical trial, the effect of Pilates on reducing pain in pregnancy is investigated. The participants include 60 pregnant women who referred to the health care centers in Shahrekord City. The participants are randomly assigned into the intervention and control groups. The intervention group women, who are at 20 weeks of gestation, are required to attend two Pilates sessions per week for 12 weeks. Each session lasted 30 minutes with moderate intensity. Followed by the intervention, pain assessment was carried out using a visual analog scale (VAS). Data are analyzed using independent t-test in SPSS software version 23. The P-values of <0.05 are statistically significant.ResultsTwo groups are matched in terms of their demographic characteristics prior to the intervention. After the intervention, low back pain (0.001) and pelvic pain (P<0.001) are significantly lower in the intervention than the control group.ConclusionPilates can decrease low back pain and pelvic pain in pregnancy.

scholarly journals SPINNING EXERCISE INTENSITAS SEDANG MENURUNKAN GEJALA DISMENORE PRIMER MAHASISWI DIII KEBIDANAN

2020 ◽  
Vol 8 (1) ◽  
pp. 92
Author(s):  
Hani Oktafiani ◽  
Hadi Susiarno ◽  
Vita Murniarti
Keyword(s):  
Quantitative Research ◽  
Statistical Tests ◽  
Intervention Group ◽  
Moderate Intensity ◽  
Target Area ◽  
Significant Difference ◽  
Post Test ◽  
Quasi Experimental ◽  
Pain Symptoms ◽  
And Control

Some young women including female students in Indonesia are still not free from complaints of dysmenorrhea syndrome. One of the effects of dysmenorrhea is a decrease in learning concentration and daily productivity. Activity that can be pursued is to change lifestyles to be more active in physical exercise, one of which is exercise training. The purpose of this study was to analyze the effect of moderate-intensity spinning exercise on reducing the symptoms of primary dysmenorrhea pain in female college students. This quantitative research uses a quasi-experimental design pre-test post-test design. Studies subjects numbered 32 where the control and intervention groups each consisted of 16 respondents. The intervention that will be given to the intervention group is a moderate intensity spinning exercise for 3 weeks with the FITT principle. The research data were analyzed by Mann Whitney and Wilcoxon statistical tests. The results of the analysis showed a decrease in dysmenorrhea pain symptoms before the intervention there was no significant difference (p> 0.05), whereas after the administration of the intervention showed there were significant differences in the intervention and control groups with a value of p = 0.001. The influence of moderate-intensity spinning exercise can reduce the symptoms of dysmenorrhea pain by 66%. Educational institutions can implement policies on the use of spinning tools in the environment of students and educate these tools to adolescents in the target area given their effective use to reduce menstrual pain.

scholarly journals Physical Exercise and Grip Strength in Patients Intervened through Bariatric Surgery

Aquichan ◽  
2019 ◽  
Vol 19 (3) ◽  
pp. 1-10
Author(s):  
Jéssica Pamela Noack Segovia ◽  
Antonio Sánchez López ◽  
Inmaculada García-García ◽  
Raquel Rodríguez-Blanque ◽  
Ximena Alejandra León Ríos ◽  
...  
Keyword(s):  
Physical Activity ◽  
Bariatric Surgery ◽  
Clinical Trial ◽  
Physical Exercise ◽  
Grip Strength ◽  
Intervention Group ◽  
Exercise Program ◽  
Moderate Intensity ◽  
Control Group ◽  
Moderate Physical Activity

Objective: This work sought to evaluate a physical exercise program of moderate intensity in patients operated of bariatric surgery and its influence on muscle strength. Method: Randomized clinical trial, with an intervention group and a control group. Forty-three patients were operated of bariatric surgery. The intervention group was applied a program of moderate physical activity during six months. Grip strength and bioimpedance were measured at their baseline form, at one month, and six months after surgery. A bivariate study was conducted to observe variable changes. Results: Upon conducting Student´s t for independent samples in all the variables (weight, body mass index, grip strength, lean mass, fat mass, and metabolism), the result is that no significant differences exist between the intervention group and the control group with p > 0.05. Conclusion: A program of moderate physical activity lasting six months in patients intervened of bariatric surgery has no significant result in the development of muscle mass evaluated through manual dynamometry and bioimpedance.

The effect of positive thinking training on the quality of life of parents of adolescent with thalassemia

2019 ◽  
Vol 0 (0) ◽  
Author(s):  
Adeleh Sadeghloo ◽  
Parna Shamsaee ◽  
Elham Hesari ◽  
Golbanhar Akhondzadeh ◽  
Hamid Hojjati
Keyword(s):  
Quality Of Life ◽  
Emotional Health ◽  
Intervention Group ◽  
T Test ◽  
World Health ◽  
Positive Thinking ◽  
Significant Difference ◽  
And Control ◽  
Paired T Test

Abstract Introduction Thalassemia, as the most common chronic hereditary blood disorder in humans, can impose many adverse effects on parents and their affected children. On the other hand, positive thinking is the method or the result of a positive focus on a constructive issue, so by teaching positive thinking, we can improve physical and social function, and promote emotional health and overall quality of life. The aim of this study was to determine the effect of positive thinking training on the quality of life of parents of adolescents with thalassemia. Methods This quasi-experimental study was performed on 52 parents of adolescents with thalassemia who attended Taleghani Hospital in Golestan province, Iran in 2017. Samples were randomly assigned into two groups of intervention and control. The positive thinking training (based on the theory of Martin Seligman) was carried out in the intervention group in 10 (45–60 min) sessions over a 5-week period. Data collection tools in this study were the World Health Organization (WHO) quality of life questionnaire (WHOQOL-BREF) and a demographic information questionnaire. Data were analyzed by SPSS-16 software using independent t-test, the paired t-test and a covariance test. Results The results of paired t-test showed a significant difference in the score of quality of life in intervention group before and after the intervention (p < 0.001). However, this test did not show any significant difference in the control group (p = 0.11). The covariance test, after removing the pre-test score, showed a significant difference between the intervention and control groups in terms of the score of quality of life, so that 13% of the changes after the intervention were due to the intervention (p = 0.009, η = 0.13). Conclusion The positive thinking training increased the quality of life of parents of adolescents with thalassemia. Therefore, using this program can be an effective way of improving the quality of life of parents. Thus, positive thinking training is suggested to be used as an effective strategy for increasing the quality of life of parents with ill children.

scholarly journals A Combination of Lactoplantibacillus plantarum Strains CECT7527, CECT7528 and CECT7529 Plus Monacolin K Reduces Blood Cholesterol: Results from a Randomized, Double-Blind, Placebo-Controlled Study

Nutrients ◽  
2021 ◽  
Vol 13 (4) ◽  
pp. 1206
Author(s):  
Rafael Guerrero-Bonmatty ◽  
Guadalupe Gil-Fernández ◽  
Francisco José Rodríguez-Velasco ◽  
Jordi Espadaler-Mazo
Keyword(s):  
Intervention Group ◽  
Study Groups ◽  
Statin Treatment ◽  
Blood Cholesterol ◽  
Controlled Study ◽  
Controlled Clinical Trial ◽  
Red Yeast Rice ◽  
Monacolin K ◽  
Double Blind ◽  
History Of

Background: Dietary supplements have been proposed to help manage blood cholesterol, including red yeast rice (RYR) extracts, plant sterols and stanols, beta-glucans, and some probiotics. This study was conducted to evaluate the efficacy of RYR (containing 10 mg of monacolin K) combined with 109 CFU of three Lactoplantibacillus plantarum strains (CECT7527, CECT7528, and CECT7529). Methods: A 12-week randomized, double-blinded, placebo-controlled clinical trial was conducted. In total, 39 adult patients were enrolled, having total cholesterol (TC) ≥200 mg/dL, and being statin-naïve or having recently stopped statin treatment because of intolerance. Active product or placebo were taken once daily, and subjects were evaluated at baseline, 6, and 12 weeks. Results: Study groups were comparable at baseline, except for history of recent hypercholesterolemia treatment (81% in active vs. 22% in placebo). Changes in LDL cholesterol and TC became significant compared to placebo (mean difference between groups and standard error of the mean = 23.6 ± 1.5 mg/dL, p = 0.023 and 31.4 ± 1.9 mg/dL, p = 0.011, respectively) upon adjusting for the baseline imbalance in hypercholesterolemia treatment. No adverse effects were noted during the study. Conclusion: This combination of 10 mg of monacolin K and L. plantarum strains was well tolerated and achieved a statistically significant greater reduction in LDL-C and TC in the intervention group compared to the placebo, once adjusting for recent history of hypercholesterolemia treatment.

scholarly journals Effect of Adherence to Physical Exercise on Cardiometabolic Profile in Postmenopausal Women

2021 ◽  
Vol 18 (2) ◽  
pp. 656
Author(s):  
Valentina Bucciarelli ◽  
Francesco Bianco ◽  
Francesco Mucedola ◽  
Andrea Di Blasio ◽  
Pascal Izzicupo ◽  
...  
Keyword(s):  
Physical Exercise ◽  
Diastolic Function ◽  
Postmenopausal Women ◽  
Serum Glucose ◽  
Moderate Intensity ◽  
Adherence Rate ◽  
Before And After ◽  
Estrogen Depletion ◽  
The Impact ◽  
Cardiometabolic Profile

Background: Menopause is associated with negative cardiovascular adaptations related to estrogen depletion, which could be counteracted by physical exercise (PhE). However, the impact of total adherence-rate (TA) to PhE and sedentary time (SedT) on cardiometabolic profile in this population has not been elucidated. Methods: For 13-weeks, 43 women (57.1 ± 4.7 years) participated in a 4-days-a-week moderate-intensity walking training. They underwent laboratory, anthropometric and echocardiographic assessment, before and after training (T0–T1). Spontaneous physical activity (PhA) was assessed with a portable multisensory device. The sample was divided according to TA to PhE program: <70% (n = 17) and ≥70% (n = 26). Results: TA ≥ 70% group experienced a significant T1 improvement of relative wall thickness (RWT), diastolic function, VO2max, cortisol, cortisol/dehydroandrostenedione-sulphate ratio and serum glucose. After adjusting for SedT and 10-min bouts of spontaneous moderate-to-vigorous PhA, TA ≥ 70% showed the most significant absolute change of RWT and diastolic function, body mass index, weight and cortisol. TA ≥ 70% was major predictor of RWT and cortisol improvement. Conclusions: In a group of untrained, postmenopausal women, a high TA to a 13-weeks aerobic PhE program confers a better improvement in cardiometabolic profile, regardless of SedT and PhA levels.

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